Skithiryx, the Blight Dragon (Commander) - Optimized Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #779
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Utility Lands
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Bitterbloom Bearer
7.7%inclusion1 decks13 decks
5%synergy
High Synergy Cards
Whispering Specter
77%inclusion17 decks22 decks
77%synergy
Plague Stinger
77%inclusion17 decks22 decks
76%synergy
Karn's Bastion
64%inclusion14 decks22 decks
59%synergy
Howl from Beyond
59%inclusion13 decks22 decks
58%synergy
Shizo, Death's Storehouse
68%inclusion15 decks22 decks
58%synergy
Plague Myr
59%inclusion13 decks22 decks
58%synergy
Blackblade Reforged
59%inclusion13 decks22 decks
56%synergy
Lashwrithe
59%inclusion13 decks22 decks
55%synergy
Hand of the Praetors
55%inclusion12 decks22 decks
54%synergy
Deadly Rollick
77%inclusion17 decks22 decks
54%synergy
Top Cards
Dark Ritual
91%inclusion20 decks22 decks
24%synergy
Jet Medallion
86%inclusion19 decks22 decks
26%synergy
Crypt Ghast
77%inclusion17 decks22 decks
29%synergy
Toxic Deluge
64%inclusion14 decks22 decks
26%synergy
Cabal Ritual
59%inclusion13 decks22 decks
41%synergy
Damnation
59%inclusion13 decks22 decks
38%synergy
Vraska's Fall
55%inclusion12 decks22 decks
51%synergy
Nightmare Lash
55%inclusion12 decks22 decks
52%synergy
Phyresis Outbreak
55%inclusion12 decks22 decks
53%synergy
Feed the Swarm
55%inclusion12 decks22 decks
3%synergy
Game Changers
Demonic Tutor
86%inclusion19 decks22 decks
59%synergy
Vampiric Tutor
82%inclusion18 decks22 decks
60%synergy
Ancient Tomb
68%inclusion15 decks22 decks
56%synergy
Necropotence
59%inclusion13 decks22 decks
44%synergy
Mana Vault
55%inclusion12 decks22 decks
48%synergy
Chrome Mox
50%inclusion11 decks22 decks
44%synergy
Imperial Seal
45%inclusion10 decks22 decks
38%synergy
Opposition Agent
45%inclusion10 decks22 decks
36%synergy
The One Ring
41%inclusion9 decks22 decks
31%synergy
Orcish Bowmasters
36%inclusion8 decks22 decks
23%synergy
Creatures
Phyrexian Crusader
50%inclusion11 decks22 decks
49%synergy
Ichor Rats
50%inclusion11 decks22 decks
47%synergy
Dauthi Voidwalker
45%inclusion10 decks22 decks
30%synergy
Sheoldred, the Apocalypse
41%inclusion9 decks22 decks
26%synergy
Phyrexian Obliterator
36%inclusion8 decks22 decks
25%synergy
Yawgmoth, Thran Physician
36%inclusion8 decks22 decks
26%synergy
K'rrik, Son of Yawgmoth
36%inclusion8 decks22 decks
18%synergy
Pestilent Syphoner
27%inclusion6 decks22 decks
27%synergy
Dark Confidant
27%inclusion6 decks22 decks
20%synergy
Reaper of Sheoldred
27%inclusion6 decks22 decks
27%synergy
Ichorclaw Myr
27%inclusion6 decks22 decks
27%synergy
Blightbelly Rat
27%inclusion6 decks22 decks
24%synergy
Gray Merchant of Asphodel
23%inclusion5 decks22 decks
-29%synergy
Flensermite
23%inclusion5 decks22 decks
22%synergy
Flesh-Eater Imp
23%inclusion5 decks22 decks
22%synergy
Bilious Skulldweller
18%inclusion4 decks22 decks
17%synergy
Blightsteel Colossus
18%inclusion4 decks22 decks
18%synergy
Contagious Nim
14%inclusion3 decks22 decks
13%synergy
Myr Convert
14%inclusion3 decks22 decks
13%synergy
Vito, Thorn of the Dusk Rose
14%inclusion3 decks22 decks
3%synergy
Corpse Cur
14%inclusion3 decks22 decks
13%synergy
Sheoldred, Whispering One
14%inclusion3 decks22 decks
2%synergy
Septic Rats
14%inclusion3 decks22 decks
12%synergy
Necropede
14%inclusion3 decks22 decks
13%synergy
Solemn Simulacrum
9.1%inclusion2 decks22 decks
-14%synergy
Core Prowler
9.1%inclusion2 decks22 decks
8%synergy
Maha, Its Feathers Night
9.1%inclusion2 decks22 decks
4%synergy
Blackcleave Goblin
9.1%inclusion2 decks22 decks
9%synergy
Lobelia Sackville-Baggins
9.1%inclusion2 decks22 decks
8%synergy
Bloodletter of Aclazotz
9.1%inclusion2 decks22 decks
-2%synergy
Swamp Mosquito
9.1%inclusion2 decks22 decks
9%synergy
Necroskitter
9.1%inclusion2 decks22 decks
6%synergy
Nirkana Revenant
9.1%inclusion2 decks22 decks
-2%synergy
Massacre Wurm
9.1%inclusion2 decks22 decks
-8%synergy
Metalworker
9.1%inclusion2 decks22 decks
9%synergy
Sheoldred's Headcleaver
9.1%inclusion2 decks22 decks
9%synergy
Nimraiser Paladin
9.1%inclusion2 decks22 decks
9%synergy
Scheming Aspirant
9.1%inclusion2 decks22 decks
9%synergy
Gulping Scraptrap
9.1%inclusion2 decks22 decks
9%synergy
Agent Venom
6.7%inclusion1 decks15 decks
4%synergy
Jecht, Reluctant Guardian
5.6%inclusion1 decks18 decks
3%synergy
Instants
Dismember
45%inclusion10 decks22 decks
34%synergy
Imp's Mischief
41%inclusion9 decks22 decks
17%synergy
Hatred
41%inclusion9 decks22 decks
40%synergy
Go for the Throat
36%inclusion8 decks22 decks
13%synergy
Sudden Spoiling
36%inclusion8 decks22 decks
27%synergy
Whisper of the Dross
27%inclusion6 decks22 decks
24%synergy
Snuff Out
27%inclusion6 decks22 decks
15%synergy
Darkness
27%inclusion6 decks22 decks
18%synergy
Hero's Downfall
23%inclusion5 decks22 decks
16%synergy
Cut Down
23%inclusion5 decks22 decks
18%synergy
Sheoldred's Edict
23%inclusion5 decks22 decks
8%synergy
Tainted Strike
23%inclusion5 decks22 decks
20%synergy
Astarion's Thirst
18%inclusion4 decks22 decks
17%synergy
Culling the Weak
18%inclusion4 decks22 decks
3%synergy
Infernal Grasp
18%inclusion4 decks22 decks
-7%synergy
Withering Torment
18%inclusion4 decks22 decks
-13%synergy
Fell the Profane
14%inclusion3 decks22 decks
-5%synergy
Force of Despair
14%inclusion3 decks22 decks
6%synergy
Defile
14%inclusion3 decks22 decks
-24%synergy
Soul Shatter
14%inclusion3 decks22 decks
1%synergy
Withering Boon
14%inclusion3 decks22 decks
9%synergy
Murder
14%inclusion3 decks22 decks
3%synergy
Malakir Rebirth
14%inclusion3 decks22 decks
-9%synergy
Fatal Push
9.1%inclusion2 decks22 decks
6%synergy
Grim Affliction
9.1%inclusion2 decks22 decks
7%synergy
Doom Blade
9.1%inclusion2 decks22 decks
1%synergy
Slaughter Pact
9.1%inclusion2 decks22 decks
6%synergy
Virulent Wound
9.1%inclusion2 decks22 decks
9%synergy
Bitter Triumph
9.1%inclusion2 decks22 decks
-1%synergy
Ad Nauseam
9.1%inclusion2 decks22 decks
6%synergy
Baleful Mastery
9.1%inclusion2 decks22 decks
0%synergy
Black Sun's Twilight
9.1%inclusion2 decks22 decks
5%synergy
Overkill
5.6%inclusion1 decks18 decks
-2%synergy
Sorceries
Infectious Inquiry
55%inclusion12 decks22 decks
52%synergy
Drown in Ichor
55%inclusion12 decks22 decks
50%synergy
Grim Tutor
55%inclusion12 decks22 decks
43%synergy
Night's Whisper
45%inclusion10 decks22 decks
21%synergy
Bubbling Muck
41%inclusion9 decks22 decks
25%synergy
Crux of Fate
41%inclusion9 decks22 decks
40%synergy
Sign in Blood
41%inclusion9 decks22 decks
5%synergy
Reanimate
32%inclusion7 decks22 decks
-7%synergy
Diabolic Tutor
23%inclusion5 decks22 decks
8%synergy
Torment of Hailfire
23%inclusion5 decks22 decks
7%synergy
Caress of Phyrexia
23%inclusion5 decks22 decks
22%synergy
Blasphemous Edict
19%inclusion4 decks21 decks
2%synergy
Vat Emergence
18%inclusion4 decks22 decks
17%synergy
Profane Tutor
18%inclusion4 decks22 decks
14%synergy
Duress
18%inclusion4 decks22 decks
11%synergy
Exsanguinate
18%inclusion4 decks22 decks
-6%synergy
Insatiable Avarice
18%inclusion4 decks22 decks
6%synergy
Beseech the Mirror
18%inclusion4 decks22 decks
11%synergy
Mutilate
14%inclusion3 decks22 decks
-5%synergy
Praetor's Grasp
14%inclusion3 decks22 decks
10%synergy
Black Sun's Zenith
9.1%inclusion2 decks22 decks
3%synergy
Victimize
9.1%inclusion2 decks22 decks
-17%synergy
Yawgmoth's Will
9.1%inclusion2 decks22 decks
6%synergy
Inquisition of Kozilek
9.1%inclusion2 decks22 decks
7%synergy
Read the Bones
9.1%inclusion2 decks22 decks
-9%synergy
Dark Petition
9.1%inclusion2 decks22 decks
5%synergy
Dreams of Steel and Oil
9.1%inclusion2 decks22 decks
9%synergy
Beseech the Queen
9.1%inclusion2 decks22 decks
3%synergy
Thoughtseize
9.1%inclusion2 decks22 decks
4%synergy
Utility Artifacts
Shadowspear
55%inclusion12 decks22 decks
51%synergy
Commander's Plate
55%inclusion12 decks22 decks
49%synergy
Lightning Greaves
45%inclusion10 decks22 decks
12%synergy
Swiftfoot Boots
41%inclusion9 decks22 decks
9%synergy
Sword of Truth and Justice
36%inclusion8 decks22 decks
36%synergy
Whispersilk Cloak
36%inclusion8 decks22 decks
30%synergy
Bolas's Citadel
32%inclusion7 decks22 decks
3%synergy
Contagion Engine
32%inclusion7 decks22 decks
30%synergy
The Darkness Crystal
28%inclusion5 decks18 decks
8%synergy
Mithril Coat
27%inclusion6 decks22 decks
22%synergy
Wishclaw Talisman
27%inclusion6 decks22 decks
21%synergy
Champion's Helm
27%inclusion6 decks22 decks
25%synergy
Sensei's Divining Top
23%inclusion5 decks22 decks
14%synergy
Expedition Map
23%inclusion5 decks22 decks
10%synergy
Conqueror's Flail
23%inclusion5 decks22 decks
22%synergy
Fireshrieker
23%inclusion5 decks22 decks
21%synergy
Contagion Clasp
18%inclusion4 decks22 decks
16%synergy
Hammer of Nazahn
18%inclusion4 decks22 decks
17%synergy
Genji Glove
17%inclusion3 decks18 decks
16%synergy
Doc Ock's Tentacles
14%inclusion2 decks14 decks
14%synergy
Thran Power Suit
14%inclusion3 decks22 decks
13%synergy
Trailblazer's Boots
14%inclusion3 decks22 decks
11%synergy
Silver Shroud Costume
14%inclusion3 decks22 decks
12%synergy
Pact Weapon
14%inclusion3 decks22 decks
11%synergy
Sword of Feast and Famine
14%inclusion3 decks22 decks
12%synergy
Sword of the Animist
14%inclusion3 decks22 decks
10%synergy
Leyline Axe
10%inclusion2 decks21 decks
9%synergy
Cranial Plating
9.1%inclusion2 decks22 decks
6%synergy
Sword of Hearth and Home
9.1%inclusion2 decks22 decks
8%synergy
Bontu's Monument
9.1%inclusion2 decks22 decks
-19%synergy
Sword of Wealth and Power
9.1%inclusion2 decks22 decks
8%synergy
Winter Moon
9.1%inclusion2 decks22 decks
7%synergy
Brotherhood Regalia
9.1%inclusion2 decks22 decks
7%synergy
Isochron Scepter
9.1%inclusion2 decks22 decks
9%synergy
Sword of Vengeance
9.1%inclusion2 decks22 decks
8%synergy
Hero's Blade
9.1%inclusion2 decks22 decks
9%synergy
Basilisk Collar
9.1%inclusion2 decks22 decks
6%synergy
Black Mage's Rod
5.6%inclusion1 decks18 decks
5%synergy
Buster Sword
5.6%inclusion1 decks18 decks
5%synergy
Dragonfire Blade
5.0%inclusion1 decks20 decks
5%synergy
Adaptive Omnitool
5.0%inclusion1 decks20 decks
5%synergy
Enchantments
Unspeakable Symbol
55%inclusion12 decks22 decks
54%synergy
Phyrexian Arena
55%inclusion12 decks22 decks
14%synergy
Black Market Connections
41%inclusion9 decks22 decks
18%synergy
Necrogen Communion
32%inclusion7 decks22 decks
30%synergy
No Mercy
27%inclusion6 decks22 decks
20%synergy
Super State
24%inclusion4 decks17 decks
23%synergy
The Meathook Massacre
18%inclusion4 decks22 decks
1%synergy
Contamination
18%inclusion4 decks22 decks
15%synergy
Phyresis
18%inclusion4 decks22 decks
16%synergy
Phyrexian Reclamation
14%inclusion3 decks22 decks
4%synergy
Leyline of the Void
14%inclusion3 decks22 decks
12%synergy
Grievous Wound
9.1%inclusion2 decks22 decks
7%synergy
Haunted One
9.1%inclusion2 decks22 decks
6%synergy
Grave Pact
9.1%inclusion2 decks22 decks
-10%synergy
Exquisite Blood
9.1%inclusion2 decks22 decks
-4%synergy
Wound Reflection
9.1%inclusion2 decks22 decks
6%synergy
Kaya's Ghostform
9.1%inclusion2 decks22 decks
-1%synergy
Dauthi Embrace
9.1%inclusion2 decks22 decks
7%synergy
Snake Cult Initiation
9.1%inclusion2 decks22 decks
9%synergy
Oubliette
9.1%inclusion2 decks22 decks
6%synergy
Demonic Embrace
9.1%inclusion2 decks22 decks
8%synergy
Infernal Darkness
9.1%inclusion2 decks22 decks
9%synergy
Heartless Summoning
9.1%inclusion2 decks22 decks
4%synergy
Bitterblossom
9.1%inclusion2 decks22 decks
-4%synergy
Planeswalkers
Liliana of the Dark Realms
55%inclusion12 decks22 decks
40%synergy
Vraska, Betrayal's Sting
41%inclusion9 decks22 decks
38%synergy
Tezzeret, Cruel Captain
5.9%inclusion1 decks17 decks
5%synergy
Utility Lands
Urborg, Tomb of Yawgmoth
77%inclusion17 decks22 decks
40%synergy
Cabal Coffers
73%inclusion16 decks22 decks
18%synergy
Rogue's Passage
68%inclusion15 decks22 decks
50%synergy
Inkmoth Nexus
50%inclusion11 decks22 decks
49%synergy
Cabal Stronghold
41%inclusion9 decks22 decks
5%synergy
Nykthos, Shrine to Nyx
41%inclusion9 decks22 decks
11%synergy
Urza's Saga
36%inclusion8 decks22 decks
28%synergy
Lake of the Dead
36%inclusion8 decks22 decks
31%synergy
Bojuka Bog
32%inclusion7 decks22 decks
-15%synergy
Strip Mine
27%inclusion6 decks22 decks
24%synergy
Cathedral of War
18%inclusion4 decks22 decks
18%synergy
Command Beacon
18%inclusion4 decks22 decks
10%synergy
Deserted Temple
18%inclusion4 decks22 decks
14%synergy
Takenuma, Abandoned Mire
18%inclusion4 decks22 decks
2%synergy
Reliquary Tower
18%inclusion4 decks22 decks
-13%synergy
Homeward Path
18%inclusion4 decks22 decks
16%synergy
Temple of the False God
18%inclusion4 decks22 decks
10%synergy
Arcane Lighthouse
14%inclusion3 decks22 decks
12%synergy
The Black Gate
14%inclusion3 decks22 decks
10%synergy
Minas Morgul, Dark Fortress
14%inclusion3 decks22 decks
11%synergy
Wasteland
9.1%inclusion2 decks22 decks
8%synergy
Phyrexian Tower
9.1%inclusion2 decks22 decks
-15%synergy
Maze of Ith
9.1%inclusion2 decks22 decks
6%synergy
War Room
9.1%inclusion2 decks22 decks
-7%synergy
Emergence Zone
9.1%inclusion2 decks22 decks
6%synergy
Mishra's Workshop
9.1%inclusion2 decks22 decks
9%synergy
Castle Locthwain
9.1%inclusion2 decks22 decks
-8%synergy
Mana Artifacts
Sol Ring
95%inclusion21 decks22 decks
9%synergy
Arcane Signet
59%inclusion13 decks22 decks
-3%synergy
Lotus Petal
41%inclusion9 decks22 decks
33%synergy
Mox Opal
41%inclusion9 decks22 decks
37%synergy
Staff of Compleation
36%inclusion8 decks22 decks
35%synergy
Glistening Sphere
36%inclusion8 decks22 decks
35%synergy
Mox Amber
32%inclusion7 decks22 decks
27%synergy
The Soul Stone
31%inclusion5 decks16 decks
18%synergy
Mox Diamond
27%inclusion6 decks22 decks
24%synergy
Caged Sun
18%inclusion4 decks22 decks
6%synergy
Heraldic Banner
18%inclusion4 decks22 decks
13%synergy
Fellwar Stone
18%inclusion4 decks22 decks
3%synergy
Gilded Lotus
18%inclusion4 decks22 decks
13%synergy
Mind Stone
18%inclusion4 decks22 decks
-12%synergy
Grim Monolith
14%inclusion3 decks22 decks
11%synergy
Throne of Eldraine
14%inclusion3 decks22 decks
3%synergy
Mox Jasper
10%inclusion2 decks20 decks
10%synergy
Charcoal Diamond
9.1%inclusion2 decks22 decks
-14%synergy
Basalt Monolith
9.1%inclusion2 decks22 decks
7%synergy
Thought Vessel
9.1%inclusion2 decks22 decks
-18%synergy
Extraplanar Lens
9.1%inclusion2 decks22 decks
4%synergy
Lands
Swamp
95%inclusion21 decks22 decks
1%synergy
Cavern of Souls
50%inclusion11 decks22 decks
43%synergy
Verdant Catacombs
27%inclusion6 decks22 decks
24%synergy
Bloodstained Mire
27%inclusion6 decks22 decks
24%synergy
Gemstone Caverns
23%inclusion5 decks22 decks
18%synergy
Marsh Flats
23%inclusion5 decks22 decks
19%synergy
Polluted Delta
23%inclusion5 decks22 decks
19%synergy
Fell the Profane
14%inclusion3 decks22 decks
-5%synergy
Command Tower
14%inclusion3 decks22 decks
8%synergy
Myriad Landscape
14%inclusion3 decks22 decks
-13%synergy
Mirrex
14%inclusion3 decks22 decks
13%synergy
Malakir Rebirth
14%inclusion3 decks22 decks
-9%synergy
Prismatic Vista
9.1%inclusion2 decks22 decks
7%synergy
The Mycosynth Gardens
9.1%inclusion2 decks22 decks
8%synergy
Fabled Passage
9.1%inclusion2 decks22 decks
7%synergy
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