Skithiryx, the Blight Dragon (Commander) - Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #779
664decks
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Enchantments
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Utility Lands
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Mornsong Aria
6.1%inclusion4 decks66 decks
4%synergy
Madame Null, Power Broker
3.8%inclusion2 decks53 decks
3%synergy
Unbury
3.1%inclusion2 decks64 decks
3%synergy
Skateboard
3.1%inclusion1 decks32 decks
3%synergy
Chronicle of Victory
3.0%inclusion2 decks66 decks
0%synergy
High Synergy Cards
Plague Stinger
80%inclusion532 decks664 decks
79%synergy
Plague Myr
78%inclusion519 decks664 decks
77%synergy
Hand of the Praetors
76%inclusion502 decks664 decks
75%synergy
Ichor Rats
78%inclusion516 decks664 decks
75%synergy
Infectious Inquiry
76%inclusion502 decks664 decks
73%synergy
Vraska's Fall
71%inclusion469 decks664 decks
67%synergy
Whispering Specter
67%inclusion442 decks664 decks
66%synergy
Karn's Bastion
69%inclusion461 decks664 decks
65%synergy
Phyrexian Crusader
65%inclusion431 decks664 decks
64%synergy
Drown in Ichor
66%inclusion439 decks664 decks
62%synergy
Top Cards
Dark Ritual
79%inclusion522 decks664 decks
12%synergy
Lashwrithe
63%inclusion421 decks664 decks
59%synergy
Jet Medallion
63%inclusion420 decks664 decks
2%synergy
Swiftfoot Boots
63%inclusion417 decks664 decks
31%synergy
Blightbelly Rat
61%inclusion407 decks664 decks
58%synergy
Crypt Ghast
61%inclusion406 decks664 decks
13%synergy
Phyresis Outbreak
61%inclusion403 decks664 decks
59%synergy
Phyrexian Arena
60%inclusion399 decks664 decks
20%synergy
Sign in Blood
57%inclusion376 decks664 decks
21%synergy
Nightmare Lash
56%inclusion373 decks664 decks
54%synergy
Game Changers
Demonic Tutor
42%inclusion276 decks664 decks
14%synergy
Vampiric Tutor
32%inclusion210 decks664 decks
11%synergy
Necropotence
22%inclusion146 decks664 decks
7%synergy
Ancient Tomb
21%inclusion138 decks664 decks
9%synergy
Bolas's Citadel
16%inclusion106 decks664 decks
-13%synergy
Mana Vault
15%inclusion102 decks664 decks
9%synergy
Opposition Agent
13%inclusion83 decks664 decks
3%synergy
Chrome Mox
11%inclusion73 decks664 decks
5%synergy
The One Ring
11%inclusion72 decks664 decks
1%synergy
Imperial Seal
9.5%inclusion63 decks664 decks
3%synergy
Creatures
Reaper of Sheoldred
53%inclusion355 decks664 decks
53%synergy
Ichorclaw Myr
46%inclusion306 decks664 decks
46%synergy
Flensermite
45%inclusion298 decks664 decks
44%synergy
Bilious Skulldweller
43%inclusion287 decks664 decks
42%synergy
Core Prowler
43%inclusion285 decks664 decks
42%synergy
Corpse Cur
42%inclusion280 decks664 decks
42%synergy
Flesh-Eater Imp
37%inclusion248 decks664 decks
37%synergy
Pestilent Syphoner
37%inclusion247 decks664 decks
37%synergy
Septic Rats
36%inclusion236 decks664 decks
34%synergy
Phyrexian Obliterator
34%inclusion227 decks664 decks
23%synergy
K'rrik, Son of Yawgmoth
31%inclusion206 decks664 decks
12%synergy
Necropede
29%inclusion190 decks664 decks
28%synergy
Myr Convert
26%inclusion173 decks664 decks
25%synergy
Yawgmoth, Thran Physician
24%inclusion157 decks664 decks
14%synergy
Blightsteel Colossus
22%inclusion146 decks664 decks
21%synergy
Gray Merchant of Asphodel
21%inclusion142 decks664 decks
-30%synergy
Contagious Nim
21%inclusion141 decks664 decks
21%synergy
Solemn Simulacrum
20%inclusion136 decks664 decks
-2%synergy
Leaden Myr
20%inclusion133 decks664 decks
14%synergy
Gulping Scraptrap
19%inclusion125 decks664 decks
18%synergy
Blackcleave Goblin
18%inclusion120 decks664 decks
18%synergy
Phyrexian Juggernaut
15%inclusion101 decks664 decks
15%synergy
Magus of the Coffers
14%inclusion95 decks664 decks
7%synergy
Defiler of Flesh
14%inclusion95 decks664 decks
10%synergy
Dauthi Voidwalker
14%inclusion95 decks664 decks
-1%synergy
Massacre Girl, Known Killer
14%inclusion94 decks664 decks
10%synergy
Necroskitter
13%inclusion86 decks664 decks
10%synergy
Dread Presence
13%inclusion85 decks664 decks
-2%synergy
Phyrexian Vatmother
13%inclusion85 decks664 decks
13%synergy
Toxic Nim
13%inclusion84 decks664 decks
12%synergy
Sheoldred, Whispering One
12%inclusion81 decks664 decks
0%synergy
Sheoldred's Headcleaver
12%inclusion79 decks664 decks
12%synergy
Filth
11%inclusion75 decks664 decks
9%synergy
Grafted Butcher
11%inclusion75 decks664 decks
11%synergy
Dark Confidant
11%inclusion74 decks664 decks
4%synergy
Silent Arbiter
10%inclusion64 decks664 decks
8%synergy
Nirkana Revenant
9.2%inclusion61 decks664 decks
-2%synergy
Phyrexian Digester
9.2%inclusion61 decks664 decks
9%synergy
Sheoldred, the Apocalypse
8.7%inclusion58 decks664 decks
-6%synergy
Burnished Hart
8.4%inclusion56 decks664 decks
1%synergy
Nimraiser Paladin
8.1%inclusion54 decks664 decks
8%synergy
Vector Asp
8.0%inclusion53 decks664 decks
8%synergy
Maha, Its Feathers Night
7.8%inclusion39 decks503 decks
3%synergy
Massacre Wurm
7.5%inclusion50 decks664 decks
-10%synergy
Orcish Bowmasters
7.5%inclusion50 decks664 decks
-6%synergy
Swamp Mosquito
7.2%inclusion48 decks664 decks
7%synergy
Surge Conductor
7.1%inclusion11 decks155 decks
7%synergy
Gwenom, Remorseless
6.8%inclusion10 decks147 decks
3%synergy
Scourge Servant
6.8%inclusion45 decks664 decks
7%synergy
Brass Squire
6.6%inclusion44 decks664 decks
6%synergy
Instants
Howl from Beyond
50%inclusion334 decks664 decks
50%synergy
Whisper of the Dross
46%inclusion308 decks664 decks
43%synergy
Defile
44%inclusion295 decks664 decks
7%synergy
Go for the Throat
41%inclusion271 decks664 decks
18%synergy
Tainted Strike
38%inclusion251 decks664 decks
35%synergy
Grim Affliction
37%inclusion244 decks664 decks
35%synergy
Infernal Grasp
33%inclusion217 decks664 decks
7%synergy
Deadly Rollick
33%inclusion216 decks664 decks
8%synergy
Withering Torment
30%inclusion127 decks427 decks
-2%synergy
Dismember
28%inclusion188 decks664 decks
18%synergy
Cabal Ritual
28%inclusion184 decks664 decks
10%synergy
Imp's Mischief
28%inclusion183 decks664 decks
3%synergy
Sugar Rush
23%inclusion155 decks664 decks
23%synergy
Supernatural Stamina
21%inclusion142 decks664 decks
14%synergy
Hatred
20%inclusion134 decks664 decks
19%synergy
Astarion's Thirst
19%inclusion125 decks664 decks
17%synergy
Virulent Wound
18%inclusion121 decks664 decks
18%synergy
Malakir Rebirth
18%inclusion121 decks664 decks
-5%synergy
Consuming Corruption
18%inclusion100 decks553 decks
2%synergy
Snuff Out
18%inclusion117 decks664 decks
5%synergy
Sudden Spoiling
17%inclusion115 decks664 decks
8%synergy
Hero's Downfall
16%inclusion107 decks664 decks
9%synergy
Archenemy's Charm
15%inclusion23 decks155 decks
6%synergy
Doom Blade
14%inclusion96 decks664 decks
7%synergy
Fell the Profane
14%inclusion79 decks559 decks
-5%synergy
Force of Despair
13%inclusion88 decks664 decks
6%synergy
Unlikely Aid
13%inclusion83 decks664 decks
12%synergy
Anoint with Affliction
12%inclusion82 decks664 decks
12%synergy
Murder
12%inclusion82 decks664 decks
2%synergy
Baleful Mastery
12%inclusion80 decks664 decks
3%synergy
Withering Boon
10%inclusion66 decks664 decks
5%synergy
Darkness
10%inclusion66 decks664 decks
0%synergy
Sheoldred's Edict
10%inclusion64 decks664 decks
-5%synergy
Undying Malice
8.7%inclusion58 decks664 decks
-1%synergy
Bitter Triumph
8.1%inclusion54 decks664 decks
-2%synergy
Culling the Weak
7.8%inclusion52 decks664 decks
-8%synergy
Cut Down
7.2%inclusion48 decks664 decks
3%synergy
Tragic Slip
7.2%inclusion48 decks664 decks
-13%synergy
Rush of Vitality
7.1%inclusion47 decks664 decks
6%synergy
Not Dead After All
7.1%inclusion47 decks664 decks
-4%synergy
Undying Evil
6.9%inclusion46 decks664 decks
4%synergy
Soul Shatter
6.6%inclusion44 decks664 decks
-5%synergy
Unnatural Endurance
6.3%inclusion42 decks664 decks
6%synergy
Slaughter Pact
5.6%inclusion37 decks664 decks
3%synergy
Blood Pact
5.1%inclusion34 decks664 decks
1%synergy
Sorceries
Feed the Swarm
54%inclusion360 decks664 decks
3%synergy
Night's Whisper
48%inclusion318 decks664 decks
23%synergy
Crux of Fate
42%inclusion276 decks664 decks
40%synergy
Toxic Deluge
40%inclusion267 decks664 decks
3%synergy
Caress of Phyrexia
38%inclusion250 decks664 decks
37%synergy
Read the Bones
33%inclusion218 decks664 decks
15%synergy
Bubbling Muck
31%inclusion209 decks664 decks
16%synergy
Damnation
28%inclusion184 decks664 decks
7%synergy
Vat Emergence
25%inclusion165 decks664 decks
23%synergy
Reanimate
24%inclusion160 decks664 decks
-15%synergy
Diabolic Tutor
23%inclusion150 decks664 decks
8%synergy
Spread the Sickness
19%inclusion126 decks664 decks
18%synergy
Mutilate
18%inclusion121 decks664 decks
1%synergy
Insatiable Avarice
18%inclusion114 decks638 decks
6%synergy
Grim Tutor
16%inclusion108 decks664 decks
5%synergy
Exsanguinate
13%inclusion86 decks664 decks
-12%synergy
Blasphemous Edict
13%inclusion45 decks353 decks
-4%synergy
Geth's Summons
12%inclusion80 decks664 decks
12%synergy
Black Sun's Zenith
12%inclusion78 decks664 decks
6%synergy
Feed the Infection
9.5%inclusion63 decks664 decks
9%synergy
Beseech the Queen
7.5%inclusion50 decks664 decks
1%synergy
Profane Tutor
7.1%inclusion47 decks664 decks
3%synergy
In Garruk's Wake
6.9%inclusion46 decks664 decks
3%synergy
Syphon Mind
6.8%inclusion45 decks664 decks
-6%synergy
Fell
6.2%inclusion31 decks503 decks
3%synergy
Torment of Hailfire
6.0%inclusion40 decks664 decks
-10%synergy
Praetor's Grasp
5.6%inclusion37 decks664 decks
2%synergy
Utility Artifacts
Blackblade Reforged
52%inclusion345 decks664 decks
49%synergy
Lightning Greaves
51%inclusion337 decks664 decks
17%synergy
Fireshrieker
46%inclusion304 decks664 decks
44%synergy
Contagion Clasp
42%inclusion281 decks664 decks
40%synergy
Whispersilk Cloak
40%inclusion267 decks664 decks
34%synergy
Contagion Engine
37%inclusion247 decks664 decks
35%synergy
Sword of Truth and Justice
36%inclusion242 decks664 decks
36%synergy
Commander's Plate
36%inclusion240 decks664 decks
30%synergy
Shadowspear
29%inclusion190 decks664 decks
25%synergy
The Darkness Crystal
23%inclusion40 decks176 decks
3%synergy
Leyline Axe
21%inclusion76 decks355 decks
20%synergy
Champion's Helm
21%inclusion140 decks664 decks
19%synergy
Hero's Blade
20%inclusion131 decks664 decks
19%synergy
Trailblazer's Boots
19%inclusion124 decks664 decks
16%synergy
Brotherhood Regalia
17%inclusion91 decks525 decks
15%synergy
Sword of the Animist
17%inclusion111 decks664 decks
13%synergy
Cranial Plating
16%inclusion103 decks664 decks
12%synergy
Mithril Coat
15%inclusion97 decks664 decks
9%synergy
Throne of Geth
14%inclusion94 decks664 decks
14%synergy
Pact Weapon
14%inclusion92 decks664 decks
12%synergy
Sword of Feast and Famine
14%inclusion91 decks664 decks
12%synergy
Wayfarer's Bauble
13%inclusion88 decks664 decks
-2%synergy
Expedition Map
13%inclusion88 decks664 decks
1%synergy
Genji Glove
13%inclusion22 decks169 decks
12%synergy
Grafted Exoskeleton
11%inclusion70 decks664 decks
9%synergy
Strata Scythe
10%inclusion68 decks664 decks
9%synergy
Inquisitor's Flail
10%inclusion68 decks664 decks
10%synergy
Sword of Vengeance
10%inclusion65 decks664 decks
9%synergy
Doc Ock's Tentacles
10%inclusion13 decks135 decks
9%synergy
Loxodon Warhammer
9.3%inclusion62 decks664 decks
8%synergy
Hammer of Nazahn
9.0%inclusion60 decks664 decks
8%synergy
Pip-Boy 3000
8.6%inclusion57 decks664 decks
8%synergy
Prowler's Helm
8.3%inclusion55 decks664 decks
7%synergy
Helm of the Host
8.1%inclusion54 decks664 decks
7%synergy
Basilisk Collar
8.0%inclusion53 decks664 decks
5%synergy
Darksteel Plate
7.8%inclusion52 decks664 decks
6%synergy
Grafted Wargear
7.7%inclusion51 decks664 decks
7%synergy
Sensei's Divining Top
7.5%inclusion50 decks664 decks
-1%synergy
Bontu's Monument
7.5%inclusion50 decks664 decks
-21%synergy
Vorpal Sword
7.4%inclusion49 decks664 decks
4%synergy
Sword of Wealth and Power
7.4%inclusion49 decks664 decks
7%synergy
Whip of Erebos
6.5%inclusion43 decks664 decks
-4%synergy
Buster Sword
6.4%inclusion11 decks173 decks
5%synergy
O-Naginata
6.2%inclusion41 decks664 decks
6%synergy
Sword of Fire and Ice
5.4%inclusion36 decks664 decks
5%synergy
Manifold Key
5.4%inclusion36 decks664 decks
4%synergy
Decimator Web
5.3%inclusion35 decks664 decks
5%synergy
Prosthetic Injector
5.1%inclusion34 decks664 decks
5%synergy
Black Mage's Rod
5.1%inclusion9 decks176 decks
4%synergy
Enchantments
Necrogen Communion
49%inclusion327 decks664 decks
47%synergy
Unspeakable Symbol
39%inclusion257 decks664 decks
38%synergy
Kaya's Ghostform
30%inclusion197 decks664 decks
20%synergy
Black Market Connections
22%inclusion148 decks664 decks
-1%synergy
Bad Moon
21%inclusion138 decks664 decks
17%synergy
Fungal Fortitude
18%inclusion121 decks664 decks
17%synergy
Phyresis
16%inclusion106 decks664 decks
14%synergy
No Mercy
15%inclusion102 decks664 decks
8%synergy
Relic Putrescence
14%inclusion95 decks664 decks
14%synergy
Endless Scream
14%inclusion91 decks664 decks
13%synergy
Dauthi Embrace
11%inclusion73 decks664 decks
9%synergy
Shade's Form
10%inclusion68 decks664 decks
10%synergy
Snake Cult Initiation
8.1%inclusion54 decks664 decks
8%synergy
Animate Dead
7.4%inclusion49 decks664 decks
-10%synergy
Super State
7.0%inclusion11 decks157 decks
7%synergy
Glistening Oil
6.2%inclusion41 decks664 decks
5%synergy
Alien Symbiosis
5.9%inclusion8 decks135 decks
6%synergy
Black Market
5.7%inclusion38 decks664 decks
-15%synergy
The Meathook Massacre
5.6%inclusion37 decks664 decks
-12%synergy
Greed
5.3%inclusion35 decks664 decks
-2%synergy
Phyrexian Reclamation
5.3%inclusion35 decks664 decks
-5%synergy
Planeswalkers
Vraska, Betrayal's Sting
47%inclusion310 decks664 decks
44%synergy
Liliana of the Dark Realms
29%inclusion191 decks664 decks
15%synergy
Utility Lands
Rogue's Passage
67%inclusion444 decks664 decks
48%synergy
Cabal Coffers
62%inclusion411 decks664 decks
7%synergy
Bojuka Bog
48%inclusion321 decks664 decks
1%synergy
Urborg, Tomb of Yawgmoth
47%inclusion315 decks664 decks
10%synergy
Shizo, Death's Storehouse
44%inclusion295 decks664 decks
34%synergy
Inkmoth Nexus
41%inclusion272 decks664 decks
40%synergy
Cabal Stronghold
38%inclusion249 decks664 decks
3%synergy
Nykthos, Shrine to Nyx
25%inclusion163 decks664 decks
-5%synergy
The Black Gate
19%inclusion129 decks664 decks
16%synergy
Cathedral of War
19%inclusion126 decks664 decks
19%synergy
Castle Locthwain
17%inclusion112 decks664 decks
0%synergy
Command Beacon
16%inclusion107 decks664 decks
8%synergy
War Room
16%inclusion105 decks664 decks
-1%synergy
Reliquary Tower
15%inclusion97 decks664 decks
-16%synergy
Witch's Cottage
13%inclusion84 decks664 decks
-12%synergy
Urza's Saga
11%inclusion76 decks664 decks
3%synergy
Minas Morgul, Dark Fortress
11%inclusion74 decks664 decks
8%synergy
Mortuary Mire
10%inclusion68 decks664 decks
-3%synergy
Temple of the False God
9.3%inclusion62 decks664 decks
1%synergy
Lake of the Dead
9.0%inclusion60 decks664 decks
4%synergy
Strip Mine
8.4%inclusion56 decks664 decks
5%synergy
Takenuma, Abandoned Mire
8.0%inclusion53 decks664 decks
-8%synergy
Barren Moor
7.7%inclusion51 decks664 decks
-2%synergy
Maze of Ith
6.3%inclusion42 decks664 decks
3%synergy
Buried Ruin
5.9%inclusion39 decks664 decks
1%synergy
Vault of Whispers
5.6%inclusion37 decks664 decks
0%synergy
Phyrexian Tower
5.4%inclusion36 decks664 decks
-19%synergy
Thespian's Stage
5.4%inclusion36 decks664 decks
0%synergy
Spymaster's Vault
5.2%inclusion29 decks559 decks
-4%synergy
Mana Artifacts
Sol Ring
91%inclusion605 decks664 decks
5%synergy
Arcane Signet
65%inclusion433 decks664 decks
3%synergy
Glistening Sphere
45%inclusion297 decks664 decks
43%synergy
Mind Stone
33%inclusion219 decks664 decks
3%synergy
Charcoal Diamond
31%inclusion208 decks664 decks
9%synergy
Staff of Compleation
28%inclusion184 decks664 decks
26%synergy
Heraldic Banner
19%inclusion126 decks664 decks
13%synergy
Thought Vessel
17%inclusion111 decks664 decks
-10%synergy
The Soul Stone
17%inclusion25 decks150 decks
3%synergy
Caged Sun
16%inclusion106 decks664 decks
4%synergy
Fellwar Stone
15%inclusion102 decks664 decks
1%synergy
Lotus Petal
13%inclusion87 decks664 decks
6%synergy
Throne of Eldraine
11%inclusion73 decks664 decks
1%synergy
Commander's Sphere
11%inclusion70 decks664 decks
2%synergy
Mox Opal
10%inclusion69 decks664 decks
7%synergy
Everflowing Chalice
10%inclusion66 decks664 decks
4%synergy
Thran Dynamo
8.3%inclusion55 decks664 decks
2%synergy
Jeweled Lotus
7.4%inclusion49 decks664 decks
6%synergy
Worn Powerstone
6.5%inclusion43 decks664 decks
2%synergy
Mana Crypt
6.3%inclusion42 decks664 decks
5%synergy
Gilded Lotus
6.2%inclusion41 decks664 decks
1%synergy
Sceptre of Eternal Glory
6.0%inclusion40 decks664 decks
-3%synergy
Phyrexian Atlas
5.9%inclusion39 decks664 decks
5%synergy
Mox Diamond
5.4%inclusion36 decks664 decks
2%synergy
Extraplanar Lens
5.1%inclusion34 decks664 decks
0%synergy
Lands
Swamp
95%inclusion632 decks664 decks
0%synergy
Myriad Landscape
24%inclusion161 decks664 decks
-2%synergy
Malakir Rebirth
18%inclusion121 decks664 decks
-5%synergy
Cavern of Souls
16%inclusion108 decks664 decks
10%synergy
Mirrex
15%inclusion101 decks664 decks
15%synergy
Fell the Profane
14%inclusion79 decks559 decks
-5%synergy
Opal Palace
7.8%inclusion52 decks664 decks
7%synergy
Urza's Cave
7.8%inclusion46 decks590 decks
-1%synergy
The Seedcore
7.7%inclusion51 decks664 decks
8%synergy
Polluted Delta
5.7%inclusion38 decks664 decks
2%synergy
Bloodstained Mire
5.7%inclusion38 decks664 decks
2%synergy
Verdant Catacombs
5.6%inclusion37 decks664 decks
2%synergy
Snow-Covered Swamp
5.6%inclusion37 decks664 decks
-1%synergy
Command Tower
5.4%inclusion36 decks664 decks
0%synergy
Marsh Flats
5.3%inclusion35 decks664 decks
2%synergy
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