Skithiryx, the Blight Dragon (Commander) - Optimized Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #779
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Bitterbloom Bearer
6.7%inclusion1 decks15 decks
4%synergy
High Synergy Cards
Plague Stinger
79%inclusion19 decks24 decks
78%synergy
Whispering Specter
75%inclusion18 decks24 decks
74%synergy
Plague Myr
63%inclusion15 decks24 decks
61%synergy
Shizo, Death's Storehouse
71%inclusion17 decks24 decks
61%synergy
Deadly Rollick
79%inclusion19 decks24 decks
56%synergy
Vraska's Fall
58%inclusion14 decks24 decks
55%synergy
Lashwrithe
58%inclusion14 decks24 decks
54%synergy
Karn's Bastion
58%inclusion14 decks24 decks
54%synergy
Howl from Beyond
54%inclusion13 decks24 decks
53%synergy
Unspeakable Symbol
54%inclusion13 decks24 decks
53%synergy
Top Cards
Dark Ritual
92%inclusion22 decks24 decks
25%synergy
Jet Medallion
88%inclusion21 decks24 decks
27%synergy
Crypt Ghast
71%inclusion17 decks24 decks
22%synergy
Cabal Ritual
63%inclusion15 decks24 decks
45%synergy
Toxic Deluge
63%inclusion15 decks24 decks
25%synergy
Commander's Plate
58%inclusion14 decks24 decks
53%synergy
Damnation
58%inclusion14 decks24 decks
38%synergy
Nightmare Lash
54%inclusion13 decks24 decks
52%synergy
Phyresis Outbreak
54%inclusion13 decks24 decks
52%synergy
Feed the Swarm
54%inclusion13 decks24 decks
3%synergy
Game Changers
Demonic Tutor
88%inclusion21 decks24 decks
60%synergy
Vampiric Tutor
83%inclusion20 decks24 decks
62%synergy
Ancient Tomb
71%inclusion17 decks24 decks
59%synergy
Mana Vault
58%inclusion14 decks24 decks
51%synergy
Necropotence
58%inclusion14 decks24 decks
43%synergy
Chrome Mox
54%inclusion13 decks24 decks
48%synergy
Opposition Agent
50%inclusion12 decks24 decks
40%synergy
Imperial Seal
46%inclusion11 decks24 decks
39%synergy
The One Ring
46%inclusion11 decks24 decks
36%synergy
Orcish Bowmasters
42%inclusion10 decks24 decks
28%synergy
Creatures
Phyrexian Crusader
50%inclusion12 decks24 decks
49%synergy
Hand of the Praetors
50%inclusion12 decks24 decks
49%synergy
Ichor Rats
50%inclusion12 decks24 decks
47%synergy
Dauthi Voidwalker
46%inclusion11 decks24 decks
30%synergy
Sheoldred, the Apocalypse
42%inclusion10 decks24 decks
27%synergy
Phyrexian Obliterator
33%inclusion8 decks24 decks
22%synergy
Yawgmoth, Thran Physician
33%inclusion8 decks24 decks
23%synergy
K'rrik, Son of Yawgmoth
33%inclusion8 decks24 decks
15%synergy
Pestilent Syphoner
25%inclusion6 decks24 decks
24%synergy
Dark Confidant
25%inclusion6 decks24 decks
18%synergy
Reaper of Sheoldred
25%inclusion6 decks24 decks
24%synergy
Flensermite
25%inclusion6 decks24 decks
24%synergy
Ichorclaw Myr
25%inclusion6 decks24 decks
24%synergy
Blightbelly Rat
25%inclusion6 decks24 decks
21%synergy
Flesh-Eater Imp
25%inclusion6 decks24 decks
24%synergy
Gray Merchant of Asphodel
21%inclusion5 decks24 decks
-31%synergy
Myr Convert
17%inclusion4 decks24 decks
16%synergy
Bilious Skulldweller
17%inclusion4 decks24 decks
16%synergy
Blightsteel Colossus
17%inclusion4 decks24 decks
16%synergy
Contagious Nim
13%inclusion3 decks24 decks
12%synergy
Vito, Thorn of the Dusk Rose
13%inclusion3 decks24 decks
2%synergy
Corpse Cur
13%inclusion3 decks24 decks
12%synergy
Sheoldred, Whispering One
13%inclusion3 decks24 decks
1%synergy
Septic Rats
13%inclusion3 decks24 decks
10%synergy
Necropede
13%inclusion3 decks24 decks
12%synergy
Solemn Simulacrum
8.3%inclusion2 decks24 decks
-15%synergy
Core Prowler
8.3%inclusion2 decks24 decks
8%synergy
Maha, Its Feathers Night
8.3%inclusion2 decks24 decks
4%synergy
Blackcleave Goblin
8.3%inclusion2 decks24 decks
8%synergy
Lobelia Sackville-Baggins
8.3%inclusion2 decks24 decks
7%synergy
Bloodletter of Aclazotz
8.3%inclusion2 decks24 decks
-2%synergy
Swamp Mosquito
8.3%inclusion2 decks24 decks
8%synergy
Necroskitter
8.3%inclusion2 decks24 decks
5%synergy
Nirkana Revenant
8.3%inclusion2 decks24 decks
-3%synergy
Massacre Wurm
8.3%inclusion2 decks24 decks
-9%synergy
Metalworker
8.3%inclusion2 decks24 decks
8%synergy
Sheoldred's Headcleaver
8.3%inclusion2 decks24 decks
8%synergy
Nimraiser Paladin
8.3%inclusion2 decks24 decks
8%synergy
Scheming Aspirant
8.3%inclusion2 decks24 decks
8%synergy
Gulping Scraptrap
8.3%inclusion2 decks24 decks
8%synergy
Blood Pet
8.3%inclusion2 decks24 decks
0%synergy
Leaden Myr
8.3%inclusion2 decks24 decks
2%synergy
Agent Venom
5.9%inclusion1 decks17 decks
4%synergy
Jecht, Reluctant Guardian
5.0%inclusion1 decks20 decks
3%synergy
Instants
Imp's Mischief
46%inclusion11 decks24 decks
22%synergy
Dismember
46%inclusion11 decks24 decks
35%synergy
Go for the Throat
42%inclusion10 decks24 decks
18%synergy
Hatred
38%inclusion9 decks24 decks
36%synergy
Sudden Spoiling
33%inclusion8 decks24 decks
24%synergy
Cut Down
25%inclusion6 decks24 decks
21%synergy
Whisper of the Dross
25%inclusion6 decks24 decks
22%synergy
Snuff Out
25%inclusion6 decks24 decks
12%synergy
Darkness
25%inclusion6 decks24 decks
15%synergy
Tainted Strike
25%inclusion6 decks24 decks
22%synergy
Withering Torment
25%inclusion6 decks24 decks
-7%synergy
Astarion's Thirst
21%inclusion5 decks24 decks
19%synergy
Hero's Downfall
21%inclusion5 decks24 decks
14%synergy
Sheoldred's Edict
21%inclusion5 decks24 decks
6%synergy
Withering Boon
21%inclusion5 decks24 decks
16%synergy
Infernal Grasp
21%inclusion5 decks24 decks
-4%synergy
Fell the Profane
17%inclusion4 decks24 decks
-2%synergy
Culling the Weak
17%inclusion4 decks24 decks
2%synergy
Force of Despair
13%inclusion3 decks24 decks
5%synergy
Defile
13%inclusion3 decks24 decks
-25%synergy
Soul Shatter
13%inclusion3 decks24 decks
0%synergy
Slaughter Pact
13%inclusion3 decks24 decks
10%synergy
Bitter Triumph
13%inclusion3 decks24 decks
2%synergy
Murder
13%inclusion3 decks24 decks
2%synergy
Malakir Rebirth
13%inclusion3 decks24 decks
-10%synergy
Baleful Mastery
13%inclusion3 decks24 decks
3%synergy
Fatal Push
8.3%inclusion2 decks24 decks
5%synergy
Anoint with Affliction
8.3%inclusion2 decks24 decks
8%synergy
Grim Affliction
8.3%inclusion2 decks24 decks
6%synergy
Doom Blade
8.3%inclusion2 decks24 decks
1%synergy
Virulent Wound
8.3%inclusion2 decks24 decks
8%synergy
Ad Nauseam
8.3%inclusion2 decks24 decks
6%synergy
Black Sun's Twilight
8.3%inclusion2 decks24 decks
4%synergy
Liliana's Triumph
8.3%inclusion2 decks24 decks
2%synergy
Archenemy's Charm
5.6%inclusion1 decks18 decks
-3%synergy
Overkill
5.0%inclusion1 decks20 decks
-3%synergy
Sorceries
Infectious Inquiry
54%inclusion13 decks24 decks
51%synergy
Drown in Ichor
50%inclusion12 decks24 decks
46%synergy
Grim Tutor
50%inclusion12 decks24 decks
38%synergy
Night's Whisper
46%inclusion11 decks24 decks
21%synergy
Bubbling Muck
42%inclusion10 decks24 decks
26%synergy
Crux of Fate
38%inclusion9 decks24 decks
36%synergy
Sign in Blood
38%inclusion9 decks24 decks
1%synergy
Reanimate
29%inclusion7 decks24 decks
-10%synergy
Blasphemous Edict
22%inclusion5 decks23 decks
5%synergy
Diabolic Tutor
21%inclusion5 decks24 decks
6%synergy
Torment of Hailfire
21%inclusion5 decks24 decks
5%synergy
Caress of Phyrexia
21%inclusion5 decks24 decks
20%synergy
Vat Emergence
17%inclusion4 decks24 decks
15%synergy
Profane Tutor
17%inclusion4 decks24 decks
12%synergy
Duress
17%inclusion4 decks24 decks
10%synergy
Praetor's Grasp
17%inclusion4 decks24 decks
13%synergy
Exsanguinate
17%inclusion4 decks24 decks
-8%synergy
Insatiable Avarice
17%inclusion4 decks24 decks
5%synergy
Beseech the Mirror
17%inclusion4 decks24 decks
10%synergy
Mutilate
13%inclusion3 decks24 decks
-6%synergy
Black Sun's Zenith
8.3%inclusion2 decks24 decks
2%synergy
Victimize
8.3%inclusion2 decks24 decks
-18%synergy
Yawgmoth's Will
8.3%inclusion2 decks24 decks
5%synergy
Inquisition of Kozilek
8.3%inclusion2 decks24 decks
6%synergy
Read the Bones
8.3%inclusion2 decks24 decks
-9%synergy
Dark Petition
8.3%inclusion2 decks24 decks
4%synergy
Dreams of Steel and Oil
8.3%inclusion2 decks24 decks
8%synergy
Beseech the Queen
8.3%inclusion2 decks24 decks
2%synergy
Thoughtseize
8.3%inclusion2 decks24 decks
3%synergy
Utility Artifacts
Shadowspear
54%inclusion13 decks24 decks
50%synergy
Blackblade Reforged
54%inclusion13 decks24 decks
51%synergy
Lightning Greaves
46%inclusion11 decks24 decks
12%synergy
Swiftfoot Boots
42%inclusion10 decks24 decks
10%synergy
Sword of Truth and Justice
38%inclusion9 decks24 decks
37%synergy
Whispersilk Cloak
33%inclusion8 decks24 decks
27%synergy
Champion's Helm
33%inclusion8 decks24 decks
31%synergy
Bolas's Citadel
29%inclusion7 decks24 decks
0%synergy
Mithril Coat
29%inclusion7 decks24 decks
24%synergy
Contagion Engine
29%inclusion7 decks24 decks
27%synergy
Wishclaw Talisman
25%inclusion6 decks24 decks
18%synergy
The Darkness Crystal
25%inclusion5 decks20 decks
5%synergy
Sensei's Divining Top
21%inclusion5 decks24 decks
12%synergy
Expedition Map
21%inclusion5 decks24 decks
8%synergy
Conqueror's Flail
21%inclusion5 decks24 decks
20%synergy
Fireshrieker
21%inclusion5 decks24 decks
19%synergy
Hammer of Nazahn
21%inclusion5 decks24 decks
20%synergy
Leyline Axe
17%inclusion4 decks23 decks
16%synergy
Contagion Clasp
17%inclusion4 decks24 decks
14%synergy
Sword of Wealth and Power
17%inclusion4 decks24 decks
16%synergy
Pact Weapon
17%inclusion4 decks24 decks
14%synergy
Genji Glove
15%inclusion3 decks20 decks
14%synergy
Thran Power Suit
13%inclusion3 decks24 decks
12%synergy
Trailblazer's Boots
13%inclusion3 decks24 decks
10%synergy
Cranial Plating
13%inclusion3 decks24 decks
9%synergy
Silver Shroud Costume
13%inclusion3 decks24 decks
11%synergy
Sword of Feast and Famine
13%inclusion3 decks24 decks
11%synergy
Brotherhood Regalia
13%inclusion3 decks24 decks
10%synergy
Sword of the Animist
13%inclusion3 decks24 decks
9%synergy
Doc Ock's Tentacles
13%inclusion2 decks16 decks
12%synergy
Buster Sword
10%inclusion2 decks20 decks
9%synergy
Sword of Hearth and Home
8.3%inclusion2 decks24 decks
7%synergy
Bontu's Monument
8.3%inclusion2 decks24 decks
-20%synergy
Winter Moon
8.3%inclusion2 decks24 decks
7%synergy
Isochron Scepter
8.3%inclusion2 decks24 decks
8%synergy
Sword of Vengeance
8.3%inclusion2 decks24 decks
7%synergy
Hero's Blade
8.3%inclusion2 decks24 decks
8%synergy
Basilisk Collar
8.3%inclusion2 decks24 decks
6%synergy
Black Mage's Rod
5.0%inclusion1 decks20 decks
4%synergy
Enchantments
Phyrexian Arena
54%inclusion13 decks24 decks
14%synergy
Black Market Connections
46%inclusion11 decks24 decks
22%synergy
Necrogen Communion
29%inclusion7 decks24 decks
27%synergy
No Mercy
25%inclusion6 decks24 decks
18%synergy
Super State
21%inclusion4 decks19 decks
21%synergy
The Meathook Massacre
17%inclusion4 decks24 decks
-1%synergy
Contamination
17%inclusion4 decks24 decks
13%synergy
Phyresis
17%inclusion4 decks24 decks
14%synergy
Phyrexian Reclamation
13%inclusion3 decks24 decks
2%synergy
Leyline of the Void
13%inclusion3 decks24 decks
11%synergy
Grievous Wound
8.3%inclusion2 decks24 decks
6%synergy
Haunted One
8.3%inclusion2 decks24 decks
6%synergy
Grave Pact
8.3%inclusion2 decks24 decks
-10%synergy
Exquisite Blood
8.3%inclusion2 decks24 decks
-5%synergy
Wound Reflection
8.3%inclusion2 decks24 decks
5%synergy
Kaya's Ghostform
8.3%inclusion2 decks24 decks
-2%synergy
Dauthi Embrace
8.3%inclusion2 decks24 decks
7%synergy
Snake Cult Initiation
8.3%inclusion2 decks24 decks
8%synergy
Oubliette
8.3%inclusion2 decks24 decks
5%synergy
Demonic Embrace
8.3%inclusion2 decks24 decks
7%synergy
Infernal Darkness
8.3%inclusion2 decks24 decks
8%synergy
Heartless Summoning
8.3%inclusion2 decks24 decks
4%synergy
Bitterblossom
8.3%inclusion2 decks24 decks
-5%synergy
Planeswalkers
Liliana of the Dark Realms
54%inclusion13 decks24 decks
40%synergy
Vraska, Betrayal's Sting
42%inclusion10 decks24 decks
39%synergy
Tezzeret, Cruel Captain
11%inclusion2 decks19 decks
9%synergy
Utility Lands
Urborg, Tomb of Yawgmoth
79%inclusion19 decks24 decks
41%synergy
Cabal Coffers
71%inclusion17 decks24 decks
16%synergy
Rogue's Passage
63%inclusion15 decks24 decks
44%synergy
Inkmoth Nexus
50%inclusion12 decks24 decks
49%synergy
Cabal Stronghold
38%inclusion9 decks24 decks
2%synergy
Urza's Saga
38%inclusion9 decks24 decks
29%synergy
Nykthos, Shrine to Nyx
38%inclusion9 decks24 decks
8%synergy
Lake of the Dead
33%inclusion8 decks24 decks
28%synergy
Bojuka Bog
29%inclusion7 decks24 decks
-18%synergy
Strip Mine
25%inclusion6 decks24 decks
22%synergy
Reliquary Tower
21%inclusion5 decks24 decks
-10%synergy
The Black Gate
17%inclusion4 decks24 decks
13%synergy
Cathedral of War
17%inclusion4 decks24 decks
16%synergy
Command Beacon
17%inclusion4 decks24 decks
8%synergy
Deserted Temple
17%inclusion4 decks24 decks
12%synergy
Takenuma, Abandoned Mire
17%inclusion4 decks24 decks
1%synergy
Homeward Path
17%inclusion4 decks24 decks
15%synergy
Temple of the False God
17%inclusion4 decks24 decks
9%synergy
Arcane Lighthouse
13%inclusion3 decks24 decks
11%synergy
Minas Morgul, Dark Fortress
13%inclusion3 decks24 decks
9%synergy
Wasteland
8.3%inclusion2 decks24 decks
7%synergy
Phyrexian Tower
8.3%inclusion2 decks24 decks
-16%synergy
Maze of Ith
8.3%inclusion2 decks24 decks
5%synergy
War Room
8.3%inclusion2 decks24 decks
-8%synergy
Emergence Zone
8.3%inclusion2 decks24 decks
5%synergy
Mishra's Workshop
8.3%inclusion2 decks24 decks
8%synergy
Castle Locthwain
8.3%inclusion2 decks24 decks
-9%synergy
Mana Artifacts
Sol Ring
96%inclusion23 decks24 decks
10%synergy
Arcane Signet
63%inclusion15 decks24 decks
0%synergy
Lotus Petal
46%inclusion11 decks24 decks
38%synergy
Mox Opal
42%inclusion10 decks24 decks
38%synergy
The Soul Stone
39%inclusion7 decks18 decks
26%synergy
Staff of Compleation
33%inclusion8 decks24 decks
32%synergy
Glistening Sphere
33%inclusion8 decks24 decks
32%synergy
Mox Amber
29%inclusion7 decks24 decks
25%synergy
Mox Diamond
29%inclusion7 decks24 decks
25%synergy
Heraldic Banner
21%inclusion5 decks24 decks
15%synergy
Fellwar Stone
21%inclusion5 decks24 decks
6%synergy
Mind Stone
21%inclusion5 decks24 decks
-10%synergy
Caged Sun
17%inclusion4 decks24 decks
5%synergy
Grim Monolith
17%inclusion4 decks24 decks
14%synergy
Throne of Eldraine
17%inclusion4 decks24 decks
6%synergy
Gilded Lotus
17%inclusion4 decks24 decks
11%synergy
Charcoal Diamond
13%inclusion3 decks24 decks
-11%synergy
Thought Vessel
13%inclusion3 decks24 decks
-14%synergy
Mox Jasper
9.1%inclusion2 decks22 decks
9%synergy
Basalt Monolith
8.3%inclusion2 decks24 decks
7%synergy
Extraplanar Lens
8.3%inclusion2 decks24 decks
3%synergy
Lands
Swamp
96%inclusion23 decks24 decks
1%synergy
Cavern of Souls
54%inclusion13 decks24 decks
48%synergy
Verdant Catacombs
29%inclusion7 decks24 decks
26%synergy
Gemstone Caverns
29%inclusion7 decks24 decks
25%synergy
Bloodstained Mire
29%inclusion7 decks24 decks
26%synergy
Marsh Flats
25%inclusion6 decks24 decks
22%synergy
Polluted Delta
25%inclusion6 decks24 decks
22%synergy
Fell the Profane
17%inclusion4 decks24 decks
-2%synergy
Command Tower
13%inclusion3 decks24 decks
7%synergy
Myriad Landscape
13%inclusion3 decks24 decks
-14%synergy
Mirrex
13%inclusion3 decks24 decks
12%synergy
Malakir Rebirth
13%inclusion3 decks24 decks
-10%synergy
Prismatic Vista
8.3%inclusion2 decks24 decks
6%synergy
The Mycosynth Gardens
8.3%inclusion2 decks24 decks
7%synergy
Fabled Passage
8.3%inclusion2 decks24 decks
7%synergy
Talon Gates of Madara
8.3%inclusion2 decks24 decks
7%synergy
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