Skithiryx, the Blight Dragon (Commander) - Expensive Optimized Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #789
2decks
As CommanderAs CardAverage DeckDecks
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Enchantments
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Utility Lands
Mana Artifacts
Lands
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Ancient Tomb
100%inclusion2 decks2 decks
88%synergy
Demonic Tutor
100%inclusion2 decks2 decks
72%synergy
Necropotence
100%inclusion2 decks2 decks
85%synergy
Mishra's Workshop
100%inclusion2 decks2 decks
100%synergy
Chrome Mox
100%inclusion2 decks2 decks
94%synergy
Vampiric Tutor
100%inclusion2 decks2 decks
78%synergy
Mox Diamond
100%inclusion2 decks2 decks
96%synergy
Imperial Seal
50%inclusion1 decks2 decks
43%synergy
Opposition Agent
50%inclusion1 decks2 decks
40%synergy
Grim Monolith
50%inclusion1 decks2 decks
47%synergy
Creatures
Whispering Specter
100%inclusion2 decks2 decks
99%synergy
Crypt Ghast
100%inclusion2 decks2 decks
52%synergy
Plague Stinger
50%inclusion1 decks2 decks
49%synergy
Dark Confidant
50%inclusion1 decks2 decks
43%synergy
Reaper of Sheoldred
50%inclusion1 decks2 decks
49%synergy
Plague Myr
50%inclusion1 decks2 decks
49%synergy
Sheoldred, the Apocalypse
50%inclusion1 decks2 decks
35%synergy
Flensermite
50%inclusion1 decks2 decks
49%synergy
Phyrexian Crusader
50%inclusion1 decks2 decks
49%synergy
Metalworker
50%inclusion1 decks2 decks
50%synergy
Yawgmoth, Thran Physician
50%inclusion1 decks2 decks
40%synergy
Archfiend of Depravity
50%inclusion1 decks2 decks
43%synergy
Chainer, Dementia Master
50%inclusion1 decks2 decks
44%synergy
Braids, Arisen Nightmare
50%inclusion1 decks2 decks
31%synergy
Deep-Cavern Bat
50%inclusion1 decks2 decks
49%synergy
Orcish Bowmasters
50%inclusion1 decks2 decks
36%synergy
Dauthi Voidwalker
50%inclusion1 decks2 decks
34%synergy
Hand of the Praetors
50%inclusion1 decks2 decks
49%synergy
Ichor Rats
50%inclusion1 decks2 decks
47%synergy
Instants
Fatal Push
100%inclusion2 decks2 decks
97%synergy
Vraska's Fall
100%inclusion2 decks2 decks
96%synergy
Dark Ritual
100%inclusion2 decks2 decks
34%synergy
Deadly Rollick
50%inclusion1 decks2 decks
27%synergy
Sheoldred's Edict
50%inclusion1 decks2 decks
36%synergy
Go for the Throat
50%inclusion1 decks2 decks
27%synergy
Cabal Ritual
50%inclusion1 decks2 decks
32%synergy
March of Wretched Sorrow
50%inclusion1 decks2 decks
48%synergy
Black Sun's Twilight
50%inclusion1 decks2 decks
46%synergy
V.A.T.S.
50%inclusion1 decks2 decks
48%synergy
Sorceries
Infectious Inquiry
100%inclusion2 decks2 decks
97%synergy
Drown in Ichor
100%inclusion2 decks2 decks
96%synergy
Duress
50%inclusion1 decks2 decks
43%synergy
Inquisition of Kozilek
50%inclusion1 decks2 decks
48%synergy
Phyresis Outbreak
50%inclusion1 decks2 decks
48%synergy
Crux of Fate
50%inclusion1 decks2 decks
49%synergy
Exsanguinate
50%inclusion1 decks2 decks
26%synergy
Toxic Deluge
50%inclusion1 decks2 decks
13%synergy
Beseech the Mirror
50%inclusion1 decks2 decks
43%synergy
Grim Tutor
50%inclusion1 decks2 decks
38%synergy
Thoughtseize
50%inclusion1 decks2 decks
45%synergy
Utility Artifacts
Wishclaw Talisman
100%inclusion2 decks2 decks
93%synergy
Sword of Wealth and Power
100%inclusion2 decks2 decks
99%synergy
Blackblade Reforged
100%inclusion2 decks2 decks
97%synergy
Lashwrithe
50%inclusion1 decks2 decks
46%synergy
Bolas's Citadel
50%inclusion1 decks2 decks
21%synergy
Thran Power Suit
50%inclusion1 decks2 decks
50%synergy
The One Ring
50%inclusion1 decks2 decks
40%synergy
Nightmare Lash
50%inclusion1 decks2 decks
48%synergy
Leyline Axe
50%inclusion1 decks2 decks
49%synergy
The Immortal Sun
50%inclusion1 decks2 decks
49%synergy
Aetherflux Reservoir
50%inclusion1 decks2 decks
40%synergy
Scroll Rack
50%inclusion1 decks2 decks
49%synergy
Nim Deathmantle
50%inclusion1 decks2 decks
47%synergy
Chalice of the Void
50%inclusion1 decks2 decks
50%synergy
Cranial Plating
50%inclusion1 decks2 decks
46%synergy
Sword of Truth and Justice
50%inclusion1 decks2 decks
49%synergy
Shadowspear
50%inclusion1 decks2 decks
46%synergy
Sword of Hearth and Home
50%inclusion1 decks2 decks
49%synergy
Conqueror's Flail
50%inclusion1 decks2 decks
49%synergy
Excalibur, Sword of Eden
50%inclusion1 decks2 decks
50%synergy
Fireshrieker
50%inclusion1 decks2 decks
48%synergy
Resurrection Orb
50%inclusion1 decks2 decks
47%synergy
Pact Weapon
50%inclusion1 decks2 decks
48%synergy
Jet Medallion
50%inclusion1 decks2 decks
-10%synergy
Champion's Helm
50%inclusion1 decks2 decks
48%synergy
Swiftfoot Boots
50%inclusion1 decks2 decks
18%synergy
Commander's Plate
50%inclusion1 decks2 decks
44%synergy
Sword of Feast and Famine
50%inclusion1 decks2 decks
48%synergy
Sword of the Animist
50%inclusion1 decks2 decks
46%synergy
Dragonfire Blade
50%inclusion1 decks2 decks
50%synergy
Adaptive Omnitool
50%inclusion1 decks2 decks
50%synergy
Basilisk Collar
50%inclusion1 decks2 decks
47%synergy
The Darkness Crystal
50%inclusion1 decks2 decks
30%synergy
Genji Glove
50%inclusion1 decks2 decks
49%synergy
Enchantments
Black Market Connections
100%inclusion2 decks2 decks
77%synergy
Phyrexian Arena
100%inclusion2 decks2 decks
60%synergy
Super State
100%inclusion1 decks1 decks
100%synergy
Eldrazi Conscription
50%inclusion1 decks2 decks
50%synergy
Contamination
50%inclusion1 decks2 decks
46%synergy
Nether Void
50%inclusion1 decks2 decks
50%synergy
Unspeakable Symbol
50%inclusion1 decks2 decks
49%synergy
Elspeth's Nightmare
50%inclusion1 decks2 decks
50%synergy
Planeswalkers
Vraska, Betrayal's Sting
50%inclusion1 decks2 decks
47%synergy
Liliana of the Dark Realms
50%inclusion1 decks2 decks
36%synergy
Utility Lands
Urza's Saga
100%inclusion2 decks2 decks
92%synergy
Shizo, Death's Storehouse
50%inclusion1 decks2 decks
40%synergy
Urza's Tower
50%inclusion1 decks2 decks
50%synergy
Urza's Mine
50%inclusion1 decks2 decks
50%synergy
Vesuva
50%inclusion1 decks2 decks
47%synergy
Inkmoth Nexus
50%inclusion1 decks2 decks
49%synergy
Urza's Workshop
50%inclusion1 decks2 decks
50%synergy
Cabal Coffers
50%inclusion1 decks2 decks
-5%synergy
Command Beacon
50%inclusion1 decks2 decks
42%synergy
Nykthos, Shrine to Nyx
50%inclusion1 decks2 decks
20%synergy
Lake of the Dead
50%inclusion1 decks2 decks
45%synergy
Urborg, Tomb of Yawgmoth
50%inclusion1 decks2 decks
12%synergy
Urza's Power Plant
50%inclusion1 decks2 decks
50%synergy
Mana Artifacts
Staff of Compleation
100%inclusion2 decks2 decks
98%synergy
Sol Ring
100%inclusion2 decks2 decks
14%synergy
Mox Opal
100%inclusion2 decks2 decks
97%synergy
Phial of Galadriel
50%inclusion1 decks2 decks
50%synergy
Caged Sun
50%inclusion1 decks2 decks
38%synergy
Arcane Signet
50%inclusion1 decks2 decks
-12%synergy
Glistening Sphere
50%inclusion1 decks2 decks
49%synergy
Lotus Petal
50%inclusion1 decks2 decks
43%synergy
Heraldic Banner
50%inclusion1 decks2 decks
44%synergy
Basalt Monolith
50%inclusion1 decks2 decks
48%synergy
Mana Vault
50%inclusion1 decks2 decks
43%synergy
Mox Amber
50%inclusion1 decks2 decks
46%synergy
Sol Talisman
50%inclusion1 decks2 decks
49%synergy
Dragon's Hoard
50%inclusion1 decks2 decks
50%synergy
Worn Powerstone
50%inclusion1 decks2 decks
46%synergy
Extraplanar Lens
50%inclusion1 decks2 decks
45%synergy
Lion's Eye Diamond
50%inclusion1 decks2 decks
49%synergy
Lands
Swamp
100%inclusion2 decks2 decks
5%synergy
Fabled Passage
50%inclusion1 decks2 decks
48%synergy
Verdant Catacombs
50%inclusion1 decks2 decks
47%synergy
Cavern of Souls
50%inclusion1 decks2 decks
43%synergy
Gemstone Caverns
50%inclusion1 decks2 decks
46%synergy
Bloodstained Mire
50%inclusion1 decks2 decks
47%synergy
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