Ad Nauseam + Angel's Grace + Skirge Familiar + Pestilence

Ad Nauseam
Angel's Grace
Skirge Familiar
Pestilence

Requires
Ad Nauseam must be in hand. Angel's Grace must be in hand. Skirge Familiar must be on the battlefield. Pestilence must be on the battlefield. The total number of cards in your library and hand is at least equal to the highest life total among your opponents. Mana needed: 3
Steps
  1. Cast Angel's Grace by paying , preventing you from losing the game this turn.
  2. Cast Ad Nauseum by paying 3, putting your entire library in your hand and losing life equal to the total converted mana cost of those cards.
  3. Activate Skirge Familiar many times by discarding your entire hand, adding for each card discarded.
  4. Actviate Pestilence many times by paying each time, dealing 1 damage to each creature and each player each time.
Results
Infinite card draw. Near-infinite black mana. Near-infinite damage.

Selenia, Dark Angel
3.36% of 685 decks 23 decks
Kraum, Ludevic's Opus // Tymna the Weaver
0.03% of 6491 decks 2 decks
Ixhel, Scion of Atraxa
0.01% of 7120 decks 1 decks
Malik, Grim Manipulator
0.04% of 2588 decks 1 decks
Verrak, Warped Sengir
0.10% of 998 decks 1 decks
Queza, Augur of Agonies
0.02% of 6366 decks 1 decks
Chromium, the Mutable
0.08% of 1281 decks 1 decks
Anikthea, Hand of Erebos
0.01% of 10155 decks 1 decks
Marneus Calgar
0.01% of 10468 decks 1 decks
New Cards
Enduring Tenacity
100% of 4 decks +96% synergy
High Synergy Cards
Jace, Wielder of Mysteries
100% of 5 decks +96% synergy
Laboratory Maniac
100% of 5 decks +95% synergy
Sickening Dreams
88% of 32 decks +87% synergy
Phyrexian Unlife
84% of 32 decks +84% synergy
Repay in Kind
75% of 32 decks +75% synergy
Children of Korlis
75% of 32 decks +74% synergy
Peer into the Abyss
72% of 32 decks +69% synergy
Sanguine Bond
72% of 32 decks +66% synergy
Bolas's Citadel
75% of 32 decks +66% synergy
Soul Echo
66% of 32 decks +66% synergy
Top Cards
Swords to Plowshares
88% of 32 decks +25% synergy
Smothering Tithe
84% of 32 decks +59% synergy
Void Rend
80% of 5 decks +65% synergy
Rhystic Study
80% of 5 decks +52% synergy
Counterspell
80% of 5 decks +37% synergy
Lotho, Corrupt Shirriff
75% of 12 decks +60% synergy
Teferi's Protection
75% of 32 decks +55% synergy
Black Market Connections
72% of 29 decks +61% synergy
Toxic Deluge
72% of 32 decks +55% synergy
Dark Ritual
72% of 32 decks +50% synergy
Creatures
Grand Abolisher
69% of 32 decks +60% synergy
Esper Sentinel
69% of 32 decks +48% synergy
Vizkopa Guildmage
62% of 32 decks +60% synergy
Triskaidekaphile
60% of 5 decks +57% synergy
Thassa's Oracle
60% of 5 decks +53% synergy
Wall of Blood
59% of 32 decks +59% synergy
Ranger-Captain of Eos
56% of 32 decks +52% synergy
Vito, Thorn of the Dusk Rose
53% of 32 decks +48% synergy
Dark Confidant
41% of 32 decks +39% synergy
Opposition Agent
41% of 32 decks +33% synergy
Crypt Ghast
34% of 32 decks +29% synergy
Platinum Angel
28% of 32 decks +27% synergy
Myrel, Shield of Argive
22% of 18 decks +19% synergy
Tree of Perdition
19% of 32 decks +18% synergy
Vilis, Broker of Blood
19% of 32 decks +15% synergy
Resolute Archangel
16% of 32 decks +15% synergy
Academy Rector
16% of 32 decks +15% synergy
Kambal, Consul of Allocation
16% of 32 decks +10% synergy
Hex Parasite
12% of 32 decks +12% synergy
Blood Celebrant
12% of 32 decks +12% synergy
Keen Duelist
12% of 32 decks +11% synergy
K'rrik, Son of Yawgmoth
12% of 32 decks +10% synergy
Solemn Simulacrum
12% of 32 decks -2% synergy
Archivist of Oghma
10% of 29 decks +4% synergy
Enduring Angel
10% of 31 decks +9% synergy
Cloudsteel Kirin
10% of 31 decks +9% synergy
Magus of the Mirror
9% of 32 decks +9% synergy
Weathered Wayfarer
9% of 32 decks +6% synergy
Serra Ascendant
9% of 32 decks +5% synergy
Knight of the White Orchid
9% of 32 decks +3% synergy
Drannith Magistrate
9% of 32 decks +3% synergy
Instants
Silence
69% of 32 decks +62% synergy
Enlightened Tutor
69% of 32 decks +51% synergy
Pact of Negation
60% of 5 decks +53% synergy
Mystical Tutor
60% of 5 decks +45% synergy
Swan Song
60% of 5 decks +43% synergy
Dovin's Veto
60% of 5 decks +41% synergy
Anguished Unmaking
59% of 32 decks +35% synergy
Intervention Pact
56% of 32 decks +56% synergy
Vampiric Tutor
56% of 32 decks +38% synergy
Generous Gift
44% of 32 decks +18% synergy
Imp's Mischief
38% of 32 decks +35% synergy
Reprieve
36% of 14 decks +31% synergy
Despark
34% of 32 decks +19% synergy
Mandate of Peace
22% of 32 decks +21% synergy
Tainted Pact
22% of 32 decks +18% synergy
Path to Exile
22% of 32 decks -24% synergy
Mana Tithe
19% of 32 decks +17% synergy
Stunning Reversal
16% of 32 decks +15% synergy
Necrologia
16% of 32 decks +15% synergy
Beacon of Immortality
16% of 32 decks +14% synergy
Faith's Shield
12% of 32 decks +12% synergy
Hatred
12% of 32 decks +12% synergy
Rebuff the Wicked
12% of 32 decks +11% synergy
Heliod's Intervention
12% of 32 decks +9% synergy
Cabal Ritual
12% of 32 decks +8% synergy
Mortify
12% of 32 decks +0% synergy
Plunge into Darkness
9% of 32 decks +9% synergy
Rain of Filth
9% of 32 decks +9% synergy
Demonic Consultation
9% of 32 decks +6% synergy
Fracture
9% of 32 decks +2% synergy
Deadly Rollick
9% of 32 decks -1% synergy
Sorceries
Oketra's Last Mercy
66% of 32 decks +66% synergy
Sign in Blood
62% of 32 decks +53% synergy
Demonic Tutor
62% of 32 decks +40% synergy
Night's Whisper
56% of 32 decks +47% synergy
Damn
56% of 32 decks +40% synergy
Farewell
55% of 31 decks +41% synergy
Grim Tutor
44% of 32 decks +39% synergy
Read the Bones
41% of 32 decks +33% synergy
Dark Petition
28% of 32 decks +27% synergy
Merciless Eviction
28% of 32 decks +23% synergy
Imperial Seal
22% of 32 decks +16% synergy
Exsanguinate
19% of 32 decks +13% synergy
Idyllic Tutor
16% of 32 decks +11% synergy
Wrath of God
16% of 32 decks +9% synergy
Reverse the Sands
12% of 32 decks +12% synergy
Profane Transfusion
12% of 32 decks +12% synergy
Diabolic Tutor
12% of 32 decks +6% synergy
Vindicate
12% of 32 decks +6% synergy
Damnation
12% of 32 decks +4% synergy
Diabolic Intent
12% of 32 decks +4% synergy
Replenish
9% of 32 decks +8% synergy
Revival // Revenge
9% of 32 decks +8% synergy
Profane Tutor
9% of 32 decks +6% synergy
Debt to the Deathless
9% of 32 decks +6% synergy
Torment of Hailfire
9% of 32 decks +4% synergy
Reanimate
9% of 32 decks -6% synergy
Utility Artifacts
Tainted Sigil
66% of 32 decks +65% synergy
Sensei's Divining Top
66% of 32 decks +60% synergy
Wishclaw Talisman
31% of 32 decks +26% synergy
The One Ring
29% of 14 decks +20% synergy
Aetherflux Reservoir
19% of 32 decks +15% synergy
Vedalken Orrery
16% of 32 decks +14% synergy
Wayfarer's Bauble
16% of 32 decks +5% synergy
Mirror Universe
12% of 32 decks +12% synergy
Expedition Map
12% of 32 decks +9% synergy
Enchantments
Necropotence
69% of 32 decks +63% synergy
Exquisite Blood
66% of 32 decks +61% synergy
Phyrexian Arena
66% of 32 decks +51% synergy
Axis of Mortality
62% of 32 decks +62% synergy
Mystic Remora
60% of 5 decks +42% synergy
Near-Death Experience
53% of 32 decks +53% synergy
Ghostly Prison
50% of 32 decks +38% synergy
Land Tax
34% of 32 decks +28% synergy
Tainted Remedy
16% of 32 decks +15% synergy
Dark Tutelage
12% of 32 decks +12% synergy
Blind Obedience
12% of 32 decks +6% synergy
Font of Agonies
9% of 32 decks +9% synergy
Underworld Connections
9% of 32 decks +8% synergy
Greed
9% of 32 decks +7% synergy
Planeswalkers
Gideon of the Trials
16% of 32 decks +15% synergy
Utility Lands
Reliquary Tower
75% of 32 decks +46% synergy
Urborg, Tomb of Yawgmoth
62% of 32 decks +53% synergy
Boseiju, Who Shelters All
47% of 32 decks +46% synergy
Cabal Coffers
47% of 32 decks +36% synergy
Ancient Tomb
44% of 32 decks +33% synergy
Kor Haven
34% of 32 decks +33% synergy
Glacial Chasm
25% of 32 decks +24% synergy
Scavenger Grounds
25% of 32 decks +22% synergy
Bojuka Bog
22% of 32 decks -8% synergy
Lake of the Dead
16% of 32 decks +15% synergy
Maze of Ith
16% of 32 decks +13% synergy
Hall of Heliod's Generosity
16% of 32 decks +9% synergy
Urza's Saga
16% of 32 decks +8% synergy
Leechridden Swamp
12% of 32 decks +11% synergy
Castle Locthwain
12% of 32 decks +7% synergy
Serra's Sanctum
9% of 32 decks +8% synergy
Volrath's Stronghold
9% of 32 decks +8% synergy
Emergence Zone
9% of 32 decks +7% synergy
Vault of Whispers
9% of 32 decks +5% synergy
Ancient Den
9% of 32 decks +4% synergy
War Room
9% of 32 decks +3% synergy
Phyrexian Tower
9% of 32 decks +1% synergy
Mana Artifacts
Sol Ring
97% of 32 decks +12% synergy
Arcane Signet
84% of 32 decks +12% synergy
Talisman of Hierarchy
72% of 32 decks +47% synergy
Orzhov Signet
72% of 32 decks +45% synergy
Fellwar Stone
56% of 32 decks +35% synergy
Thought Vessel
47% of 32 decks +30% synergy
Chrome Mox
41% of 32 decks +34% synergy
Mana Crypt
41% of 32 decks +32% synergy
Mana Vault
38% of 32 decks +31% synergy
Lotus Petal
31% of 32 decks +25% synergy
Mind Stone
22% of 32 decks +4% synergy
Mox Diamond
16% of 32 decks +11% synergy
Mox Opal
12% of 32 decks +8% synergy
Grim Monolith
9% of 32 decks +7% synergy
Gilded Lotus
9% of 32 decks +6% synergy
Thran Dynamo
9% of 32 decks +5% synergy
Jeweled Lotus
9% of 32 decks +3% synergy
Lands
Spectator Seating
100% of 3 decks +75% synergy
Blood Crypt
100% of 3 decks +61% synergy
Command Tower
97% of 32 decks +23% synergy
Godless Shrine
91% of 32 decks +50% synergy
Caves of Koilos
81% of 32 decks +53% synergy
Sea of Clouds
80% of 5 decks +54% synergy
Morphic Pool
80% of 5 decks +54% synergy
Arcane Sanctum
80% of 5 decks +52% synergy
Watery Grave
80% of 5 decks +39% synergy
Hallowed Fountain
80% of 5 decks +39% synergy
Vault of Champions
75% of 32 decks +49% synergy
Marsh Flats
72% of 32 decks +61% synergy
Isolated Chapel
66% of 32 decks +38% synergy
Shadowy Backstreet
62% of 8 decks +49% synergy
Deserted Beach
60% of 5 decks +44% synergy
Raffine's Tower
60% of 5 decks +32% synergy
Tainted Field
59% of 32 decks +46% synergy
Shattered Sanctum
58% of 31 decks +45% synergy
Silent Clearing
47% of 32 decks +42% synergy
Fetid Heath
47% of 32 decks +36% synergy
Verdant Catacombs
44% of 32 decks +32% synergy
Scrubland
41% of 32 decks +27% synergy
Prismatic Vista
38% of 32 decks +32% synergy
City of Brass
38% of 32 decks +29% synergy
Brightclimb Pathway
38% of 32 decks +27% synergy
Bloodstained Mire
38% of 32 decks +27% synergy
Mana Confluence
34% of 32 decks +27% synergy
Polluted Delta
34% of 32 decks +23% synergy
Flooded Strand
31% of 32 decks +21% synergy
Windswept Heath
28% of 32 decks +18% synergy
Arid Mesa
28% of 32 decks +17% synergy
Orzhov Basilica
28% of 32 decks +12% synergy
Exotic Orchard
28% of 32 decks -7% synergy
Reflecting Pool
12% of 32 decks +7% synergy
Temple of Silence
12% of 32 decks -5% synergy
Flagstones of Trokair
9% of 32 decks +8% synergy
Fabled Passage
9% of 32 decks +0% synergy
Shineshadow Snarl
9% of 32 decks -3% synergy
Myriad Landscape
9% of 32 decks -10% synergy