Skithiryx, the Blight Dragon (Commander) - Expensive Optimized Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #795
2decks
As CommanderAs CardAverage DeckDecks
Bracket
All12345
Budget
Any$$$$
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
Deck Filters
Cardsphere
Archidekt
Commander Spellbook
Moxfield
Scryfall
Game Changers
Creatures
Instants
Sorceries
Utility Artifacts
Enchantments
Planeswalkers
Utility Lands
Mana Artifacts
Lands
Back to Top
Ancient Tomb
100%inclusion2 decks2 decks
88%synergy
Demonic Tutor
100%inclusion2 decks2 decks
73%synergy
Chrome Mox
100%inclusion2 decks2 decks
94%synergy
Vampiric Tutor
100%inclusion2 decks2 decks
79%synergy
Mox Diamond
100%inclusion2 decks2 decks
96%synergy
Opposition Agent
50%inclusion1 decks2 decks
40%synergy
Grim Monolith
50%inclusion1 decks2 decks
47%synergy
The One Ring
50%inclusion1 decks2 decks
41%synergy
Mana Vault
50%inclusion1 decks2 decks
43%synergy
Necropotence
50%inclusion1 decks2 decks
35%synergy
Creatures
Whispering Specter
100%inclusion2 decks2 decks
99%synergy
Plague Stinger
50%inclusion1 decks2 decks
49%synergy
Dark Confidant
50%inclusion1 decks2 decks
42%synergy
Reaper of Sheoldred
50%inclusion1 decks2 decks
49%synergy
Plague Myr
50%inclusion1 decks2 decks
49%synergy
Flensermite
50%inclusion1 decks2 decks
50%synergy
Myr Convert
50%inclusion1 decks2 decks
49%synergy
Phyrexian Crusader
50%inclusion1 decks2 decks
49%synergy
Yawgmoth, Thran Physician
50%inclusion1 decks2 decks
40%synergy
Crypt Ghast
50%inclusion1 decks2 decks
2%synergy
Archfiend of Depravity
50%inclusion1 decks2 decks
43%synergy
Chainer, Dementia Master
50%inclusion1 decks2 decks
45%synergy
Braids, Arisen Nightmare
50%inclusion1 decks2 decks
30%synergy
Blood Pet
50%inclusion1 decks2 decks
42%synergy
Orcish Bowmasters
50%inclusion1 decks2 decks
37%synergy
Dauthi Voidwalker
50%inclusion1 decks2 decks
34%synergy
Hand of the Praetors
50%inclusion1 decks2 decks
49%synergy
Ichor Rats
50%inclusion1 decks2 decks
47%synergy
Instants
Deadly Rollick
100%inclusion2 decks2 decks
75%synergy
Vraska's Fall
100%inclusion2 decks2 decks
97%synergy
Dark Ritual
100%inclusion2 decks2 decks
33%synergy
Astarion's Thirst
50%inclusion1 decks2 decks
49%synergy
Fatal Push
50%inclusion1 decks2 decks
47%synergy
Cut Down
50%inclusion1 decks2 decks
46%synergy
Go for the Throat
50%inclusion1 decks2 decks
27%synergy
Imp's Mischief
50%inclusion1 decks2 decks
25%synergy
Ulcerate
50%inclusion1 decks2 decks
49%synergy
Cabal Ritual
50%inclusion1 decks2 decks
32%synergy
Withering Boon
50%inclusion1 decks2 decks
46%synergy
Bitter Triumph
50%inclusion1 decks2 decks
40%synergy
Infernal Grasp
50%inclusion1 decks2 decks
25%synergy
Baleful Mastery
50%inclusion1 decks2 decks
42%synergy
Black Sun's Twilight
50%inclusion1 decks2 decks
47%synergy
V.A.T.S.
50%inclusion1 decks2 decks
48%synergy
Dismember
50%inclusion1 decks2 decks
40%synergy
Withering Torment
50%inclusion1 decks2 decks
19%synergy
Archenemy's Charm
50%inclusion1 decks2 decks
41%synergy
Sorceries
Infectious Inquiry
100%inclusion2 decks2 decks
97%synergy
Bubbling Muck
50%inclusion1 decks2 decks
34%synergy
Phyresis Outbreak
50%inclusion1 decks2 decks
48%synergy
Feed the Swarm
50%inclusion1 decks2 decks
0%synergy
Praetor's Grasp
50%inclusion1 decks2 decks
46%synergy
Exsanguinate
50%inclusion1 decks2 decks
25%synergy
Gix's Command
50%inclusion1 decks2 decks
48%synergy
Insatiable Avarice
50%inclusion1 decks2 decks
39%synergy
Toxic Deluge
50%inclusion1 decks2 decks
13%synergy
Drown in Ichor
50%inclusion1 decks2 decks
46%synergy
Utility Artifacts
Leyline Axe
100%inclusion2 decks2 decks
99%synergy
Cranial Plating
100%inclusion2 decks2 decks
97%synergy
Sword of Wealth and Power
100%inclusion2 decks2 decks
99%synergy
Champion's Helm
100%inclusion2 decks2 decks
98%synergy
Commander's Plate
100%inclusion2 decks2 decks
94%synergy
Blackblade Reforged
100%inclusion2 decks2 decks
97%synergy
Lashwrithe
50%inclusion1 decks2 decks
46%synergy
Thran Power Suit
50%inclusion1 decks2 decks
50%synergy
Strength-Testing Hammer
50%inclusion1 decks2 decks
50%synergy
Scroll Rack
50%inclusion1 decks2 decks
49%synergy
Nim Deathmantle
50%inclusion1 decks2 decks
47%synergy
Sword of Truth and Justice
50%inclusion1 decks2 decks
49%synergy
Wishclaw Talisman
50%inclusion1 decks2 decks
43%synergy
Shadowspear
50%inclusion1 decks2 decks
46%synergy
Sword of Hearth and Home
50%inclusion1 decks2 decks
49%synergy
Conqueror's Flail
50%inclusion1 decks2 decks
49%synergy
Excalibur, Sword of Eden
50%inclusion1 decks2 decks
50%synergy
Fireshrieker
50%inclusion1 decks2 decks
48%synergy
Resurrection Orb
50%inclusion1 decks2 decks
48%synergy
Pact Weapon
50%inclusion1 decks2 decks
48%synergy
Jet Medallion
50%inclusion1 decks2 decks
-12%synergy
Swiftfoot Boots
50%inclusion1 decks2 decks
19%synergy
Sword of Feast and Famine
50%inclusion1 decks2 decks
48%synergy
Sword of the Animist
50%inclusion1 decks2 decks
46%synergy
Hammer of Nazahn
50%inclusion1 decks2 decks
49%synergy
Dragonfire Blade
50%inclusion1 decks2 decks
50%synergy
Adaptive Omnitool
50%inclusion1 decks2 decks
50%synergy
Basilisk Collar
50%inclusion1 decks2 decks
47%synergy
The Darkness Crystal
50%inclusion1 decks2 decks
30%synergy
Buster Sword
50%inclusion1 decks2 decks
49%synergy
Genji Glove
50%inclusion1 decks2 decks
49%synergy
Enchantments
Black Market Connections
100%inclusion2 decks2 decks
76%synergy
Eldrazi Conscription
50%inclusion1 decks2 decks
50%synergy
Contamination
50%inclusion1 decks2 decks
47%synergy
Unspeakable Symbol
50%inclusion1 decks2 decks
49%synergy
Phyrexian Arena
50%inclusion1 decks2 decks
10%synergy
Super State
50%inclusion1 decks2 decks
50%synergy
Planeswalkers
Liliana of the Dark Realms
100%inclusion2 decks2 decks
86%synergy
Vraska, Betrayal's Sting
50%inclusion1 decks2 decks
47%synergy
Tezzeret, Cruel Captain
50%inclusion1 decks2 decks
49%synergy
Utility Lands
Urza's Saga
100%inclusion2 decks2 decks
92%synergy
Shizo, Death's Storehouse
50%inclusion1 decks2 decks
40%synergy
The Black Gate
50%inclusion1 decks2 decks
47%synergy
Cabal Coffers
50%inclusion1 decks2 decks
-5%synergy
Nykthos, Shrine to Nyx
50%inclusion1 decks2 decks
20%synergy
Mishra's Workshop
50%inclusion1 decks2 decks
50%synergy
Urborg, Tomb of Yawgmoth
50%inclusion1 decks2 decks
12%synergy
Mana Artifacts
Staff of Compleation
100%inclusion2 decks2 decks
98%synergy
Lotus Petal
100%inclusion2 decks2 decks
93%synergy
Sol Ring
100%inclusion2 decks2 decks
14%synergy
Mox Opal
100%inclusion2 decks2 decks
97%synergy
Arcane Signet
50%inclusion1 decks2 decks
-12%synergy
Glistening Sphere
50%inclusion1 decks2 decks
49%synergy
Heraldic Banner
50%inclusion1 decks2 decks
45%synergy
Patchwork Banner
50%inclusion1 decks2 decks
46%synergy
Throne of Eldraine
50%inclusion1 decks2 decks
40%synergy
Mox Amber
50%inclusion1 decks2 decks
46%synergy
Sceptre of Eternal Glory
50%inclusion1 decks2 decks
42%synergy
Extraplanar Lens
50%inclusion1 decks2 decks
45%synergy
The Soul Stone
50%inclusion1 decks2 decks
35%synergy
Lands
Swamp
100%inclusion2 decks2 decks
5%synergy
Fabled Passage
50%inclusion1 decks2 decks
48%synergy
Verdant Catacombs
50%inclusion1 decks2 decks
47%synergy
Cavern of Souls
50%inclusion1 decks2 decks
43%synergy
Talon Gates of Madara
50%inclusion1 decks2 decks
48%synergy
Gemstone Caverns
50%inclusion1 decks2 decks
46%synergy
Bloodstained Mire
50%inclusion1 decks2 decks
46%synergy
About UsContactPrivacy PolicyTerms of Service
Space Cow MediaArchidektCardsphereCommander SpellbookFABRECSpellvoid
Space Cow MediaArchidektCommander's Herald
Commander SpellbookFABRECSpellvoid
EDHREC is unofficial Fan Content permitted under the Fan Content Policy. Not approved/endorsed by Wizards. Portions of the materials used are property of Wizards of the Coast. ©Wizards of the Coast LLC.
next@15 test