Skithiryx, the Blight Dragon (Commander) - Expensive Optimized Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #781
2decks
Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
Deck Filters
Cardsphere
Archidekt
Commander Spellbook
Moxfield
Scryfall
Ancient Tomb
100%inclusion2 decks2 decks
88%synergy
Demonic Tutor
100%inclusion2 decks2 decks
73%synergy
Chrome Mox
100%inclusion2 decks2 decks
94%synergy
Vampiric Tutor
100%inclusion2 decks2 decks
79%synergy
Mox Diamond
100%inclusion2 decks2 decks
96%synergy
Imperial Seal
50%inclusion1 decks2 decks
43%synergy
Opposition Agent
50%inclusion1 decks2 decks
40%synergy
The One Ring
50%inclusion1 decks2 decks
40%synergy
Mana Vault
50%inclusion1 decks2 decks
43%synergy
Necropotence
50%inclusion1 decks2 decks
35%synergy
Creatures
Plague Stinger
100%inclusion2 decks2 decks
99%synergy
Whispering Specter
100%inclusion2 decks2 decks
99%synergy
Crypt Ghast
100%inclusion2 decks2 decks
52%synergy
Dark Confidant
50%inclusion1 decks2 decks
43%synergy
Reaper of Sheoldred
50%inclusion1 decks2 decks
49%synergy
Sheoldred, the Apocalypse
50%inclusion1 decks2 decks
35%synergy
Flensermite
50%inclusion1 decks2 decks
49%synergy
Ophiomancer
50%inclusion1 decks2 decks
34%synergy
Phyrexian Crusader
50%inclusion1 decks2 decks
49%synergy
Yawgmoth, Thran Physician
50%inclusion1 decks2 decks
40%synergy
Archfiend of Depravity
50%inclusion1 decks2 decks
43%synergy
Chainer, Dementia Master
50%inclusion1 decks2 decks
45%synergy
K'rrik, Son of Yawgmoth
50%inclusion1 decks2 decks
31%synergy
Braids, Arisen Nightmare
50%inclusion1 decks2 decks
31%synergy
Orcish Bowmasters
50%inclusion1 decks2 decks
36%synergy
Dauthi Voidwalker
50%inclusion1 decks2 decks
34%synergy
Hand of the Praetors
50%inclusion1 decks2 decks
49%synergy
Ichor Rats
50%inclusion1 decks2 decks
47%synergy
Instants
Deadly Rollick
100%inclusion2 decks2 decks
76%synergy
Dark Ritual
100%inclusion2 decks2 decks
33%synergy
Fatal Push
50%inclusion1 decks2 decks
47%synergy
Cut Down
50%inclusion1 decks2 decks
46%synergy
Snuff Out
50%inclusion1 decks2 decks
37%synergy
Vraska's Fall
50%inclusion1 decks2 decks
46%synergy
Howl from Beyond
50%inclusion1 decks2 decks
49%synergy
Hatred
50%inclusion1 decks2 decks
49%synergy
Cabal Ritual
50%inclusion1 decks2 decks
32%synergy
Culling the Weak
50%inclusion1 decks2 decks
35%synergy
Slaughter Pact
50%inclusion1 decks2 decks
47%synergy
Black Sun's Twilight
50%inclusion1 decks2 decks
46%synergy
V.A.T.S.
50%inclusion1 decks2 decks
48%synergy
Dismember
50%inclusion1 decks2 decks
39%synergy
Sorceries
Toxic Deluge
100%inclusion2 decks2 decks
63%synergy
Bubbling Muck
50%inclusion1 decks2 decks
34%synergy
Phyresis Outbreak
50%inclusion1 decks2 decks
48%synergy
Crux of Fate
50%inclusion1 decks2 decks
49%synergy
Feed the Swarm
50%inclusion1 decks2 decks
-1%synergy
Infectious Inquiry
50%inclusion1 decks2 decks
47%synergy
Praetor's Grasp
50%inclusion1 decks2 decks
46%synergy
Dark Petition
50%inclusion1 decks2 decks
46%synergy
Exsanguinate
50%inclusion1 decks2 decks
25%synergy
Beseech the Mirror
50%inclusion1 decks2 decks
43%synergy
Beseech the Queen
50%inclusion1 decks2 decks
44%synergy
Damnation
50%inclusion1 decks2 decks
29%synergy
Drown in Ichor
50%inclusion1 decks2 decks
46%synergy
Grim Tutor
50%inclusion1 decks2 decks
38%synergy
Utility Artifacts
Lashwrithe
100%inclusion2 decks2 decks
96%synergy
Thran Power Suit
100%inclusion2 decks2 decks
100%synergy
Wishclaw Talisman
100%inclusion2 decks2 decks
93%synergy
Conqueror's Flail
100%inclusion2 decks2 decks
99%synergy
Commander's Plate
100%inclusion2 decks2 decks
94%synergy
Blackblade Reforged
100%inclusion2 decks2 decks
97%synergy
Dragonfire Blade
100%inclusion1 decks1 decks
100%synergy
Adaptive Omnitool
100%inclusion1 decks1 decks
100%synergy
The Darkness Crystal
100%inclusion1 decks1 decks
80%synergy
Genji Glove
100%inclusion1 decks1 decks
99%synergy
Sensei's Divining Top
50%inclusion1 decks2 decks
42%synergy
Masterwork of Ingenuity
50%inclusion1 decks2 decks
50%synergy
Mithril Coat
50%inclusion1 decks2 decks
44%synergy
Skyblinder Staff
50%inclusion1 decks2 decks
50%synergy
Nightmare Lash
50%inclusion1 decks2 decks
48%synergy
Leyline Axe
50%inclusion1 decks2 decks
49%synergy
Scroll Rack
50%inclusion1 decks2 decks
49%synergy
Nim Deathmantle
50%inclusion1 decks2 decks
47%synergy
Cranial Plating
50%inclusion1 decks2 decks
47%synergy
Sword of Truth and Justice
50%inclusion1 decks2 decks
49%synergy
Shadowspear
50%inclusion1 decks2 decks
46%synergy
Expedition Map
50%inclusion1 decks2 decks
38%synergy
Sword of Hearth and Home
50%inclusion1 decks2 decks
49%synergy
Whispersilk Cloak
50%inclusion1 decks2 decks
44%synergy
Excalibur, Sword of Eden
50%inclusion1 decks2 decks
50%synergy
Fireshrieker
50%inclusion1 decks2 decks
48%synergy
Sword of Wealth and Power
50%inclusion1 decks2 decks
49%synergy
Resurrection Orb
50%inclusion1 decks2 decks
47%synergy
Jet Medallion
50%inclusion1 decks2 decks
-11%synergy
Champion's Helm
50%inclusion1 decks2 decks
48%synergy
Swiftfoot Boots
50%inclusion1 decks2 decks
18%synergy
Lightning Greaves
50%inclusion1 decks2 decks
16%synergy
Sword of Feast and Famine
50%inclusion1 decks2 decks
48%synergy
Sword of the Animist
50%inclusion1 decks2 decks
46%synergy
Hammer of Nazahn
50%inclusion1 decks2 decks
49%synergy
Hero's Blade
50%inclusion1 decks2 decks
50%synergy
Basilisk Collar
50%inclusion1 decks2 decks
47%synergy
Enchantments
Contamination
100%inclusion2 decks2 decks
97%synergy
Super State
100%inclusion1 decks1 decks
100%synergy
The Meathook Massacre
50%inclusion1 decks2 decks
33%synergy
Eldrazi Conscription
50%inclusion1 decks2 decks
50%synergy
Phyrexian Reclamation
50%inclusion1 decks2 decks
40%synergy
Unspeakable Symbol
50%inclusion1 decks2 decks
49%synergy
Black Market Connections
50%inclusion1 decks2 decks
27%synergy
Phyrexian Arena
50%inclusion1 decks2 decks
10%synergy
Heartless Summoning
50%inclusion1 decks2 decks
45%synergy
Bitterblossom
50%inclusion1 decks2 decks
37%synergy
Planeswalkers
Liliana of the Dark Realms
100%inclusion2 decks2 decks
86%synergy
Vraska, Betrayal's Sting
50%inclusion1 decks2 decks
47%synergy
Utility Lands
Urza's Saga
100%inclusion2 decks2 decks
92%synergy
Shizo, Death's Storehouse
50%inclusion1 decks2 decks
40%synergy
Cabal Stronghold
50%inclusion1 decks2 decks
15%synergy
Cathedral of War
50%inclusion1 decks2 decks
50%synergy
Inkmoth Nexus
50%inclusion1 decks2 decks
49%synergy
Cabal Coffers
50%inclusion1 decks2 decks
-5%synergy
Emergence Zone
50%inclusion1 decks2 decks
47%synergy
Command Beacon
50%inclusion1 decks2 decks
42%synergy
Nykthos, Shrine to Nyx
50%inclusion1 decks2 decks
20%synergy
Mishra's Workshop
50%inclusion1 decks2 decks
50%synergy
Lake of the Dead
50%inclusion1 decks2 decks
45%synergy
Urborg, Tomb of Yawgmoth
50%inclusion1 decks2 decks
12%synergy
Rogue's Passage
50%inclusion1 decks2 decks
31%synergy
Mana Artifacts
Lotus Petal
100%inclusion2 decks2 decks
93%synergy
Sol Ring
100%inclusion2 decks2 decks
14%synergy
Mox Opal
100%inclusion2 decks2 decks
97%synergy
Arcane Signet
50%inclusion1 decks2 decks
-12%synergy
Staff of Compleation
50%inclusion1 decks2 decks
48%synergy
Heraldic Banner
50%inclusion1 decks2 decks
44%synergy
Extraplanar Lens
50%inclusion1 decks2 decks
45%synergy
Lands
Swamp
100%inclusion2 decks2 decks
5%synergy
Verdant Catacombs
100%inclusion2 decks2 decks
97%synergy
Bloodstained Mire
100%inclusion2 decks2 decks
96%synergy
Prismatic Vista
50%inclusion1 decks2 decks
48%synergy
The Mycosynth Gardens
50%inclusion1 decks2 decks
49%synergy
Command Tower
50%inclusion1 decks2 decks
44%synergy
Fabled Passage
50%inclusion1 decks2 decks
48%synergy
Cavern of Souls
50%inclusion1 decks2 decks
43%synergy
Gemstone Caverns
50%inclusion1 decks2 decks
46%synergy
Marsh Flats
50%inclusion1 decks2 decks
47%synergy
Polluted Delta
50%inclusion1 decks2 decks
47%synergy