Skithiryx, the Blight Dragon (Commander) - Optimized

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #790
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Bitterbloom Bearer
2.9%inclusion1 decks35 decks
1%synergy
High Synergy Cards
Plague Stinger
61%inclusion51 decks83 decks
60%synergy
Plague Myr
59%inclusion49 decks83 decks
58%synergy
Lashwrithe
57%inclusion47 decks83 decks
53%synergy
Infectious Inquiry
53%inclusion44 decks83 decks
50%synergy
Whispering Specter
51%inclusion42 decks83 decks
50%synergy
Commander's Plate
51%inclusion42 decks83 decks
45%synergy
Phyrexian Crusader
46%inclusion38 decks83 decks
45%synergy
Inkmoth Nexus
46%inclusion38 decks83 decks
45%synergy
Nightmare Lash
47%inclusion39 decks83 decks
45%synergy
Ichor Rats
47%inclusion39 decks83 decks
44%synergy
Top Cards
Dark Ritual
89%inclusion74 decks83 decks
23%synergy
Jet Medallion
80%inclusion66 decks83 decks
19%synergy
Crypt Ghast
63%inclusion52 decks83 decks
14%synergy
Phyrexian Arena
63%inclusion52 decks83 decks
22%synergy
Deadly Rollick
61%inclusion51 decks83 decks
38%synergy
Toxic Deluge
55%inclusion46 decks83 decks
18%synergy
Cabal Ritual
51%inclusion42 decks83 decks
33%synergy
Feed the Swarm
49%inclusion41 decks83 decks
-2%synergy
Vraska's Fall
46%inclusion38 decks83 decks
42%synergy
Lightning Greaves
46%inclusion38 decks83 decks
12%synergy
Game Changers
Demonic Tutor
77%inclusion64 decks83 decks
49%synergy
Vampiric Tutor
70%inclusion58 decks83 decks
48%synergy
Ancient Tomb
54%inclusion45 decks83 decks
42%synergy
Necropotence
53%inclusion44 decks83 decks
38%synergy
Mana Vault
47%inclusion39 decks83 decks
40%synergy
Opposition Agent
46%inclusion38 decks83 decks
36%synergy
The One Ring
41%inclusion34 decks83 decks
31%synergy
Bolas's Citadel
40%inclusion33 decks83 decks
10%synergy
Chrome Mox
39%inclusion32 decks83 decks
32%synergy
Orcish Bowmasters
36%inclusion30 decks83 decks
22%synergy
Creatures
Hand of the Praetors
45%inclusion37 decks83 decks
44%synergy
Dauthi Voidwalker
43%inclusion36 decks83 decks
28%synergy
Sheoldred, the Apocalypse
31%inclusion26 decks83 decks
16%synergy
Phyrexian Obliterator
28%inclusion23 decks83 decks
17%synergy
K'rrik, Son of Yawgmoth
28%inclusion23 decks83 decks
9%synergy
Gray Merchant of Asphodel
28%inclusion23 decks83 decks
-24%synergy
Yawgmoth, Thran Physician
27%inclusion22 decks83 decks
16%synergy
Blightbelly Rat
27%inclusion22 decks83 decks
23%synergy
Flesh-Eater Imp
25%inclusion21 decks83 decks
25%synergy
Flensermite
23%inclusion19 decks83 decks
22%synergy
Dark Confidant
23%inclusion19 decks83 decks
16%synergy
Ichorclaw Myr
18%inclusion15 decks83 decks
18%synergy
Pestilent Syphoner
17%inclusion14 decks83 decks
16%synergy
Reaper of Sheoldred
17%inclusion14 decks83 decks
16%synergy
Solemn Simulacrum
16%inclusion13 decks83 decks
-8%synergy
Myr Convert
16%inclusion13 decks83 decks
15%synergy
Sheoldred, Whispering One
16%inclusion13 decks83 decks
4%synergy
Magus of the Coffers
14%inclusion12 decks83 decks
7%synergy
Corpse Cur
14%inclusion12 decks83 decks
14%synergy
Core Prowler
13%inclusion11 decks83 decks
13%synergy
Nirkana Revenant
13%inclusion11 decks83 decks
2%synergy
Bilious Skulldweller
13%inclusion11 decks83 decks
12%synergy
Blightsteel Colossus
13%inclusion11 decks83 decks
13%synergy
Septic Rats
12%inclusion10 decks83 decks
10%synergy
Gwenom, Remorseless
11%inclusion5 decks46 decks
8%synergy
Agent Venom
10%inclusion4 decks41 decks
7%synergy
Vito, Thorn of the Dusk Rose
8.4%inclusion7 decks83 decks
-2%synergy
Massacre Wurm
8.4%inclusion7 decks83 decks
-9%synergy
Gulping Scraptrap
8.4%inclusion7 decks83 decks
8%synergy
Blood Pet
8.4%inclusion7 decks83 decks
0%synergy
Dread Presence
7.2%inclusion6 decks83 decks
-8%synergy
Necropede
7.2%inclusion6 decks83 decks
7%synergy
Contagious Nim
7.2%inclusion6 decks83 decks
7%synergy
Maha, Its Feathers Night
7.2%inclusion6 decks83 decks
2%synergy
Silent Arbiter
7.2%inclusion6 decks83 decks
6%synergy
Grafted Butcher
6.0%inclusion5 decks83 decks
6%synergy
Massacre Girl, Known Killer
6.0%inclusion5 decks83 decks
2%synergy
Scheming Aspirant
6.0%inclusion5 decks83 decks
6%synergy
Gix, Yawgmoth Praetor
6.0%inclusion5 decks83 decks
1%synergy
Braids, Arisen Nightmare
6.0%inclusion5 decks83 decks
-13%synergy
Bloodgift Demon
6.0%inclusion5 decks83 decks
3%synergy
Enduring Tenacity
6.0%inclusion5 decks83 decks
-2%synergy
Venomized Cat
5.0%inclusion2 decks40 decks
5%synergy
Instants
Imp's Mischief
43%inclusion36 decks83 decks
20%synergy
Dismember
40%inclusion33 decks83 decks
29%synergy
Howl from Beyond
37%inclusion31 decks83 decks
37%synergy
Malakir Rebirth
36%inclusion30 decks83 decks
14%synergy
Withering Torment
34%inclusion28 decks82 decks
3%synergy
Infernal Grasp
34%inclusion28 decks83 decks
9%synergy
Snuff Out
33%inclusion27 decks83 decks
20%synergy
Hatred
28%inclusion23 decks83 decks
27%synergy
Go for the Throat
27%inclusion22 decks83 decks
3%synergy
Tainted Strike
25%inclusion21 decks83 decks
22%synergy
Sudden Spoiling
23%inclusion19 decks83 decks
13%synergy
Whisper of the Dross
20%inclusion17 decks83 decks
17%synergy
Withering Boon
20%inclusion17 decks83 decks
16%synergy
Astarion's Thirst
20%inclusion17 decks83 decks
19%synergy
Darkness
20%inclusion17 decks83 decks
11%synergy
Baleful Mastery
20%inclusion17 decks83 decks
11%synergy
Cut Down
20%inclusion17 decks83 decks
16%synergy
Defile
19%inclusion16 decks83 decks
-19%synergy
Culling the Weak
17%inclusion14 decks83 decks
2%synergy
Grim Affliction
16%inclusion13 decks83 decks
13%synergy
Fell the Profane
14%inclusion12 decks83 decks
-4%synergy
Force of Despair
13%inclusion11 decks83 decks
5%synergy
Hero's Downfall
13%inclusion11 decks83 decks
6%synergy
Bitter Triumph
12%inclusion10 decks83 decks
2%synergy
Archenemy's Charm
12%inclusion6 decks51 decks
3%synergy
Sheoldred's Edict
11%inclusion9 decks83 decks
-4%synergy
Virulent Wound
10%inclusion8 decks83 decks
9%synergy
Murder
8.4%inclusion7 decks83 decks
-2%synergy
Supernatural Stamina
8.4%inclusion7 decks83 decks
1%synergy
Ad Nauseam
7.2%inclusion6 decks83 decks
5%synergy
Sugar Rush
7.2%inclusion6 decks83 decks
7%synergy
Slaughter Pact
7.2%inclusion6 decks83 decks
4%synergy
Tragic Slip
7.2%inclusion6 decks83 decks
-13%synergy
Soul Shatter
6.0%inclusion5 decks83 decks
-6%synergy
Unlikely Aid
6.0%inclusion5 decks83 decks
5%synergy
Sorceries
Damnation
45%inclusion37 decks83 decks
24%synergy
Bubbling Muck
42%inclusion35 decks83 decks
27%synergy
Crux of Fate
42%inclusion35 decks83 decks
41%synergy
Phyresis Outbreak
41%inclusion34 decks83 decks
39%synergy
Drown in Ichor
40%inclusion33 decks83 decks
35%synergy
Night's Whisper
39%inclusion32 decks83 decks
14%synergy
Grim Tutor
33%inclusion27 decks83 decks
21%synergy
Sign in Blood
33%inclusion27 decks83 decks
-4%synergy
Imperial Seal
31%inclusion26 decks83 decks
24%synergy
Reanimate
30%inclusion25 decks83 decks
-9%synergy
Caress of Phyrexia
20%inclusion17 decks83 decks
20%synergy
Insatiable Avarice
17%inclusion14 decks83 decks
5%synergy
Diabolic Tutor
17%inclusion14 decks83 decks
2%synergy
Mutilate
16%inclusion13 decks83 decks
-3%synergy
Beseech the Mirror
14%inclusion12 decks83 decks
8%synergy
Read the Bones
14%inclusion12 decks83 decks
-4%synergy
Profane Tutor
14%inclusion12 decks83 decks
10%synergy
Torment of Hailfire
14%inclusion12 decks83 decks
-1%synergy
Praetor's Grasp
13%inclusion11 decks83 decks
9%synergy
Blasphemous Edict
13%inclusion10 decks79 decks
-5%synergy
Exsanguinate
12%inclusion10 decks83 decks
-12%synergy
Black Sun's Zenith
12%inclusion10 decks83 decks
6%synergy
Vat Emergence
12%inclusion10 decks83 decks
10%synergy
Beseech the Queen
11%inclusion9 decks83 decks
5%synergy
Gix's Command
11%inclusion9 decks83 decks
9%synergy
Peer into the Abyss
8.4%inclusion7 decks83 decks
-2%synergy
Syphon Mind
7.2%inclusion6 decks83 decks
-6%synergy
Duress
7.2%inclusion6 decks83 decks
1%synergy
Thoughtseize
7.2%inclusion6 decks83 decks
2%synergy
Yawgmoth's Will
6.0%inclusion5 decks83 decks
3%synergy
Rise of the Dark Realms
6.0%inclusion5 decks83 decks
-6%synergy
Diabolic Intent
6.0%inclusion5 decks83 decks
-8%synergy
Victimize
6.0%inclusion5 decks83 decks
-20%synergy
Spread the Sickness
6.0%inclusion5 decks83 decks
5%synergy
Decree of Pain
6.0%inclusion5 decks83 decks
0%synergy
Utility Artifacts
Shadowspear
45%inclusion37 decks83 decks
41%synergy
Swiftfoot Boots
43%inclusion36 decks83 decks
12%synergy
Blackblade Reforged
39%inclusion32 decks83 decks
36%synergy
Contagion Engine
27%inclusion22 decks83 decks
24%synergy
Sword of Truth and Justice
27%inclusion22 decks83 decks
26%synergy
Whispersilk Cloak
27%inclusion22 decks83 decks
21%synergy
Champion's Helm
25%inclusion21 decks83 decks
23%synergy
The Darkness Crystal
24%inclusion14 decks59 decks
4%synergy
Fireshrieker
23%inclusion19 decks83 decks
21%synergy
Sensei's Divining Top
22%inclusion18 decks83 decks
13%synergy
Expedition Map
22%inclusion18 decks83 decks
9%synergy
Leyline Axe
20%inclusion16 decks79 decks
19%synergy
Doc Ock's Tentacles
20%inclusion8 decks40 decks
20%synergy
Cranial Plating
19%inclusion16 decks83 decks
16%synergy
Pact Weapon
19%inclusion16 decks83 decks
17%synergy
Wishclaw Talisman
18%inclusion15 decks83 decks
11%synergy
Sword of the Animist
18%inclusion15 decks83 decks
14%synergy
Contagion Clasp
17%inclusion14 decks83 decks
14%synergy
Mithril Coat
17%inclusion14 decks83 decks
11%synergy
Sword of Feast and Famine
17%inclusion14 decks83 decks
15%synergy
Hammer of Nazahn
16%inclusion13 decks83 decks
15%synergy
Sword of Wealth and Power
12%inclusion10 decks83 decks
11%synergy
Brotherhood Regalia
12%inclusion10 decks83 decks
10%synergy
Whip of Erebos
11%inclusion9 decks83 decks
0%synergy
Loxodon Warhammer
11%inclusion9 decks83 decks
9%synergy
Genji Glove
11%inclusion6 decks56 decks
10%synergy
Buster Sword
10%inclusion6 decks59 decks
9%synergy
Thran Power Suit
10%inclusion8 decks83 decks
9%synergy
Bontu's Monument
10%inclusion8 decks83 decks
-18%synergy
Strata Scythe
10%inclusion8 decks83 decks
9%synergy
Silver Shroud Costume
10%inclusion8 decks83 decks
8%synergy
Trailblazer's Boots
10%inclusion8 decks83 decks
7%synergy
Manifold Key
8.4%inclusion7 decks83 decks
7%synergy
O-Naginata
8.4%inclusion7 decks83 decks
8%synergy
Hero's Blade
8.4%inclusion7 decks83 decks
8%synergy
Aetherflux Reservoir
8.4%inclusion7 decks83 decks
-2%synergy
Vorpal Sword
7.2%inclusion6 decks83 decks
3%synergy
Grafted Exoskeleton
7.2%inclusion6 decks83 decks
6%synergy
Sword of Vengeance
7.2%inclusion6 decks83 decks
6%synergy
Helm of the Host
6.0%inclusion5 decks83 decks
5%synergy
Wayfarer's Bauble
6.0%inclusion5 decks83 decks
-10%synergy
Masterwork of Ingenuity
6.0%inclusion5 decks83 decks
6%synergy
Torpor Orb
6.0%inclusion5 decks83 decks
5%synergy
Conqueror's Flail
6.0%inclusion5 decks83 decks
5%synergy
Inquisitor's Flail
6.0%inclusion5 decks83 decks
6%synergy
Enchantments
Unspeakable Symbol
43%inclusion36 decks83 decks
42%synergy
Black Market Connections
43%inclusion36 decks83 decks
20%synergy
Necrogen Communion
27%inclusion22 decks83 decks
25%synergy
Kaya's Ghostform
22%inclusion18 decks83 decks
11%synergy
Phyresis
20%inclusion17 decks83 decks
18%synergy
No Mercy
20%inclusion17 decks83 decks
13%synergy
Contamination
18%inclusion15 decks83 decks
15%synergy
Animate Dead
17%inclusion14 decks83 decks
-1%synergy
The Meathook Massacre
14%inclusion12 decks83 decks
-3%synergy
Super State
13%inclusion7 decks53 decks
13%synergy
Dauthi Embrace
12%inclusion10 decks83 decks
10%synergy
Haunted One
11%inclusion9 decks83 decks
8%synergy
Exquisite Blood
11%inclusion9 decks83 decks
-2%synergy
Bitterblossom
11%inclusion9 decks83 decks
-2%synergy
Alien Symbiosis
10%inclusion4 decks40 decks
10%synergy
Snake Cult Initiation
10%inclusion8 decks83 decks
9%synergy
Oubliette
10%inclusion8 decks83 decks
7%synergy
Endless Scream
10%inclusion8 decks83 decks
9%synergy
Bad Moon
10%inclusion8 decks83 decks
6%synergy
Black Market
8.4%inclusion7 decks83 decks
-13%synergy
Phyrexian Reclamation
8.4%inclusion7 decks83 decks
-2%synergy
Glistening Oil
7.2%inclusion6 decks83 decks
6%synergy
Infernal Darkness
7.2%inclusion6 decks83 decks
7%synergy
Leyline of the Void
7.2%inclusion6 decks83 decks
5%synergy
Sanguine Bond
7.2%inclusion6 decks83 decks
-5%synergy
Grave Pact
6.0%inclusion5 decks83 decks
-13%synergy
Planeswalkers
Liliana of the Dark Realms
41%inclusion34 decks83 decks
27%synergy
Vraska, Betrayal's Sting
36%inclusion30 decks83 decks
33%synergy
Utility Lands
Cabal Coffers
82%inclusion68 decks83 decks
27%synergy
Urborg, Tomb of Yawgmoth
76%inclusion63 decks83 decks
38%synergy
Rogue's Passage
54%inclusion45 decks83 decks
36%synergy
Shizo, Death's Storehouse
53%inclusion44 decks83 decks
43%synergy
Karn's Bastion
45%inclusion37 decks83 decks
40%synergy
Cabal Stronghold
36%inclusion30 decks83 decks
0%synergy
Urza's Saga
36%inclusion30 decks83 decks
28%synergy
Bojuka Bog
34%inclusion28 decks83 decks
-13%synergy
Nykthos, Shrine to Nyx
29%inclusion24 decks83 decks
-1%synergy
The Black Gate
22%inclusion18 decks83 decks
18%synergy
Command Beacon
18%inclusion15 decks83 decks
10%synergy
Phyrexian Tower
17%inclusion14 decks83 decks
-7%synergy
Castle Locthwain
17%inclusion14 decks83 decks
-1%synergy
Lake of the Dead
17%inclusion14 decks83 decks
12%synergy
Strip Mine
16%inclusion13 decks83 decks
13%synergy
Takenuma, Abandoned Mire
14%inclusion12 decks83 decks
-2%synergy
Homeward Path
13%inclusion11 decks83 decks
11%synergy
Cathedral of War
13%inclusion11 decks83 decks
13%synergy
War Room
13%inclusion11 decks83 decks
-3%synergy
Reliquary Tower
12%inclusion10 decks83 decks
-19%synergy
Minas Morgul, Dark Fortress
10%inclusion8 decks83 decks
7%synergy
Deserted Temple
8.4%inclusion7 decks83 decks
4%synergy
Emergence Zone
7.2%inclusion6 decks83 decks
4%synergy
Inventors' Fair
7.2%inclusion6 decks83 decks
5%synergy
Temple of the False God
7.2%inclusion6 decks83 decks
-1%synergy
Vault of Whispers
7.2%inclusion6 decks83 decks
2%synergy
Buried Ruin
6.0%inclusion5 decks83 decks
1%synergy
Crystal Vein
6.0%inclusion5 decks83 decks
3%synergy
Wasteland
6.0%inclusion5 decks83 decks
5%synergy
Arcane Lighthouse
6.0%inclusion5 decks83 decks
4%synergy
Mana Artifacts
Sol Ring
96%inclusion80 decks83 decks
10%synergy
Arcane Signet
66%inclusion55 decks83 decks
4%synergy
The Soul Stone
39%inclusion18 decks46 decks
27%synergy
Mox Opal
39%inclusion32 decks83 decks
35%synergy
Lotus Petal
36%inclusion30 decks83 decks
29%synergy
Mox Diamond
29%inclusion24 decks83 decks
25%synergy
Glistening Sphere
27%inclusion22 decks83 decks
25%synergy
Fellwar Stone
24%inclusion20 decks83 decks
9%synergy
Mind Stone
23%inclusion19 decks83 decks
-8%synergy
Grim Monolith
23%inclusion19 decks83 decks
20%synergy
Staff of Compleation
22%inclusion18 decks83 decks
20%synergy
Heraldic Banner
18%inclusion15 decks83 decks
12%synergy
Throne of Eldraine
17%inclusion14 decks83 decks
6%synergy
Caged Sun
16%inclusion13 decks83 decks
3%synergy
Thought Vessel
16%inclusion13 decks83 decks
-11%synergy
Mox Amber
14%inclusion12 decks83 decks
10%synergy
Mox Jasper
12%inclusion9 decks73 decks
12%synergy
Extraplanar Lens
12%inclusion10 decks83 decks
7%synergy
Charcoal Diamond
10%inclusion8 decks83 decks
-14%synergy
Gilded Lotus
8.4%inclusion7 decks83 decks
3%synergy
Thran Dynamo
8.4%inclusion7 decks83 decks
2%synergy
Gauntlet of Power
7.2%inclusion6 decks83 decks
4%synergy
Patchwork Banner
7.2%inclusion6 decks83 decks
3%synergy
Everflowing Chalice
7.2%inclusion6 decks83 decks
1%synergy
Sceptre of Eternal Glory
6.0%inclusion5 decks83 decks
-3%synergy
Mox Tantalite
6.0%inclusion5 decks83 decks
6%synergy
Lands
Swamp
94%inclusion78 decks83 decks
-1%synergy
Cavern of Souls
36%inclusion30 decks83 decks
30%synergy
Malakir Rebirth
36%inclusion30 decks83 decks
14%synergy
Gemstone Caverns
24%inclusion20 decks83 decks
20%synergy
Mirrex
14%inclusion12 decks83 decks
14%synergy
Fell the Profane
14%inclusion12 decks83 decks
-4%synergy
Marsh Flats
12%inclusion10 decks83 decks
9%synergy
Myriad Landscape
12%inclusion10 decks83 decks
-15%synergy
Polluted Delta
12%inclusion10 decks83 decks
9%synergy
Bloodstained Mire
12%inclusion10 decks83 decks
9%synergy
Verdant Catacombs
11%inclusion9 decks83 decks
8%synergy
Command Tower
10%inclusion8 decks83 decks
4%synergy
Urza's Cave
10%inclusion8 decks83 decks
1%synergy
Snow-Covered Swamp
8.4%inclusion7 decks83 decks
2%synergy
Prismatic Vista
6.0%inclusion5 decks83 decks
4%synergy
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