Worldfire + Vedalken Orrery + Voldaren Epicure

Worldfire
Vedalken Orrery
Voldaren Epicure

Requires
Worldfire must be in hand. Vedalken Orrery must be on the battlefield. Voldaren Epicure must be in hand. Mana needed: 6
Steps
  1. Cast Voldaren Epicure by paying .
  2. When Voldaren Epicure enters the battlefield, it triggers.
  3. Holding priority, cast Worldfire by paying 6, exiling all permanents, all cards in all hands and graveyards, and setting each player's life total to one.
  4. Resolve the Voldran Epicure trigger from step 2, creating a Blood token and dealing one damage to each opponent.
  5. Each opponent loses the game due to having zero or less life.
Results
Each opponent loses the game. Exile all cards in all hands and graveyards. Exile all permanents. Near-infinite lifeloss.

The Infamous Cruelclaw
0.04% of 4471 decks 2 decks
Abdel Adrian, Gorion's Ward // Street Urchin
0.88% of 228 decks 2 decks
Mishra, Eminent One
0.01% of 7351 decks 1 decks
Rakdos, Lord of Riots
0.01% of 7498 decks 1 decks
Cecily, Haunted Mage
0.23% of 442 decks 1 decks
Hazezon, Shaper of Sand
0.01% of 7746 decks 1 decks
Galazeth Prismari
0.03% of 3803 decks 1 decks
Megatron, Tyrant
0.03% of 3864 decks 1 decks
Immard, the Stormcleaver
0.09% of 1157 decks 1 decks
Rowan, Scion of War
0.01% of 8452 decks 1 decks
Kenrith, the Returned King
0.00% of 21730 decks 1 decks
Mizzix of the Izmagnus
0.02% of 4902 decks 1 decks
Aragorn, the Uniter
0.01% of 17049 decks 1 decks
High Synergy Cards
Oblivion Ring
86% of 7 decks +85% synergy
Barren Glory
71% of 7 decks +71% synergy
Emergence Zone
73% of 15 decks +71% synergy
Leyline of Anticipation
71% of 7 decks +67% synergy
Teferi's Protection
86% of 7 decks +66% synergy
Cauldron Familiar
62% of 8 decks +61% synergy
Hypersonic Dragon
57% of 7 decks +57% synergy
Mystical Tutor
71% of 7 decks +56% synergy
Personal Tutor
57% of 7 decks +56% synergy
End the Festivities
53% of 15 decks +51% synergy
Top Cards
Counterspell
71% of 7 decks +29% synergy
Dark Ritual
62% of 8 decks +40% synergy
Swan Song
57% of 7 decks +41% synergy
Arcane Denial
57% of 7 decks +37% synergy
Brainstorm
57% of 7 decks +36% synergy
Jeska's Will
40% of 15 decks +23% synergy
Worldgorger Dragon
33% of 15 decks +33% synergy
Deflecting Swat
33% of 15 decks +17% synergy
Mind Stone
33% of 15 decks +16% synergy
Blasphemous Act
33% of 15 decks -0% synergy
Creatures
Tidal Barracuda
43% of 7 decks +42% synergy
Wizards of Thay
43% of 7 decks +41% synergy
Spellseeker
43% of 7 decks +39% synergy
Solemn Simulacrum
27% of 15 decks +13% synergy
Goblin Chainwhirler
20% of 15 decks +19% synergy
Storm-Kiln Artist
20% of 15 decks +11% synergy
Instants
Vampiric Tutor
75% of 8 decks +57% synergy
Blood for the Blood God!
43% of 7 decks +39% synergy
Enlightened Tutor
43% of 7 decks +25% synergy
Negate
43% of 7 decks +20% synergy
Generous Gift
43% of 7 decks +17% synergy
Path to Exile
43% of 7 decks -3% synergy
Bedevil
38% of 8 decks +23% synergy
Seething Song
27% of 15 decks +21% synergy
Chaos Warp
27% of 15 decks -5% synergy
Big Score
21% of 14 decks +12% synergy
Tibalt's Trickery
20% of 15 decks +14% synergy
Sorceries
Demonic Tutor
62% of 8 decks +40% synergy
Farewell
50% of 6 decks +37% synergy
Idyllic Tutor
43% of 7 decks +38% synergy
Ponder
43% of 7 decks +30% synergy
Toxic Deluge
38% of 8 decks +20% synergy
Overmaster
27% of 15 decks +26% synergy
Vandalblast
20% of 15 decks +4% synergy
Utility Artifacts
Lightning Greaves
27% of 15 decks +1% synergy
Scroll Rack
20% of 15 decks +18% synergy
Howling Mine
20% of 15 decks +18% synergy
Sensei's Divining Top
20% of 15 decks +15% synergy
Swiftfoot Boots
20% of 15 decks -8% synergy
Enchantments
Tocasia's Welcome
60% of 5 decks +56% synergy
Near-Death Experience
43% of 7 decks +43% synergy
Phyrexian Arena
38% of 8 decks +22% synergy
Outpost Siege
27% of 15 decks +24% synergy
Planeswalkers
Chandra, Awakened Inferno
20% of 15 decks +19% synergy
Utility Lands
Reliquary Tower
47% of 15 decks +17% synergy
Sunscorched Desert
27% of 15 decks +26% synergy
Urborg, Tomb of Yawgmoth
27% of 15 decks +17% synergy
Boseiju, Who Shelters All
20% of 15 decks +19% synergy
Ramunap Ruins
20% of 15 decks +19% synergy
Command Beacon
20% of 15 decks +15% synergy
Great Furnace
20% of 15 decks +14% synergy
Mana Artifacts
Sol Ring
100% of 15 decks +16% synergy
Arcane Signet
93% of 15 decks +21% synergy
Rakdos Signet
50% of 8 decks +20% synergy
Boros Signet
43% of 7 decks +19% synergy
Chromatic Lantern
27% of 15 decks +17% synergy
Thought Vessel
27% of 15 decks +10% synergy
Fellwar Stone
27% of 15 decks +6% synergy
Chromatic Orrery
20% of 15 decks +18% synergy
Thran Dynamo
20% of 15 decks +15% synergy
Commander's Sphere
20% of 15 decks +5% synergy
Lands
Command Tower
80% of 15 decks +6% synergy
Luxury Suite
62% of 8 decks +36% synergy
Smoldering Marsh
62% of 8 decks +30% synergy
Haunted Ridge
50% of 8 decks +34% synergy
Blood Crypt
50% of 8 decks +11% synergy
Stormcarved Coast
43% of 7 decks +25% synergy
Training Center
43% of 7 decks +15% synergy
Sulfur Falls
43% of 7 decks +12% synergy
Steam Vents
43% of 7 decks +4% synergy
Blightstep Pathway
38% of 8 decks +28% synergy
Shadowblood Ridge
38% of 8 decks +26% synergy
Dragonskull Summit
38% of 8 decks +7% synergy
Myriad Landscape
27% of 15 decks +7% synergy
Bloodstained Mire
20% of 15 decks +10% synergy
Scalding Tarn
20% of 15 decks +9% synergy
Terramorphic Expanse
20% of 15 decks +4% synergy