Skithiryx, the Blight Dragon (Commander) - Upgraded Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #789
44decks
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Bender's Waterskin
8.0%inclusion2 decks25 decks
8%synergy
The Fire Nation Drill
7.7%inclusion1 decks13 decks
7%synergy
Bitterbloom Bearer
5.0%inclusion1 decks20 decks
3%synergy
High Synergy Cards
Infectious Inquiry
89%inclusion39 decks44 decks
86%synergy
Plague Myr
80%inclusion35 decks44 decks
78%synergy
Plague Stinger
77%inclusion34 decks44 decks
76%synergy
Karn's Bastion
77%inclusion34 decks44 decks
73%synergy
Vraska's Fall
75%inclusion33 decks44 decks
71%synergy
Drown in Ichor
70%inclusion31 decks44 decks
66%synergy
Ichor Rats
68%inclusion30 decks44 decks
65%synergy
Phyresis Outbreak
61%inclusion27 decks44 decks
59%synergy
Rogue's Passage
77%inclusion34 decks44 decks
59%synergy
Phyrexian Crusader
59%inclusion26 decks44 decks
58%synergy
Top Cards
Jet Medallion
80%inclusion35 decks44 decks
19%synergy
Dark Ritual
77%inclusion34 decks44 decks
11%synergy
Crypt Ghast
73%inclusion32 decks44 decks
24%synergy
Sign in Blood
68%inclusion30 decks44 decks
32%synergy
Night's Whisper
61%inclusion27 decks44 decks
37%synergy
Swiftfoot Boots
61%inclusion27 decks44 decks
30%synergy
Phyrexian Arena
61%inclusion27 decks44 decks
21%synergy
Whispering Specter
57%inclusion25 decks44 decks
56%synergy
Hand of the Praetors
57%inclusion25 decks44 decks
56%synergy
Necrogen Communion
55%inclusion24 decks44 decks
53%synergy
Game Changers
Demonic Tutor
43%inclusion19 decks44 decks
15%synergy
Vampiric Tutor
30%inclusion13 decks44 decks
8%synergy
Mana Vault
14%inclusion6 decks44 decks
7%synergy
Imperial Seal
11%inclusion5 decks44 decks
4%synergy
Necropotence
11%inclusion5 decks44 decks
-4%synergy
Ancient Tomb
9.1%inclusion4 decks44 decks
-3%synergy
The One Ring
9.1%inclusion4 decks44 decks
-1%synergy
Tergrid, God of Fright
6.8%inclusion3 decks44 decks
-1%synergy
Creatures
Blightbelly Rat
45%inclusion20 decks44 decks
42%synergy
Reaper of Sheoldred
39%inclusion17 decks44 decks
38%synergy
Phyrexian Obliterator
34%inclusion15 decks44 decks
23%synergy
Flensermite
30%inclusion13 decks44 decks
29%synergy
K'rrik, Son of Yawgmoth
30%inclusion13 decks44 decks
11%synergy
Core Prowler
27%inclusion12 decks44 decks
27%synergy
Ichorclaw Myr
27%inclusion12 decks44 decks
27%synergy
Corpse Cur
27%inclusion12 decks44 decks
27%synergy
Yawgmoth, Thran Physician
27%inclusion12 decks44 decks
17%synergy
Bilious Skulldweller
27%inclusion12 decks44 decks
26%synergy
Flesh-Eater Imp
25%inclusion11 decks44 decks
24%synergy
Septic Rats
25%inclusion11 decks44 decks
23%synergy
Gulping Scraptrap
25%inclusion11 decks44 decks
24%synergy
Blightsteel Colossus
25%inclusion11 decks44 decks
24%synergy
Solemn Simulacrum
23%inclusion10 decks44 decks
-1%synergy
Myr Convert
23%inclusion10 decks44 decks
22%synergy
Dread Presence
20%inclusion9 decks44 decks
5%synergy
Pestilent Syphoner
20%inclusion9 decks44 decks
20%synergy
Silent Arbiter
18%inclusion8 decks44 decks
17%synergy
Gray Merchant of Asphodel
16%inclusion7 decks44 decks
-36%synergy
Filth
16%inclusion7 decks44 decks
13%synergy
Nirkana Revenant
16%inclusion7 decks44 decks
4%synergy
Massacre Girl, Known Killer
16%inclusion7 decks44 decks
12%synergy
Phyrexian Vatmother
16%inclusion7 decks44 decks
16%synergy
Magus of the Coffers
14%inclusion6 decks44 decks
6%synergy
Necroskitter
14%inclusion6 decks44 decks
10%synergy
Brass Squire
14%inclusion6 decks44 decks
13%synergy
Grafted Butcher
14%inclusion6 decks44 decks
13%synergy
Phyrexian Juggernaut
11%inclusion5 decks44 decks
11%synergy
Defiler of Flesh
11%inclusion5 decks44 decks
7%synergy
Sheoldred, Whispering One
11%inclusion5 decks44 decks
-1%synergy
Sheoldred
11%inclusion5 decks44 decks
5%synergy
Toxic Nim
11%inclusion5 decks44 decks
11%synergy
Necropede
11%inclusion5 decks44 decks
11%synergy
Dauthi Voidwalker
11%inclusion5 decks44 decks
-4%synergy
Contagious Nim
9.1%inclusion4 decks44 decks
9%synergy
Maha, Its Feathers Night
9.1%inclusion4 decks44 decks
4%synergy
Rune-Scarred Demon
9.1%inclusion4 decks44 decks
4%synergy
Dark Confidant
9.1%inclusion4 decks44 decks
2%synergy
Boggart Trawler
9.1%inclusion4 decks44 decks
0%synergy
Sheoldred's Headcleaver
9.1%inclusion4 decks44 decks
9%synergy
Leaden Myr
9.1%inclusion4 decks44 decks
3%synergy
Feral Deathgorger
7.9%inclusion3 decks38 decks
7%synergy
Scrawling Crawler
7.0%inclusion3 decks43 decks
3%synergy
Blackcleave Goblin
6.8%inclusion3 decks44 decks
7%synergy
Swamp Mosquito
6.8%inclusion3 decks44 decks
7%synergy
Bloodgift Demon
6.8%inclusion3 decks44 decks
4%synergy
Surge Conductor
6.7%inclusion2 decks30 decks
7%synergy
Scavenger Regent
5.4%inclusion2 decks37 decks
5%synergy
Qarsi Revenant
5.1%inclusion2 decks39 decks
0%synergy
Instants
Howl from Beyond
43%inclusion19 decks44 decks
42%synergy
Tainted Strike
41%inclusion18 decks44 decks
38%synergy
Withering Torment
41%inclusion18 decks44 decks
9%synergy
Malakir Rebirth
39%inclusion17 decks44 decks
16%synergy
Imp's Mischief
36%inclusion16 decks44 decks
13%synergy
Whisper of the Dross
34%inclusion15 decks44 decks
31%synergy
Archenemy's Charm
33%inclusion10 decks30 decks
25%synergy
Fell the Profane
32%inclusion14 decks44 decks
13%synergy
Defile
32%inclusion14 decks44 decks
-6%synergy
Go for the Throat
27%inclusion12 decks44 decks
4%synergy
Infernal Grasp
27%inclusion12 decks44 decks
2%synergy
Cabal Ritual
25%inclusion11 decks44 decks
7%synergy
Deadly Rollick
23%inclusion10 decks44 decks
-1%synergy
Consuming Corruption
23%inclusion10 decks44 decks
7%synergy
Grim Affliction
23%inclusion10 decks44 decks
20%synergy
Baleful Mastery
20%inclusion9 decks44 decks
11%synergy
Dismember
20%inclusion9 decks44 decks
9%synergy
Supernatural Stamina
18%inclusion8 decks44 decks
11%synergy
Astarion's Thirst
16%inclusion7 decks44 decks
14%synergy
Undying Malice
16%inclusion7 decks44 decks
6%synergy
Darkness
16%inclusion7 decks44 decks
6%synergy
Sudden Spoiling
16%inclusion7 decks44 decks
6%synergy
Force of Despair
14%inclusion6 decks44 decks
6%synergy
Snuff Out
14%inclusion6 decks44 decks
1%synergy
Anoint with Affliction
14%inclusion6 decks44 decks
13%synergy
Hatred
14%inclusion6 decks44 decks
13%synergy
Hagra Mauling
11%inclusion5 decks44 decks
7%synergy
Sheoldred's Edict
11%inclusion5 decks44 decks
-3%synergy
Armor of Shadows
11%inclusion5 decks44 decks
9%synergy
Bitter Triumph
11%inclusion5 decks44 decks
1%synergy
Fake Your Own Death
11%inclusion5 decks44 decks
5%synergy
Cut Down
9.1%inclusion4 decks44 decks
5%synergy
Undying Evil
9.1%inclusion4 decks44 decks
6%synergy
Sugar Rush
9.1%inclusion4 decks44 decks
9%synergy
Soul Shatter
9.1%inclusion4 decks44 decks
-3%synergy
Murder
9.1%inclusion4 decks44 decks
-1%synergy
Rush of Vitality
9.1%inclusion4 decks44 decks
8%synergy
Grotesque Mutation
6.8%inclusion3 decks44 decks
7%synergy
Hero's Downfall
6.8%inclusion3 decks44 decks
0%synergy
Stinging Study
6.8%inclusion3 decks44 decks
4%synergy
Village Rites
6.8%inclusion3 decks44 decks
-18%synergy
Not Dead After All
6.8%inclusion3 decks44 decks
-4%synergy
Doom Blade
6.8%inclusion3 decks44 decks
-1%synergy
Virulent Wound
6.8%inclusion3 decks44 decks
6%synergy
Black Sun's Twilight
6.8%inclusion3 decks44 decks
3%synergy
Blood Pact
6.8%inclusion3 decks44 decks
2%synergy
Vona's Hunger
6.8%inclusion3 decks44 decks
2%synergy
Overkill
6.3%inclusion2 decks32 decks
-1%synergy
Sorceries
Feed the Swarm
45%inclusion20 decks44 decks
-6%synergy
Toxic Deluge
43%inclusion19 decks44 decks
6%synergy
Read the Bones
41%inclusion18 decks44 decks
23%synergy
Vat Emergence
34%inclusion15 decks44 decks
33%synergy
Crux of Fate
34%inclusion15 decks44 decks
33%synergy
Insatiable Avarice
32%inclusion14 decks44 decks
20%synergy
Caress of Phyrexia
30%inclusion13 decks44 decks
29%synergy
Reanimate
27%inclusion12 decks44 decks
-11%synergy
Bubbling Muck
23%inclusion10 decks44 decks
7%synergy
Mutilate
20%inclusion9 decks44 decks
1%synergy
Damnation
20%inclusion9 decks44 decks
0%synergy
Diabolic Tutor
18%inclusion8 decks44 decks
3%synergy
Blasphemous Edict
16%inclusion7 decks43 decks
-1%synergy
Geth's Summons
16%inclusion7 decks44 decks
15%synergy
Black Sun's Zenith
14%inclusion6 decks44 decks
8%synergy
Spread the Sickness
14%inclusion6 decks44 decks
13%synergy
Feed the Infection
14%inclusion6 decks44 decks
13%synergy
Gix's Command
14%inclusion6 decks44 decks
12%synergy
Syphon Mind
14%inclusion6 decks44 decks
1%synergy
Beseech the Queen
11%inclusion5 decks44 decks
5%synergy
Grim Tutor
11%inclusion5 decks44 decks
-1%synergy
Exsanguinate
9.1%inclusion4 decks44 decks
-15%synergy
Beseech the Mirror
9.1%inclusion4 decks44 decks
2%synergy
Profane Tutor
6.8%inclusion3 decks44 decks
2%synergy
Torment of Hailfire
6.8%inclusion3 decks44 decks
-9%synergy
Praetor's Grasp
6.8%inclusion3 decks44 decks
3%synergy
Ambition's Cost
6.8%inclusion3 decks44 decks
4%synergy
Ancient Craving
6.8%inclusion3 decks44 decks
4%synergy
In Garruk's Wake
6.8%inclusion3 decks44 decks
3%synergy
Risky Research
6.7%inclusion2 decks30 decks
6%synergy
Utility Artifacts
Lashwrithe
52%inclusion23 decks44 decks
48%synergy
Lightning Greaves
43%inclusion19 decks44 decks
10%synergy
Fireshrieker
41%inclusion18 decks44 decks
39%synergy
Sword of Truth and Justice
41%inclusion18 decks44 decks
40%synergy
Nightmare Lash
39%inclusion17 decks44 decks
36%synergy
Contagion Clasp
39%inclusion17 decks44 decks
36%synergy
Whispersilk Cloak
34%inclusion15 decks44 decks
28%synergy
Blackblade Reforged
34%inclusion15 decks44 decks
31%synergy
Contagion Engine
32%inclusion14 decks44 decks
30%synergy
Champion's Helm
32%inclusion14 decks44 decks
30%synergy
Sword of the Animist
30%inclusion13 decks44 decks
26%synergy
Commander's Plate
30%inclusion13 decks44 decks
24%synergy
The Darkness Crystal
26%inclusion9 decks34 decks
7%synergy
Hero's Blade
25%inclusion11 decks44 decks
25%synergy
Mithril Coat
23%inclusion10 decks44 decks
17%synergy
Shadowspear
23%inclusion10 decks44 decks
19%synergy
Expedition Map
23%inclusion10 decks44 decks
10%synergy
Leyline Axe
19%inclusion8 decks43 decks
18%synergy
Trailblazer's Boots
18%inclusion8 decks44 decks
16%synergy
Sword of Feast and Famine
18%inclusion8 decks44 decks
16%synergy
Sword of Vengeance
18%inclusion8 decks44 decks
17%synergy
Basilisk Collar
18%inclusion8 decks44 decks
16%synergy
Wayfarer's Bauble
16%inclusion7 decks44 decks
0%synergy
Cranial Plating
16%inclusion7 decks44 decks
12%synergy
Brotherhood Regalia
16%inclusion7 decks44 decks
13%synergy
Genji Glove
16%inclusion5 decks32 decks
14%synergy
Throne of Geth
14%inclusion6 decks44 decks
13%synergy
Pact Weapon
14%inclusion6 decks44 decks
11%synergy
Hammer of Nazahn
14%inclusion6 decks44 decks
13%synergy
Helm of the Host
11%inclusion5 decks44 decks
10%synergy
Bontu's Monument
11%inclusion5 decks44 decks
-16%synergy
Inquisitor's Flail
11%inclusion5 decks44 decks
11%synergy
Darksteel Plate
11%inclusion5 decks44 decks
10%synergy
Grafted Wargear
11%inclusion5 decks44 decks
11%synergy
Sword of Forge and Frontier
11%inclusion5 decks44 decks
11%synergy
Peter Parker's Camera
10%inclusion2 decks21 decks
9%synergy
Doc Ock's Tentacles
10%inclusion2 decks21 decks
9%synergy
Manifold Key
9.1%inclusion4 decks44 decks
7%synergy
O-Naginata
9.1%inclusion4 decks44 decks
9%synergy
Lavaspur Boots
9.1%inclusion4 decks44 decks
7%synergy
Strata Scythe
9.1%inclusion4 decks44 decks
8%synergy
Sword of Sinew and Steel
9.1%inclusion4 decks44 decks
9%synergy
Grafted Exoskeleton
9.1%inclusion4 decks44 decks
8%synergy
Crawlspace
6.8%inclusion3 decks44 decks
6%synergy
Sword of Fire and Ice
6.8%inclusion3 decks44 decks
6%synergy
Sensei's Divining Top
6.8%inclusion3 decks44 decks
-2%synergy
Prowler's Helm
6.8%inclusion3 decks44 decks
6%synergy
Vorpal Sword
6.8%inclusion3 decks44 decks
3%synergy
Mask of Avacyn
6.8%inclusion3 decks44 decks
6%synergy
Silver Shroud Costume
6.8%inclusion3 decks44 decks
6%synergy
Enchantments
Kaya's Ghostform
27%inclusion12 decks44 decks
17%synergy
Black Market Connections
27%inclusion12 decks44 decks
4%synergy
Unspeakable Symbol
20%inclusion9 decks44 decks
20%synergy
No Mercy
16%inclusion7 decks44 decks
9%synergy
Dauthi Embrace
14%inclusion6 decks44 decks
12%synergy
Animate Dead
14%inclusion6 decks44 decks
-4%synergy
Bad Moon
14%inclusion6 decks44 decks
10%synergy
Phyresis
9.1%inclusion4 decks44 decks
7%synergy
Greed
6.8%inclusion3 decks44 decks
-1%synergy
Black Market
6.8%inclusion3 decks44 decks
-14%synergy
Vow of Torment
6.8%inclusion3 decks44 decks
7%synergy
Blessing of Leeches
6.8%inclusion3 decks44 decks
6%synergy
Endless Scream
6.8%inclusion3 decks44 decks
7%synergy
Planeswalkers
Vraska, Betrayal's Sting
50%inclusion22 decks44 decks
47%synergy
Liliana of the Dark Realms
36%inclusion16 decks44 decks
22%synergy
Utility Lands
Cabal Coffers
70%inclusion31 decks44 decks
15%synergy
Bojuka Bog
59%inclusion26 decks44 decks
12%synergy
Urborg, Tomb of Yawgmoth
50%inclusion22 decks44 decks
12%synergy
Shizo, Death's Storehouse
48%inclusion21 decks44 decks
38%synergy
Inkmoth Nexus
45%inclusion20 decks44 decks
44%synergy
War Room
43%inclusion19 decks44 decks
27%synergy
Cabal Stronghold
36%inclusion16 decks44 decks
1%synergy
Castle Locthwain
32%inclusion14 decks44 decks
14%synergy
Urza's Saga
23%inclusion10 decks44 decks
15%synergy
Cathedral of War
23%inclusion10 decks44 decks
22%synergy
Spymaster's Vault
20%inclusion9 decks44 decks
11%synergy
Witch's Cottage
20%inclusion9 decks44 decks
-4%synergy
Command Beacon
20%inclusion9 decks44 decks
12%synergy
Minas Morgul, Dark Fortress
20%inclusion9 decks44 decks
17%synergy
The Black Gate
18%inclusion8 decks44 decks
15%synergy
Nykthos, Shrine to Nyx
18%inclusion8 decks44 decks
-12%synergy
Phyrexian Tower
16%inclusion7 decks44 decks
-8%synergy
Mortuary Mire
14%inclusion6 decks44 decks
0%synergy
Temple of the False God
11%inclusion5 decks44 decks
3%synergy
Barren Moor
9.1%inclusion4 decks44 decks
-1%synergy
Buried Ruin
9.1%inclusion4 decks44 decks
4%synergy
Reliquary Tower
9.1%inclusion4 decks44 decks
-22%synergy
Volrath's Stronghold
9.1%inclusion4 decks44 decks
5%synergy
Thespian's Stage
9.1%inclusion4 decks44 decks
3%synergy
Arcane Lighthouse
6.8%inclusion3 decks44 decks
5%synergy
Tyrite Sanctum
6.8%inclusion3 decks44 decks
6%synergy
Ebon Stronghold
6.8%inclusion3 decks44 decks
6%synergy
Maze of Ith
6.8%inclusion3 decks44 decks
3%synergy
Inventors' Fair
6.8%inclusion3 decks44 decks
5%synergy
Peat Bog
6.8%inclusion3 decks44 decks
5%synergy
Terrain Generator
6.8%inclusion3 decks44 decks
5%synergy
Takenuma, Abandoned Mire
6.8%inclusion3 decks44 decks
-9%synergy
Bonders' Enclave
6.8%inclusion3 decks44 decks
6%synergy
Everglades
6.8%inclusion3 decks44 decks
5%synergy
Mana Artifacts
Sol Ring
91%inclusion40 decks44 decks
5%synergy
Arcane Signet
64%inclusion28 decks44 decks
1%synergy
Glistening Sphere
41%inclusion18 decks44 decks
40%synergy
Mind Stone
39%inclusion17 decks44 decks
8%synergy
Staff of Compleation
36%inclusion16 decks44 decks
35%synergy
Charcoal Diamond
25%inclusion11 decks44 decks
2%synergy
Everflowing Chalice
23%inclusion10 decks44 decks
17%synergy
Heraldic Banner
23%inclusion10 decks44 decks
17%synergy
Throne of Eldraine
16%inclusion7 decks44 decks
5%synergy
Fellwar Stone
14%inclusion6 decks44 decks
-1%synergy
Thought Vessel
14%inclusion6 decks44 decks
-13%synergy
Lotus Petal
11%inclusion5 decks44 decks
4%synergy
Worn Powerstone
11%inclusion5 decks44 decks
7%synergy
The Soul Stone
11%inclusion3 decks28 decks
-2%synergy
Caged Sun
9.1%inclusion4 decks44 decks
-3%synergy
Commander's Sphere
9.1%inclusion4 decks44 decks
0%synergy
Hedron Archive
9.1%inclusion4 decks44 decks
5%synergy
Thran Dynamo
9.1%inclusion4 decks44 decks
3%synergy
Pristine Talisman
6.8%inclusion3 decks44 decks
5%synergy
Sonic Screwdriver
6.8%inclusion3 decks44 decks
6%synergy
Sceptre of Eternal Glory
6.8%inclusion3 decks44 decks
-3%synergy
Prismatic Lens
6.8%inclusion3 decks44 decks
5%synergy
Mox Opal
6.8%inclusion3 decks44 decks
3%synergy
Lands
Swamp
91%inclusion40 decks44 decks
-4%synergy
Malakir Rebirth
39%inclusion17 decks44 decks
16%synergy
Fell the Profane
32%inclusion14 decks44 decks
13%synergy
Myriad Landscape
23%inclusion10 decks44 decks
-4%synergy
Mirrex
20%inclusion9 decks44 decks
20%synergy
Urza's Cave
16%inclusion7 decks44 decks
7%synergy
Hagra Mauling
11%inclusion5 decks44 decks
7%synergy
Boggart Trawler
9.1%inclusion4 decks44 decks
0%synergy
Cavern of Souls
9.1%inclusion4 decks44 decks
2%synergy
Snow-Covered Swamp
9.1%inclusion4 decks44 decks
2%synergy
The Seedcore
6.8%inclusion3 decks44 decks
7%synergy
Demolition Field
6.8%inclusion3 decks44 decks
1%synergy
Plaza of Heroes
6.8%inclusion3 decks44 decks
6%synergy
Evolving Wilds
6.8%inclusion3 decks44 decks
3%synergy
Opal Palace
6.8%inclusion3 decks44 decks
6%synergy
Path of Ancestry
6.8%inclusion3 decks44 decks
2%synergy
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