Skithiryx, the Blight Dragon (Commander) - Optimized

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #780
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Bitterbloom Bearer
2.6%inclusion1 decks39 decks
1%synergy
High Synergy Cards
Plague Myr
62%inclusion53 decks86 decks
60%synergy
Plague Stinger
60%inclusion52 decks86 decks
59%synergy
Lashwrithe
59%inclusion51 decks86 decks
55%synergy
Infectious Inquiry
56%inclusion48 decks86 decks
53%synergy
Whispering Specter
51%inclusion44 decks86 decks
50%synergy
Commander's Plate
55%inclusion47 decks86 decks
49%synergy
Shizo, Death's Storehouse
58%inclusion50 decks86 decks
48%synergy
Inkmoth Nexus
49%inclusion42 decks86 decks
48%synergy
Phyrexian Crusader
48%inclusion41 decks86 decks
47%synergy
Unspeakable Symbol
45%inclusion39 decks86 decks
44%synergy
Top Cards
Dark Ritual
90%inclusion77 decks86 decks
23%synergy
Jet Medallion
81%inclusion70 decks86 decks
21%synergy
Crypt Ghast
62%inclusion53 decks86 decks
13%synergy
Phyrexian Arena
62%inclusion53 decks86 decks
21%synergy
Deadly Rollick
60%inclusion52 decks86 decks
37%synergy
Toxic Deluge
56%inclusion48 decks86 decks
19%synergy
Feed the Swarm
52%inclusion45 decks86 decks
1%synergy
Cabal Ritual
51%inclusion44 decks86 decks
33%synergy
Lightning Greaves
47%inclusion40 decks86 decks
13%synergy
Imp's Mischief
47%inclusion40 decks86 decks
23%synergy
Game Changers
Demonic Tutor
77%inclusion66 decks86 decks
49%synergy
Vampiric Tutor
69%inclusion59 decks86 decks
47%synergy
Ancient Tomb
55%inclusion47 decks86 decks
43%synergy
Necropotence
53%inclusion46 decks86 decks
38%synergy
Mana Vault
48%inclusion41 decks86 decks
41%synergy
Opposition Agent
47%inclusion40 decks86 decks
37%synergy
The One Ring
40%inclusion34 decks86 decks
30%synergy
Chrome Mox
38%inclusion33 decks86 decks
32%synergy
Bolas's Citadel
38%inclusion33 decks86 decks
9%synergy
Orcish Bowmasters
38%inclusion33 decks86 decks
25%synergy
Creatures
Ichor Rats
47%inclusion40 decks86 decks
43%synergy
Dauthi Voidwalker
44%inclusion38 decks86 decks
28%synergy
Hand of the Praetors
44%inclusion38 decks86 decks
43%synergy
Sheoldred, the Apocalypse
31%inclusion27 decks86 decks
17%synergy
Phyrexian Obliterator
29%inclusion25 decks86 decks
18%synergy
Gray Merchant of Asphodel
28%inclusion24 decks86 decks
-24%synergy
K'rrik, Son of Yawgmoth
27%inclusion23 decks86 decks
8%synergy
Yawgmoth, Thran Physician
26%inclusion22 decks86 decks
15%synergy
Blightbelly Rat
24%inclusion21 decks86 decks
21%synergy
Dark Confidant
24%inclusion21 decks86 decks
17%synergy
Flesh-Eater Imp
24%inclusion21 decks86 decks
24%synergy
Flensermite
22%inclusion19 decks86 decks
22%synergy
Ichorclaw Myr
17%inclusion15 decks86 decks
17%synergy
Reaper of Sheoldred
16%inclusion14 decks86 decks
16%synergy
Myr Convert
16%inclusion14 decks86 decks
16%synergy
Pestilent Syphoner
16%inclusion14 decks86 decks
16%synergy
Solemn Simulacrum
15%inclusion13 decks86 decks
-8%synergy
Nirkana Revenant
14%inclusion12 decks86 decks
2%synergy
Magus of the Coffers
14%inclusion12 decks86 decks
7%synergy
Corpse Cur
14%inclusion12 decks86 decks
14%synergy
Sheoldred, Whispering One
14%inclusion12 decks86 decks
2%synergy
Core Prowler
13%inclusion11 decks86 decks
12%synergy
Blightsteel Colossus
13%inclusion11 decks86 decks
12%synergy
Bilious Skulldweller
12%inclusion10 decks86 decks
11%synergy
Septic Rats
12%inclusion10 decks86 decks
10%synergy
Blood Pet
10%inclusion9 decks86 decks
2%synergy
Gwenom, Remorseless
10%inclusion5 decks50 decks
7%synergy
Massacre Wurm
9.3%inclusion8 decks86 decks
-8%synergy
Agent Venom
8.9%inclusion4 decks45 decks
6%synergy
Maha, Its Feathers Night
8.1%inclusion7 decks86 decks
3%synergy
Contagious Nim
7.0%inclusion6 decks86 decks
7%synergy
Silent Arbiter
7.0%inclusion6 decks86 decks
6%synergy
Vito, Thorn of the Dusk Rose
7.0%inclusion6 decks86 decks
-4%synergy
Leaden Myr
7.0%inclusion6 decks86 decks
1%synergy
Dread Presence
7.0%inclusion6 decks86 decks
-8%synergy
Gulping Scraptrap
7.0%inclusion6 decks86 decks
6%synergy
Bloodgift Demon
5.8%inclusion5 decks86 decks
3%synergy
Phyrexian Vatmother
5.8%inclusion5 decks86 decks
6%synergy
Grafted Butcher
5.8%inclusion5 decks86 decks
6%synergy
Gix, Yawgmoth Praetor
5.8%inclusion5 decks86 decks
1%synergy
Toxic Nim
5.8%inclusion5 decks86 decks
6%synergy
Scheming Aspirant
5.8%inclusion5 decks86 decks
6%synergy
Necropede
5.8%inclusion5 decks86 decks
5%synergy
Instants
Vraska's Fall
45%inclusion39 decks86 decks
42%synergy
Dismember
40%inclusion34 decks86 decks
29%synergy
Howl from Beyond
38%inclusion33 decks86 decks
38%synergy
Withering Torment
35%inclusion30 decks85 decks
4%synergy
Infernal Grasp
34%inclusion29 decks86 decks
9%synergy
Malakir Rebirth
33%inclusion28 decks86 decks
10%synergy
Snuff Out
30%inclusion26 decks86 decks
18%synergy
Go for the Throat
29%inclusion25 decks86 decks
6%synergy
Hatred
29%inclusion25 decks86 decks
28%synergy
Tainted Strike
26%inclusion22 decks86 decks
22%synergy
Sudden Spoiling
23%inclusion20 decks86 decks
14%synergy
Astarion's Thirst
22%inclusion19 decks86 decks
21%synergy
Baleful Mastery
21%inclusion18 decks86 decks
12%synergy
Cut Down
21%inclusion18 decks86 decks
17%synergy
Defile
21%inclusion18 decks86 decks
-17%synergy
Withering Boon
21%inclusion18 decks86 decks
16%synergy
Whisper of the Dross
20%inclusion17 decks86 decks
17%synergy
Darkness
17%inclusion15 decks86 decks
8%synergy
Grim Affliction
17%inclusion15 decks86 decks
15%synergy
Culling the Weak
16%inclusion14 decks86 decks
1%synergy
Fell the Profane
15%inclusion13 decks86 decks
-4%synergy
Hero's Downfall
14%inclusion12 decks86 decks
7%synergy
Force of Despair
13%inclusion11 decks86 decks
5%synergy
Bitter Triumph
13%inclusion11 decks86 decks
3%synergy
Archenemy's Charm
13%inclusion7 decks55 decks
4%synergy
Sheoldred's Edict
10%inclusion9 decks86 decks
-4%synergy
Supernatural Stamina
9.3%inclusion8 decks86 decks
2%synergy
Virulent Wound
9.3%inclusion8 decks86 decks
9%synergy
Sugar Rush
8.1%inclusion7 decks86 decks
8%synergy
Murder
8.1%inclusion7 decks86 decks
-2%synergy
Tragic Slip
8.1%inclusion7 decks86 decks
-12%synergy
Ad Nauseam
7.0%inclusion6 decks86 decks
4%synergy
Soul Shatter
7.0%inclusion6 decks86 decks
-5%synergy
Slaughter Pact
7.0%inclusion6 decks86 decks
4%synergy
Unlikely Aid
5.8%inclusion5 decks86 decks
5%synergy
Sorceries
Damnation
44%inclusion38 decks86 decks
23%synergy
Crux of Fate
43%inclusion37 decks86 decks
42%synergy
Bubbling Muck
42%inclusion36 decks86 decks
26%synergy
Phyresis Outbreak
42%inclusion36 decks86 decks
40%synergy
Drown in Ichor
42%inclusion36 decks86 decks
37%synergy
Night's Whisper
38%inclusion33 decks86 decks
14%synergy
Grim Tutor
34%inclusion29 decks86 decks
22%synergy
Sign in Blood
33%inclusion28 decks86 decks
-4%synergy
Imperial Seal
31%inclusion27 decks86 decks
24%synergy
Reanimate
28%inclusion24 decks86 decks
-11%synergy
Caress of Phyrexia
21%inclusion18 decks86 decks
20%synergy
Mutilate
16%inclusion14 decks86 decks
-3%synergy
Insatiable Avarice
16%inclusion14 decks86 decks
4%synergy
Diabolic Tutor
16%inclusion14 decks86 decks
1%synergy
Read the Bones
15%inclusion13 decks86 decks
-3%synergy
Beseech the Mirror
14%inclusion12 decks86 decks
7%synergy
Black Sun's Zenith
14%inclusion12 decks86 decks
8%synergy
Profane Tutor
14%inclusion12 decks86 decks
9%synergy
Torment of Hailfire
14%inclusion12 decks86 decks
-2%synergy
Beseech the Queen
13%inclusion11 decks86 decks
7%synergy
Gix's Command
12%inclusion10 decks86 decks
10%synergy
Praetor's Grasp
12%inclusion10 decks86 decks
8%synergy
Vat Emergence
12%inclusion10 decks86 decks
10%synergy
Blasphemous Edict
11%inclusion9 decks82 decks
-6%synergy
Exsanguinate
10%inclusion9 decks86 decks
-14%synergy
Peer into the Abyss
9.3%inclusion8 decks86 decks
-2%synergy
Duress
7.0%inclusion6 decks86 decks
0%synergy
Spread the Sickness
7.0%inclusion6 decks86 decks
6%synergy
Syphon Mind
7.0%inclusion6 decks86 decks
-6%synergy
Thoughtseize
7.0%inclusion6 decks86 decks
2%synergy
Rise of the Dark Realms
7.0%inclusion6 decks86 decks
-5%synergy
Decree of Pain
5.8%inclusion5 decks86 decks
0%synergy
Victimize
5.8%inclusion5 decks86 decks
-20%synergy
Yawgmoth's Will
5.8%inclusion5 decks86 decks
2%synergy
Dark Petition
5.8%inclusion5 decks86 decks
2%synergy
Utility Artifacts
Nightmare Lash
45%inclusion39 decks86 decks
43%synergy
Swiftfoot Boots
44%inclusion38 decks86 decks
13%synergy
Shadowspear
43%inclusion37 decks86 decks
39%synergy
Blackblade Reforged
38%inclusion33 decks86 decks
35%synergy
Sword of Truth and Justice
30%inclusion26 decks86 decks
29%synergy
Whispersilk Cloak
28%inclusion24 decks86 decks
22%synergy
Contagion Engine
28%inclusion24 decks86 decks
26%synergy
Champion's Helm
24%inclusion21 decks86 decks
22%synergy
Fireshrieker
23%inclusion20 decks86 decks
21%synergy
The Darkness Crystal
22%inclusion14 decks63 decks
3%synergy
Pact Weapon
22%inclusion19 decks86 decks
20%synergy
Sensei's Divining Top
22%inclusion19 decks86 decks
14%synergy
Leyline Axe
21%inclusion17 decks82 decks
20%synergy
Doc Ock's Tentacles
20%inclusion9 decks44 decks
20%synergy
Expedition Map
20%inclusion17 decks86 decks
7%synergy
Cranial Plating
19%inclusion16 decks86 decks
15%synergy
Contagion Clasp
19%inclusion16 decks86 decks
16%synergy
Sword of the Animist
19%inclusion16 decks86 decks
15%synergy
Mithril Coat
17%inclusion15 decks86 decks
12%synergy
Wishclaw Talisman
17%inclusion15 decks86 decks
11%synergy
Sword of Feast and Famine
17%inclusion15 decks86 decks
16%synergy
Hammer of Nazahn
16%inclusion14 decks86 decks
16%synergy
Brotherhood Regalia
13%inclusion11 decks86 decks
10%synergy
Sword of Wealth and Power
13%inclusion11 decks86 decks
12%synergy
Buster Sword
13%inclusion8 decks63 decks
12%synergy
Whip of Erebos
10%inclusion9 decks86 decks
0%synergy
Strata Scythe
10%inclusion9 decks86 decks
10%synergy
Silver Shroud Costume
10%inclusion9 decks86 decks
9%synergy
Thran Power Suit
10%inclusion9 decks86 decks
10%synergy
Genji Glove
10%inclusion6 decks60 decks
9%synergy
Trailblazer's Boots
9.3%inclusion8 decks86 decks
7%synergy
Bontu's Monument
9.3%inclusion8 decks86 decks
-19%synergy
Loxodon Warhammer
9.3%inclusion8 decks86 decks
8%synergy
Hero's Blade
9.3%inclusion8 decks86 decks
9%synergy
Manifold Key
8.1%inclusion7 decks86 decks
6%synergy
Grafted Exoskeleton
8.1%inclusion7 decks86 decks
7%synergy
O-Naginata
8.1%inclusion7 decks86 decks
8%synergy
Aetherflux Reservoir
8.1%inclusion7 decks86 decks
-2%synergy
Sword of Vengeance
7.0%inclusion6 decks86 decks
6%synergy
Wayfarer's Bauble
7.0%inclusion6 decks86 decks
-9%synergy
Vorpal Sword
7.0%inclusion6 decks86 decks
3%synergy
Inquisitor's Flail
7.0%inclusion6 decks86 decks
7%synergy
Sword of Hearth and Home
5.8%inclusion5 decks86 decks
4%synergy
Strength-Testing Hammer
5.8%inclusion5 decks86 decks
6%synergy
Helm of the Host
5.8%inclusion5 decks86 decks
5%synergy
Conqueror's Flail
5.8%inclusion5 decks86 decks
5%synergy
Enchantments
Black Market Connections
47%inclusion40 decks86 decks
23%synergy
Necrogen Communion
26%inclusion22 decks86 decks
24%synergy
Kaya's Ghostform
21%inclusion18 decks86 decks
11%synergy
Phyresis
20%inclusion17 decks86 decks
18%synergy
No Mercy
19%inclusion16 decks86 decks
11%synergy
Contamination
16%inclusion14 decks86 decks
13%synergy
The Meathook Massacre
14%inclusion12 decks86 decks
-3%synergy
Animate Dead
14%inclusion12 decks86 decks
-4%synergy
Bitterblossom
13%inclusion11 decks86 decks
0%synergy
Super State
12%inclusion7 decks57 decks
12%synergy
Dauthi Embrace
12%inclusion10 decks86 decks
10%synergy
Haunted One
10%inclusion9 decks86 decks
8%synergy
Oubliette
10%inclusion9 decks86 decks
7%synergy
Snake Cult Initiation
9.3%inclusion8 decks86 decks
9%synergy
Endless Scream
9.3%inclusion8 decks86 decks
9%synergy
Bad Moon
9.3%inclusion8 decks86 decks
6%synergy
Alien Symbiosis
9.1%inclusion4 decks44 decks
9%synergy
Black Market
8.1%inclusion7 decks86 decks
-13%synergy
Phyrexian Reclamation
8.1%inclusion7 decks86 decks
-2%synergy
Exquisite Blood
8.1%inclusion7 decks86 decks
-5%synergy
Glistening Oil
8.1%inclusion7 decks86 decks
7%synergy
Infernal Darkness
7.0%inclusion6 decks86 decks
6%synergy
Leyline of the Void
7.0%inclusion6 decks86 decks
5%synergy
Relic Putrescence
5.8%inclusion5 decks86 decks
6%synergy
Shade's Form
5.8%inclusion5 decks86 decks
5%synergy
Planeswalkers
Liliana of the Dark Realms
42%inclusion36 decks86 decks
28%synergy
Vraska, Betrayal's Sting
38%inclusion33 decks86 decks
36%synergy
Tezzeret, Cruel Captain
5.2%inclusion3 decks58 decks
4%synergy
Utility Lands
Cabal Coffers
83%inclusion71 decks86 decks
27%synergy
Urborg, Tomb of Yawgmoth
76%inclusion65 decks86 decks
38%synergy
Rogue's Passage
53%inclusion46 decks86 decks
35%synergy
Karn's Bastion
45%inclusion39 decks86 decks
41%synergy
Urza's Saga
36%inclusion31 decks86 decks
28%synergy
Cabal Stronghold
35%inclusion30 decks86 decks
-1%synergy
Bojuka Bog
34%inclusion29 decks86 decks
-13%synergy
Nykthos, Shrine to Nyx
28%inclusion24 decks86 decks
-2%synergy
The Black Gate
22%inclusion19 decks86 decks
19%synergy
Command Beacon
17%inclusion15 decks86 decks
9%synergy
Castle Locthwain
17%inclusion15 decks86 decks
0%synergy
Lake of the Dead
16%inclusion14 decks86 decks
11%synergy
Phyrexian Tower
16%inclusion14 decks86 decks
-8%synergy
Strip Mine
15%inclusion13 decks86 decks
12%synergy
Cathedral of War
14%inclusion12 decks86 decks
14%synergy
Takenuma, Abandoned Mire
14%inclusion12 decks86 decks
-2%synergy
Homeward Path
13%inclusion11 decks86 decks
11%synergy
War Room
12%inclusion10 decks86 decks
-5%synergy
Reliquary Tower
12%inclusion10 decks86 decks
-20%synergy
Minas Morgul, Dark Fortress
10%inclusion9 decks86 decks
7%synergy
Deserted Temple
8.1%inclusion7 decks86 decks
4%synergy
Temple of the False God
8.1%inclusion7 decks86 decks
0%synergy
Emergence Zone
7.0%inclusion6 decks86 decks
4%synergy
Inventors' Fair
7.0%inclusion6 decks86 decks
5%synergy
Vault of Whispers
7.0%inclusion6 decks86 decks
1%synergy
Thespian's Stage
5.8%inclusion5 decks86 decks
0%synergy
Wasteland
5.8%inclusion5 decks86 decks
4%synergy
Ghost Quarter
5.8%inclusion5 decks86 decks
3%synergy
Barren Moor
5.8%inclusion5 decks86 decks
-5%synergy
Buried Ruin
5.8%inclusion5 decks86 decks
0%synergy
Mortuary Mire
5.8%inclusion5 decks86 decks
-7%synergy
Arcane Lighthouse
5.8%inclusion5 decks86 decks
4%synergy
Crystal Vein
5.8%inclusion5 decks86 decks
3%synergy
Witch's Cottage
5.8%inclusion5 decks86 decks
-19%synergy
Mana Artifacts
Sol Ring
97%inclusion83 decks86 decks
10%synergy
Arcane Signet
69%inclusion59 decks86 decks
6%synergy
Mox Opal
41%inclusion35 decks86 decks
37%synergy
Lotus Petal
38%inclusion33 decks86 decks
31%synergy
The Soul Stone
36%inclusion18 decks50 decks
23%synergy
Mox Diamond
29%inclusion25 decks86 decks
25%synergy
Glistening Sphere
27%inclusion23 decks86 decks
25%synergy
Fellwar Stone
24%inclusion21 decks86 decks
10%synergy
Staff of Compleation
23%inclusion20 decks86 decks
21%synergy
Grim Monolith
23%inclusion20 decks86 decks
20%synergy
Mind Stone
23%inclusion20 decks86 decks
-7%synergy
Throne of Eldraine
19%inclusion16 decks86 decks
8%synergy
Heraldic Banner
17%inclusion15 decks86 decks
12%synergy
Thought Vessel
17%inclusion15 decks86 decks
-10%synergy
Caged Sun
15%inclusion13 decks86 decks
3%synergy
Mox Amber
14%inclusion12 decks86 decks
10%synergy
Mox Jasper
12%inclusion9 decks77 decks
12%synergy
Extraplanar Lens
12%inclusion10 decks86 decks
7%synergy
Charcoal Diamond
10%inclusion9 decks86 decks
-13%synergy
Thran Dynamo
9.3%inclusion8 decks86 decks
3%synergy
Gilded Lotus
8.1%inclusion7 decks86 decks
2%synergy
Everflowing Chalice
7.0%inclusion6 decks86 decks
1%synergy
Sceptre of Eternal Glory
7.0%inclusion6 decks86 decks
-2%synergy
Gauntlet of Power
7.0%inclusion6 decks86 decks
3%synergy
Patchwork Banner
7.0%inclusion6 decks86 decks
3%synergy
Mox Tantalite
5.8%inclusion5 decks86 decks
6%synergy
Lands
Swamp
94%inclusion81 decks86 decks
-1%synergy
Cavern of Souls
35%inclusion30 decks86 decks
28%synergy
Malakir Rebirth
33%inclusion28 decks86 decks
10%synergy
Gemstone Caverns
24%inclusion21 decks86 decks
20%synergy
Fell the Profane
15%inclusion13 decks86 decks
-4%synergy
Mirrex
15%inclusion13 decks86 decks
14%synergy
Myriad Landscape
13%inclusion11 decks86 decks
-14%synergy
Marsh Flats
13%inclusion11 decks86 decks
9%synergy
Polluted Delta
13%inclusion11 decks86 decks
9%synergy
Bloodstained Mire
13%inclusion11 decks86 decks
9%synergy
Verdant Catacombs
12%inclusion10 decks86 decks
8%synergy
Urza's Cave
9.3%inclusion8 decks86 decks
1%synergy
Command Tower
8.1%inclusion7 decks86 decks
3%synergy
Snow-Covered Swamp
8.1%inclusion7 decks86 decks
1%synergy
Prismatic Vista
5.8%inclusion5 decks86 decks
4%synergy
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