Worldfire + Vedalken Orrery + Cauldron Familiar

Worldfire
Vedalken Orrery
Cauldron Familiar

Requires
Worldfire must be in hand. Vedalken Orrery must be on the battlefield. Cauldron Familiar must be in hand. Mana needed: 6
Steps
  1. Cast Cauldron Familiar by paying .
  2. When Cauldron Familiar enters the battlefield, it triggers.
  3. Holding priority, cast Worldfire by paying 6, exiling all permanents, all cards in all hands and graveyards, and setting each player's life total to one.
  4. Resolve the Voldran Epicure trigger from step 2, causing each opponent to lose 1 life and you to gain 1 life.
  5. Each opponent loses the game due to having 0 or less life.
Results
Each opponent loses the game. Exile all cards in all hands and graveyards. Exile all permanents. Near-infinite lifeloss.

The Infamous Cruelclaw
0.05% of 6034 decks 3 decks
Sliver Queen
0.06% of 1546 decks 1 decks
Jenson Carthalion, Druid Exile
0.04% of 2536 decks 1 decks
Megatron, Tyrant
0.02% of 4149 decks 1 decks
Kenrith, the Returned King
0.00% of 23932 decks 1 decks
Yurlok of Scorch Thrash
0.01% of 7386 decks 1 decks
Queen Marchesa
0.01% of 13698 decks 1 decks
Rakdos, the Showstopper
0.08% of 1226 decks 1 decks
Cecily, Haunted Mage
0.22% of 450 decks 1 decks
Florian, Voldaren Scion
0.09% of 1104 decks 1 decks
Jodah, Archmage Eternal
0.01% of 8148 decks 1 decks
New Cards
Mistrise Village
100% of 2 decks +94% synergy
High Synergy Cards
Emergence Zone
85% of 13 decks +82% synergy
Teferi's Protection
100% of 6 decks +81% synergy
Oblivion Ring
67% of 6 decks +66% synergy
Grand Abolisher
67% of 6 decks +58% synergy
Voldaren Epicure
54% of 13 decks +53% synergy
Chandra, Awakened Inferno
46% of 13 decks +45% synergy
End the Festivities
46% of 13 decks +44% synergy
Insatiable Avarice
44% of 9 decks +41% synergy
Blood for the Blood God!
31% of 13 decks +28% synergy
Kaya's Ghostform
31% of 13 decks +27% synergy
Top Cards
Dark Ritual
38% of 13 decks +16% synergy
Phyrexian Arena
31% of 13 decks +15% synergy
Deflecting Swat
31% of 13 decks +14% synergy
Mind Stone
31% of 13 decks +14% synergy
Swiftfoot Boots
31% of 13 decks +3% synergy
Game Changers
Mystical Tutor
100% of 5 decks +86% synergy
Enlightened Tutor
67% of 6 decks +50% synergy
Vampiric Tutor
62% of 13 decks +44% synergy
Jeska's Will
46% of 13 decks +29% synergy
Demonic Tutor
38% of 13 decks +17% synergy
Bolas's Citadel
23% of 13 decks +15% synergy
Creatures
Wizards of Thay
60% of 5 decks +59% synergy
Fiend Hunter
50% of 6 decks +49% synergy
Worldgorger Dragon
23% of 13 decks +22% synergy
Mogis, God of Slaughter
23% of 13 decks +21% synergy
Sheoldred, the Apocalypse
23% of 13 decks +18% synergy
Instants
Flare of Duplication
33% of 9 decks +31% synergy
Big Score
23% of 13 decks +14% synergy
Rakdos Charm
23% of 13 decks +9% synergy
Chaos Warp
23% of 13 decks -8% synergy
Sorceries
Personal Tutor
60% of 5 decks +58% synergy
Cultivate
60% of 5 decks +15% synergy
Doomsday
23% of 13 decks +22% synergy
Decree of Pain
23% of 13 decks +20% synergy
Peer into the Abyss
23% of 13 decks +20% synergy
Wheel of Fortune
23% of 13 decks +18% synergy
Diabolic Intent
23% of 13 decks +15% synergy
Vandalblast
23% of 13 decks +7% synergy
Faithless Looting
23% of 13 decks +7% synergy
Reanimate
23% of 13 decks +6% synergy
Blasphemous Act
23% of 13 decks -10% synergy
Utility Artifacts
Scroll Rack
23% of 13 decks +22% synergy
Lotus Petal
23% of 13 decks +16% synergy
Enchantments
Sylvan Library
60% of 5 decks +49% synergy
Journey to Nowhere
50% of 6 decks +50% synergy
Touch the Spirit Realm
50% of 6 decks +48% synergy
Utility Lands
Ancient Den
50% of 6 decks +45% synergy
Reliquary Tower
46% of 13 decks +16% synergy
Bojuka Bog
38% of 13 decks +9% synergy
Urborg, Tomb of Yawgmoth
31% of 13 decks +21% synergy
Sunscorched Desert
23% of 13 decks +22% synergy
Boseiju, Who Shelters All
23% of 13 decks +22% synergy
Ramunap Ruins
23% of 13 decks +22% synergy
Shivan Gorge
23% of 13 decks +21% synergy
Vault of Whispers
23% of 13 decks +19% synergy
Great Furnace
23% of 13 decks +18% synergy
Rogue's Passage
23% of 13 decks +3% synergy
Mana Artifacts
Arcane Signet
100% of 13 decks +28% synergy
Sol Ring
92% of 13 decks +8% synergy
Chromatic Lantern
38% of 13 decks +29% synergy
Mox Opal
31% of 13 decks +26% synergy
Rakdos Signet
31% of 13 decks +2% synergy
Chromatic Orrery
23% of 13 decks +22% synergy
Thran Dynamo
23% of 13 decks +18% synergy
Fellwar Stone
23% of 13 decks +2% synergy
Lands
Command Tower
92% of 13 decks +18% synergy
Sacred Foundry
83% of 6 decks +48% synergy
Godless Shrine
83% of 6 decks +43% synergy
Morphic Pool
80% of 5 decks +54% synergy
Training Center
80% of 5 decks +53% synergy
Overgrown Tomb
80% of 5 decks +38% synergy
Rejuvenating Springs
75% of 4 decks +47% synergy
Breeding Pool
75% of 4 decks +35% synergy
Luxury Suite
69% of 13 decks +43% synergy
Blood Crypt
69% of 13 decks +31% synergy
Spectator Seating
67% of 6 decks +42% synergy
Vault of Champions
67% of 6 decks +41% synergy
Undergrowth Stadium
60% of 5 decks +34% synergy
Steam Vents
60% of 5 decks +22% synergy
Watery Grave
60% of 5 decks +20% synergy
Myriad Landscape
46% of 13 decks +28% synergy
Sulfurous Springs
46% of 13 decks +25% synergy
Dragonskull Summit
46% of 13 decks +14% synergy
Haunted Ridge
38% of 13 decks +22% synergy
Smoldering Marsh
38% of 13 decks +5% synergy
Talon Gates of Madara
33% of 9 decks +31% synergy
Mount Doom
23% of 13 decks +17% synergy
Mana Confluence
23% of 13 decks +16% synergy
Arid Mesa
23% of 13 decks +13% synergy
Bloodstained Mire
23% of 13 decks +12% synergy
Marsh Flats
23% of 13 decks +12% synergy
Temple of Malice
23% of 13 decks +9% synergy
Terramorphic Expanse
23% of 13 decks +7% synergy
Exotic Orchard
23% of 13 decks -13% synergy