Skithiryx, the Blight Dragon (Commander) - Core Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #784
41decks
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Madame Null, Power Broker
9.1%inclusion1 decks11 decks
8%synergy
Rat King, Verminister
9.1%inclusion1 decks11 decks
6%synergy
High Synergy Cards
Plague Stinger
73%inclusion30 decks41 decks
72%synergy
Plague Myr
73%inclusion30 decks41 decks
72%synergy
Infectious Inquiry
68%inclusion28 decks41 decks
66%synergy
Hand of the Praetors
66%inclusion27 decks41 decks
65%synergy
Drown in Ichor
68%inclusion28 decks41 decks
64%synergy
Vraska's Fall
66%inclusion27 decks41 decks
62%synergy
Blightbelly Rat
66%inclusion27 decks41 decks
62%synergy
Core Prowler
61%inclusion25 decks41 decks
60%synergy
Ichor Rats
63%inclusion26 decks41 decks
60%synergy
Lashwrithe
63%inclusion26 decks41 decks
60%synergy
Top Cards
Whispering Specter
59%inclusion24 decks41 decks
58%synergy
Feed the Swarm
59%inclusion24 decks41 decks
8%synergy
Phyrexian Crusader
59%inclusion24 decks41 decks
58%synergy
Swiftfoot Boots
59%inclusion24 decks41 decks
27%synergy
Bilious Skulldweller
56%inclusion23 decks41 decks
55%synergy
Ichorclaw Myr
56%inclusion23 decks41 decks
56%synergy
Corpse Cur
56%inclusion23 decks41 decks
56%synergy
Crypt Ghast
56%inclusion23 decks41 decks
8%synergy
Blackblade Reforged
56%inclusion23 decks41 decks
53%synergy
Reaper of Sheoldred
54%inclusion22 decks41 decks
53%synergy
Creatures
Flensermite
51%inclusion21 decks41 decks
51%synergy
Septic Rats
44%inclusion18 decks41 decks
42%synergy
Pestilent Syphoner
41%inclusion17 decks41 decks
41%synergy
Flesh-Eater Imp
41%inclusion17 decks41 decks
41%synergy
Myr Convert
37%inclusion15 decks41 decks
36%synergy
Solemn Simulacrum
34%inclusion14 decks41 decks
12%synergy
Phyrexian Obliterator
32%inclusion13 decks41 decks
21%synergy
Necropede
32%inclusion13 decks41 decks
31%synergy
Phyrexian Juggernaut
29%inclusion12 decks41 decks
29%synergy
Leaden Myr
29%inclusion12 decks41 decks
23%synergy
Contagious Nim
27%inclusion11 decks41 decks
27%synergy
K'rrik, Son of Yawgmoth
27%inclusion11 decks41 decks
8%synergy
Gulping Scraptrap
24%inclusion10 decks41 decks
24%synergy
Dread Presence
20%inclusion8 decks41 decks
5%synergy
Blightsteel Colossus
20%inclusion8 decks41 decks
19%synergy
Swamp Mosquito
17%inclusion7 decks41 decks
17%synergy
Burnished Hart
17%inclusion7 decks41 decks
10%synergy
Yawgmoth, Thran Physician
17%inclusion7 decks41 decks
7%synergy
Blackcleave Goblin
15%inclusion6 decks41 decks
14%synergy
Magus of the Coffers
15%inclusion6 decks41 decks
8%synergy
Gray Merchant of Asphodel
15%inclusion6 decks41 decks
-36%synergy
Nirkana Revenant
15%inclusion6 decks41 decks
4%synergy
Sheoldred's Headcleaver
15%inclusion6 decks41 decks
14%synergy
Vector Asp
12%inclusion5 decks41 decks
12%synergy
Silent Arbiter
12%inclusion5 decks41 decks
11%synergy
Brass Squire
12%inclusion5 decks41 decks
12%synergy
Palladium Myr
12%inclusion5 decks41 decks
10%synergy
Sheoldred, Whispering One
12%inclusion5 decks41 decks
0%synergy
Toxic Nim
12%inclusion5 decks41 decks
12%synergy
Gwenom, Remorseless
10%inclusion2 decks20 decks
6%synergy
Dark Confidant
10%inclusion4 decks41 decks
2%synergy
Defiler of Flesh
10%inclusion4 decks41 decks
6%synergy
Necroskitter
10%inclusion4 decks41 decks
7%synergy
Grafted Butcher
10%inclusion4 decks41 decks
10%synergy
Nimraiser Paladin
10%inclusion4 decks41 decks
10%synergy
Massacre Girl, Known Killer
10%inclusion4 decks41 decks
6%synergy
Scheming Aspirant
10%inclusion4 decks41 decks
9%synergy
Phyrexian Vatmother
10%inclusion4 decks41 decks
10%synergy
Zenos yae Galvus
8.3%inclusion2 decks24 decks
5%synergy
Dune Mover
7.3%inclusion3 decks41 decks
7%synergy
Paragon of Open Graves
7.3%inclusion3 decks41 decks
7%synergy
Phyrexian Digester
7.3%inclusion3 decks41 decks
7%synergy
Suspicious Bookcase
7.3%inclusion3 decks41 decks
7%synergy
Scavenger Regent
6.9%inclusion2 decks29 decks
6%synergy
Qarsi Revenant
6.9%inclusion2 decks29 decks
2%synergy
Agent Venom
5.0%inclusion1 decks20 decks
3%synergy
Swarm, Being of Bees
5.0%inclusion1 decks20 decks
5%synergy
Venomized Cat
5.0%inclusion1 decks20 decks
5%synergy
Common Crook
5.0%inclusion1 decks20 decks
4%synergy
Spider-Slayer, Hatred Honed
5.0%inclusion1 decks20 decks
5%synergy
Instants
Defile
54%inclusion22 decks41 decks
17%synergy
Dark Ritual
51%inclusion21 decks41 decks
-15%synergy
Howl from Beyond
46%inclusion19 decks41 decks
46%synergy
Grim Affliction
44%inclusion18 decks41 decks
42%synergy
Tainted Strike
44%inclusion18 decks41 decks
41%synergy
Whisper of the Dross
41%inclusion17 decks41 decks
39%synergy
Go for the Throat
34%inclusion14 decks41 decks
11%synergy
Virulent Wound
29%inclusion12 decks41 decks
29%synergy
Withering Torment
26%inclusion10 decks38 decks
-5%synergy
Imp's Mischief
24%inclusion10 decks41 decks
0%synergy
Sugar Rush
24%inclusion10 decks41 decks
24%synergy
Doom Blade
24%inclusion10 decks41 decks
17%synergy
Dismember
24%inclusion10 decks41 decks
14%synergy
Snuff Out
22%inclusion9 decks41 decks
9%synergy
Murder
22%inclusion9 decks41 decks
12%synergy
Malakir Rebirth
22%inclusion9 decks41 decks
-1%synergy
Unlikely Aid
20%inclusion8 decks41 decks
19%synergy
Infernal Grasp
20%inclusion8 decks41 decks
-6%synergy
Hero's Downfall
17%inclusion7 decks41 decks
10%synergy
Anoint with Affliction
17%inclusion7 decks41 decks
17%synergy
Force of Despair
15%inclusion6 decks41 decks
7%synergy
Consuming Corruption
15%inclusion6 decks41 decks
-1%synergy
Unnatural Endurance
15%inclusion6 decks41 decks
14%synergy
Supernatural Stamina
15%inclusion6 decks41 decks
7%synergy
Astarion's Thirst
12%inclusion5 decks41 decks
11%synergy
Withering Boon
12%inclusion5 decks41 decks
8%synergy
Undying Malice
12%inclusion5 decks41 decks
2%synergy
Tragic Slip
12%inclusion5 decks41 decks
-8%synergy
Fell the Profane
10%inclusion4 decks41 decks
-9%synergy
Grotesque Mutation
10%inclusion4 decks41 decks
10%synergy
Lash of Thorns
10%inclusion4 decks41 decks
10%synergy
Armor of Shadows
10%inclusion4 decks41 decks
7%synergy
Rush of Vitality
10%inclusion4 decks41 decks
9%synergy
Professor's Warning
10%inclusion4 decks41 decks
8%synergy
Geth's Verdict
7.3%inclusion3 decks41 decks
7%synergy
Sheoldred's Edict
7.3%inclusion3 decks41 decks
-7%synergy
Hatred
7.3%inclusion3 decks41 decks
6%synergy
Grasp of Darkness
7.3%inclusion3 decks41 decks
5%synergy
Darkness
7.3%inclusion3 decks41 decks
-3%synergy
Vampire's Bite
7.3%inclusion3 decks41 decks
7%synergy
Baleful Mastery
7.3%inclusion3 decks41 decks
-1%synergy
Offer Immortality
7.3%inclusion3 decks41 decks
5%synergy
Sudden Spoiling
7.3%inclusion3 decks41 decks
-2%synergy
Sorceries
Phyresis Outbreak
51%inclusion21 decks41 decks
49%synergy
Sign in Blood
49%inclusion20 decks41 decks
13%synergy
Night's Whisper
39%inclusion16 decks41 decks
14%synergy
Caress of Phyrexia
37%inclusion15 decks41 decks
36%synergy
Crux of Fate
34%inclusion14 decks41 decks
33%synergy
Read the Bones
32%inclusion13 decks41 decks
15%synergy
Vat Emergence
29%inclusion12 decks41 decks
28%synergy
Spread the Sickness
22%inclusion9 decks41 decks
21%synergy
Diabolic Tutor
20%inclusion8 decks41 decks
5%synergy
Mutilate
20%inclusion8 decks41 decks
2%synergy
Reanimate
20%inclusion8 decks41 decks
-20%synergy
In Garruk's Wake
17%inclusion7 decks41 decks
13%synergy
Toxic Deluge
17%inclusion7 decks41 decks
-20%synergy
Feed the Infection
15%inclusion6 decks41 decks
14%synergy
Exsanguinate
15%inclusion6 decks41 decks
-10%synergy
Geth's Summons
15%inclusion6 decks41 decks
14%synergy
Black Sun's Zenith
12%inclusion5 decks41 decks
7%synergy
Ancient Craving
12%inclusion5 decks41 decks
10%synergy
Bubbling Muck
10%inclusion4 decks41 decks
-6%synergy
Innocent Blood
10%inclusion4 decks41 decks
4%synergy
Ambition's Cost
10%inclusion4 decks41 decks
7%synergy
Blasphemous Edict
8.6%inclusion3 decks35 decks
-8%synergy
Duress
7.3%inclusion3 decks41 decks
1%synergy
Syphon Mind
7.3%inclusion3 decks41 decks
-5%synergy
Nighthaze
7.3%inclusion3 decks41 decks
7%synergy
Final Vengeance
5.3%inclusion2 decks38 decks
4%synergy
Prison Break
5.0%inclusion1 decks20 decks
5%synergy
Utility Artifacts
Contagion Clasp
44%inclusion18 decks41 decks
42%synergy
Fireshrieker
44%inclusion18 decks41 decks
42%synergy
Jet Medallion
44%inclusion18 decks41 decks
-18%synergy
Nightmare Lash
41%inclusion17 decks41 decks
39%synergy
Whispersilk Cloak
37%inclusion15 decks41 decks
31%synergy
Trailblazer's Boots
34%inclusion14 decks41 decks
32%synergy
Wayfarer's Bauble
32%inclusion13 decks41 decks
16%synergy
Champion's Helm
29%inclusion12 decks41 decks
27%synergy
Contagion Engine
27%inclusion11 decks41 decks
25%synergy
Lightning Greaves
27%inclusion11 decks41 decks
-7%synergy
Hero's Blade
27%inclusion11 decks41 decks
26%synergy
Strata Scythe
20%inclusion8 decks41 decks
19%synergy
Loxodon Warhammer
20%inclusion8 decks41 decks
18%synergy
Leyline Axe
17%inclusion6 decks35 decks
16%synergy
Throne of Geth
17%inclusion7 decks41 decks
17%synergy
Inquisitor's Flail
17%inclusion7 decks41 decks
17%synergy
Commander's Plate
17%inclusion7 decks41 decks
11%synergy
The Darkness Crystal
17%inclusion4 decks24 decks
-3%synergy
Nettlecyst
15%inclusion6 decks41 decks
14%synergy
Sword of Truth and Justice
15%inclusion6 decks41 decks
14%synergy
Darksteel Plate
15%inclusion6 decks41 decks
13%synergy
Brotherhood Regalia
15%inclusion6 decks41 decks
12%synergy
Sword of Vengeance
15%inclusion6 decks41 decks
14%synergy
Genji Glove
13%inclusion3 decks24 decks
11%synergy
Expedition Map
12%inclusion5 decks41 decks
0%synergy
Sword of the Animist
12%inclusion5 decks41 decks
8%synergy
Manifold Key
10%inclusion4 decks41 decks
8%synergy
Thran Power Suit
10%inclusion4 decks41 decks
9%synergy
Prowler's Helm
10%inclusion4 decks41 decks
9%synergy
Vorpal Sword
10%inclusion4 decks41 decks
6%synergy
Cranial Plating
10%inclusion4 decks41 decks
6%synergy
Shadowspear
10%inclusion4 decks41 decks
6%synergy
Bontu's Monument
10%inclusion4 decks41 decks
-18%synergy
Silver Shroud Costume
10%inclusion4 decks41 decks
9%synergy
Pact Weapon
10%inclusion4 decks41 decks
8%synergy
Hammer of Nazahn
10%inclusion4 decks41 decks
9%synergy
Grafted Exoskeleton
10%inclusion4 decks41 decks
9%synergy
Basilisk Collar
10%inclusion4 decks41 decks
7%synergy
Bloodthorn Flail
7.3%inclusion3 decks41 decks
7%synergy
Pip-Boy 3000
7.3%inclusion3 decks41 decks
7%synergy
O-Naginata
7.3%inclusion3 decks41 decks
7%synergy
Mind Carver
7.3%inclusion3 decks41 decks
7%synergy
Prosthetic Injector
7.3%inclusion3 decks41 decks
7%synergy
Mask of Avacyn
7.3%inclusion3 decks41 decks
7%synergy
Ring of Xathrid
7.3%inclusion3 decks41 decks
7%synergy
Adaptive Omnitool
6.5%inclusion2 decks31 decks
6%synergy
Quick-Draw Katana
6.1%inclusion2 decks33 decks
6%synergy
Doc Ock's Tentacles
5.0%inclusion1 decks20 decks
5%synergy
Hot Dog Cart
5.0%inclusion1 decks20 decks
5%synergy
Enchantments
Phyrexian Arena
51%inclusion21 decks41 decks
11%synergy
Necrogen Communion
41%inclusion17 decks41 decks
40%synergy
Kaya's Ghostform
29%inclusion12 decks41 decks
19%synergy
Unspeakable Symbol
27%inclusion11 decks41 decks
26%synergy
Bad Moon
27%inclusion11 decks41 decks
24%synergy
Phyresis
20%inclusion8 decks41 decks
17%synergy
Fungal Fortitude
17%inclusion7 decks41 decks
16%synergy
Relic Putrescence
15%inclusion6 decks41 decks
14%synergy
Glistening Oil
12%inclusion5 decks41 decks
11%synergy
Dauthi Embrace
12%inclusion5 decks41 decks
10%synergy
Endless Scream
12%inclusion5 decks41 decks
12%synergy
Black Market
10%inclusion4 decks41 decks
-11%synergy
Demonic Embrace
10%inclusion4 decks41 decks
9%synergy
Black Market Connections
10%inclusion4 decks41 decks
-14%synergy
Demonic Vigor
7.3%inclusion3 decks41 decks
7%synergy
Phyrexian Scriptures
7.3%inclusion3 decks41 decks
6%synergy
Greed
7.3%inclusion3 decks41 decks
0%synergy
Underworld Connections
7.3%inclusion3 decks41 decks
5%synergy
Shade's Form
7.3%inclusion3 decks41 decks
7%synergy
Eternal Thirst
7.3%inclusion3 decks41 decks
5%synergy
Snake Cult Initiation
7.3%inclusion3 decks41 decks
7%synergy
Mornsong Aria
6.7%inclusion1 decks15 decks
5%synergy
Alien Symbiosis
5.0%inclusion1 decks20 decks
5%synergy
Planeswalkers
Vraska, Betrayal's Sting
34%inclusion14 decks41 decks
31%synergy
Liliana of the Dark Realms
24%inclusion10 decks41 decks
10%synergy
Utility Lands
Rogue's Passage
54%inclusion22 decks41 decks
35%synergy
Karn's Bastion
46%inclusion19 decks41 decks
42%synergy
Cabal Coffers
41%inclusion17 decks41 decks
-13%synergy
Bojuka Bog
39%inclusion16 decks41 decks
-8%synergy
Inkmoth Nexus
34%inclusion14 decks41 decks
33%synergy
Cabal Stronghold
29%inclusion12 decks41 decks
-5%synergy
Cathedral of War
22%inclusion9 decks41 decks
22%synergy
Shizo, Death's Storehouse
20%inclusion8 decks41 decks
9%synergy
Witch's Cottage
20%inclusion8 decks41 decks
-5%synergy
Nykthos, Shrine to Nyx
20%inclusion8 decks41 decks
-10%synergy
Barren Moor
17%inclusion7 decks41 decks
7%synergy
Mortuary Mire
15%inclusion6 decks41 decks
1%synergy
War Room
15%inclusion6 decks41 decks
-2%synergy
Castle Locthwain
12%inclusion5 decks41 decks
-5%synergy
Urborg, Tomb of Yawgmoth
12%inclusion5 decks41 decks
-25%synergy
Secret Tunnel
11%inclusion2 decks18 decks
10%synergy
Phyrexian Tower
10%inclusion4 decks41 decks
-15%synergy
Command Beacon
10%inclusion4 decks41 decks
1%synergy
Buried Ruin
7.3%inclusion3 decks41 decks
2%synergy
The Dross Pits
7.3%inclusion3 decks41 decks
6%synergy
Reliquary Tower
7.3%inclusion3 decks41 decks
-23%synergy
Temple of the False God
7.3%inclusion3 decks41 decks
-1%synergy
Mana Artifacts
Sol Ring
83%inclusion34 decks41 decks
-3%synergy
Arcane Signet
63%inclusion26 decks41 decks
2%synergy
Charcoal Diamond
44%inclusion18 decks41 decks
21%synergy
Glistening Sphere
34%inclusion14 decks41 decks
33%synergy
Staff of Compleation
22%inclusion9 decks41 decks
20%synergy
Heraldic Banner
20%inclusion8 decks41 decks
14%synergy
Mind Stone
20%inclusion8 decks41 decks
-10%synergy
Caged Sun
17%inclusion7 decks41 decks
6%synergy
Worn Powerstone
12%inclusion5 decks41 decks
8%synergy
Everflowing Chalice
10%inclusion4 decks41 decks
4%synergy
Commander's Sphere
10%inclusion4 decks41 decks
1%synergy
Hedron Archive
10%inclusion4 decks41 decks
6%synergy
Fellwar Stone
10%inclusion4 decks41 decks
-5%synergy
Throne of Eldraine
7.3%inclusion3 decks41 decks
-3%synergy
Thought Vessel
7.3%inclusion3 decks41 decks
-19%synergy
Gilded Lotus
7.3%inclusion3 decks41 decks
2%synergy
Star Compass
7.3%inclusion3 decks41 decks
6%synergy
Lands
Swamp
100%inclusion41 decks41 decks
5%synergy
Myriad Landscape
32%inclusion13 decks41 decks
6%synergy
Malakir Rebirth
22%inclusion9 decks41 decks
-1%synergy
Mirrex
20%inclusion8 decks41 decks
19%synergy
Fell the Profane
10%inclusion4 decks41 decks
-9%synergy
The Seedcore
7.3%inclusion3 decks41 decks
7%synergy
Opal Palace
7.3%inclusion3 decks41 decks
7%synergy
Daily Bugle Building
5.0%inclusion1 decks20 decks
4%synergy
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