Skithiryx, the Blight Dragon (Commander) - Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #792
545decks
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Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Swordsman's Steel
3.1%inclusion1 decks32 decks
2%synergy
Iron Man Armor
3.1%inclusion1 decks32 decks
2%synergy
Arc Reactor
2.8%inclusion1 decks36 decks
2%synergy
High Synergy Cards
Plague Stinger
78%inclusion425 decks545 decks
77%synergy
Plague Myr
76%inclusion415 decks545 decks
75%synergy
Ichor Rats
76%inclusion413 decks545 decks
73%synergy
Infectious Inquiry
75%inclusion409 decks545 decks
72%synergy
Hand of the Praetors
72%inclusion394 decks545 decks
72%synergy
Vraska's Fall
70%inclusion382 decks545 decks
67%synergy
Karn's Bastion
69%inclusion376 decks545 decks
65%synergy
Whispering Specter
64%inclusion348 decks545 decks
63%synergy
Phyrexian Crusader
64%inclusion348 decks545 decks
63%synergy
Drown in Ichor
66%inclusion357 decks545 decks
62%synergy
Top Cards
Dark Ritual
78%inclusion426 decks545 decks
11%synergy
Jet Medallion
66%inclusion359 decks545 decks
4%synergy
Swiftfoot Boots
63%inclusion341 decks545 decks
31%synergy
Lashwrithe
61%inclusion333 decks545 decks
57%synergy
Phyresis Outbreak
61%inclusion332 decks545 decks
59%synergy
Crypt Ghast
60%inclusion328 decks545 decks
13%synergy
Blightbelly Rat
60%inclusion328 decks545 decks
57%synergy
Phyrexian Arena
59%inclusion321 decks545 decks
20%synergy
Sign in Blood
56%inclusion305 decks545 decks
21%synergy
Feed the Swarm
53%inclusion287 decks545 decks
2%synergy
Game Changers
Demonic Tutor
41%inclusion222 decks545 decks
14%synergy
Vampiric Tutor
30%inclusion165 decks545 decks
9%synergy
Ancient Tomb
20%inclusion107 decks545 decks
8%synergy
Necropotence
19%inclusion105 decks545 decks
5%synergy
Bolas's Citadel
16%inclusion86 decks545 decks
-13%synergy
Mana Vault
14%inclusion74 decks545 decks
7%synergy
Opposition Agent
12%inclusion63 decks545 decks
2%synergy
The One Ring
10%inclusion55 decks545 decks
1%synergy
Chrome Mox
10%inclusion52 decks545 decks
4%synergy
Imperial Seal
8.6%inclusion47 decks545 decks
2%synergy
Creatures
Reaper of Sheoldred
52%inclusion281 decks545 decks
51%synergy
Ichorclaw Myr
45%inclusion244 decks545 decks
44%synergy
Flensermite
44%inclusion240 decks545 decks
44%synergy
Bilious Skulldweller
43%inclusion235 decks545 decks
42%synergy
Core Prowler
40%inclusion219 decks545 decks
40%synergy
Corpse Cur
39%inclusion212 decks545 decks
39%synergy
Pestilent Syphoner
38%inclusion206 decks545 decks
37%synergy
Phyrexian Obliterator
35%inclusion192 decks545 decks
24%synergy
Flesh-Eater Imp
35%inclusion189 decks545 decks
34%synergy
Septic Rats
34%inclusion183 decks545 decks
32%synergy
K'rrik, Son of Yawgmoth
33%inclusion181 decks545 decks
14%synergy
Necropede
28%inclusion150 decks545 decks
27%synergy
Myr Convert
26%inclusion140 decks545 decks
25%synergy
Yawgmoth, Thran Physician
25%inclusion134 decks545 decks
15%synergy
Blightsteel Colossus
23%inclusion126 decks545 decks
22%synergy
Gray Merchant of Asphodel
22%inclusion118 decks545 decks
-29%synergy
Leaden Myr
21%inclusion117 decks545 decks
15%synergy
Solemn Simulacrum
20%inclusion108 decks545 decks
-2%synergy
Gulping Scraptrap
19%inclusion104 decks545 decks
19%synergy
Contagious Nim
19%inclusion102 decks545 decks
18%synergy
Blackcleave Goblin
16%inclusion89 decks545 decks
16%synergy
Phyrexian Juggernaut
16%inclusion87 decks545 decks
16%synergy
Dauthi Voidwalker
15%inclusion83 decks545 decks
-0%synergy
Magus of the Coffers
14%inclusion76 decks545 decks
7%synergy
Necroskitter
14%inclusion75 decks545 decks
11%synergy
Dread Presence
13%inclusion73 decks545 decks
-0%synergy
Toxic Nim
12%inclusion68 decks545 decks
12%synergy
Phyrexian Vatmother
12%inclusion68 decks545 decks
12%synergy
Defiler of Flesh
12%inclusion66 decks545 decks
8%synergy
Sheoldred, Whispering One
12%inclusion64 decks545 decks
0%synergy
Sheoldred's Headcleaver
12%inclusion64 decks545 decks
11%synergy
Massacre Girl, Known Killer
12%inclusion63 decks545 decks
8%synergy
Dark Confidant
11%inclusion61 decks545 decks
4%synergy
Filth
11%inclusion59 decks545 decks
8%synergy
Silent Arbiter
10%inclusion55 decks545 decks
9%synergy
Nirkana Revenant
10%inclusion53 decks545 decks
-1%synergy
Sheoldred, the Apocalypse
9.4%inclusion51 decks545 decks
-5%synergy
Grafted Butcher
9.2%inclusion50 decks545 decks
9%synergy
Maha, Its Feathers Night
8.3%inclusion45 decks545 decks
4%synergy
Nimraiser Paladin
8.3%inclusion45 decks545 decks
8%synergy
Burnished Hart
8.1%inclusion44 decks545 decks
1%synergy
Phyrexian Digester
8.1%inclusion44 decks545 decks
8%synergy
Vector Asp
7.9%inclusion43 decks545 decks
8%synergy
Brass Squire
7.9%inclusion43 decks545 decks
7%synergy
Gwenom, Remorseless
7.4%inclusion15 decks204 decks
4%synergy
Swamp Mosquito
7.3%inclusion40 decks545 decks
7%synergy
Surge Conductor
7.1%inclusion15 decks211 decks
7%synergy
Orcish Bowmasters
7.0%inclusion38 decks545 decks
-6%synergy
Massacre Wurm
6.6%inclusion36 decks545 decks
-11%synergy
Scourge Servant
6.1%inclusion33 decks545 decks
6%synergy
Instants
Whisper of the Dross
46%inclusion251 decks545 decks
43%synergy
Howl from Beyond
46%inclusion248 decks545 decks
45%synergy
Defile
44%inclusion238 decks545 decks
8%synergy
Go for the Throat
38%inclusion208 decks545 decks
16%synergy
Tainted Strike
37%inclusion203 decks545 decks
34%synergy
Grim Affliction
35%inclusion193 decks545 decks
34%synergy
Deadly Rollick
33%inclusion179 decks545 decks
8%synergy
Infernal Grasp
31%inclusion169 decks545 decks
6%synergy
Imp's Mischief
30%inclusion165 decks545 decks
5%synergy
Withering Torment
30%inclusion142 decks473 decks
-1%synergy
Cabal Ritual
26%inclusion143 decks545 decks
8%synergy
Dismember
25%inclusion135 decks545 decks
14%synergy
Malakir Rebirth
19%inclusion103 decks545 decks
-4%synergy
Supernatural Stamina
19%inclusion101 decks545 decks
11%synergy
Hatred
18%inclusion100 decks545 decks
17%synergy
Astarion's Thirst
18%inclusion98 decks545 decks
17%synergy
Snuff Out
18%inclusion97 decks545 decks
4%synergy
Consuming Corruption
17%inclusion94 decks545 decks
2%synergy
Sudden Spoiling
17%inclusion94 decks545 decks
9%synergy
Archenemy's Charm
17%inclusion36 decks211 decks
8%synergy
Virulent Wound
17%inclusion91 decks545 decks
16%synergy
Sugar Rush
16%inclusion88 decks545 decks
16%synergy
Hero's Downfall
14%inclusion79 decks545 decks
8%synergy
Fell the Profane
14%inclusion79 decks545 decks
-5%synergy
Doom Blade
13%inclusion73 decks545 decks
6%synergy
Anoint with Affliction
13%inclusion72 decks545 decks
13%synergy
Darkness
13%inclusion69 decks545 decks
2%synergy
Murder
12%inclusion66 decks545 decks
2%synergy
Baleful Mastery
11%inclusion62 decks545 decks
3%synergy
Force of Despair
11%inclusion59 decks545 decks
3%synergy
Withering Boon
11%inclusion58 decks545 decks
6%synergy
Unlikely Aid
10%inclusion56 decks545 decks
10%synergy
Sheoldred's Edict
9.4%inclusion51 decks545 decks
-6%synergy
Undying Malice
9.2%inclusion50 decks545 decks
-1%synergy
Culling the Weak
8.4%inclusion46 decks545 decks
-9%synergy
Bitter Triumph
8.4%inclusion46 decks545 decks
-1%synergy
Rush of Vitality
7.3%inclusion40 decks545 decks
7%synergy
Tragic Slip
7.3%inclusion40 decks545 decks
-12%synergy
Undying Evil
7.2%inclusion39 decks545 decks
4%synergy
Cut Down
6.8%inclusion37 decks545 decks
3%synergy
Soul Shatter
6.4%inclusion35 decks545 decks
-5%synergy
Masterful Flourish
6.3%inclusion5 decks79 decks
5%synergy
Unnatural Endurance
5.9%inclusion32 decks545 decks
6%synergy
Not Dead After All
5.5%inclusion30 decks545 decks
-6%synergy
Blood Pact
5.1%inclusion28 decks545 decks
1%synergy
Sorceries
Night's Whisper
48%inclusion260 decks545 decks
23%synergy
Toxic Deluge
41%inclusion223 decks545 decks
4%synergy
Crux of Fate
41%inclusion221 decks545 decks
39%synergy
Caress of Phyrexia
36%inclusion197 decks545 decks
36%synergy
Bubbling Muck
33%inclusion179 decks545 decks
17%synergy
Read the Bones
30%inclusion164 decks545 decks
14%synergy
Vat Emergence
26%inclusion140 decks545 decks
24%synergy
Damnation
25%inclusion138 decks545 decks
5%synergy
Reanimate
25%inclusion136 decks545 decks
-15%synergy
Diabolic Tutor
20%inclusion110 decks545 decks
6%synergy
Mutilate
18%inclusion98 decks545 decks
2%synergy
Insatiable Avarice
17%inclusion94 decks545 decks
6%synergy
Spread the Sickness
17%inclusion93 decks545 decks
16%synergy
Grim Tutor
16%inclusion86 decks545 decks
4%synergy
Exsanguinate
13%inclusion71 decks545 decks
-12%synergy
Black Sun's Zenith
13%inclusion70 decks545 decks
8%synergy
Blasphemous Edict
12%inclusion49 decks401 decks
-4%synergy
Geth's Summons
12%inclusion65 decks545 decks
12%synergy
Feed the Infection
9.4%inclusion51 decks545 decks
9%synergy
Beseech the Queen
6.8%inclusion37 decks545 decks
1%synergy
Torment of Hailfire
6.4%inclusion35 decks545 decks
-9%synergy
Pox Plague
6.3%inclusion5 decks79 decks
1%synergy
Profane Tutor
6.2%inclusion34 decks545 decks
2%synergy
In Garruk's Wake
6.2%inclusion34 decks545 decks
2%synergy
Syphon Mind
6.2%inclusion34 decks545 decks
-6%synergy
Praetor's Grasp
5.9%inclusion32 decks545 decks
2%synergy
Fell
5.7%inclusion31 decks545 decks
2%synergy
Decorum Dissertation
5.1%inclusion4 decks79 decks
-1%synergy
Utility Artifacts
Nightmare Lash
52%inclusion285 decks545 decks
50%synergy
Blackblade Reforged
52%inclusion281 decks545 decks
49%synergy
Lightning Greaves
49%inclusion268 decks545 decks
15%synergy
Fireshrieker
44%inclusion241 decks545 decks
42%synergy
Contagion Clasp
42%inclusion230 decks545 decks
40%synergy
Whispersilk Cloak
38%inclusion208 decks545 decks
32%synergy
Commander's Plate
37%inclusion200 decks545 decks
31%synergy
Contagion Engine
36%inclusion197 decks545 decks
34%synergy
Sword of Truth and Justice
35%inclusion191 decks545 decks
34%synergy
Shadowspear
27%inclusion146 decks545 decks
23%synergy
The Darkness Crystal
24%inclusion56 decks229 decks
4%synergy
Champion's Helm
24%inclusion132 decks545 decks
22%synergy
Trailblazer's Boots
21%inclusion113 decks545 decks
18%synergy
Leyline Axe
21%inclusion83 decks403 decks
20%synergy
Hero's Blade
19%inclusion104 decks545 decks
19%synergy
Sword of the Animist
18%inclusion97 decks545 decks
14%synergy
Brotherhood Regalia
17%inclusion92 decks545 decks
14%synergy
Expedition Map
15%inclusion81 decks545 decks
3%synergy
Cranial Plating
14%inclusion78 decks545 decks
11%synergy
Throne of Geth
14%inclusion77 decks545 decks
14%synergy
Mithril Coat
14%inclusion77 decks545 decks
9%synergy
Pact Weapon
14%inclusion76 decks545 decks
12%synergy
Sword of Feast and Famine
13%inclusion73 decks545 decks
12%synergy
Wayfarer's Bauble
13%inclusion72 decks545 decks
-2%synergy
Genji Glove
12%inclusion26 decks222 decks
10%synergy
Grafted Exoskeleton
11%inclusion59 decks545 decks
10%synergy
Inquisitor's Flail
11%inclusion59 decks545 decks
11%synergy
Strata Scythe
10%inclusion55 decks545 decks
9%synergy
Sword of Vengeance
10%inclusion55 decks545 decks
9%synergy
Hammer of Nazahn
10%inclusion54 decks545 decks
9%synergy
Loxodon Warhammer
10%inclusion53 decks545 decks
8%synergy
Basilisk Collar
10%inclusion52 decks545 decks
7%synergy
Helm of the Host
8.8%inclusion48 decks545 decks
7%synergy
Prowler's Helm
8.6%inclusion47 decks545 decks
8%synergy
Vorpal Sword
8.4%inclusion46 decks545 decks
5%synergy
Doc Ock's Tentacles
7.8%inclusion15 decks193 decks
8%synergy
Darksteel Plate
7.5%inclusion41 decks545 decks
6%synergy
Sensei's Divining Top
7.3%inclusion40 decks545 decks
-1%synergy
Bontu's Monument
7.3%inclusion40 decks545 decks
-21%synergy
Grafted Wargear
6.8%inclusion37 decks545 decks
7%synergy
O-Naginata
6.4%inclusion35 decks545 decks
6%synergy
Sword of Wealth and Power
6.4%inclusion35 decks545 decks
6%synergy
Whip of Erebos
6.2%inclusion34 decks545 decks
-5%synergy
Pip-Boy 3000
5.9%inclusion32 decks545 decks
6%synergy
Sword of Fire and Ice
5.9%inclusion32 decks545 decks
5%synergy
Manifold Key
5.7%inclusion31 decks545 decks
4%synergy
Silver Shroud Costume
5.3%inclusion29 decks545 decks
4%synergy
Buster Sword
5.3%inclusion12 decks226 decks
4%synergy
Enchantments
Necrogen Communion
51%inclusion278 decks545 decks
49%synergy
Unspeakable Symbol
35%inclusion190 decks545 decks
34%synergy
Kaya's Ghostform
30%inclusion165 decks545 decks
20%synergy
Black Market Connections
24%inclusion131 decks545 decks
-0%synergy
Bad Moon
19%inclusion106 decks545 decks
16%synergy
No Mercy
17%inclusion90 decks545 decks
9%synergy
Phyresis
16%inclusion88 decks545 decks
14%synergy
Fungal Fortitude
16%inclusion85 decks545 decks
14%synergy
Relic Putrescence
14%inclusion78 decks545 decks
14%synergy
Endless Scream
12%inclusion67 decks545 decks
12%synergy
Dauthi Embrace
11%inclusion61 decks545 decks
9%synergy
Shade's Form
9.2%inclusion50 decks545 decks
9%synergy
Snake Cult Initiation
9.0%inclusion49 decks545 decks
9%synergy
Super State
8.5%inclusion18 decks213 decks
8%synergy
Animate Dead
8.1%inclusion44 decks545 decks
-9%synergy
Glistening Oil
6.4%inclusion35 decks545 decks
6%synergy
Greed
5.7%inclusion31 decks545 decks
-1%synergy
Black Market
5.7%inclusion31 decks545 decks
-15%synergy
Planeswalkers
Vraska, Betrayal's Sting
48%inclusion259 decks545 decks
45%synergy
Liliana of the Dark Realms
32%inclusion175 decks545 decks
18%synergy
Utility Lands
Rogue's Passage
65%inclusion356 decks545 decks
46%synergy
Cabal Coffers
62%inclusion337 decks545 decks
7%synergy
Bojuka Bog
48%inclusion259 decks545 decks
1%synergy
Urborg, Tomb of Yawgmoth
45%inclusion243 decks545 decks
7%synergy
Shizo, Death's Storehouse
43%inclusion232 decks545 decks
32%synergy
Inkmoth Nexus
40%inclusion220 decks545 decks
39%synergy
Cabal Stronghold
36%inclusion195 decks545 decks
1%synergy
Nykthos, Shrine to Nyx
23%inclusion126 decks545 decks
-7%synergy
Cathedral of War
19%inclusion106 decks545 decks
19%synergy
The Black Gate
18%inclusion97 decks545 decks
14%synergy
Reliquary Tower
16%inclusion89 decks545 decks
-14%synergy
Castle Locthwain
16%inclusion88 decks545 decks
-1%synergy
Command Beacon
15%inclusion81 decks545 decks
7%synergy
War Room
15%inclusion80 decks545 decks
-1%synergy
Witch's Cottage
14%inclusion74 decks545 decks
-11%synergy
Urza's Saga
11%inclusion62 decks545 decks
3%synergy
Mortuary Mire
10%inclusion57 decks545 decks
-3%synergy
Minas Morgul, Dark Fortress
10%inclusion53 decks545 decks
7%synergy
Temple of the False God
9.4%inclusion51 decks545 decks
2%synergy
Lake of the Dead
7.7%inclusion42 decks545 decks
3%synergy
Takenuma, Abandoned Mire
7.5%inclusion41 decks545 decks
-8%synergy
Strip Mine
7.5%inclusion41 decks545 decks
5%synergy
Barren Moor
6.6%inclusion36 decks545 decks
-3%synergy
Maze of Ith
6.2%inclusion34 decks545 decks
3%synergy
Vault of Whispers
6.1%inclusion33 decks545 decks
1%synergy
Phyrexian Tower
5.9%inclusion32 decks545 decks
-20%synergy
Thespian's Stage
5.9%inclusion32 decks545 decks
1%synergy
Buried Ruin
5.7%inclusion31 decks545 decks
1%synergy
Spymaster's Vault
5.3%inclusion29 decks545 decks
-4%synergy
Mana Artifacts
Sol Ring
89%inclusion487 decks545 decks
4%synergy
Arcane Signet
66%inclusion359 decks545 decks
4%synergy
Glistening Sphere
44%inclusion239 decks545 decks
43%synergy
Mind Stone
34%inclusion184 decks545 decks
6%synergy
Charcoal Diamond
32%inclusion174 decks545 decks
10%synergy
Staff of Compleation
29%inclusion160 decks545 decks
28%synergy
Heraldic Banner
18%inclusion100 decks545 decks
13%synergy
Thought Vessel
18%inclusion96 decks545 decks
-7%synergy
Fellwar Stone
17%inclusion92 decks545 decks
3%synergy
Caged Sun
15%inclusion82 decks545 decks
4%synergy
The Soul Stone
14%inclusion30 decks207 decks
-1%synergy
Lotus Petal
13%inclusion73 decks545 decks
6%synergy
Everflowing Chalice
11%inclusion59 decks545 decks
5%synergy
Throne of Eldraine
10%inclusion54 decks545 decks
0%synergy
Commander's Sphere
10%inclusion53 decks545 decks
2%synergy
Mox Opal
10%inclusion52 decks545 decks
6%synergy
Thran Dynamo
9.4%inclusion51 decks545 decks
4%synergy
Gilded Lotus
6.4%inclusion35 decks545 decks
1%synergy
Worn Powerstone
6.2%inclusion34 decks545 decks
2%synergy
Sceptre of Eternal Glory
5.9%inclusion32 decks545 decks
-2%synergy
Mox Amber
5.7%inclusion31 decks545 decks
1%synergy
Extraplanar Lens
5.5%inclusion30 decks545 decks
1%synergy
Lands
Swamp
94%inclusion514 decks545 decks
-1%synergy
Myriad Landscape
24%inclusion133 decks545 decks
-0%synergy
Malakir Rebirth
19%inclusion103 decks545 decks
-4%synergy
Cavern of Souls
15%inclusion83 decks545 decks
8%synergy
Mirrex
15%inclusion81 decks545 decks
14%synergy
Fell the Profane
14%inclusion79 decks545 decks
-5%synergy
Urza's Cave
7.9%inclusion43 decks545 decks
-0%synergy
The Seedcore
7.3%inclusion40 decks545 decks
7%synergy
Opal Palace
7.0%inclusion38 decks545 decks
6%synergy
Snow-Covered Swamp
6.4%inclusion35 decks545 decks
-0%synergy
Command Tower
5.9%inclusion32 decks545 decks
0%synergy
Polluted Delta
5.1%inclusion28 decks545 decks
1%synergy
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