Venom, King in Black (Commander) - Optimized Infect

Original Name:

Skithiryx, the Blight DragonSkithiryx, the Blight Dragon

Venom, King in Black
Rank #780
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Enchantments
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Utility Lands
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Madame Null, Power Broker
17%inclusion1 decks6 decks
16%synergy
Splinter's Technique
17%inclusion1 decks6 decks
15%synergy
Shredder, Shadow Master
17%inclusion1 decks6 decks
15%synergy
Bitterbloom Bearer
6.3%inclusion1 decks16 decks
1%synergy
High Synergy Cards
Plague Stinger
79%inclusion19 decks24 decks
78%synergy
Whispering Specter
67%inclusion16 decks24 decks
66%synergy
Shizo, Death's Storehouse
71%inclusion17 decks24 decks
61%synergy
Plague Myr
58%inclusion14 decks24 decks
57%synergy
Phyresis Outbreak
58%inclusion14 decks24 decks
57%synergy
Lashwrithe
58%inclusion14 decks24 decks
54%synergy
Karn's Bastion
58%inclusion14 decks24 decks
54%synergy
Howl from Beyond
54%inclusion13 decks24 decks
53%synergy
Hand of the Praetors
54%inclusion13 decks24 decks
53%synergy
Phyrexian Crusader
54%inclusion13 decks24 decks
53%synergy
Top Cards
Dark Ritual
92%inclusion22 decks24 decks
25%synergy
Jet Medallion
83%inclusion20 decks24 decks
22%synergy
Crypt Ghast
75%inclusion18 decks24 decks
27%synergy
Deadly Rollick
71%inclusion17 decks24 decks
47%synergy
Cabal Ritual
58%inclusion14 decks24 decks
40%synergy
Toxic Deluge
58%inclusion14 decks24 decks
21%synergy
Commander's Plate
58%inclusion14 decks24 decks
53%synergy
Damnation
58%inclusion14 decks24 decks
38%synergy
Vraska's Fall
54%inclusion13 decks24 decks
51%synergy
Feed the Swarm
54%inclusion13 decks24 decks
3%synergy
Game Changers
Demonic Tutor
83%inclusion20 decks24 decks
56%synergy
Vampiric Tutor
75%inclusion18 decks24 decks
54%synergy
Ancient Tomb
71%inclusion17 decks24 decks
59%synergy
Necropotence
58%inclusion14 decks24 decks
43%synergy
Mana Vault
54%inclusion13 decks24 decks
47%synergy
Chrome Mox
50%inclusion12 decks24 decks
44%synergy
Imperial Seal
46%inclusion11 decks24 decks
39%synergy
Opposition Agent
46%inclusion11 decks24 decks
36%synergy
The One Ring
46%inclusion11 decks24 decks
36%synergy
Orcish Bowmasters
33%inclusion8 decks24 decks
20%synergy
Creatures
Ichor Rats
54%inclusion13 decks24 decks
51%synergy
Dauthi Voidwalker
42%inclusion10 decks24 decks
26%synergy
K'rrik, Son of Yawgmoth
38%inclusion9 decks24 decks
19%synergy
Sheoldred, the Apocalypse
33%inclusion8 decks24 decks
19%synergy
Phyrexian Obliterator
33%inclusion8 decks24 decks
22%synergy
Reaper of Sheoldred
29%inclusion7 decks24 decks
29%synergy
Flensermite
29%inclusion7 decks24 decks
29%synergy
Yawgmoth, Thran Physician
29%inclusion7 decks24 decks
19%synergy
Blightbelly Rat
29%inclusion7 decks24 decks
26%synergy
Dark Confidant
25%inclusion6 decks24 decks
18%synergy
Pestilent Syphoner
21%inclusion5 decks24 decks
20%synergy
Ichorclaw Myr
21%inclusion5 decks24 decks
20%synergy
Gray Merchant of Asphodel
17%inclusion4 decks24 decks
-35%synergy
Sheoldred, Whispering One
17%inclusion4 decks24 decks
5%synergy
Flesh-Eater Imp
17%inclusion4 decks24 decks
16%synergy
Blightsteel Colossus
17%inclusion4 decks24 decks
16%synergy
Contagious Nim
13%inclusion3 decks24 decks
12%synergy
Core Prowler
13%inclusion3 decks24 decks
12%synergy
Myr Convert
13%inclusion3 decks24 decks
12%synergy
Nirkana Revenant
13%inclusion3 decks24 decks
1%synergy
Vito, Thorn of the Dusk Rose
13%inclusion3 decks24 decks
2%synergy
Bilious Skulldweller
13%inclusion3 decks24 decks
11%synergy
Septic Rats
13%inclusion3 decks24 decks
11%synergy
Necropede
13%inclusion3 decks24 decks
12%synergy
Phyrexian Juggernaut
8.3%inclusion2 decks24 decks
8%synergy
Solemn Simulacrum
8.3%inclusion2 decks24 decks
-14%synergy
Maha, Its Feathers Night
8.3%inclusion2 decks24 decks
4%synergy
Blackcleave Goblin
8.3%inclusion2 decks24 decks
8%synergy
Lobelia Sackville-Baggins
8.3%inclusion2 decks24 decks
7%synergy
Nightmare
8.3%inclusion2 decks24 decks
7%synergy
Bloodletter of Aclazotz
8.3%inclusion2 decks24 decks
-2%synergy
Swamp Mosquito
8.3%inclusion2 decks24 decks
8%synergy
Necroskitter
8.3%inclusion2 decks24 decks
5%synergy
Corpse Cur
8.3%inclusion2 decks24 decks
8%synergy
Massacre Wurm
8.3%inclusion2 decks24 decks
-9%synergy
Sheoldred's Headcleaver
8.3%inclusion2 decks24 decks
8%synergy
Nimraiser Paladin
8.3%inclusion2 decks24 decks
8%synergy
Scheming Aspirant
8.3%inclusion2 decks24 decks
8%synergy
Accursed Marauder
8.3%inclusion2 decks24 decks
-13%synergy
Gulping Scraptrap
8.3%inclusion2 decks24 decks
8%synergy
Leaden Myr
8.3%inclusion2 decks24 decks
2%synergy
Agent Venom
5.6%inclusion1 decks18 decks
3%synergy
Surge Conductor
5.3%inclusion1 decks19 decks
5%synergy
Gwenom, Remorseless
5.3%inclusion1 decks19 decks
2%synergy
Jecht, Reluctant Guardian
5.0%inclusion1 decks20 decks
3%synergy
Instants
Hatred
46%inclusion11 decks24 decks
45%synergy
Imp's Mischief
42%inclusion10 decks24 decks
17%synergy
Go for the Throat
38%inclusion9 decks24 decks
14%synergy
Dismember
38%inclusion9 decks24 decks
27%synergy
Tainted Strike
33%inclusion8 decks24 decks
30%synergy
Sudden Spoiling
33%inclusion8 decks24 decks
24%synergy
Withering Torment
29%inclusion7 decks24 decks
-2%synergy
Sheoldred's Edict
25%inclusion6 decks24 decks
11%synergy
Whisper of the Dross
25%inclusion6 decks24 decks
22%synergy
Snuff Out
25%inclusion6 decks24 decks
12%synergy
Darkness
25%inclusion6 decks24 decks
15%synergy
Infernal Grasp
25%inclusion6 decks24 decks
0%synergy
Hero's Downfall
21%inclusion5 decks24 decks
14%synergy
Fell the Profane
21%inclusion5 decks24 decks
2%synergy
Cut Down
21%inclusion5 decks24 decks
17%synergy
Astarion's Thirst
17%inclusion4 decks24 decks
15%synergy
Culling the Weak
17%inclusion4 decks24 decks
1%synergy
Withering Boon
17%inclusion4 decks24 decks
12%synergy
Malakir Rebirth
17%inclusion4 decks24 decks
-6%synergy
Force of Despair
13%inclusion3 decks24 decks
5%synergy
Doom Blade
13%inclusion3 decks24 decks
5%synergy
Soul Shatter
13%inclusion3 decks24 decks
1%synergy
Slaughter Pact
13%inclusion3 decks24 decks
10%synergy
Murder
13%inclusion3 decks24 decks
2%synergy
Not Dead After All
8.3%inclusion2 decks24 decks
-3%synergy
Anoint with Affliction
8.3%inclusion2 decks24 decks
8%synergy
Defile
8.3%inclusion2 decks24 decks
-29%synergy
Sugar Rush
8.3%inclusion2 decks24 decks
8%synergy
Virulent Wound
8.3%inclusion2 decks24 decks
8%synergy
Bitter Triumph
8.3%inclusion2 decks24 decks
-1%synergy
Virulent Swipe
8.3%inclusion2 decks24 decks
8%synergy
Ad Nauseam
8.3%inclusion2 decks24 decks
6%synergy
Baleful Mastery
8.3%inclusion2 decks24 decks
0%synergy
Black Sun's Twilight
8.3%inclusion2 decks24 decks
5%synergy
Liliana's Triumph
8.3%inclusion2 decks24 decks
2%synergy
Archenemy's Charm
5.3%inclusion1 decks19 decks
-4%synergy
Overkill
5.0%inclusion1 decks20 decks
-2%synergy
Sorceries
Grim Tutor
54%inclusion13 decks24 decks
43%synergy
Infectious Inquiry
50%inclusion12 decks24 decks
47%synergy
Night's Whisper
50%inclusion12 decks24 decks
25%synergy
Drown in Ichor
46%inclusion11 decks24 decks
42%synergy
Bubbling Muck
42%inclusion10 decks24 decks
26%synergy
Crux of Fate
42%inclusion10 decks24 decks
40%synergy
Sign in Blood
42%inclusion10 decks24 decks
6%synergy
Reanimate
29%inclusion7 decks24 decks
-10%synergy
Caress of Phyrexia
25%inclusion6 decks24 decks
24%synergy
Blasphemous Edict
22%inclusion5 decks23 decks
5%synergy
Diabolic Tutor
21%inclusion5 decks24 decks
6%synergy
Profane Tutor
21%inclusion5 decks24 decks
16%synergy
Vat Emergence
17%inclusion4 decks24 decks
15%synergy
Torment of Hailfire
17%inclusion4 decks24 decks
1%synergy
Duress
17%inclusion4 decks24 decks
10%synergy
Exsanguinate
17%inclusion4 decks24 decks
-8%synergy
Insatiable Avarice
17%inclusion4 decks24 decks
5%synergy
Beseech the Mirror
17%inclusion4 decks24 decks
10%synergy
Yawgmoth's Will
13%inclusion3 decks24 decks
9%synergy
Mutilate
13%inclusion3 decks24 decks
-5%synergy
Praetor's Grasp
13%inclusion3 decks24 decks
9%synergy
Dark Petition
13%inclusion3 decks24 decks
9%synergy
Beseech the Queen
13%inclusion3 decks24 decks
6%synergy
Black Sun's Zenith
8.3%inclusion2 decks24 decks
3%synergy
Read the Bones
8.3%inclusion2 decks24 decks
-9%synergy
Innocent Blood
8.3%inclusion2 decks24 decks
3%synergy
Dreams of Steel and Oil
8.3%inclusion2 decks24 decks
8%synergy
Disentomb
8.3%inclusion2 decks24 decks
7%synergy
Thoughtseize
8.3%inclusion2 decks24 decks
3%synergy
Utility Artifacts
Shadowspear
50%inclusion12 decks24 decks
46%synergy
Swiftfoot Boots
50%inclusion12 decks24 decks
19%synergy
Blackblade Reforged
46%inclusion11 decks24 decks
43%synergy
Nightmare Lash
42%inclusion10 decks24 decks
39%synergy
Lightning Greaves
42%inclusion10 decks24 decks
8%synergy
Mithril Coat
33%inclusion8 decks24 decks
28%synergy
Sword of Truth and Justice
33%inclusion8 decks24 decks
33%synergy
Whispersilk Cloak
33%inclusion8 decks24 decks
27%synergy
Bolas's Citadel
29%inclusion7 decks24 decks
0%synergy
Fireshrieker
29%inclusion7 decks24 decks
27%synergy
Champion's Helm
29%inclusion7 decks24 decks
27%synergy
Sensei's Divining Top
25%inclusion6 decks24 decks
17%synergy
Contagion Engine
25%inclusion6 decks24 decks
23%synergy
Expedition Map
25%inclusion6 decks24 decks
13%synergy
Wishclaw Talisman
21%inclusion5 decks24 decks
14%synergy
Conqueror's Flail
21%inclusion5 decks24 decks
20%synergy
The Darkness Crystal
20%inclusion4 decks20 decks
0%synergy
Doc Ock's Tentacles
18%inclusion3 decks17 decks
17%synergy
Silver Shroud Costume
17%inclusion4 decks24 decks
15%synergy
Brotherhood Regalia
17%inclusion4 decks24 decks
14%synergy
Hammer of Nazahn
17%inclusion4 decks24 decks
16%synergy
Genji Glove
15%inclusion3 decks20 decks
14%synergy
Leyline Axe
13%inclusion3 decks23 decks
12%synergy
Thran Power Suit
13%inclusion3 decks24 decks
12%synergy
Contagion Clasp
13%inclusion3 decks24 decks
10%synergy
Trailblazer's Boots
13%inclusion3 decks24 decks
10%synergy
Cranial Plating
13%inclusion3 decks24 decks
9%synergy
Winter Moon
13%inclusion3 decks24 decks
11%synergy
Sword of Feast and Famine
13%inclusion3 decks24 decks
11%synergy
Sword of the Animist
13%inclusion3 decks24 decks
9%synergy
Black Mage's Rod
10%inclusion2 decks20 decks
9%synergy
Lavaspur Boots
8.3%inclusion2 decks24 decks
7%synergy
Sword of Hearth and Home
8.3%inclusion2 decks24 decks
7%synergy
Bontu's Monument
8.3%inclusion2 decks24 decks
-20%synergy
Sword of Wealth and Power
8.3%inclusion2 decks24 decks
8%synergy
Pact Weapon
8.3%inclusion2 decks24 decks
6%synergy
Loxodon Warhammer
8.3%inclusion2 decks24 decks
7%synergy
Isochron Scepter
8.3%inclusion2 decks24 decks
8%synergy
Sword of Vengeance
8.3%inclusion2 decks24 decks
7%synergy
Hero's Blade
8.3%inclusion2 decks24 decks
8%synergy
Basilisk Collar
8.3%inclusion2 decks24 decks
6%synergy
Buster Sword
5.0%inclusion1 decks20 decks
4%synergy
Enchantments
Unspeakable Symbol
50%inclusion12 decks24 decks
49%synergy
Phyrexian Arena
50%inclusion12 decks24 decks
10%synergy
Black Market Connections
38%inclusion9 decks24 decks
14%synergy
Necrogen Communion
29%inclusion7 decks24 decks
27%synergy
No Mercy
25%inclusion6 decks24 decks
18%synergy
Phyresis
21%inclusion5 decks24 decks
19%synergy
Super State
20%inclusion4 decks20 decks
20%synergy
The Meathook Massacre
17%inclusion4 decks24 decks
-1%synergy
Contamination
17%inclusion4 decks24 decks
13%synergy
Leyline of the Void
17%inclusion4 decks24 decks
15%synergy
Glistening Oil
13%inclusion3 decks24 decks
12%synergy
Phyrexian Reclamation
13%inclusion3 decks24 decks
3%synergy
Demonic Embrace
13%inclusion3 decks24 decks
12%synergy
Infernal Darkness
13%inclusion3 decks24 decks
12%synergy
Underworld Connections
8.3%inclusion2 decks24 decks
6%synergy
Grievous Wound
8.3%inclusion2 decks24 decks
6%synergy
Haunted One
8.3%inclusion2 decks24 decks
6%synergy
Grave Pact
8.3%inclusion2 decks24 decks
-11%synergy
Exquisite Blood
8.3%inclusion2 decks24 decks
-5%synergy
Wound Reflection
8.3%inclusion2 decks24 decks
5%synergy
Kaya's Ghostform
8.3%inclusion2 decks24 decks
-2%synergy
Dauthi Embrace
8.3%inclusion2 decks24 decks
7%synergy
Snake Cult Initiation
8.3%inclusion2 decks24 decks
8%synergy
Oubliette
8.3%inclusion2 decks24 decks
5%synergy
Fungal Fortitude
8.3%inclusion2 decks24 decks
7%synergy
Heartless Summoning
8.3%inclusion2 decks24 decks
4%synergy
Bitterblossom
8.3%inclusion2 decks24 decks
-5%synergy
Planeswalkers
Liliana of the Dark Realms
54%inclusion13 decks24 decks
40%synergy
Vraska, Betrayal's Sting
38%inclusion9 decks24 decks
35%synergy
Liliana of the Veil
8.3%inclusion2 decks24 decks
1%synergy
Tezzeret, Cruel Captain
5.0%inclusion1 decks20 decks
4%synergy
Utility Lands
Urborg, Tomb of Yawgmoth
75%inclusion18 decks24 decks
37%synergy
Rogue's Passage
71%inclusion17 decks24 decks
52%synergy
Cabal Coffers
67%inclusion16 decks24 decks
12%synergy
Inkmoth Nexus
50%inclusion12 decks24 decks
49%synergy
Nykthos, Shrine to Nyx
42%inclusion10 decks24 decks
12%synergy
Urza's Saga
38%inclusion9 decks24 decks
29%synergy
Cabal Stronghold
33%inclusion8 decks24 decks
-2%synergy
Bojuka Bog
29%inclusion7 decks24 decks
-18%synergy
Lake of the Dead
29%inclusion7 decks24 decks
24%synergy
Strip Mine
25%inclusion6 decks24 decks
22%synergy
The Black Gate
17%inclusion4 decks24 decks
13%synergy
Cathedral of War
17%inclusion4 decks24 decks
16%synergy
Deserted Temple
17%inclusion4 decks24 decks
12%synergy
Takenuma, Abandoned Mire
17%inclusion4 decks24 decks
1%synergy
Reliquary Tower
17%inclusion4 decks24 decks
-14%synergy
Homeward Path
17%inclusion4 decks24 decks
15%synergy
Temple of the False God
17%inclusion4 decks24 decks
9%synergy
Vault of Whispers
13%inclusion3 decks24 decks
7%synergy
Arcane Lighthouse
13%inclusion3 decks24 decks
11%synergy
Command Beacon
13%inclusion3 decks24 decks
4%synergy
Minas Morgul, Dark Fortress
13%inclusion3 decks24 decks
9%synergy
Wasteland
8.3%inclusion2 decks24 decks
7%synergy
Phyrexian Tower
8.3%inclusion2 decks24 decks
-17%synergy
Maze of Ith
8.3%inclusion2 decks24 decks
5%synergy
War Room
8.3%inclusion2 decks24 decks
-8%synergy
Emergence Zone
8.3%inclusion2 decks24 decks
5%synergy
Thespian's Stage
8.3%inclusion2 decks24 decks
3%synergy
Castle Locthwain
8.3%inclusion2 decks24 decks
-9%synergy
Midgar, City of Mako
5.0%inclusion1 decks20 decks
-6%synergy
Mana Artifacts
Sol Ring
96%inclusion23 decks24 decks
10%synergy
Arcane Signet
58%inclusion14 decks24 decks
-4%synergy
Lotus Petal
46%inclusion11 decks24 decks
38%synergy
The Soul Stone
42%inclusion8 decks19 decks
28%synergy
Mox Opal
38%inclusion9 decks24 decks
34%synergy
Staff of Compleation
33%inclusion8 decks24 decks
32%synergy
Mox Amber
29%inclusion7 decks24 decks
25%synergy
Fellwar Stone
29%inclusion7 decks24 decks
15%synergy
Glistening Sphere
25%inclusion6 decks24 decks
24%synergy
Mind Stone
25%inclusion6 decks24 decks
-4%synergy
Mox Diamond
21%inclusion5 decks24 decks
17%synergy
Heraldic Banner
17%inclusion4 decks24 decks
11%synergy
Gilded Lotus
17%inclusion4 decks24 decks
11%synergy
Mox Jasper
14%inclusion3 decks22 decks
14%synergy
Caged Sun
13%inclusion3 decks24 decks
1%synergy
Charcoal Diamond
13%inclusion3 decks24 decks
-10%synergy
Throne of Eldraine
13%inclusion3 decks24 decks
2%synergy
Thought Vessel
13%inclusion3 decks24 decks
-14%synergy
Extraplanar Lens
13%inclusion3 decks24 decks
7%synergy
Grim Monolith
8.3%inclusion2 decks24 decks
6%synergy
Lands
Swamp
96%inclusion23 decks24 decks
1%synergy
Cavern of Souls
50%inclusion12 decks24 decks
43%synergy
Verdant Catacombs
33%inclusion8 decks24 decks
30%synergy
Bloodstained Mire
33%inclusion8 decks24 decks
30%synergy
Marsh Flats
29%inclusion7 decks24 decks
26%synergy
Polluted Delta
29%inclusion7 decks24 decks
26%synergy
Fell the Profane
21%inclusion5 decks24 decks
2%synergy
Gemstone Caverns
21%inclusion5 decks24 decks
16%synergy
Malakir Rebirth
17%inclusion4 decks24 decks
-6%synergy
Command Tower
13%inclusion3 decks24 decks
7%synergy
Fabled Passage
13%inclusion3 decks24 decks
11%synergy
Myriad Landscape
13%inclusion3 decks24 decks
-13%synergy
Mirrex
13%inclusion3 decks24 decks
12%synergy
Prismatic Vista
8.3%inclusion2 decks24 decks
6%synergy
The Mycosynth Gardens
8.3%inclusion2 decks24 decks
7%synergy
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