Sephiroth, the Savior (Commander) - Infect

Original Name:

Atraxa, Grand UnifierAtraxa, Grand Unifier

Sephiroth, the Savior
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Enchantments
Battles
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Utility Lands
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Personify
7.7%inclusion1 decks13 decks
7%synergy
High Synergy Cards
Prologue to Phyresis
76%inclusion414 decks547 decks
51%synergy
Vraska's Fall
71%inclusion391 decks547 decks
49%synergy
Infectious Inquiry
70%inclusion383 decks547 decks
47%synergy
Ixhel, Scion of Atraxa
65%inclusion358 decks547 decks
47%synergy
Venerated Rotpriest
66%inclusion363 decks547 decks
46%synergy
Skrelv, Defector Mite
65%inclusion353 decks547 decks
45%synergy
Necrogen Rotpriest
56%inclusion306 decks547 decks
45%synergy
Vishgraz, the Doomhive
55%inclusion301 decks547 decks
42%synergy
Atraxa, Praetors' Voice
45%inclusion247 decks547 decks
42%synergy
White Sun's Twilight
53%inclusion289 decks547 decks
41%synergy
Top Cards
Thrummingbird
59%inclusion325 decks547 decks
28%synergy
Bloated Contaminator
59%inclusion323 decks547 decks
38%synergy
Vraska, Betrayal's Sting
59%inclusion321 decks547 decks
27%synergy
Cankerbloom
59%inclusion321 decks547 decks
38%synergy
Ezuri, Stalker of Spheres
57%inclusion311 decks547 decks
25%synergy
Unnatural Restoration
56%inclusion309 decks547 decks
36%synergy
Infectious Bite
56%inclusion305 decks547 decks
38%synergy
Tekuthal, Inquiry Dominus
54%inclusion295 decks547 decks
16%synergy
Phyresis Outbreak
52%inclusion283 decks547 decks
33%synergy
Norn's Decree
52%inclusion282 decks547 decks
35%synergy
Game Changers
Smothering Tithe
16%inclusion87 decks547 decks
-18%synergy
Rhystic Study
15%inclusion81 decks547 decks
-26%synergy
Cyclonic Rift
12%inclusion65 decks547 decks
-23%synergy
Teferi's Protection
10%inclusion56 decks547 decks
-8%synergy
Demonic Tutor
10%inclusion55 decks547 decks
-26%synergy
Vampiric Tutor
6.9%inclusion38 decks547 decks
-23%synergy
The One Ring
5.5%inclusion30 decks547 decks
-16%synergy
Creatures
Elesh Norn, Mother of Machines
49%inclusion270 decks547 decks
37%synergy
Blightbelly Rat
49%inclusion270 decks547 decks
34%synergy
Tainted Observer
48%inclusion260 decks547 decks
33%synergy
Contaminant Grafter
44%inclusion242 decks547 decks
28%synergy
Voidwing Hybrid
44%inclusion240 decks547 decks
28%synergy
Myr Convert
38%inclusion209 decks547 decks
31%synergy
Phyrexian Censor
37%inclusion201 decks547 decks
30%synergy
Norn's Choirmaster
35%inclusion191 decks547 decks
22%synergy
Evolution Sage
34%inclusion186 decks547 decks
-1%synergy
Tyrranax Rex
33%inclusion183 decks547 decks
24%synergy
Bilious Skulldweller
33%inclusion181 decks547 decks
23%synergy
Elesh Norn
33%inclusion178 decks547 decks
27%synergy
Ichor Rats
32%inclusion174 decks547 decks
13%synergy
Vorinclex, Monstrous Raider
31%inclusion171 decks547 decks
6%synergy
Metastatic Evangel
30%inclusion117 decks395 decks
13%synergy
Elesh Norn, Grand Cenobite
29%inclusion158 decks547 decks
21%synergy
Jin-Gitaxias
28%inclusion152 decks547 decks
23%synergy
Venomous Brutalizer
27%inclusion150 decks547 decks
23%synergy
Sheoldred
27%inclusion147 decks547 decks
21%synergy
Brimaz, Blight of Oreskos
27%inclusion145 decks547 decks
21%synergy
Glissa Sunslayer
27%inclusion145 decks547 decks
22%synergy
Skithiryx, the Blight Dragon
26%inclusion143 decks547 decks
12%synergy
Pestilent Syphoner
26%inclusion142 decks547 decks
18%synergy
Phyrexian Swarmlord
26%inclusion141 decks547 decks
13%synergy
Slaughter Singer
25%inclusion139 decks547 decks
22%synergy
Glissa, Herald of Predation
24%inclusion132 decks547 decks
19%synergy
Sheoldred, Whispering One
23%inclusion128 decks547 decks
19%synergy
Blighted Agent
22%inclusion118 decks547 decks
5%synergy
Paladin of Predation
22%inclusion118 decks547 decks
19%synergy
Vorinclex
21%inclusion117 decks547 decks
18%synergy
Phyrexian Obliterator
21%inclusion117 decks547 decks
19%synergy
Crawling Chorus
21%inclusion116 decks547 decks
17%synergy
Phyrexian Vindicator
21%inclusion116 decks547 decks
19%synergy
Vorinclex, Voice of Hunger
21%inclusion113 decks547 decks
17%synergy
Zopandrel, Hunger Dominus
20%inclusion107 decks547 decks
17%synergy
Jin-Gitaxias, Progress Tyrant
19%inclusion104 decks547 decks
15%synergy
Venser, Corpse Puppet
18%inclusion97 decks547 decks
13%synergy
Sheoldred, the Apocalypse
17%inclusion95 decks547 decks
13%synergy
Scheming Aspirant
16%inclusion90 decks547 decks
10%synergy
Jin-Gitaxias, Core Augur
16%inclusion87 decks547 decks
13%synergy
Jawbone Duelist
16%inclusion87 decks547 decks
14%synergy
Birds of Paradise
15%inclusion83 decks547 decks
-29%synergy
Grafted Butcher
15%inclusion80 decks547 decks
12%synergy
Plague Myr
14%inclusion78 decks547 decks
6%synergy
Glissa's Retriever
13%inclusion72 decks547 decks
10%synergy
Tyrranax Atrocity
13%inclusion72 decks547 decks
11%synergy
Annex Sentry
12%inclusion68 decks547 decks
10%synergy
Roaming Throne
12%inclusion65 decks547 decks
9%synergy
Plague Nurse
12%inclusion64 decks547 decks
10%synergy
Ria Ivor, Bane of Bladehold
12%inclusion63 decks547 decks
10%synergy
Instants
Swords to Plowshares
48%inclusion263 decks547 decks
-11%synergy
Experimental Augury
48%inclusion260 decks547 decks
27%synergy
Reject Imperfection
33%inclusion179 decks547 decks
25%synergy
Counterspell
30%inclusion164 decks547 decks
-1%synergy
Bring the Ending
27%inclusion149 decks547 decks
23%synergy
Whisper of the Dross
26%inclusion140 decks547 decks
19%synergy
Ephemerate
24%inclusion132 decks547 decks
13%synergy
Path to Exile
22%inclusion118 decks547 decks
-10%synergy
Black Sun's Twilight
16%inclusion86 decks547 decks
14%synergy
Serum Snare
15%inclusion82 decks547 decks
10%synergy
Beast Within
15%inclusion81 decks547 decks
3%synergy
Atomize
13%inclusion66 decks519 decks
0%synergy
Anoint with Affliction
12%inclusion67 decks547 decks
10%synergy
Heroic Intervention
12%inclusion67 decks547 decks
-5%synergy
Sheoldred's Edict
12%inclusion65 decks547 decks
10%synergy
Tainted Strike
11%inclusion59 decks547 decks
3%synergy
Radstorm
10%inclusion56 decks547 decks
1%synergy
Mortify
10%inclusion53 decks547 decks
4%synergy
Noxious Revival
10%inclusion53 decks547 decks
1%synergy
Negate
10%inclusion52 decks547 decks
0%synergy
Cloudshift
10%inclusion52 decks547 decks
4%synergy
Assassin's Trophy
9.1%inclusion50 decks547 decks
-11%synergy
Putrefy
8.6%inclusion47 decks547 decks
3%synergy
Dark Ritual
8.4%inclusion46 decks547 decks
-8%synergy
Ghostly Flicker
8.4%inclusion46 decks547 decks
2%synergy
Mana Drain
8.4%inclusion46 decks547 decks
-10%synergy
Momentary Blink
8.2%inclusion45 decks547 decks
4%synergy
Tyvar's Stand
8.2%inclusion45 decks547 decks
7%synergy
Aspirant's Ascent
7.7%inclusion42 decks547 decks
6%synergy
Charge of the Mites
7.5%inclusion41 decks547 decks
7%synergy
Offer Immortality
7.1%inclusion39 decks547 decks
6%synergy
Compleat Devotion
6.4%inclusion35 decks547 decks
6%synergy
Anguished Unmaking
6.2%inclusion34 decks547 decks
-6%synergy
Eerie Interlude
5.3%inclusion29 decks547 decks
0%synergy
An Offer You Can't Refuse
5.1%inclusion28 decks547 decks
-17%synergy
Sorceries
Cultivate
48%inclusion260 decks547 decks
15%synergy
Drown in Ichor
46%inclusion250 decks547 decks
30%synergy
Expand the Sphere
45%inclusion244 decks547 decks
36%synergy
Thirsting Roots
44%inclusion242 decks547 decks
32%synergy
Farseek
41%inclusion227 decks547 decks
2%synergy
Vat Emergence
25%inclusion137 decks547 decks
19%synergy
Tezzeret's Gambit
23%inclusion125 decks547 decks
-6%synergy
Rampant Growth
22%inclusion122 decks547 decks
5%synergy
Distorted Curiosity
21%inclusion115 decks547 decks
16%synergy
Nature's Lore
21%inclusion113 decks547 decks
-5%synergy
Green Sun's Twilight
21%inclusion113 decks547 decks
19%synergy
Kodama's Reach
19%inclusion105 decks547 decks
1%synergy
Three Visits
17%inclusion95 decks547 decks
-4%synergy
Noxious Assault
16%inclusion85 decks547 decks
13%synergy
Geth's Summons
15%inclusion81 decks547 decks
11%synergy
Vivisurgeon's Insight
14%inclusion77 decks547 decks
11%synergy
Sunfall
12%inclusion63 decks547 decks
7%synergy
Carnivorous Canopy
11%inclusion62 decks547 decks
8%synergy
Farewell
11%inclusion60 decks547 decks
-6%synergy
Feed the Infection
11%inclusion58 decks547 decks
9%synergy
Blue Sun's Twilight
10%inclusion57 decks547 decks
9%synergy
Breach the Multiverse
10%inclusion57 decks547 decks
8%synergy
Phyrexian Rebirth
10%inclusion55 decks547 decks
8%synergy
Triumph of the Hordes
7.3%inclusion40 decks547 decks
3%synergy
Skyshroud Claim
6.6%inclusion36 decks547 decks
1%synergy
Contentious Plan
6.2%inclusion34 decks547 decks
-6%synergy
Against All Odds
6.0%inclusion33 decks547 decks
5%synergy
Damn
5.7%inclusion31 decks547 decks
-3%synergy
Supreme Verdict
5.5%inclusion30 decks547 decks
-6%synergy
Merciless Eviction
5.5%inclusion30 decks547 decks
0%synergy
Toxic Deluge
5.3%inclusion29 decks547 decks
-10%synergy
Utility Artifacts
Realmbreaker, the Invasion Tree
26%inclusion140 decks547 decks
22%synergy
Swiftfoot Boots
19%inclusion103 decks547 decks
4%synergy
Lightning Greaves
16%inclusion86 decks547 decks
-3%synergy
Grafted Exoskeleton
13%inclusion72 decks547 decks
8%synergy
Norn's Annex
13%inclusion70 decks547 decks
8%synergy
Infested Fleshcutter
13%inclusion70 decks547 decks
11%synergy
Ichormoon Gauntlet
11%inclusion61 decks547 decks
-1%synergy
Monument to Perfection
11%inclusion60 decks547 decks
10%synergy
Portal to Phyrexia
10%inclusion53 decks547 decks
8%synergy
Conduit of Worlds
8.8%inclusion48 decks547 decks
7%synergy
Panharmonicon
8.8%inclusion48 decks547 decks
1%synergy
Urza's Incubator
8.4%inclusion46 decks547 decks
6%synergy
Prosthetic Injector
8.0%inclusion44 decks547 decks
6%synergy
Contagion Engine
7.5%inclusion41 decks547 decks
-9%synergy
Contagion Clasp
6.9%inclusion38 decks547 decks
-2%synergy
Vat of Rebirth
6.8%inclusion37 decks547 decks
5%synergy
Trailblazer's Boots
5.1%inclusion28 decks547 decks
3%synergy
Enchantments
Phyrexian Arena
46%inclusion249 decks547 decks
31%synergy
Skrelv's Hive
42%inclusion231 decks547 decks
32%synergy
Necrogen Communion
38%inclusion209 decks547 decks
31%synergy
Inexorable Tide
24%inclusion131 decks547 decks
-4%synergy
Phyrexian Awakening
18%inclusion96 decks547 decks
14%synergy
Mesmerizing Dose
14%inclusion74 decks547 decks
11%synergy
Teleportation Circle
13%inclusion72 decks547 decks
6%synergy
Ghostly Prison
12%inclusion65 decks547 decks
2%synergy
Ossification
10%inclusion54 decks547 decks
9%synergy
Phyresis
7.9%inclusion43 decks547 decks
3%synergy
Sculpted Perfection
7.5%inclusion41 decks547 decks
5%synergy
Mystic Remora
6.8%inclusion37 decks547 decks
-21%synergy
Innkeeper's Talent
6.7%inclusion23 decks344 decks
-6%synergy
Brokers Ascendancy
6.0%inclusion33 decks547 decks
-14%synergy
Planar Disruption
5.9%inclusion32 decks547 decks
5%synergy
Propaganda
5.5%inclusion30 decks547 decks
-3%synergy
Battles
Invasion of Zendikar
6.6%inclusion36 decks547 decks
4%synergy
Invasion of Ikoria
5.1%inclusion28 decks547 decks
1%synergy
Planeswalkers
The Eternal Wanderer
26%inclusion143 decks547 decks
15%synergy
Ajani, Sleeper Agent
22%inclusion120 decks547 decks
8%synergy
Nissa, Ascended Animist
20%inclusion108 decks547 decks
15%synergy
Tamiyo, Compleated Sage
7.9%inclusion43 decks547 decks
3%synergy
Kaito, Dancing Shadow
6.0%inclusion33 decks547 decks
5%synergy
Utility Lands
Karn's Bastion
49%inclusion270 decks547 decks
14%synergy
Reliquary Tower
39%inclusion216 decks547 decks
13%synergy
The Fair Basilica
23%inclusion124 decks547 decks
21%synergy
The Hunter Maze
21%inclusion115 decks547 decks
19%synergy
The Dross Pits
19%inclusion103 decks547 decks
17%synergy
The Surgical Bay
19%inclusion103 decks547 decks
17%synergy
Rogue's Passage
12%inclusion68 decks547 decks
1%synergy
Bojuka Bog
12%inclusion67 decks547 decks
1%synergy
Yavimaya, Cradle of Growth
10%inclusion52 decks547 decks
-4%synergy
Inkmoth Nexus
8.4%inclusion46 decks547 decks
1%synergy
Boseiju, Who Endures
7.7%inclusion42 decks547 decks
-20%synergy
Temple of the False God
7.3%inclusion40 decks547 decks
1%synergy
Urborg, Tomb of Yawgmoth
6.2%inclusion34 decks547 decks
-5%synergy
Mistrise Village
6.1%inclusion6 decks98 decks
-3%synergy
The Monumental Facade
5.3%inclusion29 decks547 decks
4%synergy
Otawara, Soaring City
5.3%inclusion29 decks547 decks
-17%synergy
Mana Artifacts
Sol Ring
88%inclusion480 decks547 decks
1%synergy
Arcane Signet
79%inclusion433 decks547 decks
0%synergy
Glistening Sphere
55%inclusion301 decks547 decks
38%synergy
Chromatic Lantern
51%inclusion280 decks547 decks
15%synergy
Phyrexian Atlas
38%inclusion208 decks547 decks
33%synergy
Staff of Compleation
30%inclusion162 decks547 decks
19%synergy
Fellwar Stone
29%inclusion156 decks547 decks
-6%synergy
Commander's Sphere
27%inclusion150 decks547 decks
15%synergy
Thought Vessel
19%inclusion106 decks547 decks
9%synergy
Astral Cornucopia
8.2%inclusion45 decks547 decks
-18%synergy
Everflowing Chalice
7.7%inclusion42 decks547 decks
-15%synergy
Decanter of Endless Water
7.5%inclusion41 decks547 decks
3%synergy
Patchwork Banner
7.3%inclusion25 decks343 decks
6%synergy
Golgari Signet
5.3%inclusion29 decks547 decks
0%synergy
Talisman of Dominance
5.3%inclusion29 decks547 decks
-4%synergy
Talisman of Resilience
5.1%inclusion28 decks547 decks
0%synergy
Lands
Swamp
97%inclusion528 decks547 decks
22%synergy
Forest
97%inclusion528 decks547 decks
19%synergy
Island
96%inclusion524 decks547 decks
19%synergy
Plains
95%inclusion522 decks547 decks
20%synergy
Command Tower
89%inclusion488 decks547 decks
-3%synergy
Exotic Orchard
60%inclusion330 decks547 decks
-5%synergy
Path of Ancestry
52%inclusion286 decks547 decks
28%synergy
The Seedcore
49%inclusion266 decks547 decks
39%synergy
Sandsteppe Citadel
33%inclusion182 decks547 decks
9%synergy
Overgrown Tomb
32%inclusion173 decks547 decks
-14%synergy
Terramorphic Expanse
32%inclusion173 decks547 decks
17%synergy
Breeding Pool
29%inclusion157 decks547 decks
-24%synergy
Spara's Headquarters
28%inclusion152 decks547 decks
-4%synergy
Mirrex
28%inclusion151 decks547 decks
23%synergy
Evolving Wilds
27%inclusion149 decks547 decks
9%synergy
Indatha Triome
27%inclusion148 decks547 decks
-4%synergy
Godless Shrine
27%inclusion147 decks547 decks
-15%synergy
Temple Garden
27%inclusion147 decks547 decks
-17%synergy
Watery Grave
27%inclusion147 decks547 decks
-22%synergy
Hallowed Fountain
26%inclusion144 decks547 decks
-20%synergy
Canopy Vista
26%inclusion142 decks547 decks
10%synergy
Zagoth Triome
25%inclusion137 decks547 decks
-6%synergy
Raffine's Tower
25%inclusion135 decks547 decks
-3%synergy
Opulent Palace
23%inclusion128 decks547 decks
0%synergy
Seachrome Coast
23%inclusion127 decks547 decks
19%synergy
Arcane Sanctum
21%inclusion117 decks547 decks
0%synergy
The Mycosynth Gardens
21%inclusion113 decks547 decks
18%synergy
Seaside Citadel
20%inclusion112 decks547 decks
-2%synergy
Razorverge Thicket
19%inclusion104 decks547 decks
15%synergy
Windswept Heath
19%inclusion104 decks547 decks
-27%synergy
Misty Rainforest
19%inclusion102 decks547 decks
-27%synergy
Polluted Delta
18%inclusion101 decks547 decks
-26%synergy
Verdant Catacombs
18%inclusion100 decks547 decks
-27%synergy
Flooded Strand
18%inclusion99 decks547 decks
-27%synergy
Marsh Flats
18%inclusion97 decks547 decks
-26%synergy
Rejuvenating Springs
17%inclusion95 decks547 decks
-6%synergy
Myriad Landscape
17%inclusion92 decks547 decks
11%synergy
Darkslick Shores
17%inclusion91 decks547 decks
13%synergy
Bountiful Promenade
15%inclusion84 decks547 decks
-4%synergy
Undergrowth Stadium
15%inclusion83 decks547 decks
-5%synergy
Prairie Stream
15%inclusion82 decks547 decks
3%synergy
Morphic Pool
15%inclusion80 decks547 decks
-3%synergy
Vault of Champions
14%inclusion79 decks547 decks
-2%synergy
Sunken Hollow
14%inclusion77 decks547 decks
3%synergy
Sea of Clouds
14%inclusion74 decks547 decks
-6%synergy
Cavern of Souls
12%inclusion68 decks547 decks
2%synergy
Reflecting Pool
12%inclusion64 decks547 decks
-6%synergy
Yavimaya Coast
11%inclusion58 decks547 decks
-2%synergy
Dreamroot Cascade
10%inclusion55 decks547 decks
2%synergy
Dismal Backwater
10%inclusion55 decks547 decks
7%synergy
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