Worldfire + Vedalken Orrery + Cauldron Familiar
Worldfire
Vedalken Orrery
Cauldron Familiar
Requires
Worldfire must be in hand.
Vedalken Orrery must be on the battlefield.
Cauldron Familiar must be in hand.
Mana needed: 
Steps
- Cast Cauldron Familiar by paying .
- When Cauldron Familiar enters the battlefield, it triggers.
- Holding priority, cast Worldfire by paying , exiling all permanents, all cards in all hands and graveyards, and setting each player's life total to one.
- Resolve the Voldran Epicure trigger from step 2, causing each opponent to lose 1 life and you to gain 1 life.
- Each opponent loses the game due to having 0 or less life.
Results
Each opponent loses the game. Exile all cards in all hands and graveyards. Exile all permanents. Near-infinite lifeloss.
The Infamous Cruelclaw
0.07% of 4155 decks
3 decks
Queen Marchesa
0.01% of 12358 decks
1 decks
Yurlok of Scorch Thrash
0.02% of 6101 decks
1 decks
Kenrith, the Returned King
0.00% of 21513 decks
1 decks
Jenson Carthalion, Druid Exile
0.04% of 2454 decks
1 decks
Rakdos, the Showstopper
0.08% of 1230 decks
1 decks
Florian, Voldaren Scion
0.09% of 1143 decks
1 decks
Cecily, Haunted Mage
0.22% of 445 decks
1 decks
Megatron, Tyrant
0.03% of 3902 decks
1 decks
High Synergy Cards
Teferi's Protection
100% of 4 decks
+80% synergy
Emergence Zone
82% of 11 decks
+79% synergy
Voldaren Epicure
45% of 11 decks
+45% synergy
Chandra, Awakened Inferno
45% of 11 decks
+44% synergy
Blood for the Blood God!
44% of 9 decks
+41% synergy
Jeska's Will
55% of 11 decks
+37% synergy
End the Festivities
36% of 11 decks
+34% synergy
Kaya's Ghostform
36% of 11 decks
+32% synergy
Reliquary Tower
55% of 11 decks
+25% synergy
Dark Ritual
45% of 11 decks
+23% synergy
Top Cards
Phyrexian Arena
36% of 11 decks
+22% synergy
Mind Stone
36% of 11 decks
+19% synergy
Swiftfoot Boots
36% of 11 decks
+9% synergy
Creatures
Worldgorger Dragon
27% of 11 decks
+27% synergy
Mogis, God of Slaughter
27% of 11 decks
+25% synergy
Instants
Mystical Tutor
100% of 3 decks
+85% synergy
Enlightened Tutor
75% of 4 decks
+57% synergy
Vampiric Tutor
55% of 11 decks
+36% synergy
Rakdos Charm
27% of 11 decks
+13% synergy
Chaos Warp
27% of 11 decks
-5% synergy
Sorceries
Cultivate
100% of 3 decks
+54% synergy
Decree of Pain
27% of 11 decks
+25% synergy
Vandalblast
27% of 11 decks
+11% synergy
Demonic Tutor
27% of 11 decks
+5% synergy
Blasphemous Act
27% of 11 decks
-6% synergy
Utility Artifacts
Scroll Rack
27% of 11 decks
+26% synergy
Enchantments
Leyline of Anticipation
100% of 3 decks
+95% synergy
Journey to Nowhere
75% of 4 decks
+75% synergy
Oblivion Ring
75% of 4 decks
+74% synergy
Touch the Spirit Realm
75% of 4 decks
+73% synergy
Utility Lands
Bojuka Bog
45% of 11 decks
+15% synergy
Sunscorched Desert
27% of 11 decks
+27% synergy
Shivan Gorge
27% of 11 decks
+26% synergy
Rogue's Passage
27% of 11 decks
+8% synergy
Mana Artifacts
Arcane Signet
100% of 11 decks
+28% synergy
Sol Ring
91% of 11 decks
+6% synergy
Rakdos Signet
36% of 11 decks
+7% synergy
Chromatic Orrery
27% of 11 decks
+26% synergy
Thran Dynamo
27% of 11 decks
+22% synergy
Chromatic Lantern
27% of 11 decks
+18% synergy
Fellwar Stone
27% of 11 decks
+6% synergy
Lands
Command Tower
91% of 11 decks
+17% synergy
Sacred Foundry
75% of 4 decks
+39% synergy
Godless Shrine
75% of 4 decks
+34% synergy
Luxury Suite
64% of 11 decks
+37% synergy
Blood Crypt
64% of 11 decks
+25% synergy
Myriad Landscape
55% of 11 decks
+35% synergy
Dragonskull Summit
55% of 11 decks
+24% synergy
Haunted Ridge
45% of 11 decks
+30% synergy
Smoldering Marsh
45% of 11 decks
+13% synergy
Sulfurous Springs
36% of 11 decks
+16% synergy
Bloodstained Mire
27% of 11 decks
+17% synergy
Arid Mesa
27% of 11 decks
+17% synergy
Marsh Flats
27% of 11 decks
+16% synergy
Temple of Malice
27% of 11 decks
+13% synergy
Terramorphic Expanse
27% of 11 decks
+12% synergy
Exotic Orchard
27% of 11 decks
-8% synergy