Nekusar, the Mindrazer + Echo of Eons + Tainted Strike Combo

Nekusar on the battlefield.

Echo of Eons and Tainted Strike in hand.

if each opponent has three or more poison counters, or otherwise available

Cast Tainted Strike by paying , giving Nekusar +1/+0 and infect until end of turn.

Cast Echo of Eons by paying , causing each player to discard their hands and draw seven cards.

Nekusar triggers for each card your opponents draw.

Resolve the first trigger, causing the opponent to get a poison counter.

If the opponent has ten or more poison counters, they lose the game as a state-based action.

Repeat from step 4 for each remaining trigger.

If needed, cast Echo of Eons from your graveyard for its flashback cost by paying , causing each player to discard their hands and draw seven cards.

Repeat from step 3.

Each opponent loses the game