Wheel of Misfortune + Mindslaver + Teferi, Time Raveler Combo

Wheel of Misfortune in hand.

Mindslaver and Teferi on the battlefield.

available

Activate Teferi's +1 loyalty ability, allowing you to cast sorcery spells whenever you could cast an instant until your next turn.

Activate Mindslaver by paying , tapping it, and sacrificing it, gaining control of them during their next turn.

Move to their turn.

Cast Wheel of Misfortune by paying , selecting an arbitrarily large number for the opponent you control, and dealing that much damage to the opponent if the oponent chose the largest number.

If the opponent didn't choose the largest number, Wheel of Misfortune deals that much damage to each opponent who chose the largest number.

Significant damage to one opponent