Bloodchief Ascension + Mindcrank

Bloodchief Ascension
Mindcrank

Requires
All permanents on the battlefield. Three or more quest counters on Bloodchief Ascension. You have a way to make an opponent lose life.
Steps
  1. Cause one or more opponents to lose life
  2. Mindcrank triggers once for each life loss event, causing that player to mill cards equal to the amount of life lost
  3. Bloodchief Ascension triggers once for each card milled, causing that player to lose 2 life and you to gain 2 life for each trigger
  4. Repeat from step 2
Results
Infinite mill. Near-infinite lifeloss. Near-infinite lifegain. Near-infinite lifegain triggers.