Skithiryx, the Blight Dragon (Commander) - Expensive Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #779
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Bitterbloom Bearer
10%inclusion1 decks10 decks
8%synergy
High Synergy Cards
Plague Stinger
78%inclusion54 decks69 decks
77%synergy
Plague Myr
78%inclusion54 decks69 decks
77%synergy
Phyrexian Crusader
75%inclusion52 decks69 decks
74%synergy
Ichor Rats
77%inclusion53 decks69 decks
74%synergy
Inkmoth Nexus
74%inclusion51 decks69 decks
73%synergy
Shizo, Death's Storehouse
81%inclusion56 decks69 decks
71%synergy
Infectious Inquiry
72%inclusion50 decks69 decks
70%synergy
Whispering Specter
68%inclusion47 decks69 decks
67%synergy
Commander's Plate
71%inclusion49 decks69 decks
65%synergy
Hand of the Praetors
65%inclusion45 decks69 decks
64%synergy
Top Cards
Dark Ritual
93%inclusion64 decks69 decks
26%synergy
Deadly Rollick
80%inclusion55 decks69 decks
56%synergy
Jet Medallion
78%inclusion54 decks69 decks
18%synergy
Toxic Deluge
74%inclusion51 decks69 decks
37%synergy
Lightning Greaves
68%inclusion47 decks69 decks
35%synergy
Phyresis Outbreak
65%inclusion45 decks69 decks
63%synergy
Cabal Ritual
64%inclusion44 decks69 decks
46%synergy
Shadowspear
64%inclusion44 decks69 decks
60%synergy
Unspeakable Symbol
64%inclusion44 decks69 decks
63%synergy
Vraska's Fall
61%inclusion42 decks69 decks
57%synergy
Game Changers
Ancient Tomb
93%inclusion64 decks69 decks
81%synergy
Demonic Tutor
88%inclusion61 decks69 decks
61%synergy
Vampiric Tutor
86%inclusion59 decks69 decks
64%synergy
Mana Vault
81%inclusion56 decks69 decks
74%synergy
Chrome Mox
78%inclusion54 decks69 decks
72%synergy
Necropotence
59%inclusion41 decks69 decks
44%synergy
Mox Diamond
57%inclusion39 decks69 decks
53%synergy
The One Ring
54%inclusion37 decks69 decks
44%synergy
Opposition Agent
48%inclusion33 decks69 decks
38%synergy
Imperial Seal
42%inclusion29 decks69 decks
35%synergy
Creatures
Crypt Ghast
52%inclusion36 decks69 decks
4%synergy
Blightbelly Rat
46%inclusion32 decks69 decks
43%synergy
Dauthi Voidwalker
46%inclusion32 decks69 decks
31%synergy
K'rrik, Son of Yawgmoth
43%inclusion30 decks69 decks
25%synergy
Orcish Bowmasters
39%inclusion27 decks69 decks
25%synergy
Dark Confidant
36%inclusion25 decks69 decks
29%synergy
Yawgmoth, Thran Physician
33%inclusion23 decks69 decks
23%synergy
Bilious Skulldweller
30%inclusion21 decks69 decks
29%synergy
Myr Convert
28%inclusion19 decks69 decks
27%synergy
Ichorclaw Myr
28%inclusion19 decks69 decks
27%synergy
Sheoldred, the Apocalypse
25%inclusion17 decks69 decks
10%synergy
Flensermite
25%inclusion17 decks69 decks
24%synergy
Necropede
20%inclusion14 decks69 decks
20%synergy
Reaper of Sheoldred
19%inclusion13 decks69 decks
18%synergy
Corpse Cur
19%inclusion13 decks69 decks
18%synergy
Flesh-Eater Imp
19%inclusion13 decks69 decks
18%synergy
Blightsteel Colossus
17%inclusion12 decks69 decks
17%synergy
Pestilent Syphoner
16%inclusion11 decks69 decks
15%synergy
Septic Rats
16%inclusion11 decks69 decks
14%synergy
Phyrexian Vatmother
16%inclusion11 decks69 decks
16%synergy
Core Prowler
14%inclusion10 decks69 decks
14%synergy
Gray Merchant of Asphodel
14%inclusion10 decks69 decks
-37%synergy
Phyrexian Obliterator
14%inclusion10 decks69 decks
3%synergy
Massacre Girl, Known Killer
14%inclusion10 decks69 decks
11%synergy
Surge Conductor
14%inclusion2 decks14 decks
14%synergy
Agent Venom
9.1%inclusion1 decks11 decks
7%synergy
Filth
8.7%inclusion6 decks69 decks
6%synergy
Grafted Butcher
8.7%inclusion6 decks69 decks
8%synergy
Phyrexian Digester
8.7%inclusion6 decks69 decks
9%synergy
Maha, Its Feathers Night
8.0%inclusion4 decks50 decks
3%synergy
Magus of the Coffers
7.2%inclusion5 decks69 decks
0%synergy
Witch-king of Angmar
7.2%inclusion5 decks69 decks
6%synergy
Defiler of Flesh
7.2%inclusion5 decks69 decks
3%synergy
Leaden Myr
7.2%inclusion5 decks69 decks
1%synergy
Virulent Silencer
7.1%inclusion1 decks14 decks
7%synergy
Unstoppable Slasher
6.7%inclusion3 decks45 decks
1%synergy
Bloodthirsty Conqueror
5.9%inclusion2 decks34 decks
-3%synergy
Solemn Simulacrum
5.8%inclusion4 decks69 decks
-18%synergy
Contagious Nim
5.8%inclusion4 decks69 decks
6%synergy
Murderous Rider
5.8%inclusion4 decks69 decks
-1%synergy
Blackcleave Goblin
5.8%inclusion4 decks69 decks
6%synergy
Nazgûl
5.8%inclusion4 decks69 decks
5%synergy
Swamp Mosquito
5.8%inclusion4 decks69 decks
6%synergy
Necroskitter
5.8%inclusion4 decks69 decks
2%synergy
Mikaeus, the Unhallowed
5.8%inclusion4 decks69 decks
-2%synergy
Blood Pet
5.8%inclusion4 decks69 decks
-2%synergy
Instants
Snuff Out
51%inclusion35 decks69 decks
38%synergy
Tainted Strike
51%inclusion35 decks69 decks
48%synergy
Imp's Mischief
49%inclusion34 decks69 decks
25%synergy
Hatred
49%inclusion34 decks69 decks
48%synergy
Dismember
46%inclusion32 decks69 decks
35%synergy
Howl from Beyond
41%inclusion28 decks69 decks
40%synergy
Malakir Rebirth
29%inclusion20 decks69 decks
6%synergy
Go for the Throat
28%inclusion19 decks69 decks
4%synergy
Withering Torment
27%inclusion12 decks45 decks
-5%synergy
Whisper of the Dross
22%inclusion15 decks69 decks
19%synergy
Defile
22%inclusion15 decks69 decks
-16%synergy
Culling the Weak
22%inclusion15 decks69 decks
7%synergy
Withering Boon
22%inclusion15 decks69 decks
17%synergy
Baleful Mastery
22%inclusion15 decks69 decks
12%synergy
Archenemy's Charm
21%inclusion3 decks14 decks
13%synergy
Infernal Grasp
20%inclusion14 decks69 decks
-5%synergy
Sudden Spoiling
20%inclusion14 decks69 decks
11%synergy
Force of Despair
19%inclusion13 decks69 decks
11%synergy
Fell the Profane
18%inclusion10 decks55 decks
-1%synergy
Cut Down
16%inclusion11 decks69 decks
12%synergy
Slaughter Pact
14%inclusion10 decks69 decks
12%synergy
Bitter Triumph
14%inclusion10 decks69 decks
4%synergy
Hero's Downfall
13%inclusion9 decks69 decks
6%synergy
Darkness
13%inclusion9 decks69 decks
3%synergy
Astarion's Thirst
12%inclusion8 decks69 decks
10%synergy
Ad Nauseam
10%inclusion7 decks69 decks
8%synergy
Consuming Corruption
9.1%inclusion5 decks55 decks
-7%synergy
Blood Pact
8.7%inclusion6 decks69 decks
4%synergy
Overkill
6.7%inclusion1 decks15 decks
-1%synergy
Sheoldred's Edict
5.8%inclusion4 decks69 decks
-9%synergy
Entomb
5.8%inclusion4 decks69 decks
-6%synergy
Not Dead After All
5.8%inclusion4 decks69 decks
-6%synergy
Anoint with Affliction
5.8%inclusion4 decks69 decks
5%synergy
Grim Affliction
5.8%inclusion4 decks69 decks
4%synergy
Supernatural Stamina
5.8%inclusion4 decks69 decks
-2%synergy
Rain of Filth
5.8%inclusion4 decks69 decks
3%synergy
Tragic Slip
5.8%inclusion4 decks69 decks
-15%synergy
Sorceries
Feed the Swarm
61%inclusion42 decks69 decks
10%synergy
Night's Whisper
57%inclusion39 decks69 decks
32%synergy
Crux of Fate
51%inclusion35 decks69 decks
49%synergy
Sign in Blood
51%inclusion35 decks69 decks
14%synergy
Drown in Ichor
51%inclusion35 decks69 decks
46%synergy
Bubbling Muck
46%inclusion32 decks69 decks
31%synergy
Damnation
42%inclusion29 decks69 decks
21%synergy
Insatiable Avarice
32%inclusion19 decks59 decks
20%synergy
Reanimate
29%inclusion20 decks69 decks
-10%synergy
Grim Tutor
29%inclusion20 decks69 decks
17%synergy
Praetor's Grasp
22%inclusion15 decks69 decks
18%synergy
Caress of Phyrexia
16%inclusion11 decks69 decks
15%synergy
Blasphemous Edict
15%inclusion5 decks33 decks
-2%synergy
Beseech the Mirror
14%inclusion10 decks69 decks
8%synergy
Yawgmoth's Will
13%inclusion9 decks69 decks
10%synergy
Read the Bones
12%inclusion8 decks69 decks
-6%synergy
Black Sun's Zenith
10%inclusion7 decks69 decks
4%synergy
Torment of Hailfire
10%inclusion7 decks69 decks
-6%synergy
Exsanguinate
7.2%inclusion5 decks69 decks
-17%synergy
Diabolic Tutor
5.8%inclusion4 decks69 decks
-9%synergy
Peer into the Abyss
5.8%inclusion4 decks69 decks
-5%synergy
Agadeem's Awakening
5.8%inclusion4 decks69 decks
-1%synergy
Dark Petition
5.8%inclusion4 decks69 decks
2%synergy
Geth's Summons
5.8%inclusion4 decks69 decks
5%synergy
Beseech the Queen
5.8%inclusion4 decks69 decks
0%synergy
Thoughtseize
5.8%inclusion4 decks69 decks
1%synergy
Rush of Dread
5.1%inclusion3 decks59 decks
1%synergy
Utility Artifacts
Swiftfoot Boots
57%inclusion39 decks69 decks
25%synergy
Sword of Truth and Justice
54%inclusion37 decks69 decks
53%synergy
Lashwrithe
48%inclusion33 decks69 decks
44%synergy
Nightmare Lash
48%inclusion33 decks69 decks
45%synergy
Blackblade Reforged
39%inclusion27 decks69 decks
36%synergy
Sensei's Divining Top
36%inclusion25 decks69 decks
28%synergy
Cranial Plating
32%inclusion22 decks69 decks
28%synergy
Bolas's Citadel
30%inclusion21 decks69 decks
1%synergy
Mithril Coat
30%inclusion21 decks69 decks
25%synergy
Genji Glove
27%inclusion4 decks15 decks
26%synergy
Whispersilk Cloak
23%inclusion16 decks69 decks
17%synergy
Sword of Feast and Famine
23%inclusion16 decks69 decks
21%synergy
Doc Ock's Tentacles
20%inclusion2 decks10 decks
20%synergy
Champion's Helm
19%inclusion13 decks69 decks
17%synergy
Pip-Boy 3000
18%inclusion12 decks67 decks
18%synergy
Leyline Axe
18%inclusion6 decks34 decks
17%synergy
The Darkness Crystal
18%inclusion3 decks17 decks
-2%synergy
Umezawa's Jitte
17%inclusion12 decks69 decks
17%synergy
Contagion Engine
17%inclusion12 decks69 decks
15%synergy
Fireshrieker
17%inclusion12 decks69 decks
15%synergy
Pact Weapon
17%inclusion12 decks69 decks
15%synergy
Wishclaw Talisman
16%inclusion11 decks69 decks
9%synergy
Manifold Key
14%inclusion10 decks69 decks
13%synergy
Hammer of Nazahn
14%inclusion10 decks69 decks
14%synergy
Brotherhood Regalia
13%inclusion7 decks52 decks
11%synergy
Contagion Clasp
13%inclusion9 decks69 decks
10%synergy
Expedition Map
13%inclusion9 decks69 decks
1%synergy
Sword of the Animist
13%inclusion9 decks69 decks
9%synergy
Buster Sword
13%inclusion2 decks16 decks
12%synergy
Sword of Wealth and Power
12%inclusion8 decks67 decks
11%synergy
Black Mage's Rod
12%inclusion2 decks17 decks
11%synergy
Throne of Geth
12%inclusion8 decks69 decks
11%synergy
Aetherflux Reservoir
10%inclusion7 decks69 decks
0%synergy
Hero's Blade
10%inclusion7 decks69 decks
10%synergy
Thran Power Suit
8.7%inclusion6 decks69 decks
8%synergy
Trailblazer's Boots
8.7%inclusion6 decks69 decks
6%synergy
Conqueror's Flail
8.7%inclusion6 decks69 decks
8%synergy
Grafted Wargear
8.7%inclusion6 decks69 decks
8%synergy
Lavaspur Boots
8.3%inclusion5 decks60 decks
7%synergy
Helm of Obedience
7.2%inclusion5 decks69 decks
7%synergy
Sword of Fire and Ice
7.2%inclusion5 decks69 decks
7%synergy
O-Naginata
7.2%inclusion5 decks69 decks
7%synergy
Dark Knight's Greatsword
6.7%inclusion1 decks15 decks
6%synergy
Aettir and Priwen
6.3%inclusion1 decks16 decks
6%synergy
Silver Shroud Costume
6.0%inclusion4 decks67 decks
5%synergy
Dragonfire Blade
5.9%inclusion1 decks17 decks
6%synergy
Voltaic Key
5.8%inclusion4 decks69 decks
5%synergy
Bloodforged Battle-Axe
5.8%inclusion4 decks69 decks
6%synergy
Bontu's Monument
5.8%inclusion4 decks69 decks
-22%synergy
Mindcrank
5.8%inclusion4 decks69 decks
0%synergy
Enchantments
Phyrexian Arena
55%inclusion38 decks69 decks
15%synergy
Black Market Connections
51%inclusion35 decks69 decks
27%synergy
Necrogen Communion
36%inclusion25 decks69 decks
34%synergy
The Meathook Massacre
22%inclusion15 decks69 decks
4%synergy
Super State
21%inclusion3 decks14 decks
21%synergy
Kaya's Ghostform
17%inclusion12 decks69 decks
7%synergy
Animate Dead
16%inclusion11 decks69 decks
-2%synergy
Phyresis
14%inclusion10 decks69 decks
12%synergy
Contamination
13%inclusion9 decks69 decks
10%synergy
No Mercy
13%inclusion9 decks69 decks
6%synergy
Bitterblossom
12%inclusion8 decks69 decks
-1%synergy
Oubliette
10%inclusion7 decks69 decks
7%synergy
Endless Scream
10%inclusion7 decks69 decks
10%synergy
Leyline of the Void
10%inclusion7 decks69 decks
8%synergy
Phyrexian Reclamation
8.7%inclusion6 decks69 decks
-1%synergy
Bloodchief Ascension
8.7%inclusion6 decks69 decks
-1%synergy
Glistening Oil
7.2%inclusion5 decks69 decks
6%synergy
Shade's Form
7.2%inclusion5 decks69 decks
7%synergy
Heartless Summoning
7.2%inclusion5 decks69 decks
3%synergy
Bad Moon
7.2%inclusion5 decks69 decks
4%synergy
Relic Putrescence
5.8%inclusion4 decks69 decks
6%synergy
Call of the Ring
5.8%inclusion4 decks69 decks
3%synergy
Dauthi Embrace
5.8%inclusion4 decks69 decks
4%synergy
Planeswalkers
Vraska, Betrayal's Sting
51%inclusion35 decks69 decks
48%synergy
Liliana of the Dark Realms
35%inclusion24 decks69 decks
21%synergy
Tezzeret, Cruel Captain
14%inclusion2 decks14 decks
13%synergy
Utility Lands
Urborg, Tomb of Yawgmoth
87%inclusion60 decks69 decks
49%synergy
Cabal Coffers
86%inclusion59 decks69 decks
30%synergy
Karn's Bastion
65%inclusion45 decks69 decks
61%synergy
Rogue's Passage
58%inclusion40 decks69 decks
39%synergy
Urza's Saga
51%inclusion35 decks69 decks
43%synergy
Lake of the Dead
43%inclusion30 decks69 decks
38%synergy
The Black Gate
35%inclusion24 decks69 decks
31%synergy
Nykthos, Shrine to Nyx
35%inclusion24 decks69 decks
5%synergy
Strip Mine
33%inclusion23 decks69 decks
30%synergy
Bojuka Bog
32%inclusion22 decks69 decks
-15%synergy
Command Beacon
25%inclusion17 decks69 decks
16%synergy
Cabal Stronghold
23%inclusion16 decks69 decks
-12%synergy
Minas Morgul, Dark Fortress
22%inclusion15 decks69 decks
19%synergy
Vault of Whispers
20%inclusion14 decks69 decks
15%synergy
Takenuma, Abandoned Mire
20%inclusion14 decks69 decks
4%synergy
Castle Locthwain
20%inclusion14 decks69 decks
3%synergy
Volrath's Stronghold
16%inclusion11 decks69 decks
12%synergy
Homeward Path
16%inclusion11 decks69 decks
14%synergy
Phyrexian Tower
13%inclusion9 decks69 decks
-11%synergy
Cathedral of War
13%inclusion9 decks69 decks
13%synergy
City of Traitors
12%inclusion8 decks69 decks
10%synergy
Wasteland
10%inclusion7 decks69 decks
9%synergy
War Room
10%inclusion7 decks69 decks
-6%synergy
Reliquary Tower
10%inclusion7 decks69 decks
-21%synergy
Deserted Temple
8.7%inclusion6 decks69 decks
4%synergy
Maze of Ith
7.2%inclusion5 decks69 decks
4%synergy
Hall of the Bandit Lord
5.8%inclusion4 decks69 decks
5%synergy
Darksteel Citadel
5.8%inclusion4 decks69 decks
4%synergy
Thespian's Stage
5.8%inclusion4 decks69 decks
0%synergy
Mishra's Workshop
5.8%inclusion4 decks69 decks
5%synergy
Dark Depths
5.8%inclusion4 decks69 decks
5%synergy
Spymaster's Vault
5.5%inclusion3 decks55 decks
-4%synergy
Mana Artifacts
Sol Ring
97%inclusion67 decks69 decks
11%synergy
Arcane Signet
83%inclusion57 decks69 decks
20%synergy
Mox Opal
72%inclusion50 decks69 decks
69%synergy
Lotus Petal
67%inclusion46 decks69 decks
59%synergy
The Soul Stone
50%inclusion7 decks14 decks
37%synergy
Glistening Sphere
43%inclusion30 decks69 decks
42%synergy
Grim Monolith
39%inclusion27 decks69 decks
36%synergy
Staff of Compleation
36%inclusion25 decks69 decks
34%synergy
Mana Crypt
32%inclusion22 decks69 decks
30%synergy
Jeweled Lotus
30%inclusion21 decks69 decks
28%synergy
Mox Amber
25%inclusion17 decks69 decks
20%synergy
Throne of Eldraine
23%inclusion16 decks69 decks
13%synergy
Fellwar Stone
23%inclusion16 decks69 decks
8%synergy
Mind Stone
20%inclusion14 decks69 decks
-10%synergy
Everflowing Chalice
13%inclusion9 decks69 decks
7%synergy
Heraldic Banner
13%inclusion9 decks69 decks
7%synergy
Mox Jasper
12%inclusion2 decks17 decks
12%synergy
Thran Dynamo
8.7%inclusion6 decks69 decks
3%synergy
Sceptre of Eternal Glory
8.7%inclusion6 decks69 decks
0%synergy
Caged Sun
7.2%inclusion5 decks69 decks
-5%synergy
Charcoal Diamond
7.2%inclusion5 decks69 decks
-16%synergy
Thought Vessel
7.2%inclusion5 decks69 decks
-20%synergy
Mox Tantalite
7.2%inclusion5 decks69 decks
7%synergy
Patchwork Banner
6.0%inclusion3 decks50 decks
2%synergy
Worn Powerstone
5.8%inclusion4 decks69 decks
1%synergy
Extraplanar Lens
5.8%inclusion4 decks69 decks
1%synergy
Lands
Swamp
88%inclusion61 decks69 decks
-6%synergy
Cavern of Souls
72%inclusion50 decks69 decks
66%synergy
Gemstone Caverns
35%inclusion24 decks69 decks
30%synergy
Malakir Rebirth
29%inclusion20 decks69 decks
6%synergy
Verdant Catacombs
23%inclusion16 decks69 decks
20%synergy
Polluted Delta
22%inclusion15 decks69 decks
18%synergy
Bloodstained Mire
22%inclusion15 decks69 decks
18%synergy
Marsh Flats
20%inclusion14 decks69 decks
17%synergy
Fell the Profane
18%inclusion10 decks55 decks
-1%synergy
Plaza of Heroes
16%inclusion11 decks69 decks
15%synergy
Mirrex
14%inclusion10 decks69 decks
14%synergy
Snow-Covered Swamp
13%inclusion9 decks69 decks
6%synergy
Prismatic Vista
10%inclusion7 decks69 decks
8%synergy
Command Tower
10%inclusion7 decks69 decks
5%synergy
Fabled Passage
5.8%inclusion4 decks69 decks
4%synergy
The Seedcore
5.8%inclusion4 decks69 decks
6%synergy
Agadeem's Awakening
5.8%inclusion4 decks69 decks
-1%synergy
Urza's Cave
5.3%inclusion3 decks57 decks
-3%synergy
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