Skithiryx, the Blight Dragon (Commander) - Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #789
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Utility Lands
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Bender's Waterskin
3.1%inclusion3 decks97 decks
3%synergy
Bitterbloom Bearer
2.7%inclusion2 decks73 decks
1%synergy
Swampsnare Trap
2.2%inclusion1 decks45 decks
2%synergy
Koh, the Face Stealer
2.2%inclusion1 decks45 decks
1%synergy
Realm of Koh
2.2%inclusion1 decks45 decks
-1%synergy
High Synergy Cards
Plague Stinger
82%inclusion615 decks751 decks
81%synergy
Plague Myr
78%inclusion589 decks751 decks
77%synergy
Hand of the Praetors
77%inclusion581 decks751 decks
77%synergy
Ichor Rats
79%inclusion594 decks751 decks
76%synergy
Infectious Inquiry
76%inclusion574 decks751 decks
73%synergy
Whispering Specter
69%inclusion516 decks751 decks
68%synergy
Vraska's Fall
72%inclusion537 decks751 decks
68%synergy
Phyrexian Crusader
65%inclusion490 decks751 decks
64%synergy
Karn's Bastion
68%inclusion514 decks751 decks
64%synergy
Drown in Ichor
67%inclusion505 decks751 decks
63%synergy
Top Cards
Dark Ritual
79%inclusion597 decks751 decks
13%synergy
Swiftfoot Boots
65%inclusion485 decks751 decks
33%synergy
Lashwrithe
64%inclusion484 decks751 decks
60%synergy
Jet Medallion
63%inclusion470 decks751 decks
2%synergy
Blightbelly Rat
62%inclusion466 decks751 decks
58%synergy
Phyrexian Arena
62%inclusion462 decks751 decks
21%synergy
Phyresis Outbreak
61%inclusion457 decks751 decks
59%synergy
Crypt Ghast
60%inclusion451 decks751 decks
12%synergy
Sign in Blood
58%inclusion437 decks751 decks
22%synergy
Nightmare Lash
57%inclusion431 decks751 decks
55%synergy
Game Changers
Demonic Tutor
41%inclusion311 decks751 decks
14%synergy
Vampiric Tutor
30%inclusion229 decks751 decks
9%synergy
Necropotence
22%inclusion163 decks751 decks
6%synergy
Ancient Tomb
20%inclusion153 decks751 decks
9%synergy
Bolas's Citadel
16%inclusion118 decks751 decks
-14%synergy
Mana Vault
15%inclusion114 decks751 decks
8%synergy
Opposition Agent
12%inclusion92 decks751 decks
2%synergy
The One Ring
11%inclusion82 decks751 decks
1%synergy
Chrome Mox
11%inclusion79 decks751 decks
4%synergy
Imperial Seal
8.9%inclusion67 decks751 decks
2%synergy
Creatures
Reaper of Sheoldred
54%inclusion405 decks751 decks
53%synergy
Ichorclaw Myr
48%inclusion360 decks751 decks
47%synergy
Core Prowler
46%inclusion348 decks751 decks
46%synergy
Flensermite
46%inclusion343 decks751 decks
45%synergy
Bilious Skulldweller
44%inclusion334 decks751 decks
43%synergy
Corpse Cur
44%inclusion333 decks751 decks
44%synergy
Flesh-Eater Imp
40%inclusion299 decks751 decks
39%synergy
Pestilent Syphoner
38%inclusion288 decks751 decks
38%synergy
Septic Rats
37%inclusion277 decks751 decks
35%synergy
Phyrexian Obliterator
33%inclusion251 decks751 decks
22%synergy
K'rrik, Son of Yawgmoth
31%inclusion232 decks751 decks
12%synergy
Necropede
30%inclusion222 decks751 decks
29%synergy
Myr Convert
28%inclusion209 decks751 decks
27%synergy
Yawgmoth, Thran Physician
24%inclusion180 decks751 decks
14%synergy
Blightsteel Colossus
23%inclusion169 decks751 decks
22%synergy
Solemn Simulacrum
22%inclusion166 decks751 decks
-1%synergy
Gray Merchant of Asphodel
22%inclusion165 decks751 decks
-30%synergy
Contagious Nim
21%inclusion160 decks751 decks
21%synergy
Leaden Myr
20%inclusion148 decks751 decks
13%synergy
Gulping Scraptrap
19%inclusion145 decks751 decks
19%synergy
Blackcleave Goblin
18%inclusion138 decks751 decks
18%synergy
Phyrexian Juggernaut
17%inclusion125 decks751 decks
16%synergy
Massacre Girl, Known Killer
15%inclusion104 decks716 decks
11%synergy
Magus of the Coffers
15%inclusion109 decks751 decks
7%synergy
Defiler of Flesh
15%inclusion109 decks751 decks
10%synergy
Necroskitter
14%inclusion103 decks751 decks
10%synergy
Sheoldred, Whispering One
14%inclusion102 decks751 decks
2%synergy
Toxic Nim
13%inclusion99 decks751 decks
13%synergy
Dauthi Voidwalker
13%inclusion99 decks751 decks
-3%synergy
Phyrexian Vatmother
13%inclusion98 decks751 decks
13%synergy
Grafted Butcher
12%inclusion92 decks751 decks
12%synergy
Sheoldred's Headcleaver
12%inclusion91 decks751 decks
12%synergy
Dread Presence
12%inclusion90 decks751 decks
-3%synergy
Filth
11%inclusion86 decks751 decks
9%synergy
Dark Confidant
10%inclusion77 decks751 decks
3%synergy
Phyrexian Digester
9.5%inclusion71 decks751 decks
9%synergy
Silent Arbiter
9.3%inclusion70 decks751 decks
8%synergy
Burnished Hart
9.2%inclusion69 decks751 decks
1%synergy
Nirkana Revenant
9.1%inclusion68 decks751 decks
-3%synergy
Nimraiser Paladin
8.7%inclusion65 decks751 decks
8%synergy
Sheoldred, the Apocalypse
8.5%inclusion64 decks751 decks
-6%synergy
Maha, Its Feathers Night
8.5%inclusion42 decks493 decks
4%synergy
Orcish Bowmasters
7.9%inclusion59 decks751 decks
-6%synergy
Vector Asp
7.7%inclusion58 decks751 decks
8%synergy
Swamp Mosquito
7.3%inclusion55 decks751 decks
7%synergy
Massacre Wurm
7.2%inclusion54 decks751 decks
-10%synergy
Scourge Servant
6.9%inclusion52 decks751 decks
7%synergy
Murderous Rider
6.5%inclusion49 decks751 decks
0%synergy
Surge Conductor
6.4%inclusion7 decks109 decks
6%synergy
Paragon of Open Graves
6.4%inclusion48 decks751 decks
6%synergy
Instants
Howl from Beyond
53%inclusion401 decks751 decks
53%synergy
Whisper of the Dross
47%inclusion354 decks751 decks
44%synergy
Defile
45%inclusion335 decks751 decks
7%synergy
Go for the Throat
41%inclusion306 decks751 decks
17%synergy
Tainted Strike
39%inclusion293 decks751 decks
36%synergy
Grim Affliction
37%inclusion278 decks751 decks
35%synergy
Infernal Grasp
32%inclusion244 decks751 decks
7%synergy
Deadly Rollick
32%inclusion241 decks751 decks
9%synergy
Withering Torment
29%inclusion116 decks405 decks
-3%synergy
Dismember
29%inclusion215 decks751 decks
18%synergy
Cabal Ritual
27%inclusion206 decks751 decks
10%synergy
Imp's Mischief
26%inclusion198 decks751 decks
3%synergy
Sugar Rush
26%inclusion192 decks751 decks
25%synergy
Supernatural Stamina
24%inclusion178 decks751 decks
16%synergy
Hatred
20%inclusion149 decks751 decks
19%synergy
Astarion's Thirst
19%inclusion143 decks751 decks
18%synergy
Sudden Spoiling
19%inclusion142 decks751 decks
9%synergy
Virulent Wound
19%inclusion140 decks751 decks
18%synergy
Consuming Corruption
18%inclusion96 decks545 decks
1%synergy
Snuff Out
17%inclusion127 decks751 decks
4%synergy
Malakir Rebirth
17%inclusion126 decks751 decks
-6%synergy
Hero's Downfall
16%inclusion118 decks751 decks
9%synergy
Doom Blade
16%inclusion117 decks751 decks
8%synergy
Archenemy's Charm
15%inclusion16 decks109 decks
6%synergy
Force of Despair
14%inclusion102 decks751 decks
6%synergy
Fell the Profane
13%inclusion73 decks551 decks
-5%synergy
Unlikely Aid
13%inclusion98 decks751 decks
12%synergy
Murder
12%inclusion90 decks751 decks
2%synergy
Anoint with Affliction
12%inclusion89 decks751 decks
11%synergy
Baleful Mastery
11%inclusion82 decks751 decks
2%synergy
Withering Boon
10%inclusion75 decks751 decks
5%synergy
Sheoldred's Edict
10%inclusion73 decks751 decks
-5%synergy
Darkness
10%inclusion72 decks751 decks
0%synergy
Undying Malice
8.7%inclusion65 decks751 decks
-1%synergy
Rush of Vitality
8.7%inclusion65 decks751 decks
8%synergy
Tragic Slip
8.4%inclusion63 decks751 decks
-12%synergy
Bitter Triumph
8.1%inclusion61 decks751 decks
-2%synergy
Culling the Weak
7.9%inclusion59 decks751 decks
-7%synergy
Undying Evil
7.6%inclusion57 decks751 decks
4%synergy
Not Dead After All
7.5%inclusion56 decks751 decks
-4%synergy
Cut Down
7.2%inclusion54 decks751 decks
3%synergy
Soul Shatter
6.5%inclusion49 decks751 decks
-6%synergy
Unnatural Endurance
6.5%inclusion49 decks751 decks
6%synergy
Overkill
6.4%inclusion8 decks125 decks
-1%synergy
Slaughter Pact
6.0%inclusion45 decks751 decks
3%synergy
Professor's Warning
5.2%inclusion39 decks751 decks
4%synergy
Blood Pact
5.1%inclusion38 decks751 decks
1%synergy
Sorceries
Feed the Swarm
54%inclusion404 decks751 decks
2%synergy
Night's Whisper
46%inclusion349 decks751 decks
22%synergy
Crux of Fate
41%inclusion305 decks751 decks
39%synergy
Caress of Phyrexia
40%inclusion298 decks751 decks
39%synergy
Toxic Deluge
38%inclusion289 decks751 decks
1%synergy
Read the Bones
34%inclusion254 decks751 decks
16%synergy
Bubbling Muck
31%inclusion230 decks751 decks
15%synergy
Damnation
27%inclusion202 decks751 decks
6%synergy
Vat Emergence
25%inclusion186 decks751 decks
23%synergy
Reanimate
24%inclusion178 decks751 decks
-15%synergy
Diabolic Tutor
23%inclusion171 decks751 decks
8%synergy
Mutilate
19%inclusion140 decks751 decks
0%synergy
Spread the Sickness
18%inclusion138 decks751 decks
18%synergy
Insatiable Avarice
18%inclusion112 decks637 decks
5%synergy
Grim Tutor
15%inclusion114 decks751 decks
3%synergy
Blasphemous Edict
14%inclusion45 decks324 decks
-3%synergy
Geth's Summons
13%inclusion100 decks751 decks
13%synergy
Black Sun's Zenith
12%inclusion92 decks751 decks
6%synergy
Exsanguinate
12%inclusion92 decks751 decks
-12%synergy
Feed the Infection
8.9%inclusion67 decks751 decks
8%synergy
In Garruk's Wake
7.3%inclusion55 decks751 decks
3%synergy
Syphon Mind
7.2%inclusion54 decks751 decks
-6%synergy
Beseech the Queen
7.2%inclusion54 decks751 decks
1%synergy
Profane Tutor
6.8%inclusion51 decks751 decks
2%synergy
Torment of Hailfire
6.5%inclusion49 decks751 decks
-9%synergy
Fell
6.1%inclusion30 decks493 decks
2%synergy
Ancient Craving
5.3%inclusion40 decks751 decks
3%synergy
Praetor's Grasp
5.2%inclusion39 decks751 decks
1%synergy
Utility Artifacts
Lightning Greaves
52%inclusion394 decks751 decks
19%synergy
Blackblade Reforged
52%inclusion389 decks751 decks
49%synergy
Fireshrieker
47%inclusion350 decks751 decks
45%synergy
Contagion Clasp
44%inclusion328 decks751 decks
41%synergy
Whispersilk Cloak
41%inclusion310 decks751 decks
35%synergy
Contagion Engine
38%inclusion284 decks751 decks
36%synergy
Sword of Truth and Justice
36%inclusion272 decks751 decks
35%synergy
Commander's Plate
35%inclusion265 decks751 decks
30%synergy
Shadowspear
28%inclusion208 decks751 decks
24%synergy
The Darkness Crystal
26%inclusion34 decks131 decks
6%synergy
Leyline Axe
21%inclusion70 decks326 decks
21%synergy
Hero's Blade
20%inclusion149 decks751 decks
19%synergy
Champion's Helm
20%inclusion147 decks751 decks
18%synergy
Trailblazer's Boots
19%inclusion143 decks751 decks
17%synergy
Brotherhood Regalia
18%inclusion91 decks516 decks
15%synergy
Sword of the Animist
16%inclusion122 decks751 decks
12%synergy
Cranial Plating
15%inclusion109 decks751 decks
11%synergy
Mithril Coat
14%inclusion105 decks751 decks
8%synergy
Throne of Geth
14%inclusion103 decks751 decks
13%synergy
Pact Weapon
14%inclusion102 decks751 decks
11%synergy
Expedition Map
13%inclusion99 decks751 decks
1%synergy
Genji Glove
13%inclusion16 decks124 decks
12%synergy
Sword of Feast and Famine
13%inclusion96 decks751 decks
11%synergy
Wayfarer's Bauble
12%inclusion91 decks751 decks
-4%synergy
Grafted Exoskeleton
11%inclusion86 decks751 decks
10%synergy
Strata Scythe
10%inclusion78 decks751 decks
10%synergy
Inquisitor's Flail
10%inclusion78 decks751 decks
10%synergy
Sword of Vengeance
9.3%inclusion70 decks751 decks
8%synergy
Bontu's Monument
9.1%inclusion68 decks751 decks
-19%synergy
Helm of the Host
8.4%inclusion63 decks751 decks
7%synergy
Pip-Boy 3000
8.4%inclusion57 decks682 decks
8%synergy
Prowler's Helm
8.3%inclusion62 decks751 decks
7%synergy
Doc Ock's Tentacles
8.2%inclusion7 decks85 decks
8%synergy
Loxodon Warhammer
7.7%inclusion58 decks751 decks
6%synergy
Hammer of Nazahn
7.7%inclusion58 decks751 decks
7%synergy
Grafted Wargear
7.6%inclusion57 decks751 decks
7%synergy
Darksteel Plate
7.6%inclusion57 decks751 decks
6%synergy
Sensei's Divining Top
7.2%inclusion54 decks751 decks
-1%synergy
Whip of Erebos
7.1%inclusion53 decks751 decks
-4%synergy
Vorpal Sword
7.1%inclusion53 decks751 decks
3%synergy
Basilisk Collar
7.1%inclusion53 decks751 decks
4%synergy
Sword of Wealth and Power
6.7%inclusion46 decks683 decks
6%synergy
O-Naginata
6.4%inclusion48 decks751 decks
6%synergy
Decimator Web
5.5%inclusion41 decks751 decks
5%synergy
Black Mage's Rod
5.3%inclusion7 decks131 decks
5%synergy
Manifold Key
5.2%inclusion39 decks751 decks
3%synergy
Prosthetic Injector
5.2%inclusion39 decks751 decks
5%synergy
Enchantments
Necrogen Communion
51%inclusion381 decks751 decks
49%synergy
Unspeakable Symbol
39%inclusion294 decks751 decks
38%synergy
Kaya's Ghostform
30%inclusion227 decks751 decks
20%synergy
Black Market Connections
21%inclusion158 decks751 decks
-2%synergy
Bad Moon
21%inclusion158 decks751 decks
18%synergy
Fungal Fortitude
19%inclusion144 decks751 decks
18%synergy
Phyresis
16%inclusion120 decks751 decks
14%synergy
Endless Scream
15%inclusion113 decks751 decks
15%synergy
Relic Putrescence
15%inclusion112 decks751 decks
15%synergy
No Mercy
15%inclusion112 decks751 decks
8%synergy
Shade's Form
11%inclusion86 decks751 decks
11%synergy
Dauthi Embrace
10%inclusion77 decks751 decks
9%synergy
Snake Cult Initiation
8.0%inclusion60 decks751 decks
8%synergy
Animate Dead
7.3%inclusion55 decks751 decks
-10%synergy
Black Market
7.2%inclusion54 decks751 decks
-14%synergy
Super State
6.3%inclusion7 decks111 decks
6%synergy
Alien Symbiosis
5.9%inclusion5 decks85 decks
5%synergy
Glistening Oil
5.9%inclusion44 decks751 decks
5%synergy
Greed
5.6%inclusion42 decks751 decks
-2%synergy
The Meathook Massacre
5.5%inclusion41 decks751 decks
-12%synergy
Phyrexian Reclamation
5.5%inclusion41 decks751 decks
-5%synergy
Planeswalkers
Vraska, Betrayal's Sting
46%inclusion347 decks751 decks
43%synergy
Liliana of the Dark Realms
27%inclusion205 decks751 decks
13%synergy
Utility Lands
Rogue's Passage
68%inclusion512 decks751 decks
50%synergy
Cabal Coffers
61%inclusion456 decks751 decks
6%synergy
Bojuka Bog
48%inclusion361 decks751 decks
1%synergy
Urborg, Tomb of Yawgmoth
47%inclusion352 decks751 decks
9%synergy
Shizo, Death's Storehouse
43%inclusion326 decks751 decks
33%synergy
Inkmoth Nexus
40%inclusion301 decks751 decks
39%synergy
Cabal Stronghold
38%inclusion282 decks751 decks
2%synergy
Nykthos, Shrine to Nyx
25%inclusion187 decks751 decks
-5%synergy
The Black Gate
21%inclusion154 decks751 decks
17%synergy
Cathedral of War
19%inclusion141 decks751 decks
18%synergy
Castle Locthwain
18%inclusion134 decks751 decks
0%synergy
Command Beacon
17%inclusion124 decks751 decks
8%synergy
War Room
15%inclusion114 decks751 decks
-1%synergy
Reliquary Tower
15%inclusion109 decks751 decks
-17%synergy
Witch's Cottage
12%inclusion93 decks751 decks
-12%synergy
Minas Morgul, Dark Fortress
11%inclusion85 decks751 decks
8%synergy
Urza's Saga
11%inclusion81 decks751 decks
3%synergy
Mortuary Mire
11%inclusion79 decks751 decks
-3%synergy
Temple of the False God
10%inclusion73 decks751 decks
2%synergy
Lake of the Dead
9.1%inclusion68 decks751 decks
4%synergy
Strip Mine
8.4%inclusion63 decks751 decks
5%synergy
Takenuma, Abandoned Mire
8.1%inclusion61 decks751 decks
-8%synergy
Barren Moor
8.0%inclusion60 decks751 decks
-3%synergy
Maze of Ith
7.1%inclusion53 decks751 decks
4%synergy
Buried Ruin
6.4%inclusion48 decks751 decks
1%synergy
Phyrexian Tower
6.1%inclusion46 decks751 decks
-18%synergy
Thespian's Stage
5.7%inclusion43 decks751 decks
0%synergy
Spymaster's Vault
5.3%inclusion29 decks551 decks
-5%synergy
Mana Artifacts
Sol Ring
91%inclusion680 decks751 decks
4%synergy
Arcane Signet
65%inclusion488 decks751 decks
2%synergy
Glistening Sphere
46%inclusion344 decks751 decks
44%synergy
Mind Stone
33%inclusion245 decks751 decks
2%synergy
Charcoal Diamond
30%inclusion229 decks751 decks
7%synergy
Staff of Compleation
27%inclusion206 decks751 decks
26%synergy
Heraldic Banner
18%inclusion137 decks751 decks
13%synergy
Caged Sun
17%inclusion130 decks751 decks
5%synergy
Thought Vessel
16%inclusion118 decks751 decks
-11%synergy
The Soul Stone
15%inclusion15 decks103 decks
2%synergy
Fellwar Stone
14%inclusion108 decks751 decks
0%synergy
Lotus Petal
12%inclusion93 decks751 decks
5%synergy
Throne of Eldraine
11%inclusion85 decks751 decks
1%synergy
Commander's Sphere
11%inclusion84 decks751 decks
2%synergy
Everflowing Chalice
10%inclusion75 decks751 decks
4%synergy
Mox Opal
9.5%inclusion71 decks751 decks
6%synergy
Jeweled Lotus
9.3%inclusion70 decks751 decks
7%synergy
Mana Crypt
7.7%inclusion58 decks751 decks
5%synergy
Thran Dynamo
7.6%inclusion57 decks751 decks
1%synergy
Sceptre of Eternal Glory
6.9%inclusion52 decks751 decks
-2%synergy
Worn Powerstone
6.0%inclusion45 decks751 decks
2%synergy
Gilded Lotus
5.7%inclusion43 decks751 decks
0%synergy
Nyx Lotus
5.6%inclusion42 decks751 decks
-1%synergy
Mox Diamond
5.3%inclusion40 decks751 decks
2%synergy
Mox Jasper
5.1%inclusion9 decks175 decks
5%synergy
Lands
Swamp
95%inclusion714 decks751 decks
0%synergy
Myriad Landscape
24%inclusion183 decks751 decks
-2%synergy
Malakir Rebirth
17%inclusion126 decks751 decks
-6%synergy
Mirrex
16%inclusion118 decks751 decks
15%synergy
Cavern of Souls
15%inclusion112 decks751 decks
8%synergy
Fell the Profane
13%inclusion73 decks551 decks
-5%synergy
Opal Palace
8.8%inclusion66 decks751 decks
8%synergy
Urza's Cave
7.5%inclusion44 decks586 decks
-1%synergy
The Seedcore
7.3%inclusion55 decks751 decks
7%synergy
Snow-Covered Swamp
6.0%inclusion45 decks751 decks
-1%synergy
Command Tower
5.3%inclusion40 decks751 decks
0%synergy
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