Sephiroth, the Savior (Commander) - Expensive Infect

Original Name:

Atraxa, Grand UnifierAtraxa, Grand Unifier

Sephiroth, the Savior
Rank #74
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Atraxa, Praetors' Voice
67%inclusion36 decks54 decks
63%synergy
Prologue to Phyresis
87%inclusion47 decks54 decks
63%synergy
Phyresis Outbreak
76%inclusion41 decks54 decks
58%synergy
Venerated Rotpriest
78%inclusion42 decks54 decks
57%synergy
Ixhel, Scion of Atraxa
72%inclusion39 decks54 decks
54%synergy
Infectious Inquiry
76%inclusion41 decks54 decks
53%synergy
Skrelv, Defector Mite
72%inclusion39 decks54 decks
53%synergy
Vraska's Fall
74%inclusion40 decks54 decks
52%synergy
Infectious Bite
65%inclusion35 decks54 decks
47%synergy
Elesh Norn, Mother of Machines
57%inclusion31 decks54 decks
45%synergy
Top Cards
Vraska, Betrayal's Sting
67%inclusion36 decks54 decks
35%synergy
Tekuthal, Inquiry Dominus
67%inclusion36 decks54 decks
29%synergy
Vorinclex, Monstrous Raider
65%inclusion35 decks54 decks
39%synergy
Swords to Plowshares
59%inclusion32 decks54 decks
0%synergy
Bloated Contaminator
56%inclusion30 decks54 decks
35%synergy
Farseek
56%inclusion30 decks54 decks
16%synergy
Thrummingbird
56%inclusion30 decks54 decks
25%synergy
Ezuri, Stalker of Spheres
52%inclusion28 decks54 decks
20%synergy
Contaminant Grafter
50%inclusion27 decks54 decks
34%synergy
Three Visits
48%inclusion26 decks54 decks
27%synergy
Game Changers
Rhystic Study
61%inclusion33 decks54 decks
20%synergy
Smothering Tithe
54%inclusion29 decks54 decks
19%synergy
Cyclonic Rift
50%inclusion27 decks54 decks
16%synergy
Demonic Tutor
44%inclusion24 decks54 decks
9%synergy
Vampiric Tutor
39%inclusion21 decks54 decks
9%synergy
Teferi's Protection
37%inclusion20 decks54 decks
19%synergy
The One Ring
28%inclusion15 decks54 decks
6%synergy
Ancient Tomb
24%inclusion13 decks54 decks
3%synergy
Fierce Guardianship
24%inclusion13 decks54 decks
0%synergy
Force of Will
22%inclusion12 decks54 decks
1%synergy
Creatures
Vishgraz, the Doomhive
48%inclusion26 decks54 decks
35%synergy
Skithiryx, the Blight Dragon
48%inclusion26 decks54 decks
34%synergy
Ichor Rats
46%inclusion25 decks54 decks
27%synergy
Elesh Norn, Grand Cenobite
44%inclusion24 decks54 decks
37%synergy
Cankerbloom
43%inclusion23 decks54 decks
22%synergy
Blighted Agent
43%inclusion23 decks54 decks
26%synergy
Metastatic Evangel
42%inclusion18 decks43 decks
25%synergy
Birds of Paradise
41%inclusion22 decks54 decks
-3%synergy
Phyrexian Censor
39%inclusion21 decks54 decks
32%synergy
Sheoldred
39%inclusion21 decks54 decks
33%synergy
Evolution Sage
39%inclusion21 decks54 decks
4%synergy
Jin-Gitaxias, Progress Tyrant
39%inclusion21 decks54 decks
35%synergy
Elesh Norn
37%inclusion20 decks54 decks
31%synergy
Sheoldred, Whispering One
37%inclusion20 decks54 decks
33%synergy
Brimaz, Blight of Oreskos
37%inclusion20 decks54 decks
31%synergy
Tyrranax Rex
35%inclusion19 decks54 decks
26%synergy
Jin-Gitaxias
35%inclusion19 decks54 decks
31%synergy
Sheoldred, the Apocalypse
33%inclusion18 decks54 decks
29%synergy
Vorinclex, Voice of Hunger
33%inclusion18 decks54 decks
29%synergy
Phyrexian Metamorph
30%inclusion16 decks54 decks
19%synergy
Tainted Observer
30%inclusion16 decks54 decks
15%synergy
Necrogen Rotpriest
30%inclusion16 decks54 decks
19%synergy
Norn's Choirmaster
30%inclusion16 decks54 decks
17%synergy
Bloom Tender
28%inclusion15 decks54 decks
4%synergy
Plague Myr
28%inclusion15 decks54 decks
20%synergy
Blightbelly Rat
28%inclusion15 decks54 decks
13%synergy
Roaming Throne
26%inclusion14 decks54 decks
23%synergy
Phyrexian Swarmlord
26%inclusion14 decks54 decks
14%synergy
Y'shtola Rhul
25%inclusion2 decks8 decks
22%synergy
Vorinclex
24%inclusion13 decks54 decks
21%synergy
Myr Convert
24%inclusion13 decks54 decks
17%synergy
Delighted Halfling
24%inclusion13 decks54 decks
-2%synergy
Flux Channeler
22%inclusion12 decks54 decks
0%synergy
Glissa Sunslayer
22%inclusion12 decks54 decks
18%synergy
Zopandrel, Hunger Dominus
22%inclusion12 decks54 decks
19%synergy
Glissa, Herald of Predation
22%inclusion12 decks54 decks
17%synergy
Esper Sentinel
20%inclusion11 decks54 decks
-9%synergy
Jin-Gitaxias, Core Augur
20%inclusion11 decks54 decks
17%synergy
Gix, Yawgmoth Praetor
20%inclusion11 decks54 decks
19%synergy
Voidwing Hybrid
19%inclusion10 decks54 decks
3%synergy
Phyrexian Obliterator
19%inclusion10 decks54 decks
16%synergy
Displacer Kitten
15%inclusion8 decks54 decks
1%synergy
Blightsteel Colossus
15%inclusion8 decks54 decks
12%synergy
Dreamtide Whale
14%inclusion6 decks43 decks
-4%synergy
Venser, Corpse Puppet
13%inclusion7 decks54 decks
9%synergy
Noble Hierarch
13%inclusion7 decks54 decks
-14%synergy
Phyrexian Crusader
13%inclusion7 decks54 decks
8%synergy
Phyrexian Vindicator
13%inclusion7 decks54 decks
10%synergy
Yawgmoth, Thran Physician
13%inclusion7 decks54 decks
10%synergy
Plague Nurse
13%inclusion7 decks54 decks
11%synergy
Instants
Mana Drain
48%inclusion26 decks54 decks
30%synergy
Experimental Augury
39%inclusion21 decks54 decks
19%synergy
Ephemerate
35%inclusion19 decks54 decks
24%synergy
Counterspell
33%inclusion18 decks54 decks
2%synergy
Heroic Intervention
31%inclusion17 decks54 decks
14%synergy
Tainted Strike
30%inclusion16 decks54 decks
22%synergy
Path to Exile
30%inclusion16 decks54 decks
-2%synergy
Swan Song
20%inclusion11 decks54 decks
-5%synergy
Enlightened Tutor
20%inclusion11 decks54 decks
-5%synergy
Worldly Tutor
19%inclusion10 decks54 decks
0%synergy
Arcane Denial
17%inclusion9 decks54 decks
8%synergy
Assassin's Trophy
17%inclusion9 decks54 decks
-3%synergy
Dark Ritual
17%inclusion9 decks54 decks
0%synergy
Radstorm
17%inclusion9 decks54 decks
7%synergy
Anguished Unmaking
17%inclusion9 decks54 decks
5%synergy
Dawn's Truce
15%inclusion6 decks41 decks
13%synergy
An Offer You Can't Refuse
13%inclusion7 decks54 decks
-9%synergy
Whisper of the Dross
13%inclusion7 decks54 decks
7%synergy
Noxious Revival
13%inclusion7 decks54 decks
5%synergy
Force of Negation
13%inclusion7 decks54 decks
-6%synergy
Mystical Tutor
13%inclusion7 decks54 decks
-1%synergy
Atomize
11%inclusion6 decks54 decks
-1%synergy
Beast Within
11%inclusion6 decks54 decks
-1%synergy
Cloudshift
11%inclusion6 decks54 decks
5%synergy
Ghostly Flicker
11%inclusion6 decks54 decks
5%synergy
Brokers Confluence
9.3%inclusion5 decks54 decks
3%synergy
Eerie Interlude
7.4%inclusion4 decks54 decks
2%synergy
Abrupt Decay
7.4%inclusion4 decks54 decks
-7%synergy
Reject Imperfection
7.4%inclusion4 decks54 decks
-1%synergy
Momentary Blink
7.4%inclusion4 decks54 decks
3%synergy
Pact of Negation
7.4%inclusion4 decks54 decks
-10%synergy
Strix Serenade
7.0%inclusion3 decks43 decks
4%synergy
Deadly Rollick
5.6%inclusion3 decks54 decks
-7%synergy
Negate
5.6%inclusion3 decks54 decks
-4%synergy
Flawless Maneuver
5.6%inclusion3 decks54 decks
3%synergy
Black Sun's Twilight
5.6%inclusion3 decks54 decks
4%synergy
Aspirant's Ascent
5.6%inclusion3 decks54 decks
4%synergy
Harrow
5.6%inclusion3 decks54 decks
4%synergy
Demonic Consultation
5.6%inclusion3 decks54 decks
-11%synergy
Serum Snare
5.6%inclusion3 decks54 decks
0%synergy
Sorceries
White Sun's Twilight
48%inclusion26 decks54 decks
36%synergy
Unnatural Restoration
46%inclusion25 decks54 decks
26%synergy
Nature's Lore
41%inclusion22 decks54 decks
15%synergy
Tezzeret's Gambit
39%inclusion21 decks54 decks
10%synergy
Cultivate
37%inclusion20 decks54 decks
4%synergy
Drown in Ichor
31%inclusion17 decks54 decks
16%synergy
Expand the Sphere
30%inclusion16 decks54 decks
21%synergy
Toxic Deluge
24%inclusion13 decks54 decks
9%synergy
Thirsting Roots
22%inclusion12 decks54 decks
10%synergy
Triumph of the Hordes
20%inclusion11 decks54 decks
16%synergy
Farewell
19%inclusion10 decks54 decks
1%synergy
Kodama's Reach
17%inclusion9 decks54 decks
-1%synergy
Fated Clash
17%inclusion1 decks6 decks
17%synergy
Rampant Growth
15%inclusion8 decks54 decks
-2%synergy
Reanimate
13%inclusion7 decks54 decks
5%synergy
Supreme Verdict
11%inclusion6 decks54 decks
-1%synergy
Skyshroud Claim
11%inclusion6 decks54 decks
5%synergy
Geth's Summons
11%inclusion6 decks54 decks
7%synergy
Breach the Multiverse
11%inclusion6 decks54 decks
9%synergy
Sunfall
11%inclusion6 decks54 decks
6%synergy
Green Sun's Twilight
9.3%inclusion5 decks54 decks
8%synergy
Contentious Plan
9.3%inclusion5 decks54 decks
-3%synergy
Culling Ritual
9.3%inclusion5 decks54 decks
-5%synergy
Imperial Seal
9.3%inclusion5 decks54 decks
-4%synergy
Raise the Palisade
7.4%inclusion4 decks54 decks
7%synergy
Vat Emergence
5.6%inclusion3 decks54 decks
0%synergy
Noxious Assault
5.6%inclusion3 decks54 decks
3%synergy
Utility Artifacts
Realmbreaker, the Invasion Tree
37%inclusion20 decks54 decks
34%synergy
Lightning Greaves
26%inclusion14 decks54 decks
8%synergy
Urza's Incubator
24%inclusion13 decks54 decks
22%synergy
Portal to Phyrexia
19%inclusion10 decks54 decks
17%synergy
The Great Henge
17%inclusion9 decks54 decks
10%synergy
Swiftfoot Boots
13%inclusion7 decks54 decks
-2%synergy
Buster Sword
13%inclusion1 decks8 decks
12%synergy
Insight Engine
13%inclusion1 decks8 decks
8%synergy
The Dominion Bracelet
13%inclusion1 decks8 decks
12%synergy
Contagion Engine
11%inclusion6 decks54 decks
-5%synergy
Dragonfire Blade
10%inclusion1 decks10 decks
9%synergy
Sword of Truth and Justice
9.3%inclusion5 decks54 decks
0%synergy
Ichormoon Gauntlet
9.3%inclusion5 decks54 decks
-3%synergy
Conjurer's Closet
9.3%inclusion5 decks54 decks
4%synergy
Grafted Exoskeleton
9.3%inclusion5 decks54 decks
4%synergy
Panharmonicon
7.4%inclusion4 decks54 decks
0%synergy
Norn's Annex
7.4%inclusion4 decks54 decks
2%synergy
Wishclaw Talisman
5.6%inclusion3 decks54 decks
-5%synergy
Birthing Pod
5.6%inclusion3 decks54 decks
3%synergy
Enchantments
Norn's Decree
46%inclusion25 decks54 decks
30%synergy
Phyrexian Arena
41%inclusion22 decks54 decks
26%synergy
Skrelv's Hive
37%inclusion20 decks54 decks
27%synergy
Inexorable Tide
35%inclusion19 decks54 decks
7%synergy
Necrogen Communion
19%inclusion10 decks54 decks
12%synergy
Teleportation Circle
19%inclusion10 decks54 decks
12%synergy
Mystic Remora
17%inclusion9 decks54 decks
-11%synergy
Phyresis
15%inclusion8 decks54 decks
10%synergy
Sylvan Library
13%inclusion7 decks54 decks
2%synergy
Sphere Grid
13%inclusion1 decks8 decks
10%synergy
Innkeeper's Talent
12%inclusion5 decks41 decks
0%synergy
Brokers Ascendancy
11%inclusion6 decks54 decks
-9%synergy
Food Chain
11%inclusion6 decks54 decks
5%synergy
Doubling Season
9.3%inclusion5 decks54 decks
-10%synergy
Exploration
7.4%inclusion4 decks54 decks
4%synergy
Wild Growth
7.4%inclusion4 decks54 decks
4%synergy
Mirari's Wake
7.4%inclusion4 decks54 decks
2%synergy
Ghostly Prison
7.4%inclusion4 decks54 decks
-2%synergy
Lurking Predators
5.6%inclusion3 decks54 decks
5%synergy
Phyrexian Reclamation
5.6%inclusion3 decks54 decks
4%synergy
Burgeoning
5.6%inclusion3 decks54 decks
4%synergy
Glistening Oil
5.6%inclusion3 decks54 decks
5%synergy
Corrupted Conscience
5.6%inclusion3 decks54 decks
2%synergy
Trouble in Pairs
5.6%inclusion3 decks54 decks
3%synergy
Battles
Invasion of Ikoria
9.3%inclusion5 decks54 decks
5%synergy
Invasion of Shandalar
5.6%inclusion3 decks54 decks
4%synergy
Planeswalkers
Ajani, Sleeper Agent
37%inclusion20 decks54 decks
23%synergy
The Eternal Wanderer
17%inclusion9 decks54 decks
5%synergy
Nissa, Ascended Animist
7.4%inclusion4 decks54 decks
3%synergy
Tamiyo, Compleated Sage
5.6%inclusion3 decks54 decks
0%synergy
Aminatou, the Fateshifter
5.6%inclusion3 decks54 decks
0%synergy
Tamiyo, Field Researcher
5.6%inclusion3 decks54 decks
-10%synergy
Teferi, Time Raveler
5.6%inclusion3 decks54 decks
-11%synergy
Utility Lands
Karn's Bastion
61%inclusion33 decks54 decks
25%synergy
Reliquary Tower
54%inclusion29 decks54 decks
27%synergy
Yavimaya, Cradle of Growth
31%inclusion17 decks54 decks
18%synergy
Boseiju, Who Endures
31%inclusion17 decks54 decks
4%synergy
Inkmoth Nexus
26%inclusion14 decks54 decks
18%synergy
Urborg, Tomb of Yawgmoth
26%inclusion14 decks54 decks
14%synergy
Evendo, Waking Haven
13%inclusion1 decks8 decks
11%synergy
Three Tree City
12%inclusion5 decks42 decks
11%synergy
Otawara, Soaring City
11%inclusion6 decks54 decks
-11%synergy
Rogue's Passage
11%inclusion6 decks54 decks
0%synergy
Mistrise Village
10%inclusion1 decks10 decks
1%synergy
Cabal Coffers
9.3%inclusion5 decks54 decks
8%synergy
Urza's Saga
9.3%inclusion5 decks54 decks
5%synergy
Bojuka Bog
5.6%inclusion3 decks54 decks
-6%synergy
Phyrexian Tower
5.6%inclusion3 decks54 decks
4%synergy
Gaea's Cradle
5.6%inclusion3 decks54 decks
-7%synergy
Command Beacon
5.6%inclusion3 decks54 decks
3%synergy
Mana Artifacts
Sol Ring
96%inclusion52 decks54 decks
9%synergy
Arcane Signet
85%inclusion46 decks54 decks
6%synergy
Glistening Sphere
63%inclusion34 decks54 decks
45%synergy
Chromatic Lantern
48%inclusion26 decks54 decks
12%synergy
Staff of Compleation
31%inclusion17 decks54 decks
21%synergy
Fellwar Stone
31%inclusion17 decks54 decks
-3%synergy
Thought Vessel
22%inclusion12 decks54 decks
12%synergy
Chrome Mox
19%inclusion10 decks54 decks
-1%synergy
Jeweled Lotus
15%inclusion8 decks54 decks
12%synergy
Lotus Petal
15%inclusion8 decks54 decks
-5%synergy
Mana Crypt
15%inclusion8 decks54 decks
10%synergy
Talisman of Resilience
13%inclusion7 decks54 decks
8%synergy
Talisman of Dominance
13%inclusion7 decks54 decks
4%synergy
Mana Vault
13%inclusion7 decks54 decks
-5%synergy
Mox Opal
13%inclusion7 decks54 decks
4%synergy
Mox Amber
13%inclusion7 decks54 decks
-1%synergy
Talisman of Curiosity
11%inclusion6 decks54 decks
3%synergy
Talisman of Hierarchy
11%inclusion6 decks54 decks
7%synergy
Mox Diamond
11%inclusion6 decks54 decks
-5%synergy
Herd Heirloom
10%inclusion1 decks10 decks
9%synergy
Astral Cornucopia
9.3%inclusion5 decks54 decks
-17%synergy
Talisman of Progress
7.4%inclusion4 decks54 decks
1%synergy
Everflowing Chalice
7.4%inclusion4 decks54 decks
-15%synergy
Phyrexian Atlas
7.4%inclusion4 decks54 decks
2%synergy
Talisman of Unity
5.6%inclusion3 decks54 decks
2%synergy
Decanter of Endless Water
5.6%inclusion3 decks54 decks
1%synergy
Lands
Command Tower
96%inclusion52 decks54 decks
4%synergy
Breeding Pool
83%inclusion45 decks54 decks
31%synergy
Hallowed Fountain
83%inclusion45 decks54 decks
37%synergy
Swamp
81%inclusion44 decks54 decks
6%synergy
Forest
81%inclusion44 decks54 decks
4%synergy
Island
80%inclusion43 decks54 decks
2%synergy
Godless Shrine
80%inclusion43 decks54 decks
38%synergy
Overgrown Tomb
78%inclusion42 decks54 decks
32%synergy
Plains
76%inclusion41 decks54 decks
1%synergy
Temple Garden
76%inclusion41 decks54 decks
32%synergy
Windswept Heath
74%inclusion40 decks54 decks
28%synergy
Watery Grave
74%inclusion40 decks54 decks
25%synergy
Flooded Strand
74%inclusion40 decks54 decks
29%synergy
Misty Rainforest
70%inclusion38 decks54 decks
25%synergy
Polluted Delta
70%inclusion38 decks54 decks
26%synergy
Verdant Catacombs
67%inclusion36 decks54 decks
21%synergy
Exotic Orchard
63%inclusion34 decks54 decks
-2%synergy
Marsh Flats
61%inclusion33 decks54 decks
17%synergy
Indatha Triome
54%inclusion29 decks54 decks
23%synergy
Spara's Headquarters
52%inclusion28 decks54 decks
20%synergy
Zagoth Triome
52%inclusion28 decks54 decks
21%synergy
Cavern of Souls
46%inclusion25 decks54 decks
35%synergy
Tropical Island
44%inclusion24 decks54 decks
19%synergy
Raffine's Tower
44%inclusion24 decks54 decks
17%synergy
Savannah
44%inclusion24 decks54 decks
19%synergy
Mana Confluence
43%inclusion23 decks54 decks
12%synergy
Bountiful Promenade
41%inclusion22 decks54 decks
22%synergy
Rejuvenating Springs
41%inclusion22 decks54 decks
17%synergy
City of Brass
39%inclusion21 decks54 decks
8%synergy
Undergrowth Stadium
39%inclusion21 decks54 decks
19%synergy
Bayou
39%inclusion21 decks54 decks
14%synergy
Tundra
37%inclusion20 decks54 decks
12%synergy
Morphic Pool
37%inclusion20 decks54 decks
19%synergy
Vault of Champions
37%inclusion20 decks54 decks
21%synergy
Sea of Clouds
35%inclusion19 decks54 decks
16%synergy
Path of Ancestry
35%inclusion19 decks54 decks
11%synergy
Scrubland
35%inclusion19 decks54 decks
11%synergy
Underground Sea
33%inclusion18 decks54 decks
9%synergy
The Seedcore
33%inclusion18 decks54 decks
24%synergy
Reflecting Pool
31%inclusion17 decks54 decks
14%synergy
Bloodstained Mire
24%inclusion13 decks54 decks
7%synergy
Scalding Tarn
20%inclusion11 decks54 decks
1%synergy
Sandsteppe Citadel
19%inclusion10 decks54 decks
-6%synergy
Wooded Foothills
19%inclusion10 decks54 decks
1%synergy
Arid Mesa
19%inclusion10 decks54 decks
6%synergy
Mirrex
15%inclusion8 decks54 decks
10%synergy
Gemstone Caverns
15%inclusion8 decks54 decks
-2%synergy
Gemstone Mine
13%inclusion7 decks54 decks
7%synergy
Seaside Citadel
13%inclusion7 decks54 decks
-9%synergy
Arcane Sanctum
13%inclusion7 decks54 decks
-9%synergy
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