Skithiryx, the Blight Dragon (Commander) - Optimized Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #790
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Utility Lands
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Bitterbloom Bearer
7.1%inclusion1 decks14 decks
5%synergy
High Synergy Cards
Whispering Specter
74%inclusion17 decks23 decks
73%synergy
Plague Stinger
70%inclusion16 decks23 decks
69%synergy
Unspeakable Symbol
57%inclusion13 decks23 decks
56%synergy
Plague Myr
57%inclusion13 decks23 decks
55%synergy
Commander's Plate
61%inclusion14 decks23 decks
55%synergy
Shizo, Death's Storehouse
65%inclusion15 decks23 decks
55%synergy
Deadly Rollick
78%inclusion18 decks23 decks
55%synergy
Shadowspear
57%inclusion13 decks23 decks
53%synergy
Lashwrithe
57%inclusion13 decks23 decks
52%synergy
Karn's Bastion
57%inclusion13 decks23 decks
52%synergy
Top Cards
Dark Ritual
91%inclusion21 decks23 decks
25%synergy
Jet Medallion
87%inclusion20 decks23 decks
27%synergy
Crypt Ghast
74%inclusion17 decks23 decks
25%synergy
Feed the Swarm
61%inclusion14 decks23 decks
9%synergy
Cabal Ritual
61%inclusion14 decks23 decks
43%synergy
Toxic Deluge
61%inclusion14 decks23 decks
24%synergy
Liliana of the Dark Realms
57%inclusion13 decks23 decks
42%synergy
Grim Tutor
57%inclusion13 decks23 decks
45%synergy
Phyrexian Arena
57%inclusion13 decks23 decks
16%synergy
Vraska's Fall
52%inclusion12 decks23 decks
48%synergy
Game Changers
Demonic Tutor
87%inclusion20 decks23 decks
59%synergy
Vampiric Tutor
83%inclusion19 decks23 decks
61%synergy
Ancient Tomb
74%inclusion17 decks23 decks
62%synergy
Mana Vault
61%inclusion14 decks23 decks
54%synergy
Necropotence
57%inclusion13 decks23 decks
41%synergy
Chrome Mox
57%inclusion13 decks23 decks
50%synergy
Opposition Agent
48%inclusion11 decks23 decks
38%synergy
The One Ring
48%inclusion11 decks23 decks
38%synergy
Imperial Seal
43%inclusion10 decks23 decks
36%synergy
Orcish Bowmasters
39%inclusion9 decks23 decks
25%synergy
Creatures
Dauthi Voidwalker
48%inclusion11 decks23 decks
32%synergy
Hand of the Praetors
48%inclusion11 decks23 decks
47%synergy
Phyrexian Crusader
43%inclusion10 decks23 decks
43%synergy
Ichor Rats
43%inclusion10 decks23 decks
40%synergy
Sheoldred, the Apocalypse
35%inclusion8 decks23 decks
20%synergy
K'rrik, Son of Yawgmoth
35%inclusion8 decks23 decks
16%synergy
Phyrexian Obliterator
30%inclusion7 decks23 decks
19%synergy
Yawgmoth, Thran Physician
30%inclusion7 decks23 decks
20%synergy
Dark Confidant
26%inclusion6 decks23 decks
19%synergy
Reaper of Sheoldred
26%inclusion6 decks23 decks
25%synergy
Blightbelly Rat
26%inclusion6 decks23 decks
22%synergy
Pestilent Syphoner
22%inclusion5 decks23 decks
21%synergy
Flensermite
22%inclusion5 decks23 decks
21%synergy
Ichorclaw Myr
22%inclusion5 decks23 decks
21%synergy
Gray Merchant of Asphodel
17%inclusion4 decks23 decks
-34%synergy
Myr Convert
17%inclusion4 decks23 decks
17%synergy
Flesh-Eater Imp
17%inclusion4 decks23 decks
17%synergy
Blightsteel Colossus
17%inclusion4 decks23 decks
17%synergy
Contagious Nim
13%inclusion3 decks23 decks
13%synergy
Nirkana Revenant
13%inclusion3 decks23 decks
1%synergy
Vito, Thorn of the Dusk Rose
13%inclusion3 decks23 decks
2%synergy
Bilious Skulldweller
13%inclusion3 decks23 decks
12%synergy
Sheoldred, Whispering One
13%inclusion3 decks23 decks
1%synergy
Necropede
13%inclusion3 decks23 decks
13%synergy
Solemn Simulacrum
8.7%inclusion2 decks23 decks
-15%synergy
Core Prowler
8.7%inclusion2 decks23 decks
8%synergy
Maha, Its Feathers Night
8.7%inclusion2 decks23 decks
4%synergy
Blackcleave Goblin
8.7%inclusion2 decks23 decks
8%synergy
Lobelia Sackville-Baggins
8.7%inclusion2 decks23 decks
8%synergy
Bloodletter of Aclazotz
8.7%inclusion2 decks23 decks
-2%synergy
Swamp Mosquito
8.7%inclusion2 decks23 decks
9%synergy
Necroskitter
8.7%inclusion2 decks23 decks
5%synergy
Corpse Cur
8.7%inclusion2 decks23 decks
8%synergy
Massacre Wurm
8.7%inclusion2 decks23 decks
-9%synergy
Metalworker
8.7%inclusion2 decks23 decks
8%synergy
Sheoldred's Headcleaver
8.7%inclusion2 decks23 decks
8%synergy
Septic Rats
8.7%inclusion2 decks23 decks
7%synergy
Nimraiser Paladin
8.7%inclusion2 decks23 decks
8%synergy
Scheming Aspirant
8.7%inclusion2 decks23 decks
8%synergy
Gulping Scraptrap
8.7%inclusion2 decks23 decks
8%synergy
Agent Venom
6.3%inclusion1 decks16 decks
4%synergy
Jecht, Reluctant Guardian
5.3%inclusion1 decks19 decks
3%synergy
Instants
Howl from Beyond
52%inclusion12 decks23 decks
51%synergy
Imp's Mischief
43%inclusion10 decks23 decks
20%synergy
Hatred
43%inclusion10 decks23 decks
42%synergy
Dismember
43%inclusion10 decks23 decks
32%synergy
Go for the Throat
35%inclusion8 decks23 decks
11%synergy
Sudden Spoiling
35%inclusion8 decks23 decks
25%synergy
Darkness
30%inclusion7 decks23 decks
21%synergy
Cut Down
26%inclusion6 decks23 decks
22%synergy
Snuff Out
26%inclusion6 decks23 decks
14%synergy
Tainted Strike
26%inclusion6 decks23 decks
23%synergy
Astarion's Thirst
22%inclusion5 decks23 decks
20%synergy
Hero's Downfall
22%inclusion5 decks23 decks
15%synergy
Sheoldred's Edict
22%inclusion5 decks23 decks
7%synergy
Whisper of the Dross
22%inclusion5 decks23 decks
19%synergy
Infernal Grasp
22%inclusion5 decks23 decks
-3%synergy
Withering Torment
22%inclusion5 decks23 decks
-10%synergy
Culling the Weak
17%inclusion4 decks23 decks
3%synergy
Withering Boon
17%inclusion4 decks23 decks
13%synergy
Fell the Profane
13%inclusion3 decks23 decks
-6%synergy
Force of Despair
13%inclusion3 decks23 decks
5%synergy
Soul Shatter
13%inclusion3 decks23 decks
1%synergy
Bitter Triumph
13%inclusion3 decks23 decks
3%synergy
Murder
13%inclusion3 decks23 decks
3%synergy
Malakir Rebirth
13%inclusion3 decks23 decks
-9%synergy
Baleful Mastery
13%inclusion3 decks23 decks
4%synergy
Fatal Push
8.7%inclusion2 decks23 decks
6%synergy
Defile
8.7%inclusion2 decks23 decks
-29%synergy
Doom Blade
8.7%inclusion2 decks23 decks
1%synergy
Slaughter Pact
8.7%inclusion2 decks23 decks
6%synergy
Virulent Wound
8.7%inclusion2 decks23 decks
8%synergy
Ad Nauseam
8.7%inclusion2 decks23 decks
6%synergy
Black Sun's Twilight
8.7%inclusion2 decks23 decks
4%synergy
Tragic Slip
8.7%inclusion2 decks23 decks
-12%synergy
Archenemy's Charm
5.9%inclusion1 decks17 decks
-3%synergy
Overkill
5.3%inclusion1 decks19 decks
-2%synergy
Sorceries
Infectious Inquiry
52%inclusion12 decks23 decks
49%synergy
Damnation
52%inclusion12 decks23 decks
31%synergy
Phyresis Outbreak
48%inclusion11 decks23 decks
46%synergy
Drown in Ichor
48%inclusion11 decks23 decks
43%synergy
Bubbling Muck
43%inclusion10 decks23 decks
28%synergy
Crux of Fate
39%inclusion9 decks23 decks
38%synergy
Night's Whisper
39%inclusion9 decks23 decks
15%synergy
Sign in Blood
35%inclusion8 decks23 decks
-2%synergy
Reanimate
26%inclusion6 decks23 decks
-13%synergy
Diabolic Tutor
22%inclusion5 decks23 decks
7%synergy
Profane Tutor
22%inclusion5 decks23 decks
17%synergy
Caress of Phyrexia
22%inclusion5 decks23 decks
21%synergy
Insatiable Avarice
22%inclusion5 decks23 decks
10%synergy
Beseech the Mirror
22%inclusion5 decks23 decks
15%synergy
Blasphemous Edict
18%inclusion4 decks22 decks
1%synergy
Vat Emergence
17%inclusion4 decks23 decks
16%synergy
Torment of Hailfire
17%inclusion4 decks23 decks
1%synergy
Duress
17%inclusion4 decks23 decks
11%synergy
Praetor's Grasp
17%inclusion4 decks23 decks
13%synergy
Yawgmoth's Will
13%inclusion3 decks23 decks
10%synergy
Mutilate
13%inclusion3 decks23 decks
-6%synergy
Exsanguinate
13%inclusion3 decks23 decks
-11%synergy
Diabolic Intent
8.7%inclusion2 decks23 decks
-6%synergy
Black Sun's Zenith
8.7%inclusion2 decks23 decks
3%synergy
Inquisition of Kozilek
8.7%inclusion2 decks23 decks
7%synergy
Dark Petition
8.7%inclusion2 decks23 decks
5%synergy
Dreams of Steel and Oil
8.7%inclusion2 decks23 decks
9%synergy
Beseech the Queen
8.7%inclusion2 decks23 decks
3%synergy
Thoughtseize
8.7%inclusion2 decks23 decks
4%synergy
Utility Artifacts
Nightmare Lash
52%inclusion12 decks23 decks
50%synergy
Blackblade Reforged
52%inclusion12 decks23 decks
49%synergy
Swiftfoot Boots
39%inclusion9 decks23 decks
8%synergy
Lightning Greaves
39%inclusion9 decks23 decks
6%synergy
Bolas's Citadel
30%inclusion7 decks23 decks
1%synergy
Sword of Truth and Justice
30%inclusion7 decks23 decks
30%synergy
Whispersilk Cloak
30%inclusion7 decks23 decks
24%synergy
Champion's Helm
30%inclusion7 decks23 decks
29%synergy
The Darkness Crystal
26%inclusion5 decks19 decks
7%synergy
Sensei's Divining Top
26%inclusion6 decks23 decks
18%synergy
Mithril Coat
26%inclusion6 decks23 decks
20%synergy
Contagion Engine
26%inclusion6 decks23 decks
24%synergy
Wishclaw Talisman
26%inclusion6 decks23 decks
19%synergy
Expedition Map
22%inclusion5 decks23 decks
9%synergy
Conqueror's Flail
22%inclusion5 decks23 decks
21%synergy
Fireshrieker
22%inclusion5 decks23 decks
20%synergy
Hammer of Nazahn
22%inclusion5 decks23 decks
21%synergy
Thran Power Suit
17%inclusion4 decks23 decks
17%synergy
Sword of Wealth and Power
17%inclusion4 decks23 decks
17%synergy
Pact Weapon
17%inclusion4 decks23 decks
15%synergy
Sword of Feast and Famine
17%inclusion4 decks23 decks
16%synergy
Sword of the Animist
17%inclusion4 decks23 decks
13%synergy
Genji Glove
16%inclusion3 decks19 decks
15%synergy
Leyline Axe
14%inclusion3 decks22 decks
13%synergy
Doc Ock's Tentacles
13%inclusion2 decks15 decks
13%synergy
Contagion Clasp
13%inclusion3 decks23 decks
10%synergy
Trailblazer's Boots
13%inclusion3 decks23 decks
11%synergy
Cranial Plating
13%inclusion3 decks23 decks
9%synergy
Sword of Hearth and Home
13%inclusion3 decks23 decks
12%synergy
Silver Shroud Costume
13%inclusion3 decks23 decks
12%synergy
Black Mage's Rod
11%inclusion2 decks19 decks
10%synergy
The Immortal Sun
8.7%inclusion2 decks23 decks
8%synergy
Bitterthorn, Nissa's Animus
8.7%inclusion2 decks23 decks
8%synergy
Bontu's Monument
8.7%inclusion2 decks23 decks
-19%synergy
Winter Moon
8.7%inclusion2 decks23 decks
7%synergy
Sword of Sinew and Steel
8.7%inclusion2 decks23 decks
8%synergy
Brotherhood Regalia
8.7%inclusion2 decks23 decks
6%synergy
Isochron Scepter
8.7%inclusion2 decks23 decks
8%synergy
Sword of Vengeance
8.7%inclusion2 decks23 decks
8%synergy
Hero's Blade
8.7%inclusion2 decks23 decks
8%synergy
Basilisk Collar
8.7%inclusion2 decks23 decks
6%synergy
Buster Sword
5.3%inclusion1 decks19 decks
4%synergy
Enchantments
Black Market Connections
43%inclusion10 decks23 decks
20%synergy
No Mercy
26%inclusion6 decks23 decks
19%synergy
Necrogen Communion
26%inclusion6 decks23 decks
24%synergy
Super State
22%inclusion4 decks18 decks
22%synergy
The Meathook Massacre
22%inclusion5 decks23 decks
4%synergy
Contamination
22%inclusion5 decks23 decks
18%synergy
Phyresis
17%inclusion4 decks23 decks
15%synergy
Phyrexian Reclamation
13%inclusion3 decks23 decks
3%synergy
Leyline of the Void
13%inclusion3 decks23 decks
11%synergy
Grievous Wound
8.7%inclusion2 decks23 decks
6%synergy
Haunted One
8.7%inclusion2 decks23 decks
6%synergy
Grave Pact
8.7%inclusion2 decks23 decks
-10%synergy
Exquisite Blood
8.7%inclusion2 decks23 decks
-5%synergy
Wound Reflection
8.7%inclusion2 decks23 decks
5%synergy
Kaya's Ghostform
8.7%inclusion2 decks23 decks
-1%synergy
Dauthi Embrace
8.7%inclusion2 decks23 decks
7%synergy
Snake Cult Initiation
8.7%inclusion2 decks23 decks
9%synergy
Oubliette
8.7%inclusion2 decks23 decks
6%synergy
Demonic Embrace
8.7%inclusion2 decks23 decks
8%synergy
Infernal Darkness
8.7%inclusion2 decks23 decks
8%synergy
Heartless Summoning
8.7%inclusion2 decks23 decks
4%synergy
Bitterblossom
8.7%inclusion2 decks23 decks
-4%synergy
Planeswalkers
Vraska, Betrayal's Sting
35%inclusion8 decks23 decks
32%synergy
Tezzeret, Cruel Captain
11%inclusion2 decks18 decks
10%synergy
Utility Lands
Urborg, Tomb of Yawgmoth
78%inclusion18 decks23 decks
41%synergy
Cabal Coffers
74%inclusion17 decks23 decks
19%synergy
Rogue's Passage
65%inclusion15 decks23 decks
47%synergy
Inkmoth Nexus
48%inclusion11 decks23 decks
47%synergy
Urza's Saga
43%inclusion10 decks23 decks
35%synergy
Nykthos, Shrine to Nyx
39%inclusion9 decks23 decks
9%synergy
Cabal Stronghold
35%inclusion8 decks23 decks
-1%synergy
Lake of the Dead
35%inclusion8 decks23 decks
30%synergy
Bojuka Bog
30%inclusion7 decks23 decks
-16%synergy
Strip Mine
26%inclusion6 decks23 decks
23%synergy
The Black Gate
17%inclusion4 decks23 decks
14%synergy
Cathedral of War
17%inclusion4 decks23 decks
17%synergy
Command Beacon
17%inclusion4 decks23 decks
9%synergy
Deserted Temple
17%inclusion4 decks23 decks
13%synergy
Takenuma, Abandoned Mire
17%inclusion4 decks23 decks
1%synergy
Homeward Path
17%inclusion4 decks23 decks
16%synergy
Temple of the False God
17%inclusion4 decks23 decks
9%synergy
Arcane Lighthouse
13%inclusion3 decks23 decks
11%synergy
Minas Morgul, Dark Fortress
13%inclusion3 decks23 decks
10%synergy
Castle Locthwain
13%inclusion3 decks23 decks
-5%synergy
Reliquary Tower
13%inclusion3 decks23 decks
-18%synergy
Vault of Whispers
8.7%inclusion2 decks23 decks
3%synergy
Wasteland
8.7%inclusion2 decks23 decks
7%synergy
Phyrexian Tower
8.7%inclusion2 decks23 decks
-15%synergy
Maze of Ith
8.7%inclusion2 decks23 decks
5%synergy
War Room
8.7%inclusion2 decks23 decks
-8%synergy
Emergence Zone
8.7%inclusion2 decks23 decks
5%synergy
Mishra's Workshop
8.7%inclusion2 decks23 decks
8%synergy
Midgar, City of Mako
5.3%inclusion1 decks19 decks
-7%synergy
Mana Artifacts
Sol Ring
96%inclusion22 decks23 decks
9%synergy
Arcane Signet
65%inclusion15 decks23 decks
3%synergy
Lotus Petal
48%inclusion11 decks23 decks
40%synergy
Mox Opal
48%inclusion11 decks23 decks
44%synergy
The Soul Stone
35%inclusion6 decks17 decks
23%synergy
Staff of Compleation
35%inclusion8 decks23 decks
33%synergy
Mox Amber
35%inclusion8 decks23 decks
30%synergy
Glistening Sphere
30%inclusion7 decks23 decks
29%synergy
Mox Diamond
30%inclusion7 decks23 decks
27%synergy
Caged Sun
22%inclusion5 decks23 decks
9%synergy
Heraldic Banner
22%inclusion5 decks23 decks
16%synergy
Fellwar Stone
22%inclusion5 decks23 decks
7%synergy
Mind Stone
22%inclusion5 decks23 decks
-9%synergy
Grim Monolith
17%inclusion4 decks23 decks
15%synergy
Throne of Eldraine
17%inclusion4 decks23 decks
7%synergy
Gilded Lotus
17%inclusion4 decks23 decks
12%synergy
Mox Jasper
14%inclusion3 decks21 decks
14%synergy
Extraplanar Lens
13%inclusion3 decks23 decks
8%synergy
Charcoal Diamond
8.7%inclusion2 decks23 decks
-15%synergy
Basalt Monolith
8.7%inclusion2 decks23 decks
7%synergy
Thought Vessel
8.7%inclusion2 decks23 decks
-18%synergy
Lands
Swamp
96%inclusion22 decks23 decks
1%synergy
Cavern of Souls
52%inclusion12 decks23 decks
46%synergy
Verdant Catacombs
30%inclusion7 decks23 decks
27%synergy
Bloodstained Mire
30%inclusion7 decks23 decks
27%synergy
Gemstone Caverns
26%inclusion6 decks23 decks
22%synergy
Marsh Flats
26%inclusion6 decks23 decks
23%synergy
Polluted Delta
26%inclusion6 decks23 decks
23%synergy
Fell the Profane
13%inclusion3 decks23 decks
-6%synergy
Command Tower
13%inclusion3 decks23 decks
8%synergy
Fabled Passage
13%inclusion3 decks23 decks
11%synergy
Myriad Landscape
13%inclusion3 decks23 decks
-14%synergy
Mirrex
13%inclusion3 decks23 decks
12%synergy
Malakir Rebirth
13%inclusion3 decks23 decks
-9%synergy
Prismatic Vista
8.7%inclusion2 decks23 decks
6%synergy
The Mycosynth Gardens
8.7%inclusion2 decks23 decks
7%synergy
Plaza of Heroes
8.7%inclusion2 decks23 decks
8%synergy
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