Worldfire + Vedalken Orrery + Voldaren Epicure

Worldfire
Vedalken Orrery
Voldaren Epicure

Requires
Worldfire must be in hand. Vedalken Orrery must be on the battlefield. Voldaren Epicure must be in hand. Mana needed: 6
Steps
  1. Cast Voldaren Epicure by paying .
  2. When Voldaren Epicure enters the battlefield, it triggers.
  3. Holding priority, cast Worldfire by paying 6, exiling all permanents, all cards in all hands and graveyards, and setting each player's life total to one.
  4. Resolve the Voldran Epicure trigger from step 2, creating a Blood token and dealing one damage to each opponent.
  5. Each opponent loses the game due to having zero or less life.
Results
Each opponent loses the game. Exile all cards in all hands and graveyards. Exile all permanents. Near-infinite lifeloss.

The Infamous Cruelclaw
0.05% of 4155 decks 2 decks
Kenrith, the Returned King
0.00% of 21513 decks 1 decks
Rowan, Scion of War
0.01% of 8209 decks 1 decks
Mizzix of the Izmagnus
0.02% of 4857 decks 1 decks
Galazeth Prismari
0.03% of 3782 decks 1 decks
Abdel Adrian, Gorion's Ward // Street Urchin
0.49% of 206 decks 1 decks
Cecily, Haunted Mage
0.22% of 445 decks 1 decks
Megatron, Tyrant
0.03% of 3902 decks 1 decks
Immard, the Stormcleaver
0.09% of 1152 decks 1 decks
Hazezon, Shaper of Sand
0.01% of 7646 decks 1 decks
High Synergy Cards
Mystical Tutor
100% of 5 decks +85% synergy
Cauldron Familiar
83% of 6 decks +82% synergy
Teferi's Protection
100% of 5 decks +80% synergy
Barren Glory
80% of 5 decks +80% synergy
Hypersonic Dragon
80% of 5 decks +80% synergy
Emergence Zone
82% of 11 decks +79% synergy
Oblivion Ring
80% of 5 decks +79% synergy
Leyline of Anticipation
80% of 5 decks +75% synergy
End the Festivities
73% of 11 decks +71% synergy
Swan Song
80% of 5 decks +63% synergy
Top Cards
Dark Ritual
83% of 6 decks +61% synergy
Arcane Denial
80% of 5 decks +60% synergy
Brainstorm
80% of 5 decks +59% synergy
Counterspell
80% of 5 decks +37% synergy
Jeska's Will
55% of 11 decks +37% synergy
Worldgorger Dragon
45% of 11 decks +45% synergy
Seething Song
36% of 11 decks +30% synergy
Deflecting Swat
36% of 11 decks +20% synergy
Mind Stone
36% of 11 decks +19% synergy
Blasphemous Act
36% of 11 decks +3% synergy
Creatures
Wizards of Thay
60% of 5 decks +58% synergy
Storm-Kiln Artist
27% of 11 decks +18% synergy
Instants
Vampiric Tutor
83% of 6 decks +65% synergy
Blood for the Blood God!
60% of 5 decks +56% synergy
Enlightened Tutor
60% of 5 decks +42% synergy
Negate
60% of 5 decks +37% synergy
Chaos Warp
27% of 11 decks -5% synergy
Sorceries
Personal Tutor
60% of 5 decks +59% synergy
Ponder
60% of 5 decks +47% synergy
Demonic Tutor
50% of 6 decks +28% synergy
Utility Artifacts
Scroll Rack
27% of 11 decks +26% synergy
Howling Mine
27% of 11 decks +25% synergy
Lightning Greaves
27% of 11 decks +2% synergy
Enchantments
Near-Death Experience
60% of 5 decks +60% synergy
Phyrexian Arena
50% of 6 decks +35% synergy
Outpost Siege
27% of 11 decks +25% synergy
Planeswalkers
Chandra, Awakened Inferno
27% of 11 decks +26% synergy
Utility Lands
Reliquary Tower
45% of 11 decks +16% synergy
Sunscorched Desert
36% of 11 decks +36% synergy
Boseiju, Who Shelters All
27% of 11 decks +27% synergy
Ramunap Ruins
27% of 11 decks +26% synergy
Urborg, Tomb of Yawgmoth
27% of 11 decks +17% synergy
Mana Artifacts
Arcane Signet
100% of 11 decks +28% synergy
Sol Ring
100% of 11 decks +16% synergy
Rakdos Signet
50% of 6 decks +20% synergy
Thought Vessel
36% of 11 decks +20% synergy
Chromatic Orrery
27% of 11 decks +26% synergy
Chromatic Lantern
27% of 11 decks +18% synergy
Lands
Command Tower
73% of 11 decks -1% synergy
Luxury Suite
67% of 6 decks +40% synergy
Training Center
60% of 5 decks +32% synergy
Sulfur Falls
60% of 5 decks +30% synergy
Haunted Ridge
50% of 6 decks +34% synergy
Dragonskull Summit
50% of 6 decks +19% synergy
Smoldering Marsh
50% of 6 decks +18% synergy
Blood Crypt
50% of 6 decks +11% synergy
Scalding Tarn
27% of 11 decks +16% synergy
Myriad Landscape
27% of 11 decks +8% synergy