Skithiryx, the Blight Dragon (Commander) - Core Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #781
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Plague Stinger
73%inclusion30 decks41 decks
72%synergy
Plague Myr
71%inclusion29 decks41 decks
69%synergy
Lashwrithe
71%inclusion29 decks41 decks
67%synergy
Infectious Inquiry
68%inclusion28 decks41 decks
65%synergy
Hand of the Praetors
66%inclusion27 decks41 decks
65%synergy
Drown in Ichor
68%inclusion28 decks41 decks
64%synergy
Vraska's Fall
63%inclusion26 decks41 decks
60%synergy
Ichor Rats
61%inclusion25 decks41 decks
58%synergy
Phyrexian Crusader
59%inclusion24 decks41 decks
58%synergy
Ichorclaw Myr
56%inclusion23 decks41 decks
56%synergy
Top Cards
Feed the Swarm
61%inclusion25 decks41 decks
10%synergy
Swiftfoot Boots
61%inclusion25 decks41 decks
29%synergy
Dark Ritual
59%inclusion24 decks41 decks
-8%synergy
Whispering Specter
56%inclusion23 decks41 decks
55%synergy
Defile
56%inclusion23 decks41 decks
19%synergy
Crypt Ghast
56%inclusion23 decks41 decks
8%synergy
Blightbelly Rat
56%inclusion23 decks41 decks
52%synergy
Blackblade Reforged
56%inclusion23 decks41 decks
53%synergy
Core Prowler
54%inclusion22 decks41 decks
53%synergy
Corpse Cur
54%inclusion22 decks41 decks
53%synergy
Creatures
Bilious Skulldweller
51%inclusion21 decks41 decks
50%synergy
Reaper of Sheoldred
49%inclusion20 decks41 decks
48%synergy
Flensermite
46%inclusion19 decks41 decks
46%synergy
Flesh-Eater Imp
39%inclusion16 decks41 decks
38%synergy
Septic Rats
39%inclusion16 decks41 decks
37%synergy
Solemn Simulacrum
34%inclusion14 decks41 decks
11%synergy
Pestilent Syphoner
34%inclusion14 decks41 decks
33%synergy
Phyrexian Obliterator
34%inclusion14 decks41 decks
23%synergy
Myr Convert
34%inclusion14 decks41 decks
33%synergy
Necropede
32%inclusion13 decks41 decks
31%synergy
Phyrexian Juggernaut
27%inclusion11 decks41 decks
27%synergy
Leaden Myr
27%inclusion11 decks41 decks
21%synergy
K'rrik, Son of Yawgmoth
24%inclusion10 decks41 decks
6%synergy
Gulping Scraptrap
22%inclusion9 decks41 decks
21%synergy
Contagious Nim
20%inclusion8 decks41 decks
19%synergy
Dread Presence
20%inclusion8 decks41 decks
5%synergy
Gray Merchant of Asphodel
17%inclusion7 decks41 decks
-34%synergy
Swamp Mosquito
17%inclusion7 decks41 decks
17%synergy
Yawgmoth, Thran Physician
17%inclusion7 decks41 decks
7%synergy
Silent Arbiter
15%inclusion6 decks41 decks
13%synergy
Dark Confidant
15%inclusion6 decks41 decks
7%synergy
Defiler of Flesh
15%inclusion6 decks41 decks
11%synergy
Burnished Hart
15%inclusion6 decks41 decks
7%synergy
Massacre Girl, Known Killer
15%inclusion6 decks41 decks
11%synergy
Vector Asp
12%inclusion5 decks41 decks
12%synergy
Magus of the Coffers
12%inclusion5 decks41 decks
5%synergy
Brass Squire
12%inclusion5 decks41 decks
12%synergy
Grafted Butcher
12%inclusion5 decks41 decks
12%synergy
Nirkana Revenant
12%inclusion5 decks41 decks
1%synergy
Sheoldred's Headcleaver
12%inclusion5 decks41 decks
12%synergy
Blightsteel Colossus
12%inclusion5 decks41 decks
12%synergy
Blackcleave Goblin
10%inclusion4 decks41 decks
10%synergy
Necroskitter
10%inclusion4 decks41 decks
7%synergy
Palladium Myr
10%inclusion4 decks41 decks
8%synergy
Sheoldred, Whispering One
10%inclusion4 decks41 decks
-2%synergy
Nimraiser Paladin
10%inclusion4 decks41 decks
10%synergy
Phyrexian Vatmother
10%inclusion4 decks41 decks
10%synergy
Feral Deathgorger
8.0%inclusion2 decks25 decks
8%synergy
Scavenger Regent
8.0%inclusion2 decks25 decks
7%synergy
Qarsi Revenant
8.0%inclusion2 decks25 decks
3%synergy
Dune Mover
7.3%inclusion3 decks41 decks
7%synergy
Paragon of Open Graves
7.3%inclusion3 decks41 decks
7%synergy
Massacre Girl
7.3%inclusion3 decks41 decks
0%synergy
Massacre Wurm
7.3%inclusion3 decks41 decks
-10%synergy
Toxic Nim
7.3%inclusion3 decks41 decks
7%synergy
Suspicious Bookcase
7.3%inclusion3 decks41 decks
7%synergy
Scheming Aspirant
7.3%inclusion3 decks41 decks
7%synergy
Agent Venom
7.1%inclusion1 decks14 decks
5%synergy
Swarm, Being of Bees
7.1%inclusion1 decks14 decks
7%synergy
Venomized Cat
7.1%inclusion1 decks14 decks
7%synergy
Instants
Howl from Beyond
51%inclusion21 decks41 decks
50%synergy
Grim Affliction
46%inclusion19 decks41 decks
44%synergy
Tainted Strike
44%inclusion18 decks41 decks
41%synergy
Whisper of the Dross
39%inclusion16 decks41 decks
36%synergy
Go for the Throat
29%inclusion12 decks41 decks
6%synergy
Virulent Wound
29%inclusion12 decks41 decks
29%synergy
Dismember
29%inclusion12 decks41 decks
19%synergy
Withering Torment
29%inclusion10 decks35 decks
-3%synergy
Imp's Mischief
24%inclusion10 decks41 decks
0%synergy
Sugar Rush
24%inclusion10 decks41 decks
24%synergy
Infernal Grasp
24%inclusion10 decks41 decks
-1%synergy
Supernatural Stamina
22%inclusion9 decks41 decks
14%synergy
Doom Blade
20%inclusion8 decks41 decks
12%synergy
Malakir Rebirth
20%inclusion8 decks41 decks
-3%synergy
Astarion's Thirst
17%inclusion7 decks41 decks
16%synergy
Hero's Downfall
17%inclusion7 decks41 decks
10%synergy
Anoint with Affliction
17%inclusion7 decks41 decks
16%synergy
Unlikely Aid
17%inclusion7 decks41 decks
16%synergy
Murder
17%inclusion7 decks41 decks
7%synergy
Consuming Corruption
16%inclusion6 decks38 decks
0%synergy
Force of Despair
15%inclusion6 decks41 decks
7%synergy
Snuff Out
15%inclusion6 decks41 decks
2%synergy
Undying Malice
15%inclusion6 decks41 decks
5%synergy
Withering Boon
12%inclusion5 decks41 decks
8%synergy
Sudden Spoiling
12%inclusion5 decks41 decks
3%synergy
Tragic Slip
12%inclusion5 decks41 decks
-8%synergy
Fell the Profane
11%inclusion4 decks38 decks
-8%synergy
Grotesque Mutation
10%inclusion4 decks41 decks
10%synergy
Sheoldred's Edict
10%inclusion4 decks41 decks
-5%synergy
Hatred
10%inclusion4 decks41 decks
9%synergy
Grasp of Darkness
10%inclusion4 decks41 decks
8%synergy
Unnatural Endurance
10%inclusion4 decks41 decks
9%synergy
Armor of Shadows
10%inclusion4 decks41 decks
7%synergy
Baleful Mastery
10%inclusion4 decks41 decks
1%synergy
Professor's Warning
10%inclusion4 decks41 decks
8%synergy
Cabal Ritual
7.3%inclusion3 decks41 decks
-11%synergy
Lash of Thorns
7.3%inclusion3 decks41 decks
7%synergy
Rush of Vitality
7.3%inclusion3 decks41 decks
7%synergy
Darkness
7.3%inclusion3 decks41 decks
-2%synergy
Offer Immortality
7.3%inclusion3 decks41 decks
5%synergy
Scorpion's Sting
6.3%inclusion1 decks16 decks
6%synergy
Archenemy's Charm
5.9%inclusion1 decks17 decks
-3%synergy
Sorceries
Phyresis Outbreak
51%inclusion21 decks41 decks
49%synergy
Sign in Blood
49%inclusion20 decks41 decks
13%synergy
Night's Whisper
44%inclusion18 decks41 decks
19%synergy
Read the Bones
37%inclusion15 decks41 decks
19%synergy
Caress of Phyrexia
37%inclusion15 decks41 decks
36%synergy
Crux of Fate
32%inclusion13 decks41 decks
30%synergy
Vat Emergence
27%inclusion11 decks41 decks
25%synergy
Spread the Sickness
24%inclusion10 decks41 decks
24%synergy
Diabolic Tutor
24%inclusion10 decks41 decks
10%synergy
Mutilate
24%inclusion10 decks41 decks
6%synergy
Toxic Deluge
22%inclusion9 decks41 decks
-15%synergy
Black Sun's Zenith
20%inclusion8 decks41 decks
14%synergy
In Garruk's Wake
17%inclusion7 decks41 decks
13%synergy
Bubbling Muck
15%inclusion6 decks41 decks
-1%synergy
Exsanguinate
15%inclusion6 decks41 decks
-10%synergy
Reanimate
15%inclusion6 decks41 decks
-25%synergy
Feed the Infection
12%inclusion5 decks41 decks
11%synergy
Geth's Summons
12%inclusion5 decks41 decks
12%synergy
Ancient Craving
10%inclusion4 decks41 decks
8%synergy
Ambition's Cost
10%inclusion4 decks41 decks
7%synergy
Blasphemous Edict
9.4%inclusion3 decks32 decks
-8%synergy
Insatiable Avarice
7.7%inclusion3 decks39 decks
-4%synergy
Extinction Event
7.3%inclusion3 decks41 decks
7%synergy
Profane Tutor
7.3%inclusion3 decks41 decks
3%synergy
Syphon Mind
7.3%inclusion3 decks41 decks
-5%synergy
Nighthaze
7.3%inclusion3 decks41 decks
7%synergy
Damnation
7.3%inclusion3 decks41 decks
-13%synergy
Languish
7.3%inclusion3 decks41 decks
6%synergy
Prison Break
7.1%inclusion1 decks14 decks
7%synergy
Risky Research
6.3%inclusion1 decks16 decks
5%synergy
Lethal Protection
6.3%inclusion1 decks16 decks
6%synergy
Venom's Hunger
6.3%inclusion1 decks16 decks
6%synergy
Final Vengeance
5.7%inclusion2 decks35 decks
4%synergy
Cornered by Black Mages
5.0%inclusion1 decks20 decks
4%synergy
Resentful Revelation
5.0%inclusion1 decks20 decks
3%synergy
Utility Artifacts
Nightmare Lash
49%inclusion20 decks41 decks
46%synergy
Fireshrieker
49%inclusion20 decks41 decks
47%synergy
Contagion Clasp
46%inclusion19 decks41 decks
44%synergy
Jet Medallion
39%inclusion16 decks41 decks
-22%synergy
Wayfarer's Bauble
34%inclusion14 decks41 decks
18%synergy
Whispersilk Cloak
34%inclusion14 decks41 decks
28%synergy
Lightning Greaves
34%inclusion14 decks41 decks
1%synergy
Contagion Engine
32%inclusion13 decks41 decks
30%synergy
Champion's Helm
29%inclusion12 decks41 decks
27%synergy
Hero's Blade
29%inclusion12 decks41 decks
29%synergy
Trailblazer's Boots
27%inclusion11 decks41 decks
25%synergy
Nettlecyst
20%inclusion8 decks41 decks
19%synergy
Cranial Plating
20%inclusion8 decks41 decks
16%synergy
Strata Scythe
20%inclusion8 decks41 decks
19%synergy
Leyline Axe
19%inclusion6 decks32 decks
18%synergy
Throne of Geth
17%inclusion7 decks41 decks
17%synergy
Inquisitor's Flail
17%inclusion7 decks41 decks
17%synergy
Loxodon Warhammer
17%inclusion7 decks41 decks
16%synergy
Sword of Vengeance
17%inclusion7 decks41 decks
16%synergy
Expedition Map
15%inclusion6 decks41 decks
2%synergy
Commander's Plate
15%inclusion6 decks41 decks
9%synergy
Brotherhood Regalia
13%inclusion5 decks38 decks
11%synergy
Manifold Key
12%inclusion5 decks41 decks
10%synergy
Prowler's Helm
12%inclusion5 decks41 decks
11%synergy
Sword of Truth and Justice
12%inclusion5 decks41 decks
11%synergy
Shadowspear
12%inclusion5 decks41 decks
8%synergy
Sword of the Animist
12%inclusion5 decks41 decks
8%synergy
The Darkness Crystal
10%inclusion2 decks20 decks
-10%synergy
Genji Glove
10%inclusion2 decks20 decks
9%synergy
Thran Power Suit
10%inclusion4 decks41 decks
9%synergy
Livewire Lash
10%inclusion4 decks41 decks
10%synergy
Silver Shroud Costume
10%inclusion4 decks41 decks
9%synergy
Darksteel Plate
10%inclusion4 decks41 decks
8%synergy
Pact Weapon
10%inclusion4 decks41 decks
8%synergy
Hammer of Nazahn
10%inclusion4 decks41 decks
9%synergy
Basilisk Collar
10%inclusion4 decks41 decks
7%synergy
Bloodthorn Flail
7.3%inclusion3 decks41 decks
7%synergy
Viridian Claw
7.3%inclusion3 decks41 decks
7%synergy
Pip-Boy 3000
7.3%inclusion3 decks41 decks
7%synergy
Armillary Sphere
7.3%inclusion3 decks41 decks
7%synergy
Sword of the Chosen
7.3%inclusion3 decks41 decks
7%synergy
Whip of Erebos
7.3%inclusion3 decks41 decks
-3%synergy
O-Naginata
7.3%inclusion3 decks41 decks
7%synergy
Vorpal Sword
7.3%inclusion3 decks41 decks
3%synergy
Mind Carver
7.3%inclusion3 decks41 decks
7%synergy
Heirloom Blade
7.3%inclusion3 decks41 decks
7%synergy
Prosthetic Injector
7.3%inclusion3 decks41 decks
7%synergy
Bontu's Monument
7.3%inclusion3 decks41 decks
-21%synergy
Strider Harness
7.3%inclusion3 decks41 decks
7%synergy
Ring of Xathrid
7.3%inclusion3 decks41 decks
7%synergy
Enchantments
Phyrexian Arena
46%inclusion19 decks41 decks
6%synergy
Necrogen Communion
39%inclusion16 decks41 decks
37%synergy
Kaya's Ghostform
34%inclusion14 decks41 decks
24%synergy
Unspeakable Symbol
27%inclusion11 decks41 decks
26%synergy
Bad Moon
22%inclusion9 decks41 decks
19%synergy
Fungal Fortitude
20%inclusion8 decks41 decks
18%synergy
Phyresis
17%inclusion7 decks41 decks
15%synergy
Relic Putrescence
15%inclusion6 decks41 decks
14%synergy
Greed
10%inclusion4 decks41 decks
3%synergy
Glistening Oil
10%inclusion4 decks41 decks
9%synergy
Endless Scream
10%inclusion4 decks41 decks
9%synergy
Demonic Embrace
10%inclusion4 decks41 decks
9%synergy
Demonic Vigor
7.3%inclusion3 decks41 decks
7%synergy
Phyrexian Scriptures
7.3%inclusion3 decks41 decks
6%synergy
Black Market
7.3%inclusion3 decks41 decks
-14%synergy
Underworld Connections
7.3%inclusion3 decks41 decks
5%synergy
Shade's Form
7.3%inclusion3 decks41 decks
7%synergy
Eternal Thirst
7.3%inclusion3 decks41 decks
5%synergy
Dauthi Embrace
7.3%inclusion3 decks41 decks
6%synergy
Black Market Connections
7.3%inclusion3 decks41 decks
-16%synergy
Alien Symbiosis
7.1%inclusion1 decks14 decks
7%synergy
Super State
5.9%inclusion1 decks17 decks
6%synergy
Planeswalkers
Vraska, Betrayal's Sting
34%inclusion14 decks41 decks
31%synergy
Liliana of the Dark Realms
22%inclusion9 decks41 decks
8%synergy
Utility Lands
Rogue's Passage
59%inclusion24 decks41 decks
40%synergy
Karn's Bastion
51%inclusion21 decks41 decks
47%synergy
Cabal Coffers
44%inclusion18 decks41 decks
-11%synergy
Bojuka Bog
39%inclusion16 decks41 decks
-8%synergy
Inkmoth Nexus
37%inclusion15 decks41 decks
36%synergy
Cabal Stronghold
32%inclusion13 decks41 decks
-3%synergy
Cathedral of War
29%inclusion12 decks41 decks
29%synergy
Shizo, Death's Storehouse
22%inclusion9 decks41 decks
12%synergy
Urborg, Tomb of Yawgmoth
20%inclusion8 decks41 decks
-18%synergy
Barren Moor
17%inclusion7 decks41 decks
7%synergy
Witch's Cottage
17%inclusion7 decks41 decks
-8%synergy
War Room
17%inclusion7 decks41 decks
1%synergy
Command Beacon
15%inclusion6 decks41 decks
6%synergy
Nykthos, Shrine to Nyx
15%inclusion6 decks41 decks
-15%synergy
Castle Locthwain
15%inclusion6 decks41 decks
-3%synergy
Mortuary Mire
12%inclusion5 decks41 decks
-1%synergy
Phyrexian Tower
10%inclusion4 decks41 decks
-15%synergy
Secret Tunnel
8.3%inclusion1 decks12 decks
7%synergy
Buried Ruin
7.3%inclusion3 decks41 decks
2%synergy
The Black Gate
7.3%inclusion3 decks41 decks
4%synergy
The Dross Pits
7.3%inclusion3 decks41 decks
6%synergy
Polluted Mire
7.3%inclusion3 decks41 decks
3%synergy
Temple of the False God
7.3%inclusion3 decks41 decks
-1%synergy
Mana Artifacts
Sol Ring
85%inclusion35 decks41 decks
-1%synergy
Arcane Signet
63%inclusion26 decks41 decks
1%synergy
Charcoal Diamond
41%inclusion17 decks41 decks
19%synergy
Glistening Sphere
34%inclusion14 decks41 decks
33%synergy
Heraldic Banner
27%inclusion11 decks41 decks
21%synergy
Mind Stone
27%inclusion11 decks41 decks
-3%synergy
Staff of Compleation
24%inclusion10 decks41 decks
23%synergy
Caged Sun
22%inclusion9 decks41 decks
10%synergy
Fellwar Stone
15%inclusion6 decks41 decks
0%synergy
Thought Vessel
12%inclusion5 decks41 decks
-14%synergy
Worn Powerstone
12%inclusion5 decks41 decks
8%synergy
Commander's Sphere
10%inclusion4 decks41 decks
1%synergy
Hedron Archive
10%inclusion4 decks41 decks
6%synergy
Everflowing Chalice
7.3%inclusion3 decks41 decks
1%synergy
Gilded Lotus
7.3%inclusion3 decks41 decks
2%synergy
The Soul Stone
6.7%inclusion1 decks15 decks
-7%synergy
Lands
Swamp
100%inclusion41 decks41 decks
5%synergy
Myriad Landscape
34%inclusion14 decks41 decks
8%synergy
Mirrex
22%inclusion9 decks41 decks
21%synergy
Malakir Rebirth
20%inclusion8 decks41 decks
-3%synergy
Fell the Profane
11%inclusion4 decks38 decks
-8%synergy
Opal Palace
10%inclusion4 decks41 decks
9%synergy
The Seedcore
7.3%inclusion3 decks41 decks
7%synergy
Daily Bugle Building
7.1%inclusion1 decks14 decks
7%synergy
Urza's Cave
5.3%inclusion2 decks38 decks
-3%synergy
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