Skithiryx, the Blight Dragon (Commander) - Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #781
645decks
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Shredder's Technique
6.0%inclusion3 decks50 decks
3%synergy
Madame Null, Power Broker
5.9%inclusion4 decks68 decks
5%synergy
Splinter's Technique
4.4%inclusion3 decks68 decks
3%synergy
Ninja Teen
3.0%inclusion2 decks67 decks
2%synergy
Skateboard
2.1%inclusion1 decks48 decks
2%synergy
High Synergy Cards
Plague Stinger
80%inclusion517 decks645 decks
79%synergy
Plague Myr
78%inclusion503 decks645 decks
77%synergy
Ichor Rats
78%inclusion503 decks645 decks
75%synergy
Hand of the Praetors
76%inclusion487 decks645 decks
75%synergy
Infectious Inquiry
75%inclusion486 decks645 decks
73%synergy
Vraska's Fall
71%inclusion455 decks645 decks
67%synergy
Whispering Specter
67%inclusion429 decks645 decks
66%synergy
Karn's Bastion
69%inclusion448 decks645 decks
65%synergy
Phyrexian Crusader
65%inclusion417 decks645 decks
64%synergy
Drown in Ichor
66%inclusion428 decks645 decks
62%synergy
Top Cards
Dark Ritual
78%inclusion503 decks645 decks
11%synergy
Jet Medallion
64%inclusion413 decks645 decks
3%synergy
Lashwrithe
64%inclusion410 decks645 decks
60%synergy
Swiftfoot Boots
63%inclusion406 decks645 decks
31%synergy
Blightbelly Rat
62%inclusion399 decks645 decks
58%synergy
Crypt Ghast
62%inclusion397 decks645 decks
14%synergy
Phyresis Outbreak
61%inclusion393 decks645 decks
59%synergy
Phyrexian Arena
60%inclusion385 decks645 decks
20%synergy
Sign in Blood
56%inclusion363 decks645 decks
21%synergy
Nightmare Lash
55%inclusion357 decks645 decks
53%synergy
Game Changers
Demonic Tutor
40%inclusion261 decks645 decks
13%synergy
Vampiric Tutor
31%inclusion199 decks645 decks
10%synergy
Necropotence
22%inclusion139 decks645 decks
7%synergy
Ancient Tomb
20%inclusion129 decks645 decks
8%synergy
Bolas's Citadel
16%inclusion102 decks645 decks
-13%synergy
Mana Vault
14%inclusion93 decks645 decks
8%synergy
Opposition Agent
12%inclusion77 decks645 decks
2%synergy
Chrome Mox
10%inclusion67 decks645 decks
4%synergy
The One Ring
10%inclusion65 decks645 decks
1%synergy
Imperial Seal
9.3%inclusion60 decks645 decks
2%synergy
Creatures
Reaper of Sheoldred
54%inclusion347 decks645 decks
53%synergy
Ichorclaw Myr
45%inclusion293 decks645 decks
45%synergy
Flensermite
45%inclusion292 decks645 decks
45%synergy
Core Prowler
43%inclusion279 decks645 decks
43%synergy
Bilious Skulldweller
43%inclusion279 decks645 decks
42%synergy
Corpse Cur
42%inclusion270 decks645 decks
41%synergy
Pestilent Syphoner
38%inclusion242 decks645 decks
37%synergy
Flesh-Eater Imp
37%inclusion239 decks645 decks
36%synergy
Septic Rats
35%inclusion228 decks645 decks
33%synergy
Phyrexian Obliterator
34%inclusion221 decks645 decks
23%synergy
K'rrik, Son of Yawgmoth
31%inclusion203 decks645 decks
13%synergy
Necropede
28%inclusion182 decks645 decks
28%synergy
Myr Convert
26%inclusion165 decks645 decks
25%synergy
Yawgmoth, Thran Physician
24%inclusion154 decks645 decks
14%synergy
Blightsteel Colossus
23%inclusion147 decks645 decks
22%synergy
Gray Merchant of Asphodel
21%inclusion137 decks645 decks
-30%synergy
Contagious Nim
21%inclusion136 decks645 decks
21%synergy
Solemn Simulacrum
21%inclusion133 decks645 decks
-2%synergy
Leaden Myr
21%inclusion133 decks645 decks
15%synergy
Gulping Scraptrap
19%inclusion124 decks645 decks
19%synergy
Blackcleave Goblin
18%inclusion117 decks645 decks
18%synergy
Phyrexian Juggernaut
16%inclusion101 decks645 decks
15%synergy
Magus of the Coffers
14%inclusion93 decks645 decks
8%synergy
Defiler of Flesh
14%inclusion91 decks645 decks
10%synergy
Massacre Girl, Known Killer
14%inclusion88 decks645 decks
10%synergy
Necroskitter
13%inclusion85 decks645 decks
10%synergy
Dauthi Voidwalker
13%inclusion85 decks645 decks
-2%synergy
Phyrexian Vatmother
13%inclusion84 decks645 decks
13%synergy
Dread Presence
13%inclusion82 decks645 decks
-2%synergy
Toxic Nim
13%inclusion82 decks645 decks
13%synergy
Sheoldred, Whispering One
12%inclusion78 decks645 decks
0%synergy
Sheoldred's Headcleaver
12%inclusion76 decks645 decks
12%synergy
Filth
12%inclusion75 decks645 decks
9%synergy
Grafted Butcher
11%inclusion71 decks645 decks
11%synergy
Dark Confidant
10%inclusion64 decks645 decks
3%synergy
Silent Arbiter
10%inclusion62 decks645 decks
8%synergy
Nirkana Revenant
9.3%inclusion60 decks645 decks
-2%synergy
Phyrexian Digester
9.1%inclusion59 decks645 decks
9%synergy
Burnished Hart
8.8%inclusion57 decks645 decks
1%synergy
Sheoldred, the Apocalypse
8.7%inclusion56 decks645 decks
-6%synergy
Vector Asp
8.4%inclusion54 decks645 decks
8%synergy
Nimraiser Paladin
7.8%inclusion50 decks645 decks
8%synergy
Maha, Its Feathers Night
7.6%inclusion39 decks512 decks
3%synergy
Massacre Wurm
7.6%inclusion49 decks645 decks
-9%synergy
Surge Conductor
7.3%inclusion12 decks165 decks
7%synergy
Brass Squire
7.1%inclusion46 decks645 decks
7%synergy
Gwenom, Remorseless
7.0%inclusion11 decks157 decks
3%synergy
Swamp Mosquito
7.0%inclusion45 decks645 decks
7%synergy
Orcish Bowmasters
7.0%inclusion45 decks645 decks
-6%synergy
Scourge Servant
6.8%inclusion44 decks645 decks
7%synergy
Instants
Howl from Beyond
50%inclusion324 decks645 decks
49%synergy
Whisper of the Dross
47%inclusion305 decks645 decks
44%synergy
Defile
45%inclusion291 decks645 decks
8%synergy
Go for the Throat
40%inclusion261 decks645 decks
17%synergy
Grim Affliction
38%inclusion242 decks645 decks
36%synergy
Tainted Strike
38%inclusion242 decks645 decks
34%synergy
Infernal Grasp
32%inclusion208 decks645 decks
7%synergy
Deadly Rollick
31%inclusion202 decks645 decks
7%synergy
Withering Torment
29%inclusion127 decks436 decks
-2%synergy
Cabal Ritual
28%inclusion178 decks645 decks
9%synergy
Dismember
28%inclusion178 decks645 decks
17%synergy
Imp's Mischief
27%inclusion177 decks645 decks
3%synergy
Sugar Rush
23%inclusion151 decks645 decks
23%synergy
Supernatural Stamina
21%inclusion133 decks645 decks
13%synergy
Hatred
20%inclusion127 decks645 decks
19%synergy
Astarion's Thirst
19%inclusion121 decks645 decks
17%synergy
Malakir Rebirth
19%inclusion120 decks645 decks
-4%synergy
Virulent Wound
18%inclusion118 decks645 decks
18%synergy
Consuming Corruption
18%inclusion102 decks562 decks
3%synergy
Sudden Spoiling
18%inclusion114 decks645 decks
9%synergy
Snuff Out
17%inclusion111 decks645 decks
4%synergy
Hero's Downfall
16%inclusion104 decks645 decks
9%synergy
Doom Blade
15%inclusion95 decks645 decks
7%synergy
Archenemy's Charm
14%inclusion23 decks165 decks
5%synergy
Fell the Profane
14%inclusion79 decks568 decks
-5%synergy
Force of Despair
13%inclusion82 decks645 decks
5%synergy
Unlikely Aid
13%inclusion81 decks645 decks
12%synergy
Anoint with Affliction
12%inclusion80 decks645 decks
12%synergy
Murder
12%inclusion79 decks645 decks
2%synergy
Baleful Mastery
11%inclusion73 decks645 decks
3%synergy
Darkness
10%inclusion67 decks645 decks
0%synergy
Withering Boon
10%inclusion64 decks645 decks
5%synergy
Sheoldred's Edict
10%inclusion63 decks645 decks
-5%synergy
Undying Malice
9.0%inclusion58 decks645 decks
-1%synergy
Culling the Weak
7.8%inclusion50 decks645 decks
-8%synergy
Bitter Triumph
7.8%inclusion50 decks645 decks
-2%synergy
Tragic Slip
7.4%inclusion48 decks645 decks
-13%synergy
Cut Down
7.3%inclusion47 decks645 decks
3%synergy
Rush of Vitality
7.3%inclusion47 decks645 decks
7%synergy
Not Dead After All
6.8%inclusion44 decks645 decks
-4%synergy
Undying Evil
6.7%inclusion43 decks645 decks
3%synergy
Soul Shatter
6.5%inclusion42 decks645 decks
-5%synergy
Unnatural Endurance
6.4%inclusion41 decks645 decks
6%synergy
Slaughter Pact
5.3%inclusion34 decks645 decks
3%synergy
Sorceries
Feed the Swarm
54%inclusion348 decks645 decks
3%synergy
Night's Whisper
48%inclusion307 decks645 decks
23%synergy
Crux of Fate
42%inclusion271 decks645 decks
41%synergy
Toxic Deluge
40%inclusion255 decks645 decks
3%synergy
Caress of Phyrexia
38%inclusion244 decks645 decks
37%synergy
Read the Bones
32%inclusion206 decks645 decks
15%synergy
Bubbling Muck
31%inclusion201 decks645 decks
16%synergy
Damnation
27%inclusion176 decks645 decks
7%synergy
Vat Emergence
26%inclusion165 decks645 decks
24%synergy
Reanimate
25%inclusion160 decks645 decks
-15%synergy
Diabolic Tutor
21%inclusion137 decks645 decks
7%synergy
Spread the Sickness
19%inclusion121 decks645 decks
18%synergy
Mutilate
18%inclusion115 decks645 decks
0%synergy
Insatiable Avarice
18%inclusion114 decks645 decks
6%synergy
Grim Tutor
16%inclusion106 decks645 decks
5%synergy
Exsanguinate
13%inclusion82 decks645 decks
-12%synergy
Blasphemous Edict
12%inclusion44 decks362 decks
-5%synergy
Black Sun's Zenith
12%inclusion76 decks645 decks
6%synergy
Geth's Summons
12%inclusion76 decks645 decks
11%synergy
Feed the Infection
9.3%inclusion60 decks645 decks
9%synergy
Beseech the Queen
7.6%inclusion49 decks645 decks
2%synergy
Profane Tutor
7.1%inclusion46 decks645 decks
3%synergy
In Garruk's Wake
6.5%inclusion42 decks645 decks
2%synergy
Syphon Mind
6.4%inclusion41 decks645 decks
-6%synergy
Fell
6.1%inclusion31 decks512 decks
2%synergy
Torment of Hailfire
5.7%inclusion37 decks645 decks
-10%synergy
Praetor's Grasp
5.4%inclusion35 decks645 decks
2%synergy
Utility Artifacts
Blackblade Reforged
52%inclusion338 decks645 decks
50%synergy
Lightning Greaves
51%inclusion328 decks645 decks
17%synergy
Fireshrieker
45%inclusion292 decks645 decks
43%synergy
Contagion Clasp
43%inclusion278 decks645 decks
41%synergy
Whispersilk Cloak
40%inclusion260 decks645 decks
34%synergy
Contagion Engine
38%inclusion242 decks645 decks
36%synergy
Sword of Truth and Justice
37%inclusion236 decks645 decks
36%synergy
Commander's Plate
35%inclusion228 decks645 decks
30%synergy
Shadowspear
28%inclusion178 decks645 decks
24%synergy
The Darkness Crystal
22%inclusion41 decks185 decks
2%synergy
Champion's Helm
21%inclusion138 decks645 decks
19%synergy
Leyline Axe
21%inclusion76 decks364 decks
20%synergy
Hero's Blade
20%inclusion128 decks645 decks
19%synergy
Trailblazer's Boots
19%inclusion125 decks645 decks
17%synergy
Sword of the Animist
18%inclusion113 decks645 decks
14%synergy
Brotherhood Regalia
17%inclusion92 decks534 decks
15%synergy
Throne of Geth
14%inclusion93 decks645 decks
14%synergy
Cranial Plating
14%inclusion93 decks645 decks
11%synergy
Mithril Coat
14%inclusion91 decks645 decks
9%synergy
Sword of Feast and Famine
14%inclusion88 decks645 decks
12%synergy
Wayfarer's Bauble
13%inclusion86 decks645 decks
-2%synergy
Expedition Map
13%inclusion86 decks645 decks
1%synergy
Pact Weapon
13%inclusion84 decks645 decks
11%synergy
Genji Glove
13%inclusion23 decks178 decks
12%synergy
Grafted Exoskeleton
11%inclusion69 decks645 decks
10%synergy
Strata Scythe
10%inclusion66 decks645 decks
9%synergy
Inquisitor's Flail
10%inclusion66 decks645 decks
10%synergy
Loxodon Warhammer
10%inclusion62 decks645 decks
8%synergy
Sword of Vengeance
9.3%inclusion60 decks645 decks
8%synergy
Hammer of Nazahn
9.1%inclusion59 decks645 decks
8%synergy
Doc Ock's Tentacles
9.0%inclusion13 decks145 decks
9%synergy
Pip-Boy 3000
8.7%inclusion56 decks645 decks
8%synergy
Helm of the Host
8.5%inclusion55 decks645 decks
7%synergy
Darksteel Plate
8.4%inclusion54 decks645 decks
6%synergy
Prowler's Helm
8.2%inclusion53 decks645 decks
7%synergy
Basilisk Collar
8.2%inclusion53 decks645 decks
5%synergy
Bontu's Monument
7.9%inclusion51 decks645 decks
-20%synergy
Grafted Wargear
7.8%inclusion50 decks645 decks
8%synergy
Sword of Wealth and Power
7.4%inclusion48 decks645 decks
7%synergy
Vorpal Sword
7.1%inclusion46 decks645 decks
3%synergy
Sensei's Divining Top
7.0%inclusion45 decks645 decks
-1%synergy
Whip of Erebos
6.4%inclusion41 decks645 decks
-4%synergy
O-Naginata
6.4%inclusion41 decks645 decks
6%synergy
Buster Sword
5.5%inclusion10 decks182 decks
5%synergy
Sword of Fire and Ice
5.4%inclusion35 decks645 decks
5%synergy
Manifold Key
5.4%inclusion35 decks645 decks
4%synergy
Decimator Web
5.3%inclusion34 decks645 decks
5%synergy
Prosthetic Injector
5.1%inclusion33 decks645 decks
5%synergy
Enchantments
Necrogen Communion
49%inclusion316 decks645 decks
47%synergy
Unspeakable Symbol
38%inclusion246 decks645 decks
37%synergy
Kaya's Ghostform
30%inclusion195 decks645 decks
20%synergy
Black Market Connections
22%inclusion142 decks645 decks
-2%synergy
Bad Moon
21%inclusion137 decks645 decks
18%synergy
Fungal Fortitude
19%inclusion121 decks645 decks
17%synergy
Phyresis
16%inclusion103 decks645 decks
14%synergy
No Mercy
15%inclusion98 decks645 decks
8%synergy
Relic Putrescence
14%inclusion89 decks645 decks
14%synergy
Endless Scream
14%inclusion88 decks645 decks
13%synergy
Dauthi Embrace
11%inclusion73 decks645 decks
10%synergy
Shade's Form
10%inclusion64 decks645 decks
9%synergy
Snake Cult Initiation
8.5%inclusion55 decks645 decks
8%synergy
Animate Dead
7.3%inclusion47 decks645 decks
-10%synergy
Super State
7.2%inclusion12 decks167 decks
7%synergy
Glistening Oil
6.2%inclusion40 decks645 decks
5%synergy
Black Market
5.9%inclusion38 decks645 decks
-15%synergy
Greed
5.6%inclusion36 decks645 decks
-1%synergy
Alien Symbiosis
5.5%inclusion8 decks145 decks
5%synergy
Phyrexian Reclamation
5.4%inclusion35 decks645 decks
-5%synergy
The Meathook Massacre
5.1%inclusion33 decks645 decks
-12%synergy
Mornsong Aria
5.0%inclusion4 decks80 decks
3%synergy
Planeswalkers
Vraska, Betrayal's Sting
46%inclusion299 decks645 decks
44%synergy
Liliana of the Dark Realms
30%inclusion191 decks645 decks
16%synergy
Utility Lands
Rogue's Passage
66%inclusion427 decks645 decks
47%synergy
Cabal Coffers
61%inclusion396 decks645 decks
7%synergy
Bojuka Bog
48%inclusion311 decks645 decks
1%synergy
Urborg, Tomb of Yawgmoth
46%inclusion297 decks645 decks
9%synergy
Shizo, Death's Storehouse
44%inclusion284 decks645 decks
34%synergy
Inkmoth Nexus
40%inclusion261 decks645 decks
39%synergy
Cabal Stronghold
38%inclusion248 decks645 decks
4%synergy
Nykthos, Shrine to Nyx
25%inclusion159 decks645 decks
-5%synergy
Cathedral of War
19%inclusion123 decks645 decks
19%synergy
The Black Gate
19%inclusion121 decks645 decks
15%synergy
Castle Locthwain
17%inclusion112 decks645 decks
0%synergy
Command Beacon
16%inclusion105 decks645 decks
8%synergy
War Room
16%inclusion102 decks645 decks
0%synergy
Reliquary Tower
15%inclusion96 decks645 decks
-16%synergy
Witch's Cottage
13%inclusion84 decks645 decks
-12%synergy
Urza's Saga
11%inclusion71 decks645 decks
3%synergy
Minas Morgul, Dark Fortress
11%inclusion69 decks645 decks
8%synergy
Mortuary Mire
11%inclusion68 decks645 decks
-3%synergy
Temple of the False God
9.1%inclusion59 decks645 decks
1%synergy
Lake of the Dead
8.5%inclusion55 decks645 decks
3%synergy
Takenuma, Abandoned Mire
7.8%inclusion50 decks645 decks
-8%synergy
Strip Mine
7.6%inclusion49 decks645 decks
5%synergy
Barren Moor
7.3%inclusion47 decks645 decks
-3%synergy
Maze of Ith
6.2%inclusion40 decks645 decks
3%synergy
Buried Ruin
5.9%inclusion38 decks645 decks
1%synergy
Vault of Whispers
5.6%inclusion36 decks645 decks
0%synergy
Phyrexian Tower
5.6%inclusion36 decks645 decks
-19%synergy
Thespian's Stage
5.4%inclusion35 decks645 decks
0%synergy
Spymaster's Vault
5.1%inclusion29 decks568 decks
-4%synergy
Mana Artifacts
Sol Ring
91%inclusion584 decks645 decks
5%synergy
Arcane Signet
65%inclusion421 decks645 decks
3%synergy
Glistening Sphere
45%inclusion290 decks645 decks
44%synergy
Mind Stone
33%inclusion215 decks645 decks
4%synergy
Charcoal Diamond
33%inclusion210 decks645 decks
10%synergy
Staff of Compleation
28%inclusion180 decks645 decks
26%synergy
Heraldic Banner
19%inclusion122 decks645 decks
13%synergy
Thought Vessel
17%inclusion107 decks645 decks
-9%synergy
Caged Sun
16%inclusion104 decks645 decks
5%synergy
Fellwar Stone
16%inclusion100 decks645 decks
1%synergy
The Soul Stone
15%inclusion24 decks160 decks
1%synergy
Lotus Petal
13%inclusion83 decks645 decks
5%synergy
Commander's Sphere
10%inclusion67 decks645 decks
2%synergy
Throne of Eldraine
10%inclusion66 decks645 decks
0%synergy
Everflowing Chalice
10%inclusion64 decks645 decks
4%synergy
Mox Opal
10%inclusion62 decks645 decks
6%synergy
Thran Dynamo
8.2%inclusion53 decks645 decks
2%synergy
Worn Powerstone
6.5%inclusion42 decks645 decks
2%synergy
Jeweled Lotus
6.4%inclusion41 decks645 decks
5%synergy
Gilded Lotus
6.0%inclusion39 decks645 decks
1%synergy
Phyrexian Atlas
5.7%inclusion37 decks645 decks
5%synergy
Sceptre of Eternal Glory
5.7%inclusion37 decks645 decks
-3%synergy
Mana Crypt
5.3%inclusion34 decks645 decks
4%synergy
Extraplanar Lens
5.3%inclusion34 decks645 decks
0%synergy
Lands
Swamp
95%inclusion613 decks645 decks
0%synergy
Myriad Landscape
25%inclusion160 decks645 decks
-1%synergy
Malakir Rebirth
19%inclusion120 decks645 decks
-4%synergy
Mirrex
16%inclusion103 decks645 decks
15%synergy
Cavern of Souls
16%inclusion100 decks645 decks
9%synergy
Fell the Profane
14%inclusion79 decks568 decks
-5%synergy
Opal Palace
8.1%inclusion52 decks645 decks
7%synergy
The Seedcore
7.9%inclusion51 decks645 decks
8%synergy
Urza's Cave
7.5%inclusion45 decks599 decks
-1%synergy
Polluted Delta
5.7%inclusion37 decks645 decks
2%synergy
Bloodstained Mire
5.7%inclusion37 decks645 decks
2%synergy
Verdant Catacombs
5.6%inclusion36 decks645 decks
2%synergy
Snow-Covered Swamp
5.4%inclusion35 decks645 decks
-1%synergy
Command Tower
5.3%inclusion34 decks645 decks
0%synergy
Marsh Flats
5.3%inclusion34 decks645 decks
2%synergy
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