Skithiryx, the Blight Dragon (Commander) - Core Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #779
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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10%inclusion1 decks10 decks
9%synergy
High Synergy Cards
Plague Stinger
78%inclusion31 decks40 decks
76%synergy
Plague Myr
73%inclusion29 decks40 decks
71%synergy
Infectious Inquiry
73%inclusion29 decks40 decks
70%synergy
Hand of the Praetors
70%inclusion28 decks40 decks
69%synergy
Lashwrithe
73%inclusion29 decks40 decks
68%synergy
Ichor Rats
68%inclusion27 decks40 decks
64%synergy
Phyrexian Crusader
65%inclusion26 decks40 decks
64%synergy
Drown in Ichor
68%inclusion27 decks40 decks
63%synergy
Vraska's Fall
65%inclusion26 decks40 decks
61%synergy
Ichorclaw Myr
60%inclusion24 decks40 decks
59%synergy
Top Cards
Feed the Swarm
65%inclusion26 decks40 decks
14%synergy
Crypt Ghast
63%inclusion25 decks40 decks
14%synergy
Dark Ritual
60%inclusion24 decks40 decks
-7%synergy
Swiftfoot Boots
60%inclusion24 decks40 decks
28%synergy
Whispering Specter
57%inclusion23 decks40 decks
57%synergy
Corpse Cur
57%inclusion23 decks40 decks
57%synergy
Blightbelly Rat
57%inclusion23 decks40 decks
54%synergy
Blackblade Reforged
57%inclusion23 decks40 decks
55%synergy
Core Prowler
55%inclusion22 decks40 decks
54%synergy
Phyresis Outbreak
55%inclusion22 decks40 decks
53%synergy
Game Changers
Necropotence
5.0%inclusion2 decks40 decks
-10%synergy
Creatures
Reaper of Sheoldred
53%inclusion21 decks40 decks
52%synergy
Bilious Skulldweller
50%inclusion20 decks40 decks
49%synergy
Flensermite
48%inclusion19 decks40 decks
47%synergy
Flesh-Eater Imp
43%inclusion17 decks40 decks
42%synergy
Septic Rats
40%inclusion16 decks40 decks
38%synergy
Pestilent Syphoner
35%inclusion14 decks40 decks
34%synergy
Phyrexian Obliterator
35%inclusion14 decks40 decks
24%synergy
Myr Convert
35%inclusion14 decks40 decks
34%synergy
Necropede
33%inclusion13 decks40 decks
32%synergy
Solemn Simulacrum
30%inclusion12 decks40 decks
7%synergy
Phyrexian Juggernaut
28%inclusion11 decks40 decks
27%synergy
K'rrik, Son of Yawgmoth
25%inclusion10 decks40 decks
6%synergy
Leaden Myr
25%inclusion10 decks40 decks
19%synergy
Contagious Nim
23%inclusion9 decks40 decks
22%synergy
Yawgmoth, Thran Physician
23%inclusion9 decks40 decks
12%synergy
Dread Presence
20%inclusion8 decks40 decks
5%synergy
Gulping Scraptrap
20%inclusion8 decks40 decks
19%synergy
Gray Merchant of Asphodel
18%inclusion7 decks40 decks
-34%synergy
Swamp Mosquito
18%inclusion7 decks40 decks
17%synergy
Silent Arbiter
15%inclusion6 decks40 decks
14%synergy
Dark Confidant
15%inclusion6 decks40 decks
8%synergy
Defiler of Flesh
15%inclusion6 decks40 decks
11%synergy
Nirkana Revenant
15%inclusion6 decks40 decks
3%synergy
Sheoldred, Whispering One
15%inclusion6 decks40 decks
3%synergy
Massacre Girl, Known Killer
15%inclusion6 decks40 decks
11%synergy
Blightsteel Colossus
15%inclusion6 decks40 decks
14%synergy
Blackcleave Goblin
13%inclusion5 decks40 decks
12%synergy
Vector Asp
13%inclusion5 decks40 decks
12%synergy
Magus of the Coffers
13%inclusion5 decks40 decks
5%synergy
Necroskitter
13%inclusion5 decks40 decks
9%synergy
Brass Squire
13%inclusion5 decks40 decks
12%synergy
Grafted Butcher
13%inclusion5 decks40 decks
12%synergy
Burnished Hart
13%inclusion5 decks40 decks
5%synergy
Sheoldred's Headcleaver
13%inclusion5 decks40 decks
12%synergy
Toxic Nim
10%inclusion4 decks40 decks
10%synergy
Nimraiser Paladin
10%inclusion4 decks40 decks
10%synergy
Phyrexian Vatmother
10%inclusion4 decks40 decks
10%synergy
Agent Venom
8.3%inclusion1 decks12 decks
6%synergy
Dune Mover
7.5%inclusion3 decks40 decks
7%synergy
Paragon of Open Graves
7.5%inclusion3 decks40 decks
7%synergy
Filth
7.5%inclusion3 decks40 decks
5%synergy
Massacre Girl
7.5%inclusion3 decks40 decks
0%synergy
Palladium Myr
7.5%inclusion3 decks40 decks
6%synergy
Massacre Wurm
7.5%inclusion3 decks40 decks
-10%synergy
Phyrexian Digester
7.5%inclusion3 decks40 decks
7%synergy
Suspicious Bookcase
7.5%inclusion3 decks40 decks
7%synergy
Scheming Aspirant
7.5%inclusion3 decks40 decks
7%synergy
Unstoppable Slasher
5.9%inclusion2 decks34 decks
0%synergy
Emperor of Bones
5.4%inclusion2 decks37 decks
4%synergy
Zenos yae Galvus
5.3%inclusion1 decks19 decks
1%synergy
Instants
Defile
55%inclusion22 decks40 decks
17%synergy
Howl from Beyond
53%inclusion21 decks40 decks
52%synergy
Grim Affliction
43%inclusion17 decks40 decks
40%synergy
Tainted Strike
43%inclusion17 decks40 decks
39%synergy
Whisper of the Dross
40%inclusion16 decks40 decks
37%synergy
Go for the Throat
35%inclusion14 decks40 decks
12%synergy
Dismember
33%inclusion13 decks40 decks
21%synergy
Imp's Mischief
28%inclusion11 decks40 decks
4%synergy
Virulent Wound
28%inclusion11 decks40 decks
27%synergy
Infernal Grasp
28%inclusion11 decks40 decks
2%synergy
Withering Torment
26%inclusion9 decks34 decks
-5%synergy
Doom Blade
25%inclusion10 decks40 decks
17%synergy
Sugar Rush
23%inclusion9 decks40 decks
22%synergy
Supernatural Stamina
23%inclusion9 decks40 decks
15%synergy
Force of Despair
20%inclusion8 decks40 decks
12%synergy
Unlikely Aid
20%inclusion8 decks40 decks
19%synergy
Malakir Rebirth
20%inclusion8 decks40 decks
-3%synergy
Astarion's Thirst
18%inclusion7 decks40 decks
16%synergy
Hero's Downfall
18%inclusion7 decks40 decks
11%synergy
Snuff Out
18%inclusion7 decks40 decks
5%synergy
Consuming Corruption
16%inclusion6 decks37 decks
0%synergy
Anoint with Affliction
15%inclusion6 decks40 decks
14%synergy
Undying Malice
15%inclusion6 decks40 decks
5%synergy
Withering Boon
13%inclusion5 decks40 decks
8%synergy
Murder
13%inclusion5 decks40 decks
2%synergy
Sudden Spoiling
13%inclusion5 decks40 decks
3%synergy
Tragic Slip
13%inclusion5 decks40 decks
-8%synergy
Grotesque Mutation
10%inclusion4 decks40 decks
10%synergy
Sheoldred's Edict
10%inclusion4 decks40 decks
-4%synergy
Hatred
10%inclusion4 decks40 decks
9%synergy
Grasp of Darkness
10%inclusion4 decks40 decks
8%synergy
Unnatural Endurance
10%inclusion4 decks40 decks
10%synergy
Darkness
10%inclusion4 decks40 decks
0%synergy
Baleful Mastery
10%inclusion4 decks40 decks
1%synergy
Professor's Warning
10%inclusion4 decks40 decks
9%synergy
Fell the Profane
8.1%inclusion3 decks37 decks
-11%synergy
Deadly Rollick
7.5%inclusion3 decks40 decks
-16%synergy
Cabal Ritual
7.5%inclusion3 decks40 decks
-10%synergy
Lash of Thorns
7.5%inclusion3 decks40 decks
7%synergy
Armor of Shadows
7.5%inclusion3 decks40 decks
5%synergy
Rush of Vitality
7.5%inclusion3 decks40 decks
7%synergy
Offer Immortality
7.5%inclusion3 decks40 decks
5%synergy
Archenemy's Charm
6.3%inclusion1 decks16 decks
-3%synergy
Geth's Verdict
5.0%inclusion2 decks40 decks
5%synergy
Malicious Affliction
5.0%inclusion2 decks40 decks
2%synergy
Heartless Act
5.0%inclusion2 decks40 decks
3%synergy
Boon of Erebos
5.0%inclusion2 decks40 decks
5%synergy
Skeletal Scrying
5.0%inclusion2 decks40 decks
4%synergy
Culling the Weak
5.0%inclusion2 decks40 decks
-10%synergy
Bitter Triumph
5.0%inclusion2 decks40 decks
-5%synergy
Sorceries
Sign in Blood
53%inclusion21 decks40 decks
16%synergy
Night's Whisper
43%inclusion17 decks40 decks
18%synergy
Read the Bones
38%inclusion15 decks40 decks
20%synergy
Caress of Phyrexia
35%inclusion14 decks40 decks
34%synergy
Crux of Fate
33%inclusion13 decks40 decks
31%synergy
Mutilate
28%inclusion11 decks40 decks
9%synergy
Vat Emergence
25%inclusion10 decks40 decks
23%synergy
Spread the Sickness
25%inclusion10 decks40 decks
24%synergy
Toxic Deluge
25%inclusion10 decks40 decks
-12%synergy
Diabolic Tutor
23%inclusion9 decks40 decks
8%synergy
Black Sun's Zenith
20%inclusion8 decks40 decks
14%synergy
In Garruk's Wake
20%inclusion8 decks40 decks
16%synergy
Reanimate
18%inclusion7 decks40 decks
-21%synergy
Bubbling Muck
15%inclusion6 decks40 decks
-1%synergy
Exsanguinate
15%inclusion6 decks40 decks
-9%synergy
Geth's Summons
15%inclusion6 decks40 decks
15%synergy
Feed the Infection
13%inclusion5 decks40 decks
12%synergy
Damnation
13%inclusion5 decks40 decks
-8%synergy
Ancient Craving
10%inclusion4 decks40 decks
8%synergy
Ambition's Cost
10%inclusion4 decks40 decks
7%synergy
Blasphemous Edict
10%inclusion3 decks31 decks
-7%synergy
Insatiable Avarice
7.9%inclusion3 decks38 decks
-4%synergy
Extinction Event
7.5%inclusion3 decks40 decks
7%synergy
Profane Tutor
7.5%inclusion3 decks40 decks
3%synergy
Syphon Mind
7.5%inclusion3 decks40 decks
-5%synergy
Nighthaze
7.5%inclusion3 decks40 decks
7%synergy
Languish
7.5%inclusion3 decks40 decks
6%synergy
Dread Return
5.0%inclusion2 decks40 decks
-7%synergy
Agadeem's Awakening
5.0%inclusion2 decks40 decks
-2%synergy
Innocent Blood
5.0%inclusion2 decks40 decks
-1%synergy
Praetor's Grasp
5.0%inclusion2 decks40 decks
1%synergy
Gix's Command
5.0%inclusion2 decks40 decks
3%synergy
Decree of Pain
5.0%inclusion2 decks40 decks
-1%synergy
Corrupt
5.0%inclusion2 decks40 decks
2%synergy
Necromantic Selection
5.0%inclusion2 decks40 decks
3%synergy
Beseech the Queen
5.0%inclusion2 decks40 decks
-1%synergy
Grim Tutor
5.0%inclusion2 decks40 decks
-7%synergy
Utility Artifacts
Nightmare Lash
53%inclusion21 decks40 decks
50%synergy
Fireshrieker
53%inclusion21 decks40 decks
51%synergy
Contagion Clasp
45%inclusion18 decks40 decks
42%synergy
Jet Medallion
43%inclusion17 decks40 decks
-18%synergy
Lightning Greaves
38%inclusion15 decks40 decks
4%synergy
Whispersilk Cloak
35%inclusion14 decks40 decks
29%synergy
Wayfarer's Bauble
33%inclusion13 decks40 decks
16%synergy
Champion's Helm
33%inclusion13 decks40 decks
31%synergy
Hero's Blade
33%inclusion13 decks40 decks
32%synergy
Contagion Engine
30%inclusion12 decks40 decks
28%synergy
Trailblazer's Boots
28%inclusion11 decks40 decks
25%synergy
The Darkness Crystal
26%inclusion5 decks19 decks
7%synergy
Leyline Axe
23%inclusion7 decks31 decks
22%synergy
Nettlecyst
20%inclusion8 decks40 decks
19%synergy
Cranial Plating
20%inclusion8 decks40 decks
16%synergy
Strata Scythe
20%inclusion8 decks40 decks
19%synergy
Throne of Geth
18%inclusion7 decks40 decks
17%synergy
Inquisitor's Flail
18%inclusion7 decks40 decks
17%synergy
Commander's Plate
18%inclusion7 decks40 decks
12%synergy
Loxodon Warhammer
18%inclusion7 decks40 decks
16%synergy
Sword of Vengeance
18%inclusion7 decks40 decks
17%synergy
Sword of Truth and Justice
15%inclusion6 decks40 decks
14%synergy
Brotherhood Regalia
14%inclusion5 decks37 decks
11%synergy
Manifold Key
13%inclusion5 decks40 decks
11%synergy
Prowler's Helm
13%inclusion5 decks40 decks
12%synergy
Expedition Map
13%inclusion5 decks40 decks
0%synergy
Sword of the Animist
13%inclusion5 decks40 decks
9%synergy
Hammer of Nazahn
13%inclusion5 decks40 decks
12%synergy
Genji Glove
11%inclusion2 decks19 decks
9%synergy
Thran Power Suit
10%inclusion4 decks40 decks
10%synergy
Shadowspear
10%inclusion4 decks40 decks
6%synergy
Bontu's Monument
10%inclusion4 decks40 decks
-18%synergy
Livewire Lash
10%inclusion4 decks40 decks
10%synergy
Silver Shroud Costume
10%inclusion4 decks40 decks
9%synergy
Darksteel Plate
10%inclusion4 decks40 decks
8%synergy
Pact Weapon
10%inclusion4 decks40 decks
8%synergy
Basilisk Collar
10%inclusion4 decks40 decks
7%synergy
Bloodthorn Flail
7.5%inclusion3 decks40 decks
7%synergy
Viridian Claw
7.5%inclusion3 decks40 decks
7%synergy
Pip-Boy 3000
7.5%inclusion3 decks40 decks
7%synergy
Armillary Sphere
7.5%inclusion3 decks40 decks
7%synergy
Sword of the Chosen
7.5%inclusion3 decks40 decks
7%synergy
Whip of Erebos
7.5%inclusion3 decks40 decks
-3%synergy
O-Naginata
7.5%inclusion3 decks40 decks
7%synergy
Vorpal Sword
7.5%inclusion3 decks40 decks
4%synergy
Heirloom Blade
7.5%inclusion3 decks40 decks
7%synergy
Prosthetic Injector
7.5%inclusion3 decks40 decks
7%synergy
Ring of Xathrid
7.5%inclusion3 decks40 decks
7%synergy
Sword of Feast and Famine
7.5%inclusion3 decks40 decks
6%synergy
Grafted Exoskeleton
7.5%inclusion3 decks40 decks
6%synergy
Enchantments
Phyrexian Arena
50%inclusion20 decks40 decks
10%synergy
Necrogen Communion
40%inclusion16 decks40 decks
38%synergy
Kaya's Ghostform
35%inclusion14 decks40 decks
25%synergy
Unspeakable Symbol
30%inclusion12 decks40 decks
29%synergy
Bad Moon
23%inclusion9 decks40 decks
19%synergy
Fungal Fortitude
20%inclusion8 decks40 decks
19%synergy
Relic Putrescence
15%inclusion6 decks40 decks
15%synergy
Phyresis
15%inclusion6 decks40 decks
13%synergy
Super State
13%inclusion2 decks16 decks
12%synergy
Greed
10%inclusion4 decks40 decks
3%synergy
Black Market
10%inclusion4 decks40 decks
-11%synergy
Shade's Form
10%inclusion4 decks40 decks
9%synergy
Dauthi Embrace
10%inclusion4 decks40 decks
8%synergy
No Mercy
10%inclusion4 decks40 decks
3%synergy
Endless Scream
10%inclusion4 decks40 decks
10%synergy
Demonic Embrace
10%inclusion4 decks40 decks
9%synergy
Demonic Vigor
7.5%inclusion3 decks40 decks
7%synergy
Phyrexian Scriptures
7.5%inclusion3 decks40 decks
6%synergy
Underworld Connections
7.5%inclusion3 decks40 decks
5%synergy
Glistening Oil
7.5%inclusion3 decks40 decks
7%synergy
Eternal Thirst
7.5%inclusion3 decks40 decks
5%synergy
Black Market Connections
7.5%inclusion3 decks40 decks
-16%synergy
Eldrazi Conscription
5.0%inclusion2 decks40 decks
5%synergy
Phyrexian Reclamation
5.0%inclusion2 decks40 decks
-5%synergy
Necrosynthesis
5.0%inclusion2 decks40 decks
4%synergy
Dictate of Erebos
5.0%inclusion2 decks40 decks
-6%synergy
Snake Cult Initiation
5.0%inclusion2 decks40 decks
5%synergy
Oubliette
5.0%inclusion2 decks40 decks
2%synergy
Midnight Covenant
5.0%inclusion2 decks40 decks
5%synergy
Planeswalkers
Vraska, Betrayal's Sting
30%inclusion12 decks40 decks
27%synergy
Liliana of the Dark Realms
20%inclusion8 decks40 decks
6%synergy
Utility Lands
Rogue's Passage
57%inclusion23 decks40 decks
39%synergy
Cabal Coffers
50%inclusion20 decks40 decks
-5%synergy
Karn's Bastion
50%inclusion20 decks40 decks
46%synergy
Inkmoth Nexus
38%inclusion15 decks40 decks
36%synergy
Bojuka Bog
35%inclusion14 decks40 decks
-12%synergy
Cabal Stronghold
35%inclusion14 decks40 decks
0%synergy
Cathedral of War
30%inclusion12 decks40 decks
30%synergy
Shizo, Death's Storehouse
28%inclusion11 decks40 decks
17%synergy
War Room
20%inclusion8 decks40 decks
3%synergy
Urborg, Tomb of Yawgmoth
20%inclusion8 decks40 decks
-18%synergy
Nykthos, Shrine to Nyx
18%inclusion7 decks40 decks
-12%synergy
Witch's Cottage
15%inclusion6 decks40 decks
-10%synergy
Command Beacon
15%inclusion6 decks40 decks
7%synergy
Castle Locthwain
15%inclusion6 decks40 decks
-3%synergy
Barren Moor
13%inclusion5 decks40 decks
2%synergy
Phyrexian Tower
10%inclusion4 decks40 decks
-14%synergy
Mortuary Mire
10%inclusion4 decks40 decks
-3%synergy
Buried Ruin
7.5%inclusion3 decks40 decks
2%synergy
The Black Gate
7.5%inclusion3 decks40 decks
4%synergy
The Dross Pits
7.5%inclusion3 decks40 decks
6%synergy
Polluted Mire
7.5%inclusion3 decks40 decks
4%synergy
Temple of the False God
7.5%inclusion3 decks40 decks
0%synergy
Spawning Pool
7.5%inclusion3 decks40 decks
7%synergy
Vault of Whispers
5.0%inclusion2 decks40 decks
-1%synergy
Roadside Reliquary
5.0%inclusion2 decks40 decks
5%synergy
Vesuva
5.0%inclusion2 decks40 decks
2%synergy
Crypt of Agadeem
5.0%inclusion2 decks40 decks
-6%synergy
Forge of Heroes
5.0%inclusion2 decks40 decks
5%synergy
Minas Morgul, Dark Fortress
5.0%inclusion2 decks40 decks
2%synergy
Darksteel Citadel
5.0%inclusion2 decks40 decks
4%synergy
Thespian's Stage
5.0%inclusion2 decks40 decks
-1%synergy
Reliquary Tower
5.0%inclusion2 decks40 decks
-26%synergy
Strip Mine
5.0%inclusion2 decks40 decks
2%synergy
Access Tunnel
5.0%inclusion2 decks40 decks
2%synergy
Mana Artifacts
Sol Ring
90%inclusion36 decks40 decks
4%synergy
Arcane Signet
65%inclusion26 decks40 decks
3%synergy
Charcoal Diamond
40%inclusion16 decks40 decks
17%synergy
Glistening Sphere
40%inclusion16 decks40 decks
39%synergy
Heraldic Banner
28%inclusion11 decks40 decks
22%synergy
Mind Stone
28%inclusion11 decks40 decks
-3%synergy
Caged Sun
23%inclusion9 decks40 decks
10%synergy
Staff of Compleation
23%inclusion9 decks40 decks
21%synergy
Fellwar Stone
13%inclusion5 decks40 decks
-2%synergy
Thought Vessel
13%inclusion5 decks40 decks
-14%synergy
Worn Powerstone
13%inclusion5 decks40 decks
8%synergy
Commander's Sphere
10%inclusion4 decks40 decks
1%synergy
Hedron Archive
10%inclusion4 decks40 decks
6%synergy
Throne of Eldraine
10%inclusion4 decks40 decks
-1%synergy
Gilded Lotus
7.5%inclusion3 decks40 decks
2%synergy
The Soul Stone
7.1%inclusion1 decks14 decks
-6%synergy
Everflowing Chalice
5.0%inclusion2 decks40 decks
-1%synergy
Thran Dynamo
5.0%inclusion2 decks40 decks
-1%synergy
Star Compass
5.0%inclusion2 decks40 decks
4%synergy
Liquimetal Torque
5.0%inclusion2 decks40 decks
2%synergy
Sonic Screwdriver
5.0%inclusion2 decks40 decks
4%synergy
Sceptre of Eternal Glory
5.0%inclusion2 decks40 decks
-4%synergy
Lands
Swamp
100%inclusion40 decks40 decks
5%synergy
Myriad Landscape
33%inclusion13 decks40 decks
6%synergy
Mirrex
23%inclusion9 decks40 decks
22%synergy
Malakir Rebirth
20%inclusion8 decks40 decks
-3%synergy
Opal Palace
10%inclusion4 decks40 decks
9%synergy
Daily Bugle Building
8.3%inclusion1 decks12 decks
8%synergy
Fell the Profane
8.1%inclusion3 decks37 decks
-11%synergy
The Seedcore
7.5%inclusion3 decks40 decks
7%synergy
Urza's Cave
5.4%inclusion2 decks37 decks
-3%synergy
Agadeem's Awakening
5.0%inclusion2 decks40 decks
-2%synergy
Cavern of Souls
5.0%inclusion2 decks40 decks
-2%synergy
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